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Assessment Of Trabecular Bone Micro Architecture Using Pqct And Micro Ct
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Book Synopsis Quantitative Ultrasound by : Thomas Fuerst PhD
Download or read book Quantitative Ultrasound written by Thomas Fuerst PhD and published by CRC Press. This book was released on 1999-10-13 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound is quickly becoming the technique of choice in the measurement of bone density. Proving cheaper and more portable than previous techniques, and also having the advantage of not using ionizing radiation, it is likely that the use of various ultrasound systems will become increasingly widespread in clinical practice. This book is a comprehensive review of the systems currently available, preceded by a summary of the basic science of ultrasound and concluding with a section on clinical studies, trials and experience in a number of countries. Likely future developments are also discussed, bringing the book completely up to date.
Book Synopsis Noninvasive Assessment of Trabecular Bone Architecture and The Competence of Bone by : Sharmila Majumdar
Download or read book Noninvasive Assessment of Trabecular Bone Architecture and The Competence of Bone written by Sharmila Majumdar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of bone microarchitecture is flourishing because of a recent shift in perspective that has taken researchers beyond utilizing bone mineral density as the primary source of information about certain matters related to bone. In the area of osteoporosis and skeletal changes, bone mineral density (BMD) is widely used for screening, monitoring and assessing therapeutic efficacy, and yet, it is currently accepted that BMD does not fully explain the pathogenesis of osteoporosis, the process of aging, nor mechanisms of therapeutic efficacy. In this context, the study of trabecular microarchitecture has much to contribute. The emerging field of trabecular microarchitecture, however, is diverse, inter-disciplinary and encompasses many different imaging modalities. This volume represents a compilation of papers from world-renowned researchers, reflecting the most current research in the area of noninvasive assessment of trabecular microcarchitecture. This varied research applies sophisticated imaging tools to questions of bone biomechanics at both the basic science and clinical levels. The authors' works range from review articles and research articles to works in progress. Taken together, they offer a foray into the "state of the art" of investigating bone at its most basic levels.
Book Synopsis Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data by : Eva Klintström
Download or read book Image Analysis for Trabecular Bone Properties on Cone-Beam CT Data written by Eva Klintström and published by Linköping University Electronic Press. This book was released on 2017-10-20 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trabecular bone structure as well as bone mineral density (BMD) have impact on the biomechanical competence of bone. In osteoporosis-related fractures, there have been shown to exist disconnections in the trabecular network as well as low bone mineral density. Imaging of bone parameters is therefore of importance in detecting osteoporosis. One available imaging device is cone-beam computed tomography (CBCT). This device is often used in pre-operative imaging of dental implants, for which the trabecular network also has great importance. Fourteen or 15 trabecular bone specimens from the radius were imaged for conducting this in vitro project. The imaging data from one dual-energy X-ray absorptiometry (DXA), two multi-slice computed tomography (MSCT), one high-resolution peripheral quantitative computed tomography (HR-pQCT) and four CBCT devices were segmented using an in-house developed code based on homogeneity thresholding. Seven trabecular microarchitecture parameters, as well as two trabecular bone stiffness parameters, were computed from the segmented data. Measurements from micro-computed tomography (micro-CT) data of the same bone specimens were regarded as gold standard. Correlations between MSCT and micro-CT data showed great variations, depending on device, imaging parameters and between the bone parameters. Only the bone-volume fraction (BV/TV) parameter was stable with strong correlations. Regarding both HR-pQCT and CBCT, the correlations to micro-CT were strong for bone structure parameters as well as bone stiffness parameters. The CBCT device 3D Accuitomo showed the strongest correlations, but overestimated BV/TV more than three times compared to micro-CT. The imaging protocol most often used in clinical imaging practice at our clinic demonstrated strong correlations as well as low radiation dose. CBCT data of trabecular bone can be used for analysing trabecular bone properties, like bone microstructure and bone biomechanics, showing strong correlations to the reference method of micro-CT. The results depend on choice of CBCT device as well as segmentation method used. The in-house developed code based on homogeneity thresholding is appropriate for CBCT data. The overestimations of BV/TV must be considered when estimating bone properties in future clinical dental implant and osteoporosis research.
Book Synopsis Haschek and Rousseaux's Handbook of Toxicologic Pathology by : Wanda M Haschek
Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology written by Wanda M Haschek and published by Academic Press. This book was released on 2013-05-01 with total page 3055 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. - Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Book Synopsis Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials by : L. Qin
Download or read book Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials written by L. Qin and published by Springer Science & Business Media. This book was released on 2007-07-28 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound.
Book Synopsis Bone Stress Injuries by : Adam S. Tenforde, MD
Download or read book Bone Stress Injuries written by Adam S. Tenforde, MD and published by Springer Publishing Company. This book was released on 2021-07-17 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This book gives a nice summary of the current state of diagnosis, treatment, and prevention of bone stress injuries. It is particularly useful for sports medicine fellows and residents with an interest in athletes and active patients." ---Doody's Review Service, 3 stars Bone stress injuries are commonly seen in athletes and active individuals across a full spectrum of physical activity, age, and gender. While most overuse injuries can be addressed through non-operative care, injuries may progress to full fractures that require surgery if misdiagnosed or not correctly managed. Written by leaders in sports medicine including physical medicine and rehabilitation, orthopaedics, endocrinology and allied health professionals of biomechanics, physical therapy and dietetics, Bone Stress Injuries offers state-of-the-art guidelines and up-to-date science and terminology to practitioners. Using a holistic approach to understand the management of bone stress injuries, this book highlights specific considerations by injury, gender, and risk factor to ensure that a comprehensive treatment plan can be developed to optimize bone health, neuromuscular re-education, gait mechanics, and injury prevention. Organized into four parts, opening chapters cover the general need-to-know topics, including clinical history, imaging, and risk factors including biological and biomechanical factors. The book proceeds anatomically through the body from upper extremity to foot and ankle injuries, with each chapter underscoring diagnostic and treatment strategies specific to that region. Chapters dedicated to special populations discuss the differences in injury evaluation and management according to age, gender, and military background. Final chapters review the prevention of injuries and examine both common and novel treatment strategies, such as medications, nutrition, gait retraining, orthobiologics, and other interventions. Invaluable in its scope and approach, Bone Stress Injuries is the go-to resource for sports medicine physicians, physiatrists, and primary care providers who manage the care of athletes and individuals leading active lifestyles. Key Features: Promotes evidence-based practice for diagnosis, treatment, and prevention of bone stress injuries Covers specific anatomy that is prone to bone stress injuries with dedicated chapters on upper and lower extremities, pelvis and hip, spine, and foot and ankle Considers evaluation and management differences according to specific populations of pediatric, male, female, and military personnel Discusses emerging strategies to treat bone stress injuries, such as gait retraining, orthobiologics, and other non-pharmacological treatments
Book Synopsis Micro-computed Tomography (micro-CT) in Medicine and Engineering by : Kaan Orhan
Download or read book Micro-computed Tomography (micro-CT) in Medicine and Engineering written by Kaan Orhan and published by Springer. This book was released on 2019-07-25 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on applications of micro CT, CBCT and CT in medicine and engineering, comprehensively explaining the basic principles of these techniques in detail, and describing their increasing use in the imaging field. It particularly highlights the scanning procedure, which represents the most crucial step in micro CT, and discusses in detail the reconstruction process and the artifacts related to the scanning processes, as well as the imaging software used in analysis. Written by international experts, the book illustrates the application of micro CT in different areas, such as dentistry, medicine, tissue engineering, aerospace engineering, geology, material engineering, civil engineering and additive manufacturing. Covering different areas of application, the book is of interest not only to specialists in the respective fields, but also to broader audience of professionals working in the fields of imaging and analysis, as well as to students of the different disciplines.
Book Synopsis Radiology of Osteoporosis by : Stephan Grampp
Download or read book Radiology of Osteoporosis written by Stephan Grampp and published by Springer Science & Business Media. This book was released on 2008-03-18 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of "Radiology of Osteoporosis" has been fully updated so as to represent the current state-of-the-art. It provides a comprehensive overview of osteoporosis, the pathologic conditions that give rise to osteoporosis, and the complications that are frequently encountered. A collection of difficult cases involving pitfalls is presented, with guidance to their solution. The book will be invaluable to all with an interest in osteoporosis.
Book Synopsis Medical Image Analysis and Informatics by : Paulo Mazzoncini de Azevedo-Marques
Download or read book Medical Image Analysis and Informatics written by Paulo Mazzoncini de Azevedo-Marques and published by CRC Press. This book was released on 2017-11-23 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the development of rapidly increasing medical imaging modalities and their applications, the need for computers and computing in image generation, processing, visualization, archival, transmission, modeling, and analysis has grown substantially. Computers are being integrated into almost every medical imaging system. Medical Image Analysis and Informatics demonstrates how quantitative analysis becomes possible by the application of computational procedures to medical images. Furthermore, it shows how quantitative and objective analysis facilitated by medical image informatics, CBIR, and CAD could lead to improved diagnosis by physicians. Whereas CAD has become a part of the clinical workflow in the detection of breast cancer with mammograms, it is not yet established in other applications. CBIR is an alternative and complementary approach for image retrieval based on measures derived from images, which could also facilitate CAD. This book shows how digital image processing techniques can assist in quantitative analysis of medical images, how pattern recognition and classification techniques can facilitate CAD, and how CAD systems can assist in achieving efficient diagnosis, in designing optimal treatment protocols, in analyzing the effects of or response to treatment, and in clinical management of various conditions. The book affirms that medical imaging, medical image analysis, medical image informatics, CBIR, and CAD are proven as well as essential techniques for health care.
Book Synopsis Putting the "Why" Back into Bone "Archytecture" by : Phil Salmon
Download or read book Putting the "Why" Back into Bone "Archytecture" written by Phil Salmon and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: A large literature exists on trabecular and cortical bone morphology. The engineering performance of bone, implied from its 3d architecture, is often the endpoint of bone biology experiments, being clinically relevant to bone fracture. How and why does bone travel along its complex spatio-temporal trajectory to acquire its architecture? The question "why" can have two meanings. The first, "teleological - why is an architecture advantageous?" – is the domain of substantial biomechanical research to date. The second, "etiological – how did an architecture come about?" – has received far less attention. This Frontiers Bone Research Topic invited contributions addressing this "etiological why" – what mechanisms can coordinate the activity of bone forming and resorbing cells to produce the observed complex and efficient bone architectures? One mechanism is proposed – chaotic nonlinear pattern formation (NPF) which underlies – in a unifying way – natural structures as disparate as trabecular bone, swarms of birds flying or shoaling fish, island formation, fluid turbulence and others. At the heart of NPF is the fact that simple rules operating between interacting elements multiplied and repeated many times, lead to complex and structured patterns. This paradigm of growth and form leads to a profound link between bone regulation and its architecture: in bone "the architecture is the regulation". The former is the emergent consequence of the latter. Whatever mechanism does determine bone's developing architecture has to operate at the level of individual sites of formation and resorption and coupling between the two. This has implications as to how we understand the effect on bone of agents such as gene products or drugs. It may be for instance that the "tuning" of coupling between formation and resorption might be as important as the achievement of enhanced bone volume. The ten articles that were contributed to this Topic were just what we hoped for – a snapshot of leading edge bone biology research which addresses the question of how bone gets its shape. We hope that you find these papers thought-provoking, and that they might stimulate new ideas in the research into bone architecture, growth and adaptation, and how to preserve healthy bone from gestation and childhood until old age.
Download or read book Skeletonization written by Punam K Saha and published by Academic Press. This book was released on 2017-06-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletonization: Theory, Methods and Applications is a comprehensive reference on skeletonization, written by the world's leading researchers in the field. The book presents theory, methods, algorithms and their evaluation, together with applications. Skeletonization is used in many image processing and computer vision applications such as shape recognition and analysis, shape decomposition and character recognition, as well as medical imaging for pulmonary, cardiac, mammographic applications. Part I includes theories and methods unique to skeletonization. Part II includes novel applications including skeleton-based characterization of human trabecular bone micro-architecture, image registration and correspondence establishment in anatomical structures, skeleton-based fast, fully automated generation of vessel tree structure for clinical evaluation of blood vessel systems. - Offers a complete picture of skeletonization and its application to image processing, computer vision, pattern recognition and biomedical engineering - Provides an in-depth presentation on various topics of skeletonization, including principles, theory, methods, algorithms, evaluation and real-life applications - Discusses distance-analysis, geometry, topology, scale and symmetry-analysis in the context of object understanding and analysis using medial axis and skeletonization
Book Synopsis The Parathyroids by : John P. Bilezikian
Download or read book The Parathyroids written by John P. Bilezikian and published by Elsevier. This book was released on 2001-07-21 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians.Key Features* Offers objective and authoritative reviews on controversial clinical issues* Written by world experts on parathyroid hormone and its disorders* Superb, state-of-the-art compendium in one convenient volume* Bridges basic science of parathyroid hormone to major clinical disorders* Practical information on clinical management of parathyroid hormone disorders
Book Synopsis The Guide to Investigation of Mouse Pregnancy by : B. Anne Croy
Download or read book The Guide to Investigation of Mouse Pregnancy written by B. Anne Croy and published by Academic Press. This book was released on 2013-12-09 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success
Book Synopsis The Duration and Safety of Osteoporosis Treatment by : Stuart Silverman
Download or read book The Duration and Safety of Osteoporosis Treatment written by Stuart Silverman and published by Springer. This book was released on 2015-12-29 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is also discussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, The Duration and Safety of Osteoporosis Treatment is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care.
Book Synopsis Ectopic Mineralization of Tissues: Mechanisms, Risk Factors, Diseases and Prevention by : Monzur Murshed
Download or read book Ectopic Mineralization of Tissues: Mechanisms, Risk Factors, Diseases and Prevention written by Monzur Murshed and published by Frontiers Media SA. This book was released on 2022-01-17 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Principles of Bone Biology by : John P. Bilezikian
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2019-08-22 with total page 2034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology. - Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world's experts - THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases - Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management - Allows readers to easily search and locate information quickly in the online format - Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research
Book Synopsis The Physical Measurement of Bone by : C.M. Langton
Download or read book The Physical Measurement of Bone written by C.M. Langton and published by CRC Press. This book was released on 2016-04-19 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone is a complex biological material that consists of both an inorganic and organic phase, which undergoes continuous dynamic biological processes within the body. This complex structure and the need to acquire accurate data have resulted in a wide variety of methods applied in the physical analysis of bone in vivo and in vitro. Each method has it
