Antiviral Drug Development

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Antiviral Drug Discovery and Development

Author : Xinyong Liu
Publisher : Springer Nature
ISBN 13 : 9811602670
Total Pages : 357 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Antiviral Drug Discovery and Development by : Xinyong Liu

Download or read book Antiviral Drug Discovery and Development written by Xinyong Liu and published by Springer Nature. This book was released on 2021-07-13 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527343377
Total Pages : 530 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2022-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

Antiviral Drugs

Author : Wieslaw M. Kazmierski
Publisher : John Wiley & Sons
ISBN 13 : 0470455632
Total Pages : 468 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Antiviral Drugs by : Wieslaw M. Kazmierski

Download or read book Antiviral Drugs written by Wieslaw M. Kazmierski and published by John Wiley & Sons. This book was released on 2011-08-23 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.

Antiviral Drug Strategies

Author : Erik De Clercq
Publisher : John Wiley & Sons
ISBN 13 : 3527635963
Total Pages : 632 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Antiviral Drug Strategies by : Erik De Clercq

Download or read book Antiviral Drug Strategies written by Erik De Clercq and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

Antiviral Drug Development

Author : Erik De Clercq
Publisher : Springer Science & Business Media
ISBN 13 : 1468472755
Total Pages : 313 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Antiviral Drug Development by : Erik De Clercq

Download or read book Antiviral Drug Development written by Erik De Clercq and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Successful Strategies for the Discovery of Antiviral Drugs

Author : Manoj C. Desai
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737819
Total Pages : 551 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Successful Strategies for the Discovery of Antiviral Drugs by : Manoj C. Desai

Download or read book Successful Strategies for the Discovery of Antiviral Drugs written by Manoj C. Desai and published by Royal Society of Chemistry. This book was released on 2013-06-17 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The antiviral therapeutic area continues to rapidly generate meaningful new chemical entities; for example, for HIV alone more than 25 drugs have been approved, and in the next few years many individual drugs and single tablet regimens will be approved for the treatment of hepatitis C virus infection. The increasing success in the antiviral area could be due to targeting drugs at "non-self" genomes and to the patient population that is tolerant of manageable side effects and adaptable to inconvenient dosing. Aimed at medicinal chemists and emerging drug discovery scientists, the book is organized according to the various strategies deployed for the discovery and optimization of initial lead compounds. This book focuses on capturing tactical aspects of problem solving in antiviral drug design, an approach that holds special appeal for those engaged in antiviral drug development, but also appeals to the broader medicinal chemistry community based on its focus on tactical aspects of drug design.

Antiviral Drugs

Author : Wieslaw M. Kazmierski
Publisher : John Wiley & Sons
ISBN 13 : 0470934689
Total Pages : 472 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Antiviral Drugs by : Wieslaw M. Kazmierski

Download or read book Antiviral Drugs written by Wieslaw M. Kazmierski and published by John Wiley & Sons. This book was released on 2011-07-08 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats

Author : Paul F. Torrence
Publisher : John Wiley & Sons
ISBN 13 : 0471716707
Total Pages : 440 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats by : Paul F. Torrence

Download or read book Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats written by Paul F. Torrence and published by John Wiley & Sons. This book was released on 2005-08-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.

Antiviral Discovery for Highly Pathogenic Emerging Viruses

Author : César Muñoz-Fontela
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160535
Total Pages : 209 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Antiviral Discovery for Highly Pathogenic Emerging Viruses by : César Muñoz-Fontela

Download or read book Antiviral Discovery for Highly Pathogenic Emerging Viruses written by César Muñoz-Fontela and published by Royal Society of Chemistry. This book was released on 2021-11-26 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: New antiviral drugs are urgently needed. Recent outbreaks caused by viruses with great epidemiological impact such as Zika, or extraordinary virulence such as Ebola, Nipah, Lassa, Crimean-Congo haemorrhagic fever highlight the current lack of clinically proven vaccines and treatments for these potentially catastrophic agents. Antiviral Discovery for Highly Pathogenic Emerging Viruses comprehensively outlines the state of the art in antiviral drug discovery including identification of targets, screening strategies and the current pipeline of antiviral candidates including regulatory issues. The book also addresses the challenges faced in proceeding from pre-clinical studies to animal models and clinical trials with these highly pathogenic agents. Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents. Illustrated throughout with case studies this book is a valuable resource in this complex and multidisciplinary field.

Combating the Threat of Pandemic Influenza

Author : Paul F. Torrence
Publisher : John Wiley & Sons
ISBN 13 : 0470179708
Total Pages : 308 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Combating the Threat of Pandemic Influenza by : Paul F. Torrence

Download or read book Combating the Threat of Pandemic Influenza written by Paul F. Torrence and published by John Wiley & Sons. This book was released on 2007-09-28 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery for influenza antivirals Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health–related endeavor. With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering: Existing antivirals, including broadly effective anti-respiratory virus agents The development of high-throughput screening assays IFN resistance The development of nucleic acid–based antiviral drugs Antiviral RNAi strategies targeting influenza virus Other promising antiviral drug discovery strategies Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Viral Pathogenesis

Author : Michael G. Katze
Publisher : Academic Press
ISBN 13 : 0128011742
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Pathogenesis by : Michael G. Katze

Download or read book Viral Pathogenesis written by Michael G. Katze and published by Academic Press. This book was released on 2015-12-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field

Advances in Antiviral Drug Design

Author : E. De Clercq
Publisher : Elsevier
ISBN 13 : 0080522262
Total Pages : 231 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Advances in Antiviral Drug Design by : E. De Clercq

Download or read book Advances in Antiviral Drug Design written by E. De Clercq and published by Elsevier. This book was released on 2003-12-17 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses six specific directions that have opened new avenues for the treatment of HIV and other virus infections.First, as the introductory chapter, the different new anti-HIV agents that are now in preclinical or clinical development are reviewed by E. De Clercq. This includes new NRTIs, NNRTIs and PIs, but also HIV entry/fusion inhibitors as well as integrase inhibitors, and some of these agents, such as the NRTI emtricitabine [(-)FTC] and the PI atazanavir, may soon be licensed for clinical use.Second, high expectations are vested in the potential therapeutic usefulness of inhibitors of HIV integration, a point of no return in the life cycle of HIV, and this approach is highlighted by D.J. Hazuda and S.D. Young.Third, as all currently available PIs can be described as "peptidomimetic", and, therefore, expected to demonstrate overlapping virus-drug resistance and side effect profiles, it would be interesting to see how a non-peptidic protease inhibitor such as tipranavir behaves, and this is covered by D. Mayers, K. Curry, V. Kohlbrenner and S. McCallister.Fourth, neuraminidase inhibitors such as zanamivir (that has to be inhaled) and oseltamivir (that can be administered via the oral route) have gained a definitive status as antiviral drugs useful for both therapy and prophylaxis of influenza A and B virus infections; as they target a specific influenza viral enzyme, neuraminidase (or sialidase), they may be expected to block newly emerging influenza viruses as well, and the design of neuraminidase inhibitors has received due attention of H. Jin and C.U. Kim.Fifth, while the major current efforts in antiviral drug development have shifted from herpesviruses towards HIV and hepatitis viruses [hepatitis B virus (HBV), hepatitis C virus (HCV)], it is interesting to note that by switching from the classical five-membered sugar or acyclic nucleoside strategy, J. Wang, M. Froeyen and P. Herdewijn have gone "upstream" in designing six-membered carbocyclic nucleosides as potential anti-herpesvirus agents.Sixth, following up on the nucleotide prodrug strategy introduced above under ix, to deliver the biologically active nucleotides inside the cells, C. Meier has elaborated on a particular class of such pronucleotides, namely that of the cyclosaligenyl pronucleotides, an approach that should have far reaching implications for compounds effective against HIV, HBV and other viruses.The six topics covered in this fourth volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the design and development of new therapeutic agents for virus infections. They pertain to the combat against three of the most important viral pathogens of current times: HIV, HBV, influenza virus and herpesviruses.

Advances in Antiviral Research

Author : Naveen Kumar
Publisher : Springer Nature
ISBN 13 : 9819991951
Total Pages : 463 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Advances in Antiviral Research by : Naveen Kumar

Download or read book Advances in Antiviral Research written by Naveen Kumar and published by Springer Nature. This book was released on with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trends in Antiviral Drug Development

Author : M. J. Sofia
Publisher : VCH
ISBN 13 : 9783527353019
Total Pages : 0 pages
Book Rating : 4.3/5 (53 download)

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Book Synopsis Trends in Antiviral Drug Development by : M. J. Sofia

Download or read book Trends in Antiviral Drug Development written by M. J. Sofia and published by VCH. This book was released on 2025-07-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antiviral Research

Author : Robert L. LaFemina
Publisher :
ISBN 13 : 9781555814397
Total Pages : 0 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Antiviral Research by : Robert L. LaFemina

Download or read book Antiviral Research written by Robert L. LaFemina and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Antiviral Drug Design

Author : E. De Clercq
Publisher : Elsevier
ISBN 13 : 0080548245
Total Pages : 265 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Advances in Antiviral Drug Design by : E. De Clercq

Download or read book Advances in Antiviral Drug Design written by E. De Clercq and published by Elsevier. This book was released on 2007-07-30 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.