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Author : Robin L. Shepard
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.:/5 (89 download)
Download or read book Beyond Superficial Targeting written by Robin L. Shepard and published by . This book was released on 1993 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (121 download)
Download or read book Proceedings written by and published by . This book was released on 1997 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lara Scheherazade Milane
Publisher : CRC Press
ISBN 13 : 1000505936
Total Pages : 511 pages
Book Rating : 4.0/5 (5 download)
Download or read book Organelle and Molecular Targeting written by Lara Scheherazade Milane and published by CRC Press. This book was released on 2021-12-27 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.
Author : John Lewis
Publisher : Boost Template LLC
ISBN 13 :
Total Pages : 121 pages
Book Rating : 4./5 ( download)
Download or read book Digital Marketing Content Creation: Engaging Your Target Audience written by John Lewis and published by Boost Template LLC. This book was released on 2023-09-16 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unleash the Digital Marketing Revolution! Are you ready to revolutionize your digital marketing game? Dive into the world of digital marketing and discover the strategies, tactics, and techniques that will take your business to the next level. With 5.18 billion internet users and 4.8 billion social media users worldwide, the digital landscape offers unprecedented opportunities to connect with your target audience. But success requires more than just a flashy website. It demands a clear path and a focus on what truly matters. In this book, you'll explore the role of content in digital marketing – the lifeblood that fuels interactions between businesses and their audience. Learn how to create compelling content that engages, educates, and entertains, transcending traditional advertising boundaries to build genuine connections and trust. Discover the power of compelling content in driving engagement and conversions. Captivate attention, create emotional connections, encourage interaction, and provide real value to your audience. By showcasing your expertise, integrating persuasive calls to action, and amplifying your reach through organic sharing, you'll unlock the full potential of your digital marketing efforts. Don't miss out on the digital marketing revolution. Invest your time and resources in crafting high-quality, unique, and valuable content that resonates with your audience. Get ready to engage, captivate, and convert with compelling content. It's time to make a lasting impact in the digital world.
Author : Susan L. Ostermann
Publisher : Oxford University Press
ISBN 13 : 0197661130
Total Pages : 249 pages
Book Rating : 4.1/5 (976 download)
Download or read book Capacity beyond Coercion written by Susan L. Ostermann and published by Oxford University Press. This book was released on 2022-10-28 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: State capacity is often equated with coercion. However, history has shown that it is extremely difficult for states with weak capacity to ensure compliance with their laws. In Capacity beyond Coercion, Susan L. Ostermann examines the largely unexplored capacities that allow coercively weak states to promote law-following behavior. Utilizing extensive data collected in adjacent districts in India and Nepal, she demonstrates how coercively weak states can significantly increase compliance by behaving pragmatically and designing implementation strategies around known barriers to compliance. In particular, she examines variation in compliance with conservation, education, and child labor regulations, investigating the mechanisms by which the Indian and Nepali states have, despite limited enforcement capacity, secured compliance with regulations that run counter to customary norms and to the self-interest of target populations. She argues that one such barrier is imperfect legal knowledge and shows how states that have engaged in what she terms "regulatory pragmatism" may circumvent this compliance barrier. They do so by designing implementation strategies for on-the-ground realities. Exploring two such efforts--delegated enforcement and information dissemination through local leaders, Ostermann demonstrates that states that suffer from limited coercive capacity but behave pragmatically can still bring about large-scale compliance. Given that many states have weak enforcement capacity, the findings in Capacity beyond Coercion point a way forward for more effective and responsive governance throughout the developing world.
Author : Maie A. St. John
Publisher : Academic Press
ISBN 13 : 0128209291
Total Pages : 268 pages
Book Rating : 4.1/5 (282 download)
Download or read book Novel Therapies in Head and Neck Cancer: Beyond the Horizon written by Maie A. St. John and published by Academic Press. This book was released on 2020-06-29 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. - Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types - Discusses the application of immunotherapy to treat rare types of head and neck cancer - Presents updated information on targeted therapies, specifically focusing on skin cancer in the region
Author : Placido Neri
Publisher : Springer
ISBN 13 : 3319318675
Total Pages : 1053 pages
Book Rating : 4.3/5 (193 download)
Download or read book Calixarenes and Beyond written by Placido Neri and published by Springer. This book was released on 2016-08-12 with total page 1053 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributions featuring the chemistry and applications of a family of macrocyclic compounds collectively known as 'calixarenes' are presented in this edited volume. The arsenal of structures based on calixarenes provides tools which are effective in numerous areas of supramolecular chemistry. The Editors have compiled a timely volume which contains up to date, high calibre contributions from a large number of international authors. A broad perspective on the progress and future of calixarene chemistry is presented. Aimed at students and researchers active in Supramolecular Chemistry.
Author : J. Verweij
Publisher : Springer Science & Business Media
ISBN 13 : 1402078560
Total Pages : 185 pages
Book Rating : 4.4/5 (2 download)
Download or read book Targeting Treatment of Soft Tissue Sarcomas written by J. Verweij and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Discusses the latest drug treatments in the field - Gleevec arranged a bulk sale for this title - Written by leaders in the industry
Author : Peter R. Hoskins
Publisher : Cambridge University Press
ISBN 13 : 1139488902
Total Pages : pages
Book Rating : 4.1/5 (394 download)
Download or read book Diagnostic Ultrasound written by Peter R. Hoskins and published by Cambridge University Press. This book was released on 2010-06-17 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: All healthcare professionals practising ultrasound in a clinical setting should receive accredited training in the principles and practice of ultrasound scanning. This second edition of Diagnostic Ultrasound: Physics and Equipment provides a comprehensive introduction to the physics, technology and safety of ultrasound equipment, with high quality ultrasound images and diagrams throughout. It covers all aspects of the field at a level intended to meet the requirements of UK sonography courses. New to this edition: • Updated descriptions of ultrasound technology, quality assurance and safety. • Additional chapters dedicated to 3D ultrasound, contrast agents and elastography. • New glossary containing definitions of over 500 terms. The editors and contributing authors are all authorities in their areas, with contributions to the scientific and professional development of ultrasound at national and international level.
Author : Patricia Eifel
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496362454
Total Pages : 814 pages
Book Rating : 4.4/5 (963 download)
Download or read book Gynecologic Radiation Oncology: A Practical Guide written by Patricia Eifel and published by Lippincott Williams & Wilkins. This book was released on 2016-07-13 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering practical approaches to common clinical problems, Gynecologic Radiation Oncology: A Practical Guide compiles the extensive clinical experience of Drs. Patricia J. Eifel and Ann H. Klopp from MD Anderson Cancer Center into one user-friendly volume. This reference addresses practical aspects of the field: how to evaluate the role of radiation therapy in various clinical settings, how to explain the rationale for treatment recommendations to referring physicians and patients, when and how to apply various external beam and brachytherapy techniques to address specific clinical problems, and how to monitor and manage patients during and after treatment. The book focuses on the following items, which can have immediate application to the treatment of patients with gynecologic cancers.
Author : Jessica Lilian Bell
Publisher : Frontiers Media SA
ISBN 13 : 2889715876
Total Pages : 134 pages
Book Rating : 4.8/5 (897 download)
Download or read book Ubiquitin-modifying Enzymes as Drug Targets and Biomarkers in Cancer written by Jessica Lilian Bell and published by Frontiers Media SA. This book was released on 2021-11-03 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Weiye Li
Publisher : Elsevier Health Sciences
ISBN 13 : 0323930654
Total Pages : 324 pages
Book Rating : 4.3/5 (239 download)
Download or read book Therapeutic Targets of Diabetic Retinopathy written by Weiye Li and published by Elsevier Health Sciences. This book was released on 2023-01-12 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Targets of Diabetic Retinopathy: A Translational Approach offers a consolidated view of this complex disorder by summarizing the latest evidence-based studies and translating their findings into practical, actionable knowledge. This concise resource covers the fundamentals of diabetic retinopathy and diabetic macular edema with an emphasis on basic science and therapeutic targets on the horizon. Ophthalmologists, optometrists, and researchers will find the translational approach to this common eye disorder to be useful in both research and clinical practice settings. - Takes a concise yet comprehensive approach to diabetic eye disorders, covering basic science as well as therapeutic agents with both current and future clinical applications. - Covers current diagnostic and management guidelines as well developments on the horizon that are likely to improve patient outcomes. - Explains the pathophysiological mechanisms of diabetic retinopathy and diabetic macular edema from both a basic and clinical perspective, helping readers seek promising new therapeutic targets. - Consolidates today's available information on this timely topic into a single, convenient resource.
Author : Harold D. Stolovitch
Publisher : Association for Talent Development
ISBN 13 : 1607284588
Total Pages : 234 pages
Book Rating : 4.6/5 (72 download)
Download or read book Beyond Training Ain't Performance Fieldbook written by Harold D. Stolovitch and published by Association for Talent Development. This book was released on 2006-04-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential companion manual to Training Ain't Performance, the Beyond Training Ain't Performance Fieldbook is an HPI theory implementation guide. The included CD-ROM features worksheets, assessments, tools, and practical advice that will propel your organization toward the performance approach.
Author : Justyna Świdrak
Publisher : Frontiers Media SA
ISBN 13 : 2832555233
Total Pages : 163 pages
Book Rating : 4.8/5 (325 download)
Download or read book Beyond audiovisual: novel multisensory stimulation techniques and their applications written by Justyna Świdrak and published by Frontiers Media SA. This book was released on 2024-10-03 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immersive virtual reality technology has been developing extremely dynamically in the last decade. One of the reasons is the impressive progress in 3D graphics and the increasing accessibility of hardware with sufficient computational power to smoothly render high-quality 3D environments. Virtual reality overwhelms the user by replacing the physical world with a computer-generated 3D scenario. Its power lies in embodied, complex, and vivid scenarios rich in context and dynamic engagement of the sensorimotor system, which provokes more naturalistic behavioural and physiological responses than abstract stimuli. Congruent multisensory stimulation builds virtual experience and makes us forget about the real world. Strong presence and embodiment illusions can cause deep cognitive, affective, and behavioural changes, leading to enhanced learning, perspective-taking, and treatments. Some types of sensory input have received much more attention than others. This includes mainly visual and auditory cues, but also, to some extent, nociception and touch. However, the human sensory system is much richer and more complex and includes many other senses, such as smell, and taste, but also thermoception, interoception, equilibrioception, and others. Most VR experiences are built on rich audiovisual cues since these two modalities allow us to perceive the virtual world and interact with it. For example, touch, although extremely important, is often represented in a reductionist form, and other modalities, such as the sense of smell or thermoception, are completely ignored.
Author : Jeremy Price
Publisher : Cambridge University Press
ISBN 13 : 052113966X
Total Pages : 231 pages
Book Rating : 4.5/5 (211 download)
Download or read book Handbook of Breast MRI written by Jeremy Price and published by Cambridge University Press. This book was released on 2011-11-17 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to breast MRI providing core knowledge and clinical guidelines essential for any clinician involved in breast imaging.
Author : Rebecca Dolton
Publisher : Wryting Ltd
ISBN 13 : 1913871061
Total Pages : 125 pages
Book Rating : 4.9/5 (138 download)
Download or read book Beyond Persuasion written by Rebecca Dolton and published by Wryting Ltd. This book was released on 2020-08-16 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to master the art of manipulation to improve your career and work life and have more successful personal relationships. The word manipulation gets a bad rap, but what it’s really about is understanding human thought patterns and behaviors. Maybe you’re a manager having a hard time getting your team members to listen to you. Maybe you have a manipulator in your life and you want to learn new ways to deal with them or combat their manipulations. Perhaps you’re just curious about the concept and want to understand how humans can be manipulated. Whatever your purpose or need, Beyond Persuasion can open your eyes to the world of dark psychology. A human brain is a fascinating place, and this book will give you a unique view of what goes on inside it. By examining the concepts that make up dark psychology, you’ll begin to understand things like mind control, neuro-linguistic programming, body language, and more. If you’re concerned about the ethical implications of dark psychology, there’s even a section on how to use the techniques discussed responsibly. In addition, you’ll discover: How manipulation differs from persuasion and why that matters The basics of dark psychology These real-world applications of neuro-linguistic programming How to read body language Techniques to help you defend yourself from manipulative people Manipulation is part of human existence. It has always been around, and it always will be. What you can do is learn the techniques and tricks so that you can either use them effectively or protect yourself from others who would use them against you. The knowledge is in front of you. All you have to do is reach out and take it. If you’re ready to learn the art of manipulation and gain the power to influence others, click “add to cart.”
Author :
Publisher :
ISBN 13 :
Total Pages : 740 pages
Book Rating : 4.0/5 (57 download)
Download or read book Engineering written by and published by . This book was released on 1879 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
