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Author : Eric Reid
Publisher : North-Holland
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (45 download)
Download or read book Assay of Drugs and Other Trace Compounds in Biological Fluids written by Eric Reid and published by North-Holland. This book was released on 1976 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Assay of drugs an dother trace compounds in biological fluids written by and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph Chamberlain
Publisher : CRC Press
ISBN 13 : 1351411446
Total Pages : 368 pages
Book Rating : 4.3/5 (514 download)
Download or read book The Analysis of Drugs in Biological Fluids written by Joseph Chamberlain and published by CRC Press. This book was released on 2018-02-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth.
Author : Eric Reid
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (465 download)
Download or read book Assay of Drugs and Other Trace Compounds in Biologica Fluids written by Eric Reid and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Emil T. Lin
Publisher :
ISBN 13 :
Total Pages : 175 pages
Book Rating : 4.:/5 (227 download)
Download or read book Analysis of Investigational Drugs in Biological Fluids Method Development and Routine Assay written by Emil T. Lin and published by . This book was released on 1992 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report describes technical work accomplished and information gained in performance of contract number DAMDl786-C-6150, entitled Analysis of Investigational Drugs in Biological Fluids - Method Development and Routine Assay, for the US Army Medical Research and Development Command (USAMRDC). We were able to complete ten projects for determination of test article concentrations in terms of method development, validation, and characterization. We demonstrated sensitivity, specificity, linearity, lack of interferences, accuracy, and reproducibility of the analytical method, described the extent of recovery for the method, and reported on the stability of compounds of interest in specimens during storage and drug analysis. Methods developed were such that a single technician could complete at least 15 clinical samples in one day. These methods were robust and portable enough to be transported to other laboratories. Six projects on ten compounds were begun during the contract period, one of which was cancelled, and the remaining five have reached various stages of completeness at the end of the contract period. Routine analyses of samples were performed for 33 studies (or pilot studies) designated by WRAIR. The breakdown of routine analyses studies by compound(s) follows: Halofantrine and/or WR 178,460,8 studies; Mefloquine 3 studies, Physostigmine and/or Eseroline, 6 studies; Pyridostigmine, 10 studies; WR 238605,3 studies; and WR 6026 and/or WR 211789,3 studies. Final, Method, Development, Routine Assay.
Author : Joseph Chamberlain
Publisher :
ISBN 13 : 9780138737191
Total Pages : 0 pages
Book Rating : 4.7/5 (371 download)
Download or read book The Analysis of Drugs in Biological Fluids 2nd Edition written by Joseph Chamberlain and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth."--Provided by publisher.
Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
ISBN 13 : 1588297802
Total Pages : 441 pages
Book Rating : 4.5/5 (882 download)
Download or read book Handbook of Drug Monitoring Methods written by Amitava Dasgupta and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.
Author :
Publisher :
ISBN 13 :
Total Pages : 148 pages
Book Rating : 4.:/5 (946 download)
Download or read book Analysis of Investigational Drugs in Biological Fluids - Method Development and Analysis of Pre-Clinical and Clinical Samples written by and published by . This book was released on 1999 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the procedures described in this report, we were able to work sequentially or simultaneously on development, validation and characterization of assays for WR 6026 (and its metabolites, WR 211789 and WR 254421), mefloquine (and its metabolite, WR 160972), p-aminoheptanophenone (and related compounds), WR 242511, halofantrine (and its metabolite, WR 178,460, and their stereoisomers), chloroquine (and its metabolites, monodesethylchloroquine and didesethylchloroquine), WR 243,251, WR 238,605, doxycycline, gentamicin, paromomycin and artelinic add. Work on routine analyses of biological specimens during this period was performed for studies that required determination of concentrations of artelinic acid, gentamicin and paromomycin. We worked on demonstrating sensitivity, specificity, linearity, lack of interferences, accuracy, and reproducibility of the analytical method, describing the extent of recovery for the method, and reporting on the stability of compounds of interest in specimens during storage and drug analysis to provide documentation in support of Investigational New Drug (IND) submissions to the Food and Drug Administration (FDA).
Author : Robert J. Flanagan
Publisher : John Wiley & Sons
ISBN 13 : 0470319348
Total Pages : 605 pages
Book Rating : 4.4/5 (73 download)
Download or read book Fundamentals of Analytical Toxicology written by Robert J. Flanagan and published by John Wiley & Sons. This book was released on 2008-03-03 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry
Author : Steen Honoré Hansen
Publisher : John Wiley & Sons
ISBN 13 : 1118716825
Total Pages : 332 pages
Book Rating : 4.1/5 (187 download)
Download or read book Bioanalysis of Pharmaceuticals written by Steen Honoré Hansen and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry is the first student textbook on the separation science and mass spectrometry of pharmaceuticals present in biological fluids with an educational presentation of the principles, concepts and applications. It discusses the chemical structures and properties of low- and high-molecular drug substances; the different types of biological samples and fluids that are used; how to prepare the samples by extraction, and how to perform the appropriate analytical measurements by chromatographic and mass spectrometric methods. Bioanalysis of Pharmaceuticals: Sample Preparation, Separation Techniques and Mass Spectrometry: Is an introductory student textbook discussing the different principles and concepts clearly and comprehensively, with many relevant and educational examples Focuses on substances that are administered as human drugs, including low-molecular drug substances, peptides, and proteins Presents both the basic principles that are regularly taught in universities, along with the practical use of bioanalysis as carried out by researchers in the pharmaceutical industry and in hospital laboratories Is aimed at undergraduate students, scientists, technicians and researchers in industry working in the areas of pharmaceutical analyses, biopharmaceutical analyses, biological and life sciences The book includes multiple examples to illustrate the theory and application, with many practical aspects including calculations, thus helping the student to learn how to convert the data recorded by instruments into the real concentration of the drug substances within the biological sample.
Author : James Lawrence
Publisher : Elsevier
ISBN 13 : 0323157025
Total Pages : 301 pages
Book Rating : 4.3/5 (231 download)
Download or read book Organic Trace Analysis by Liquid Chromatography written by James Lawrence and published by Elsevier. This book was released on 2012-12-02 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Trace Analysis by Liquid Chromatography focuses on high-performance liquid chromatography in the field of formulations analysis, which includes quality control of pharmaceutical preparations, pesticide formulations, cosmetics, and food colors. This book explores the application of liquid chromatography to trace analysis. Organized into 10 chapters, this book starts with an overview of the special requirements of liquid chromatography for trace analysis. This text then compares the approach to gas chromatography and formulations analysis, noting the significant difference. Other chapters consider the liquid chromatography equipment and examine the best types and conditions of instrumentation suitable for trace analysis. This book discusses as well the chromatography theory and includes descriptive accounts of the principles of the different forms of chromatography. The final chapter describes the typical approaches that are used for trace analysis. This book is a valuable resource for analysts engaged in the determination of trace organics in many various substrates.
Author : Hans Brandenberger
Publisher : Walter de Gruyter
ISBN 13 : 9783110107319
Total Pages : 772 pages
Book Rating : 4.1/5 (73 download)
Download or read book Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists written by Hans Brandenberger and published by Walter de Gruyter. This book was released on 1997 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pokar M. Kabra
Publisher : Springer Science & Business Media
ISBN 13 : 1603274049
Total Pages : 463 pages
Book Rating : 4.6/5 (32 download)
Download or read book Liquid Chromatography in Clinical Analysis written by Pokar M. Kabra and published by Springer Science & Business Media. This book was released on 2008-02-07 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography in Clinical Analysis
Author : Eric Reid
Publisher : Springer Science & Business Media
ISBN 13 : 1468444840
Total Pages : 281 pages
Book Rating : 4.4/5 (684 download)
Download or read book Drug Metabolite Isolation and Determination written by Eric Reid and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scope of the book, and acknowledgements.- The articles are focused on 'real problems' in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre ciation is also expressed for permission to reproduce published mat erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.
Author : Irena Baranowska
Publisher : Springer
ISBN 13 : 3319196146
Total Pages : 458 pages
Book Rating : 4.3/5 (191 download)
Download or read book Handbook of Trace Analysis written by Irena Baranowska and published by Springer. This book was released on 2015-08-13 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is unique in its comprehensive coverage of the subject and focus on practical applications in diverse fields. It includes methods for sample preparation, the role of certified reference materials, calibration methods and statistical evaluation of the results. Problems concerning inorganic and bioinorganic speciation analysis, as well as special aspects such as trace analysis of noble metals, radionuclides and volatile organic compounds are also discussed. A significant part of the content presents applications of methods and procedures in medicine (metabolomics and therapeutic drug monitoring); pharmacy (the analysis of contaminants in drugs); studies of environmental samples; food samples and forensic analytics – essential examples that will also facilitate problem solving in related areas.
Author : E. Reid
Publisher : Springer Science & Business Media
ISBN 13 : 1475718926
Total Pages : 411 pages
Book Rating : 4.4/5 (757 download)
Download or read book BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers written by E. Reid and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert A. Copeland
Publisher : John Wiley & Sons
ISBN 13 : 0471723266
Total Pages : 295 pages
Book Rating : 4.4/5 (717 download)
Download or read book Evaluation of Enzyme Inhibitors in Drug Discovery written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2005-04-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.
