Biochemistry Of Drug Resistance

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Biochemistry of Drug Resistance

Author : Sarfraz Ahmed
Publisher : Springer Nature
ISBN 13 : 303076320X
Total Pages : 559 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Biochemistry of Drug Resistance by : Sarfraz Ahmed

Download or read book Biochemistry of Drug Resistance written by Sarfraz Ahmed and published by Springer Nature. This book was released on 2021-08-05 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included.

Biochemistry and Molecular Biology of Antimicrobial Drug Action

Author : T. J. Franklin
Publisher : Springer Science & Business Media
ISBN 13 : 1475745990
Total Pages : 173 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biochemistry and Molecular Biology of Antimicrobial Drug Action by : T. J. Franklin

Download or read book Biochemistry and Molecular Biology of Antimicrobial Drug Action written by T. J. Franklin and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Biochemistry and Molecular Biology of Antimicrobial Drug Action

Author : Trevor J. Franklin
Publisher : Springer Science & Business Media
ISBN 13 : 0387275665
Total Pages : 188 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Biochemistry and Molecular Biology of Antimicrobial Drug Action by : Trevor J. Franklin

Download or read book Biochemistry and Molecular Biology of Antimicrobial Drug Action written by Trevor J. Franklin and published by Springer Science & Business Media. This book was released on 2006-10-31 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Biochemistry of Antimicrobial Action

Author : Trevor John Franklin
Publisher : Springer
ISBN 13 : 148993412X
Total Pages : 235 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Biochemistry of Antimicrobial Action by : Trevor John Franklin

Download or read book Biochemistry of Antimicrobial Action written by Trevor John Franklin and published by Springer. This book was released on 2013-11-11 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical processes. The literature in this field is so extensive however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lecture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicrobial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in biochemistry. Our aim has been to present the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Chemistry of Antibiotics and Related Drugs

Author : Mrinal K. Bhattacharjee
Publisher : Springer Nature
ISBN 13 : 303107582X
Total Pages : 276 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Chemistry of Antibiotics and Related Drugs by : Mrinal K. Bhattacharjee

Download or read book Chemistry of Antibiotics and Related Drugs written by Mrinal K. Bhattacharjee and published by Springer Nature. This book was released on 2022-08-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Drug Resistance in Bacteria

Author : Susumu Mitsuhashi
Publisher : Thieme Medical Publishers
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Resistance in Bacteria by : Susumu Mitsuhashi

Download or read book Drug Resistance in Bacteria written by Susumu Mitsuhashi and published by Thieme Medical Publishers. This book was released on 1982 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antibiotic Drug Resistance

Author : José-Luis Capelo-Martínez
Publisher : John Wiley & Sons
ISBN 13 : 1119282527
Total Pages : 730 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Antibiotic Drug Resistance by : José-Luis Capelo-Martínez

Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer

Author : Gunjan Arora
Publisher : Springer
ISBN 13 : 3319486837
Total Pages : 630 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Drug Resistance in Bacteria, Fungi, Malaria, and Cancer by : Gunjan Arora

Download or read book Drug Resistance in Bacteria, Fungi, Malaria, and Cancer written by Gunjan Arora and published by Springer. This book was released on 2017-03-21 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Aminoglycoside Antibiotics

Author : Dev P. Arya
Publisher : John Wiley & Sons
ISBN 13 : 047174302X
Total Pages : 338 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Aminoglycoside Antibiotics by : Dev P. Arya

Download or read book Aminoglycoside Antibiotics written by Dev P. Arya and published by John Wiley & Sons. This book was released on 2007-06-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.

Drug Resistance and Selectivity: Biochemical and Cellular Basis

Author : Enrico Mihich
Publisher :
ISBN 13 :
Total Pages : 552 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Resistance and Selectivity: Biochemical and Cellular Basis by : Enrico Mihich

Download or read book Drug Resistance and Selectivity: Biochemical and Cellular Basis written by Enrico Mihich and published by . This book was released on 1973 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biochemistry of Antimicrobial Action

Author : T. J. Franklin
Publisher : Springer
ISBN 13 : 9789401068574
Total Pages : 216 pages
Book Rating : 4.0/5 (685 download)

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Book Synopsis Biochemistry of Antimicrobial Action by : T. J. Franklin

Download or read book Biochemistry of Antimicrobial Action written by T. J. Franklin and published by Springer. This book was released on 2011-11-03 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division. The use of antimicrobial agents as highly specific inhibitors has in turn substantially assisted the investigation of complex biochemical pro cesses. The literature in Ihis field is so extensive however, that we considered an attempt should be made to draw together in an introductory book the more significant studies of recent years. This book, which is in fact based on lec ture courses given by us to undergraduates at Liverpool and Manchester Universities, is therefore intended as an introduction 'to the biochemistry of antimicrobial action for advanced students in many disciplines. We hope that it may also be useful to established scientists who are new to this area of research. The book is concerned with a discussion of medically important antimicro bial compounds and also a number of agents that, although having no medical uses, have proved invaluable as research tools in biochemistry. Our aim has been to esent pr the available information in a simple and readable way, emphasizing the established facts rather than more controversial material. Whenever possible, however, we have indicated the gaps in the present knowledge of the subject where further information is required.

Handbook of Antimicrobial Resistance

Author : Matthias Gotte
Publisher : Springer
ISBN 13 : 9781493906932
Total Pages : 0 pages
Book Rating : 4.9/5 (69 download)

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Book Synopsis Handbook of Antimicrobial Resistance by : Matthias Gotte

Download or read book Handbook of Antimicrobial Resistance written by Matthias Gotte and published by Springer. This book was released on 2018-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Comparative Biochemistry of Parasitic Helminths

Author : Eva Bennett
Publisher : Springer Science & Business Media
ISBN 13 : 9400908334
Total Pages : 183 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Comparative Biochemistry of Parasitic Helminths by : Eva Bennett

Download or read book Comparative Biochemistry of Parasitic Helminths written by Eva Bennett and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Professor John Sprent first suggested, in 1982, that the Australian Society for Parasitology should bid for the opportunity to mount the Sixth International Congress of Parasitology, the immediate reaction was one of disbelief. However, in the two years or so before ICOPA 5, in Toronto, he used his considerable powers to the utmost and spent himself unstintingly in persuading Australian parasitologists to put together a bid. The Society inevitably agreed, for it is difficult to prevent such a determined and eminent man from getting his own way! A case for an Australian venue was prepared and, as President, I was charged with the task of convincing the delegates in Toronto that Australia was worth going all the way to see. The events of that meeting are now far in the past; suffice to say that, in the end, Australia won by the narrowest of margins, largely due to the energy of my inventive colleagues who put the case for Australia at every possible and improbable moment. I do not remember a great deal about the scientific aspects of ICOPA 5. I was far too preoccupied with an awful spectre, that of telling John Sprent that I had failed, to pay attention to much other than lobbying for votes. I do remember, however, telling myself how much I would enjoy the next ICOPA without the terrible responsibility of capturing ICOPA 7.

Origins of Resistance to Toxic Agents

Author : M Sevag
Publisher : Academic Press
ISBN 13 : 0323148328
Total Pages : 489 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Origins of Resistance to Toxic Agents by : M Sevag

Download or read book Origins of Resistance to Toxic Agents written by M Sevag and published by Academic Press. This book was released on 2012-12-02 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on March 25-27, 1954. Contributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other processes. This text is organized into five sections encompassing 25 chapters and begins with an overview of the evolutionary aspects of resistance to antibacterial agents, herbicides, and insecticides. The book then discusses spontaneous and induced mutations to drug resistance in Escherichia coli, along with the mechanism of drug resistance in protozoa and bacteria, the physiological aspects of insect resistance to insecticides, and the enzymatic detoxication of DDT. The next chapters focus on the origins of tolerance and addiction to drugs and the problem of alcoholism; biochemical effects of narcotics and alcohol administration; tolerance and physical dependence to narcotics; and resistance and dependence in cancer cells. The book concludes by analyzing the significance of protein configuration to the specificity of biological interaction. This book is a valuable source of information for physicians, biochemists, pharmacologists, entomologists, plant physiologists, students of cancer, and those who are interested in the theory of the evolution of living matter.

Resolving the Antibiotic Paradox

Author : Barry P. Rosen
Publisher : Springer Science & Business Media
ISBN 13 : 1461548977
Total Pages : 295 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Resolving the Antibiotic Paradox by : Barry P. Rosen

Download or read book Resolving the Antibiotic Paradox written by Barry P. Rosen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic resistance, once a term appreciated only by microbiologists, has become a common topic in the popular press. Stuart Levy, one of the contributors to this collection, bears some of the responsibility for increasing public awareness with the publication of his book "The Antibiotic Paradox" in 1992: Misuse of antibiotics resulting in increased bacterial resistance had previously been recognized in the infectious disease community. However, Dr. Levy's eloquent public warning about the shrinking efficacy of our antibi otic armamentarium served to alert the lay person to the potential consequences of this de mise in useful therapy. Because of the proliferation of diverse antibiotic classes with increasing potency and broader activity spectra, it had been assumed that any ordinary bacterial infection could be eradicated with the proper selection of drug. However, it has become evident that we are surrounded by resistant bacteria, many of which were introduced unwittingly into our en vironment through the unnecessary use of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist ent ear infections or non-responsive bronchitis, questions were raised about the antibiotic treatments that were being prescribed. Bacteria resistant to common antibiotic regimens were being isolated more frequently, often as organisms classified as "multi-resistant" with decreased susceptibilities to two or more structural classes of agents. Nosocomial spread of these resistances was aided by the transmission of plasmid-mediated resistance factors between species.

The Quinolones

Author : Vincent T. Andriole
Publisher : Elsevier
ISBN 13 : 0080525784
Total Pages : 540 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Quinolones by : Vincent T. Andriole

Download or read book The Quinolones written by Vincent T. Andriole and published by Elsevier. This book was released on 2000-10-09 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual struggle to conquer disease. Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research. Edited by one of the world's foremost authorities on the subject, the third edition of this highly successful title will serve as a valuable tool for primary care physicians and researchers interested in a comprehensive, up-to-date reference on the chemistry, mechanisms of action, development of resistance, and clinical efficacy of both currently available and newer quinolone compounds under investigation. This is the eagerly anticipated fully revised edition of the standard reference in the field. Eagerly anticipated updated edition of noted title covering synthetic microbial agents that are useful against infectious disease, particularly those caused by bacteria Edited by one of the foremost experts in the field of quinolone research and infectious disease History of quinolones, chemistry & mechanisms of action, pharmacology, safety aspects Role of quinolones in treating various types of infections, including respiratory infections, gastrointestinal infections, urinary tract infections, prostatitis, STDs and bacterial meningitis as well as their use in immunocompromised patients