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Beta Interferon And Glatiramer Acetate For The Treatment Of Multiple Sclerosis
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Author :National Institute for Clinical Excellence (Great Britain) Publisher : ISBN 13 :9781842571453 Total Pages :22 pages Book Rating :4.5/5 (714 download)
Book Synopsis Beta interferon and glatiramer acetate for the treatment of multiple sclerosis by : National Institute for Clinical Excellence (Great Britain)
Download or read book Beta interferon and glatiramer acetate for the treatment of multiple sclerosis written by National Institute for Clinical Excellence (Great Britain) and published by . This book was released on 2002 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Beta Interferon and Glatiramer Acetate for the Treatment of Multiple Sclerosis by : National Institute for Clinical Excellence
Download or read book Beta Interferon and Glatiramer Acetate for the Treatment of Multiple Sclerosis written by National Institute for Clinical Excellence and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Sclerosis by : Institute of Medicine
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Book Synopsis The Clinical Effectiveness and Cost-effectiveness of Interferon-beta and Glatiramer Acetate in the Management of Relapsing/remitting and Secondary-progressive Multiple Sclerosis by :
Download or read book The Clinical Effectiveness and Cost-effectiveness of Interferon-beta and Glatiramer Acetate in the Management of Relapsing/remitting and Secondary-progressive Multiple Sclerosis written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This report describes one of two studies undertaken to address a Congressional mandate to evaluate the cost-effectiveness of expanded drug coverage to Medicare under the Medicare Replacement Drug Demonstration. The demonstration aimed to improve beneficiary access to selected new oral anti-cancer drugs and other self-injected medications such as those used to treat multiple sclerosis (MS). Currently, treatment of MS using IFN beta-1a is covered under Medicare Part B when administered intra-muscularly by a physician. Until the new prescription drug benefit (Medicare Part D) began in 2006, subcutaneous injection of IFN beta-1a administered by the patient was not covered. The MRDD provided temporary national coverage to all self-administered treatments during the 16 months before Medicare Part D was implemented. Patient cost-sharing under the MRDD was structured to resemble Part D.
Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Book Synopsis Milestones in MS Therapy by : Yvette Zwick
Download or read book Milestones in MS Therapy written by Yvette Zwick and published by Schattauer Verlag. This book was released on 2003 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Sclerosis 2 by : W. Ian McDonald
Download or read book Multiple Sclerosis 2 written by W. Ian McDonald and published by Butterworth-Heinemann. This book was released on 2003 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This practical resource encompasses the newest essential information on multiple sclerosis-focusing on those areas where progress has been made in research, bringing about new concepts of patient management"--Back cover.
Book Synopsis Clinical Effectiveness and Cost-effectiveness of Beta-interferon and Glatiramer Acetate for Treating Multiple Sclerosis by :
Download or read book Clinical Effectiveness and Cost-effectiveness of Beta-interferon and Glatiramer Acetate for Treating Multiple Sclerosis written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Class Review by : Marian S. McDonagh
Download or read book Drug Class Review written by Marian S. McDonagh and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: PURPOSE: We compared the effectiveness and harms of fingolimod (Gilenya) to other disease-modifying drugs in the treatment of multiple sclerosis. DATA SOURCES: We searched Ovid MEDLINE(r) and the Cochrane Library and the Database of Abstracts of Reviews of Effects through November 2010. For additional data we also hand searched reference lists, US Food and Drug Administration medical and statistical reviews, and dossiers submitted by pharmaceutical companies. REVIEW METHODS: Study selection, data abstraction, validity assessment, grading the strength of the evidence, and data synthesis were all carried out according to standard Drug Effectiveness Review Project review methods. RESULTS AND CONCLUSIONS: In patients with relapsing-remitting multiple sclerosis, fingolimod 0.5 mg and 1.25 mg once daily was superior to interferon beta-1a in improving relapse-related outcomes, including annualized relapse rates and proportion without relapse, over a 1 year period. Progression of disability was not different between the treatments at 12 months. The higher dose (1.25 mg once daily) of fingolimod resulted in higher numbers and more severe adverse events, including herpes zoster infections and symptomatic bradycardia after the first dose, as well as more patients discontinuing treatment. Differences in adverse events between 0.5 mg fingolimod (the dose approved by the US Food and Drug Administration) and interferon beta-1a were limited to more patients with pyrexia, myalgia, and flu-like symptoms with interferon, and more patients with elevated liver enzymes with fingolimod. While the absolute event rates were low, ongoing concerns with the safety of fingolimod included the risk of macular edema, the effect of lung function, cancers, and serious viral infections. Further studies are underway to better determine the risk with fingolimod.
Book Synopsis Comparison of Drug Treatments for Multiple Sclerosis by : Nicolaas Otten
Download or read book Comparison of Drug Treatments for Multiple Sclerosis written by Nicolaas Otten and published by . This book was released on 1998 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rapid assessment brings together the major studies involving the four drugs available in various countries for the treatment of Multiple Sclerosis; Avonex® (interferon beta 1-a), Rebif® (interferon beta 1-a), Betaseron® (interferon beta 1-b), and Copaxone® (glatiramer acetate or copolymer 1). Although these drugs are priced similarly, clinical trial methodology have been sufficiently different that definitive conclusions as to their comparability cannot be made. This review focuses on the major trials used to support market claims of their usefulness. Particular emphasis has been placed on Rebif® since this is the newest agent available. Comments and inferences regarding the various interferon preparations are outlined which may be helpful when comparing these products. All of the products now appear to have evidence that they impact the progression of the disease. However variations in endpoints, definition of endpoints, patient characteristics, and differences in doses (for the interferons) make any comparative evaluation difficult. Regardless of the methodology used (cost/QALY or cost/EDSS disability years avoided) these drugs are incrementally more expensive for the improvement expected than many interventions currently used i various health conditions.
Book Synopsis MicroRNA and MessengerRNA Expression Changes During Interferon-beta and Glatiramer Acetate Treatment in Peripheral Blood Cells of Multiple Sclerosis Patients by : Madhan Thamilarasan
Download or read book MicroRNA and MessengerRNA Expression Changes During Interferon-beta and Glatiramer Acetate Treatment in Peripheral Blood Cells of Multiple Sclerosis Patients written by Madhan Thamilarasan and published by . This book was released on 2015 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunological Effects of Interferon-[beta] and Glatiramer Acetate in Multiple Sclerosis by :
Download or read book Immunological Effects of Interferon-[beta] and Glatiramer Acetate in Multiple Sclerosis written by and published by . This book was released on 2004 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interferon Therapy of Multiple Sclerosis by : Anthony Reder
Download or read book Interferon Therapy of Multiple Sclerosis written by Anthony Reder and published by CRC Press. This book was released on 1997-01-28 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN-1a (
Book Synopsis Neuroimmune Diseases by : Hiroshi Mitoma
Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Book Synopsis Neurology and Pregnancy by : Eric A.P. Steegers
Download or read book Neurology and Pregnancy written by Eric A.P. Steegers and published by Elsevier. This book was released on 2020-08-05 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurology and Pregnancy provides a comprehensive multidisciplinary guide to best practices for research and practicing neurologists, as well as obstetricians and other specialists caring for women with an acute or chronic neurological disorder. The book encompasses preconception care, genetic counseling, pregnancy in patients with chronic neurological disorders, and acute pregnancy-related neurological complications. Postpartum care and complications, including lactation concerns, are also addressed, as well as the long-term effects of pregnancy and its complications on maternal brain health. Vol 1 summarizes the complex neurophysiological changes in pregnancy from a basic and translational science perspective. This includes neuroimaging, principles of neuro-obstetric critical care, and ethical and medicolegal concerns, describes normal fetal cerebral development and summarizes the management of the most common prenatal neurological diagnoses. Vol 2 focuses on chronic neurological conditions in pregnancy such as epilepsy, migraine, and multiple sclerosis, as well as acute neurological disorders including preeclampsia/ eclampsia, ischemic and hemorrhagic stroke, and CNS infections. Each chapter introduction includes data on epidemiology, when applicable. In discussing management, comments of safety profiles of medications preconceptionally, during pregnancy and lactation are summarized. Each chapter includes 1-2 illustrative cases. Encompasses both chronic and acute neurological disorders in pregnancy Includes epilepsy, sleep disorders, MS, headaches, neuromuscular disorders Covers spinal injury and movement disorders Contains cerebrovascular diseases and brain tumors Examines stroke, hemorrhage, TBI, preeclampsia and more Supplies illustrative case study examples
Book Synopsis Multiple Sclerosis by : Ian S. Zagon
Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Sclerosis Therapeutics by : Richard Rudick
Download or read book Multiple Sclerosis Therapeutics written by Richard Rudick and published by CRC Press. This book was released on 1999-09-01 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.
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