The Orexin System. Basic Science and Role in Sleep Pathology

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068446
Total Pages : 165 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis The Orexin System. Basic Science and Role in Sleep Pathology by : M.A. Steiner

Download or read book The Orexin System. Basic Science and Role in Sleep Pathology written by M.A. Steiner and published by Karger Medical and Scientific Publishers. This book was released on 2021-05-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Hypocretins

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Publisher : Springer Science & Business Media
ISBN 13 : 0387254463
Total Pages : 438 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Hypocretins by : Luis De Lecea

Download or read book Hypocretins written by Luis De Lecea and published by Springer Science & Business Media. This book was released on 2007-04-25 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

The Orexin/Hypocretin System

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Author :
Publisher : Academic Press
ISBN 13 : 0128137525
Total Pages : 190 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Orexin/Hypocretin System by : Jim R. Fadel

Download or read book The Orexin/Hypocretin System written by Jim R. Fadel and published by Academic Press. This book was released on 2019-01-03 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. - Provides an overview of new research on orexins/hypocretins - Includes an overview of intracellular signaling and orexin physiology - Discusses the effects on arousal, appetite, cognition, addiction and anxiety - Examines orexin based therapies and their potential use in disorders - Explores orexin receptors for drug development

Behavioral Neuroscience of Orexin/Hypocretin

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Author :
Publisher : Springer
ISBN 13 : 331957535X
Total Pages : 328 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Behavioral Neuroscience of Orexin/Hypocretin by : Andrew J Lawrence

Download or read book Behavioral Neuroscience of Orexin/Hypocretin written by Andrew J Lawrence and published by Springer. This book was released on 2017-05-29 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal states, critical for higher order functioning. From a clinical perspective, genetic polymorphisms in hypocretin/orexin and orexin receptors are implicated in a number of psychiatric disorders. In addition, advanced clinical trials are currently underway for orexin receptor antagonists in the treatment of insomnia and sleep disorders. We aim to capture a broad audience of basic scientists and clinicians.

The Orexin/Hypocretin System

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Publisher : Springer Science & Business Media
ISBN 13 : 1592599508
Total Pages : 390 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis The Orexin/Hypocretin System by : Seiji Nishino

Download or read book The Orexin/Hypocretin System written by Seiji Nishino and published by Springer Science & Business Media. This book was released on 2007-11-22 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

Handbook of Biologically Active Peptides

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Publisher : Elsevier
ISBN 13 : 0080463797
Total Pages : 1682 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Handbook of Biologically Active Peptides by : Abba Kastin

Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

Orexin/Hypocretin System

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Author :
Publisher : Elsevier
ISBN 13 : 0444594892
Total Pages : 208 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Orexin/Hypocretin System by : Anantha Shekhar

Download or read book Orexin/Hypocretin System written by Anantha Shekhar and published by Elsevier. This book was released on 2012-09-05 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations." "Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding and body weight regulation."--Résumé de l'éditeur.

Muscle Cells

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789239672
Total Pages : 182 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Muscle Cells by : Mani T. Valarmathi

Download or read book Muscle Cells written by Mani T. Valarmathi and published by BoD – Books on Demand. This book was released on 2020-01-22 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three different types of muscle tissue found in the animal kingdom are cardiac, skeletal, and smooth. The muscle cells are not only complex but also fascinating. In recent years there has been substantial advances in our understanding of muscle cell biology, especially in areas of molecular anatomy, basic physiology, understanding disease mechanisms, and therapeutic targets. Consequently, this book mainly focuses not only on the biology of myocytes, but also on all-encompassing disciplines pertaining to muscle tissue, such as fundamental physiology, molecular mechanisms of diseases, muscle regeneration, etc. for all three types of muscle, namely, skeletal, cardiac, and smooth muscle. As a result, the goal of this book is to consolidate the recent advances in the area of muscle biology/diseases/regeneration covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in muscle cell biology, exercise physiology/science, stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough knowledge pertaining to recent advances in muscle biology in the context of health and disease.

Sleep, Neuronal Plasticity and Brain Function

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Publisher : Springer
ISBN 13 : 3662468786
Total Pages : 561 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Sleep, Neuronal Plasticity and Brain Function by : Peter Meerlo

Download or read book Sleep, Neuronal Plasticity and Brain Function written by Peter Meerlo and published by Springer. This book was released on 2015-05-18 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current knowledge on the importance of sleep for brain function, from molecular mechanisms to behavioral output, with special emphasis on the question of how sleep and sleep loss ultimately affect cognition and mood. It provides an extensive overview of the latest insights in the role of sleep in regulating gene expression, synaptic plasticity and neurogenesis and how that in turn is linked to learning and memory processes. In addition, readers will learn about the potential clinical implications of insufficient sleep and discover how chronically restricted or disrupted sleep may contribute to age-related cognitive decline and the development of psychiatric disorders such as schizophrenia and depression. The book consists of 19 chapters, written by experts in basic sleep research and sleep medicine, which together cover a wide range of topics on the importance of sleep and consequences of sleep disruption. This book will be of interest to students, researchers and clinicians with a general interest in brain function or a specific interest in sleep.

The Assessment and Treatment of Addiction

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323548571
Total Pages : 253 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis The Assessment and Treatment of Addiction by : Itai Danovitch

Download or read book The Assessment and Treatment of Addiction written by Itai Danovitch and published by Elsevier Health Sciences. This book was released on 2018-11-15 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of all types of addiction – from substance use disorders to behavioral addictions and more. This practical resource presents a focused summary of today's current knowledge on topics of interest to all health care professionals who work with those who suffer from this wide-ranging problem. It provides current, relevant information on emerging findings, best practices, and treatment challenges, covering a variety of assessment and treatment strategies and making it a one-stop resource for staying up to date in this critical area. - Discusses precision health in addiction; the latest trend of electronic cigarettes; state-of-the-art treatments for opioid use disorder and cannabis use disorder; best practices for chronic pain; prevention among adolescents; the role of physicians in the prescription drug epidemic; and the role of integrative interventions in addiction treatment. - Includes coverage of behavioral addictions such as internet, sex, and gambling; food addiction; PTSD and substance use disorders; preventing relapse; the neurobiology of addiction; and more. - Consolidates today's available information on this timely topic into one convenient resource.

Foundations of Psychiatric Sleep Medicine

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Publisher : Cambridge University Press
ISBN 13 : 1139494341
Total Pages : 435 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Foundations of Psychiatric Sleep Medicine by : John W. Winkelman

Download or read book Foundations of Psychiatric Sleep Medicine written by John W. Winkelman and published by Cambridge University Press. This book was released on 2010-12-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Brain Peptides

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Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 1054 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Brain Peptides by : Dorothy T. Krieger

Download or read book Brain Peptides written by Dorothy T. Krieger and published by Wiley-Interscience. This book was released on 1983-11-14 with total page 1054 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first major comprehensive overview of the anatomical, physiological, evolutionary, and embryological aspects of brain peptides, focusing on peptides described in the past decade. Examines the role of peptides in affecting major homeostatic systems. Presents the methodologies applicable to the study of brain peptides. Summarizes current knowledge of individual peptides.

Sleep Hormones

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Publisher : Academic Press
ISBN 13 : 0123946239
Total Pages : 400 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Sleep Hormones by : Gerald Litwack

Download or read book Sleep Hormones written by Gerald Litwack and published by Academic Press. This book was released on 2012-06-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on sleep hormones. Contributions from leading authorities Informs and updates on all the latest developments in the field

Encyclopedia of Behavioral Neuroscience

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Publisher : Elsevier
ISBN 13 : 0080453961
Total Pages : 1819 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Encyclopedia of Behavioral Neuroscience by :

Download or read book Encyclopedia of Behavioral Neuroscience written by and published by Elsevier. This book was released on 2010-06-03 with total page 1819 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Narcolepsy

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Publisher : Springer Science & Business Media
ISBN 13 : 1441908552
Total Pages : 325 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Narcolepsy by : Meeta Goswami

Download or read book Narcolepsy written by Meeta Goswami and published by Springer Science & Business Media. This book was released on 2011-04-08 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Narcolepsy serves as a prototype of how the interaction of high quality clinical research and groundbreaking basic science can collaborate to defne the cause of a disease and change forever how we evaluate and treat it. There is scarcely a topic in this book that would have been covered in the same way 10 years ago as it is d- cussed today. We are also fortunate that many of the players in this dramatic tu- around have contributed to this volume, so that the result is a tapestry of the events that have transformed the feld over the last decade that is both authentic and detailed. The frst section of the book provides much of the basic science background. As described in the frst two chapters, the dramatic convergence of lines of evidence from two different laboratories frst demonstrated in 1999 that narcolepsy is a disease of loss of neurotransmission by lateral hypothalamic neurons making the peptides that have been called orexins or hypocretins. These fndings did much to clarify and unify a feld that had puzzled for decades over the fundamental nature of this puzzling disease, as refected in the chapters that review its epidemiology and neuroanatomical and imaging fndings.

Sleep and Mental Illness

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Publisher : Cambridge University Press
ISBN 13 : 1139483706
Total Pages : 451 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Sleep and Mental Illness by : S. R. Pandi-Perumal

Download or read book Sleep and Mental Illness written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2010-04-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.

The Brain and Behavior

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Publisher : Cambridge University Press
ISBN 13 : 9780521840507
Total Pages : 290 pages
Book Rating : 4.8/5 (45 download)

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Book Synopsis The Brain and Behavior by : David L. Clark

Download or read book The Brain and Behavior written by David L. Clark and published by Cambridge University Press. This book was released on 2005-09-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition building on the success of previous one. Retains core aim of providing an accessible introduction to behavioral neuroanatomy.