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Assessing The Role Of Protease Activated Receptors In The Release Of Inflammatory Mediators From Mast Cells
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Book Synopsis Assessing the Role of Protease-activated Receptors in the Release of Inflammatory Mediators from Mast Cells by : Hashem Alshurafa
Download or read book Assessing the Role of Protease-activated Receptors in the Release of Inflammatory Mediators from Mast Cells written by Hashem Alshurafa and published by . This book was released on 2001 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Hashem Alshurafa Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 : Total Pages :326 pages Book Rating :4.:/5 (76 download)
Book Synopsis Assessing the Role of Protease-activated Receptors in the Release of Inflammatory Mediators from Mast Cells [microform] by : Hashem Alshurafa
Download or read book Assessing the Role of Protease-activated Receptors in the Release of Inflammatory Mediators from Mast Cells [microform] written by Hashem Alshurafa and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2001 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Assessing the Role of Protease-activitated Receptors in the Release of Inflammatory Mediators from Mast Cells by : Hashem Alshurafa
Download or read book Assessing the Role of Protease-activitated Receptors in the Release of Inflammatory Mediators from Mast Cells written by Hashem Alshurafa and published by . This book was released on 2001 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Deciphering new molecular mechanisms of mast cell activation by : Ulrich Blank
Download or read book Deciphering new molecular mechanisms of mast cell activation written by Ulrich Blank and published by Frontiers E-books. This book was released on 2014-03-20 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells are tissue-localized cells that play an important role in immunity and inflammation. Following an offensive event they act as cellular sensors that via the activation of cell surface receptors launch a cellular response culminating in the release of a whole set of inflammatory mediators and products. This response is initially destined to restore tissue homeostasis, but in case of chronic injury or deregulation also promotes pathology. To further understand the action of mast cells in their environmental context it is necessary to decipher the molecular mechanisms of their activation as well as the ensuing cellular responses. This will allow identification of new strategies to promote their beneficial actions or, at the contrary, to interfere with their pathological consequences. While in the past many studies have focused on responses engaged by high affinity IgE receptor because of its implication in the allergic response, it has become clear that mast cells can be activated by multiple types of receptors initiating an intense molecular crosstalk between receptors and signaling pathways that can either synergize, antagonize and in some cases produce new types of responses. Mast cells can indeed react with an astounding diverse array of cellular responses that sometimes are engaged selectively. This Research Topic will focus on selected articles that shed some new light on the molecular mechanisms of mast cell activation, the possible crosstalk between signaling pathways and the ensuing cellular responses that allow mast cells to act as cellular sensors in tissues.
Author :Alasdair M. Gilfillan Publisher :Springer Science & Business Media ISBN 13 :1441995331 Total Pages :312 pages Book Rating :4.4/5 (419 download)
Book Synopsis Mast Cell Biology by : Alasdair M. Gilfillan
Download or read book Mast Cell Biology written by Alasdair M. Gilfillan and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.
Book Synopsis Mast Cells and Basophils by : Derek J. Chadwick
Download or read book Mast Cells and Basophils written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-01-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.
Book Synopsis Mast Cells, Mediators and Disease by : Stephen T. Holgate
Download or read book Mast Cells, Mediators and Disease written by Stephen T. Holgate and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.
Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Book Synopsis Mediators of Inflammation by : Gerald Weissmann
Download or read book Mediators of Inflammation written by Gerald Weissmann and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lewis Thomas has suggested that "Perhaps the inflammatory reaction should be regarded as a defense of an individual against all the rest of nature, symbolizing his individuality and announcing his existence as an entity. " Provision of these symbols and announcements is the task of various mediators of inflammation and this volume has been designed to present our current understanding of their biochemistry, cellular origins, pharmacology, and role in pathology. Unlike other volumes of collected papers, this book did not result from a specific conference or symposium at which each contributor presented his own, narrowly framed research experience. Rather, each of the chapters represents, in the form of a general review, a summary of our knowledge of the mediators and the mecha nisms by which they are released to launch the inflammatory response. Much effort has been taken to insure that the often conflicting terminology in this field is defmed in detail: many synonyms (e. g. , of the properdin system or the alternate pathway of complement activation) have been repeatedly presented, in order to avoid confusion. Although each of the contributors is actively engaged in the field of inflammation, few text figures or tables of ongoing research have been included; the overall aim was to provide a volume readily accessible to workers in other areas as well as to the general reader.
Book Synopsis Pro-inflammatory Actions of Human Mast Cell Tryptase by : Mogib El-Rahman Mohamed Shokry Khedr
Download or read book Pro-inflammatory Actions of Human Mast Cell Tryptase written by Mogib El-Rahman Mohamed Shokry Khedr and published by . This book was released on 2012 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Encyclopedia of Inflammatory Diseases by :
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Book Synopsis Pro-inflammatory Actions of Human Mast Cell Tryotase by : Mogib Khedr
Download or read book Pro-inflammatory Actions of Human Mast Cell Tryotase written by Mogib Khedr and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mast Cells and Basophils by : Gianni Marone
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Book Synopsis Activation-induced Changes in the Histamine Content of Murine Mast Cells and Their Adhesion to NIH-3T3 Fibroblasts by : Lori J. Fitz
Download or read book Activation-induced Changes in the Histamine Content of Murine Mast Cells and Their Adhesion to NIH-3T3 Fibroblasts written by Lori J. Fitz and published by . This book was released on 2006 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mast cells are immune effectors that are localized in tissues, proximal to sites of entry for allergens and other external stimuli. The mediators produced by mast cells are involved in innate immunity against bacteria and parasites, and are key effectors of allergic and asthmatic responses. Mast cell mediators also contribute to fibrosis in asthma, pulmonary fibrosis, scleroderma, and rheumatoid arthritis. The aim of this study was to test the hypothesis that mast cell interactions with fibroblasts are affected by their activation state, in a way that could contribute to the progression of fibrosis. Bone marrow mast cells (BMMC) were derived in vitro from bone marrow progenitors and connective tissue mast cells (CTMC) were harvested from mouse peritoneal cavity. An ELISA was used to measure histamine in the supernatants and cell lysates of activated BMMC and CTMC. Following activation by crosslinking the high affinity IgE receptor, histamine was released from BMMC and CTMC. Starting 24 hours after activation, the total cellular histamine concentration of BMMC was 755+/-14 ng/10 6 cells, and exceeded the amount in resting BMMC (214+/-9 ng/10 6 cells). The over-accumulation of histamine peaked 72 hours after activation (3136+/-394 ng/10 6 cells), and was transient, returning toward the amount in resting BMMC by 96 hours (1787+/-280 ng/10 6 cells). The increase in histamine was accompanied by an increase in the expression of histidine decarboxylase mRNA, and a 70 kD form of the protein encoded by this mRNA. Similar changes in histamine concentration did not occur in CTMC, indicating that histamine over-accumulation is associated with mast cell phenotype. To study changes in mast cell adhesion to fibroblasts following activation, an assay was developed to quantify adhesion between mast cells and the NIH-3T3 fibroblast cell line. Resting or activated BMMC or CTMC were cocultured with the fibroblasts for various times to allow adhesion to occur. Nonadherent cells were washed away and adherent mast cells were quantified based on recovery of histamine from the adherent cells. Following activation, adhesion of both BMMC and CTMC to fibroblasts was increased three to six fold. This increased adhesion was not due to increased integrin expression, cell proliferation, or inflammatory mediators released from the mast cells. These findings offer new insights into the role of activated mast cells in fibrotic diseases.
Book Synopsis Advances in Pain Research by : Bai-Chuang Shyu
Download or read book Advances in Pain Research written by Bai-Chuang Shyu and published by Advances in Experimental Medic. This book was released on 2019-11-03 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Book Synopsis Mast Cells in Kainate Receptor Knockout Mice by : Andrea J. Elkovich
Download or read book Mast Cells in Kainate Receptor Knockout Mice written by Andrea J. Elkovich and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Kainate receptor knockout mice have unique differences within their immune system. They exhibit an attenuated T[subscriptH]2 branch, while maintaining a robust T[subscriptH]1 response. Specifically, blocking the formation of functional kainate receptors affects mast cells and their related pathologies. While they seem to develop and activate normally in vivo and in vitro, KAR KO mast cells release more inflammatory mediators upon degranulation. These mice experience severe anaphylactic shock due to two compounding abnormalities. First, KAR KO mast cells release significantly more histamine in vivo upon IgE-mediated activation. Second, the animals over-respond to exogenous histamine with drastic temperature drops compared to WT. This report shows that the kainate receptor plays an important role in mast cell-mediated immune responses.
Book Synopsis Adverse Effects of Vaccines by : Institute of Medicine
Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.
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