Basic and Clinical Toxicology of Organophosphorus Compounds

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Publisher : Springer Science & Business Media
ISBN 13 : 1447156250
Total Pages : 264 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Basic and Clinical Toxicology of Organophosphorus Compounds by : Mahdi Balali-Mood

Download or read book Basic and Clinical Toxicology of Organophosphorus Compounds written by Mahdi Balali-Mood and published by Springer Science & Business Media. This book was released on 2013-12-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

Clinical and Experimental Toxicology of Organophosphates and Carbamates

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Publisher : Elsevier
ISBN 13 : 1483193659
Total Pages : 662 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Clinical and Experimental Toxicology of Organophosphates and Carbamates by : Bryan Ballantyne

Download or read book Clinical and Experimental Toxicology of Organophosphates and Carbamates written by Bryan Ballantyne and published by Elsevier. This book was released on 2017-01-31 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical & Experimental Toxicology of Organophosphates and Carbamates considers the histochemical localization of cholinesterase in anticholinesterase poisoning. This book is organized into eight parts encompassing 59 chapters that discuss the pharmacology and toxicology of carbamates, as well as the neurobehavioral toxicology of anticholinesterases. Some of the topics covered in the book are the overview of biological and clinical aspects of organophosphates and carbamates; biochemical determination of cholinesterase activity in fluids and tissues; intermediate syndrome in anticholinesterase neurotoxicity; structure-activity relationships and anticholinesterase activity; and the molecular events in delayed neuropathy. Other parts deal with the cardiac effects of anticholinesterase agents and the ecotoxicological consequences of interactions between avian esterases and organophosphorus compounds. These topics are followed by discussions on the analysis of the cutaneous and respiratory tract absorption of anticholinesterases and the use of organophosphorus compounds as chemical warfare agents. The final parts are devoted to the toxicity of anticholinesterases to aquatic organisms. The book can provide useful information to toxicologists, doctors, students, and researchers.

Toxicology of Organophosphate and Carbamate Compounds

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Publisher : Academic Press
ISBN 13 : 0080543103
Total Pages : 781 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Toxicology of Organophosphate and Carbamate Compounds by : Ramesh C Gupta

Download or read book Toxicology of Organophosphate and Carbamate Compounds written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-28 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

Organophosphates And Health

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Publisher : World Scientific
ISBN 13 : 1783261439
Total Pages : 511 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Organophosphates And Health by : Stanley Feldman

Download or read book Organophosphates And Health written by Stanley Feldman and published by World Scientific. This book was released on 2001-07-24 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few chemical compounds created by man have caused greater controversy than organophosphates. Conceived as insecticides, they have also been developed to become the most feared of chemical weapons. The control of vectors of diseases from which millions die or are disabled is heavily dependent on organophosphates, as are efforts to maintain food production in the face of uncontrolled population growth, diminishing arable land and the possibility of global warming. As the toxicity of organophosphates is non-specific, it has caused ill health and death in man, and has contributed to adverse ecological effects.This book, written by recognised experts, studies and presents information in a manner that basic scientists, medical personnel, environmentalists, agriculturists and those in public health and occupational medicine will find essential when considering the use of organophosphates in their disciplines. The text primarily covers health aspects, with discussions on related social, economic, environmental and agricultural issues that concern all inhabitants of the global village.

Toxicology of Organophosphate Poisoning

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Publisher : Springer Nature
ISBN 13 : 3030791289
Total Pages : 112 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Toxicology of Organophosphate Poisoning by : Anuj Ranjan

Download or read book Toxicology of Organophosphate Poisoning written by Anuj Ranjan and published by Springer Nature. This book was released on 2021-10-11 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the consequences of high agricultural pesticide use over the last few decades in the form of organophosphate poisoning. The authors provide a background overview of organophosphate compounds, their environmental toxicity, non-target exposures and cases of human poisoning. The authors also compile and analyze data from the last two decades to demonstrate the toxicological aspects of organophosphates, and how they can pose a threat to human health. Readers will learn about the clinical manifestation of organophosphate exposure in humans, as well as the enzymatic pathways and mechanisms by which organophosphates are processed in the body and cause harm. The book concludes by providing techniques, practices and recommendations for how to manage organophosphate exposure and poisoning. It will be useful for clinicians and public health professionals, scientists, medical practitioners, researchers and environmental toxicologists.

Organophosphates Chemistry, Fate, and Effects

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Publisher : Elsevier
ISBN 13 : 0080917267
Total Pages : 462 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Organophosphates Chemistry, Fate, and Effects by : Janice E. Chambers

Download or read book Organophosphates Chemistry, Fate, and Effects written by Janice E. Chambers and published by Elsevier. This book was released on 2013-10-22 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity. Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds Examines organophosphorus compound-induced toxicity mediated by mechanisms other than inhibition of acetylcholinesterase Covers new research on differences in toxicity induced by the variety of organophosphorus Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity in vivo

Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables

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Author :
Publisher : Elsevier
ISBN 13 : 0123914825
Total Pages : 90 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables by : Jiri Bajgar

Download or read book Nerve Agents Poisoning and its Treatment in Schematic Figures and Tables written by Jiri Bajgar and published by Elsevier. This book was released on 2012-03-15 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organophosphate compounds, first synthesized in the 1800s, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning. This book provides an in-depth examination of the effects of organophosphates and nerve agents and offers therapeutic and prophylactic countermeasures. Beginning with an overview of milestones in the use of toxic chemicals and chemical warfare agents, the formulae and toxicities of compounds are given, along with tables outlining animal toxicities. Data on various compounds’ inhibitions and subsequent accumulations are also provided. Along with data on organophosphates and nerve agents, possible first aid and medical responses are compared among potential responses in the United States and other countries in the east and west. Using clear schematics and tables, this book provides a detailed account of the most common organophosphates and nerve agents, ideas of how to countermeasure their effects, and offers detailed suggestions for where research needs to proceed in the future. This book will prove useful to students, researchers, and military personnel needing to know more about how to deal with nerve agents. Dedicated to organophosphates/nerve agent, this book contains tables on toxicities in animals and simple figures useable for brief orientation and education

MANAGEMENT OF ORGANOPHOSPHORUS PESTICIDE POISONING: COMMON QUESTIONS AND ANSWERS

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Author :
Publisher : Notion Press
ISBN 13 : 1638735980
Total Pages : 208 pages
Book Rating : 4.6/5 (387 download)

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Book Synopsis MANAGEMENT OF ORGANOPHOSPHORUS PESTICIDE POISONING: COMMON QUESTIONS AND ANSWERS by : Kirti S Pawar

Download or read book MANAGEMENT OF ORGANOPHOSPHORUS PESTICIDE POISONING: COMMON QUESTIONS AND ANSWERS written by Kirti S Pawar and published by Notion Press. This book was released on 2021-09-17 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although managing mild organophosphorus poisoning could be quite simple, management of moderate to severe organophosphorus poisoning requires skill and extensive knowledge of this emergency. This book is a comprehensive guide to manage organophosphorus poisoning cases, covering everything from the identification of poison to the treatment. We have endeavored to cover every aspect of diagnosis and treatment, including common names of organophosphorus, carbamates, pyrethroids, and organo-chloro poisons, the types of presentation in organophosphorus poisoning, interpretation of cholinesterase level reports, prevention of intermediate syndrome/reintubation, decisions regarding doses of atropine and pralidoxime (2PAM) and other treatment options in organophosphorus poisoning, how to overcome difficulties in weaning from ventilator, delayed complications and their prevention, differences in treatment of organophosphorus poisoning and carbamates/ pyrethroids/organo-chloro poisons and many more frequently asked questions. This book provides detailed evidence-based answers to 64 questions related to organophosphorus poisoning and would prove invaluable to medical students for conceptual understanding of this topic and to clinicians for the effective management of patients with organophosphorus poisoning.

Basic and Clinical Toxicology of Mustard Compounds

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Author :
Publisher : Springer
ISBN 13 : 3319238744
Total Pages : 416 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Basic and Clinical Toxicology of Mustard Compounds by : Mahdi Balali-Mood

Download or read book Basic and Clinical Toxicology of Mustard Compounds written by Mahdi Balali-Mood and published by Springer. This book was released on 2015-12-01 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a practical guide to the clinical management of sulphur and nitrogen mustard exposure including information on the history, pharmacology and toxicology of mustard compounds (MC). Basic and Clinical Toxicology of Mustard Compounds details the many resulting complications of sulphur mustard (SM) poisoning such as respiratory, Dermatological, Ophthalmological and Psychiatric. This volume is a key resource for clinical toxicologists, military and emergency physicians who are involved in the teaching and research of MC and for all medical and health professions who are responsible for the prevention, diagnosis and treatment of MC poisonings.

Gulf War and Health

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Publisher : National Academies Press
ISBN 13 : 0309165776
Total Pages : 132 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Gulf War and Health by : Institute of Medicine

Download or read book Gulf War and Health written by Institute of Medicine and published by National Academies Press. This book was released on 2004-10-11 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Gulf War in 1990-1991 was considered a brief and successful military operation, with few injuries or deaths of US troops. The war began in August 1990, and the last US ground troops returned home by June 1991. Although most Gulf War veterans resumed their normal activities, many soon began reporting a variety of nonexplained health problems that they attributed to their participation in the Gulf War, including chronic fatigue, muscle and joint pain, loss of concentration, forgetfulness, headache, and rash. Because of concerns about the veterans' health problems, the Department of Veterans Affairs (VA) requested that the Institute of Medicine (IOM) review the scientific and medical literature on the long-term adverse health effects of agents to which the Gulf War veterans may have been exposed. This report is a broad overview of the toxicology of sarin and cyclosarin. It assesses the biologic plausibility with respect to the compounds in question and health effects.

Organophosphorus Pesticides

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Publisher : Nova Science Publishers
ISBN 13 : 9781634854504
Total Pages : 0 pages
Book Rating : 4.8/5 (545 download)

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Book Synopsis Organophosphorus Pesticides by : Neil Wilkinson

Download or read book Organophosphorus Pesticides written by Neil Wilkinson and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: At present, organophosphorus compounds (OP) are considered some of the most toxic substances synthesised by man. These compounds are widely used in agriculture, residential gardening and in pest control programs, as well as in veterinary practices of the modern world. The primary toxicity of organophosphates is associated with the inhibition of acetylcholinesterase in the central and peripheral nervous system, resulting in acetylcholine accumulation and consequently disrupted neurotransmission. In this book, Chapter One provides an overview of recent studies regarding toxic effects of organophosphates, the methods of their removal, and detoxification in live organisms. Chapter Two summarizes the results of monitoring agricultural products for the presence of organophosphorus pesticides, putting a special emphasis on potential ways for reduction of their levels. The final chapter focuses specifically on the structural features, applications, toxicity mechanisms and effects of exposure on human health of fenitrothion, a non-systemic organophosphorous insecticide.

Recognition and Management of Pesticide Poisonings (5th Ed. )

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Publisher : DIANE Publishing
ISBN 13 : 1437914527
Total Pages : 238 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Recognition and Management of Pesticide Poisonings (5th Ed. ) by : J. Routt Reigart

Download or read book Recognition and Management of Pesticide Poisonings (5th Ed. ) written by J. Routt Reigart and published by DIANE Publishing. This book was released on 2009-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 5th ed. is an update and expansion of the 1989 4th ed. This EPA manual provides health professionals with information on the health hazards of pesticides currently in use, and current consensus recommendations for management of poisonings and injuries caused by them. As with previous updates, this new ed. incorporates new pesticide products that are not necessarily widely known among health professionals. Contents: (1) General Information: Introduction; General Principles in the Management of Acute Pesticide Poisonings; Environmental and Occupational History; (2) Insecticides; (3) Herbicides; (4) Other Pesticides; (5) Index of Signs and Symptoms; Index of Pesticide Products. Charts and tables.

Paraoxonase (PON1) in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9781402072826
Total Pages : 242 pages
Book Rating : 4.0/5 (728 download)

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Book Synopsis Paraoxonase (PON1) in Health and Disease by : Lucio G. Costa

Download or read book Paraoxonase (PON1) in Health and Disease written by Lucio G. Costa and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: The journey to find genes responsible for determining sensitivity or resistance to specific insecticides led to the paraoxonase (PON1) gene on human chromosome 7. This gene encodes a 355 amino acid protein that is localized on the high density lipoprotein (HDL) particles in plasma. Characterization of this gene revealed that different individuals expressed both different forms of this enzyme with amino acid substitutions at positions 55 and 192 as well as different levels of this protein. Additional studies showed that mutations in the regulatory region of the PON1 gene contributed to the very different levels of plasma PON1 among individuals. It turned out that both the level of the enzyme as well as the amino acid present at position 192 (glutamine or arginine) are important in determining resistance to the active forms of specific organophosphorus insecticides, especially diazinon and chlorpyrifos. The position 192 amino acid also determined whether an individual's plasma hydrolyzed the nerve agents soman and sarin at high or low rates. It is not yet known whether these different rates of hydrolysis observed in biochemical assays reflect differences in sensitivity of individuals to nerve agents. Taken together, all of the experiments carried out to date indicate that engineered recombinant PON1 is an excellent candidate to use for treating cases of poisoning by specific organophosphorus compounds. The available data on the relationship of PON1 levels and position 192 genotype led us to introduce the term PON1 status to describe an individual's PON1 plasma level as well as their position 192 genotype.The characterization of the genetic variations of the PON1 gene together with experiments showing that HDL can protect the lipids in low density lipoprotein particles (LDL) from oxidation and that it was PON1 that was responsible for this protection have opened an entirely new area of investigation, the role of PON1 in protecting against vascular disease.More recent reports have noted that PON1 also metabolizes a number of drugs, activating some and inactivating others.This book describes the recent advances in understanding the role of PON1 in both cardiovascular disease and toxicology of insecticide exposure as well as some of the recent information indicating an important possible role in the pharmacokinetics of drug metabolism. The final chapter of the book provides an overview of the areas of PON1 research and suggests future directions for research on PON1 as well as the related, linked genes PON2 and PON3.

Handbook of Toxicology of Chemical Warfare Agents

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Publisher : Academic Press
ISBN 13 : 0080922732
Total Pages : 1182 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Toxicology of Chemical Warfare Agents by : Ramesh C Gupta

Download or read book Handbook of Toxicology of Chemical Warfare Agents written by Ramesh C Gupta and published by Academic Press. This book was released on 2009-04-02 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with

Chemical Warfare Toxicology

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 178262807X
Total Pages : 346 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Chemical Warfare Toxicology by : Franz Worek

Download or read book Chemical Warfare Toxicology written by Franz Worek and published by Royal Society of Chemistry. This book was released on 2016-05-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This book provides an up-to-date treatise on the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the most important representative nerve and blistering agents, whilst also covering other potential chemical warfare agents, this book will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The text will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.

Hayes' Handbook of Pesticide Toxicology

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Author :
Publisher : Academic Press
ISBN 13 : 0080922015
Total Pages : 2407 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Hayes' Handbook of Pesticide Toxicology by :

Download or read book Hayes' Handbook of Pesticide Toxicology written by and published by Academic Press. This book was released on 2010-02-15 with total page 2407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions All major classes of pesticide considered Different routes of exposure critically evaluated

Toxicological Profile for Chlorpyrifos

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Author :
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Chlorpyrifos by :

Download or read book Toxicological Profile for Chlorpyrifos written by and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: