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Antitumor Antibiotics
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Book Synopsis Antitumor Antibiotics by : S.K. Carter
Download or read book Antitumor Antibiotics written by S.K. Carter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific collaboration between the United States and Japan in the field of cancer goes back many years. In this successful international collaboration cancer chemotherapy has been one of the most productive areas. Pioneers such as YOSHIDA, UMEZAWA, SHEAR, and GOLDIN established firm links of mutual trust and respect in the period after the Second Great War. Japanese drugs, such as mitomycin C and bleomycin have become mainstays of clinical oncology in the U. S. and throughout the world. Many drugs developed in the U. S. have become established in Japanese cancer therapy. Within the cancer chemotherapy field the antitumor antibiotics rank as one of the most important groups. In the U . S. -J apanese collaboration this group of drugs has taken the paramount role. The Japanese, under the leadership of U mezawa, are considered to be among the most innovative and productive in this area which has also had great emphasis in the United States as part of the National Cancer Institute's drug development program and in the pharmaceutical industry. This extended collaboration in general oncology, and chemotherapy in particular, has received increased impetus by and support from the official U . S. -J apan Joint Agreement on cancer research, which was established in 1974 between the National Cancer Institute and the Japanese Society for the Promotion of Science. One of the subsections of this agreement is cancer therapy with emphasis on chemotherapy.
Book Synopsis The Chemistry of Antitumor Antibiotics, Volume 2 by : William A. Remers
Download or read book The Chemistry of Antitumor Antibiotics, Volume 2 written by William A. Remers and published by Wiley-Interscience. This book was released on 1988-10-31 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The large number of new antitumour antibiotics that have been discovered and evaluated since the first volume of The Chemistry of Antitumour Antibiotics was published in 1978 are described in this up-to-date work. It covers the results of mode and action studies which have benefitted from high-field NMR, including 2-D techniques, computer modelling and DNA sequencing methods. The volume also notes how biosynthesis has been helped by NMR to follow the incorporation of compounds containing stable isotopes.
Download or read book Doxorubicin written by Federico Arcamone and published by Elsevier. This book was released on 2012-12-02 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doxorubicin: Anticancer Antibiotics details the development of doxorubicin as a wide-spectrum antitumor antibiotic. The book begins by tracing the discovery and development of doxorubicin, highlighting factors such as (a) the involvement of organic chemistry at an early stage, which allowed the rapid identification of doxorubicin and ensured its prompt availability for the clinical trials; (b) the well-established, pioneering expertise in experimental chemotherapy of Professor Aurelio di Marco and his group at Istituto Nazionale Tumori, Milan; and (c) the highly motivated interest of experienced clinicians. The remaining chapters provide an overview of basic studies in the area of medicinal chemistry and related fields that have resulted from doxorubicin development. Such studies have been concerned with both biochemical and biophysical investigations at the molecular level and at different levels of biological organization. A large body of work aimed at developing synthetic procedures for the drug and for new related analogs of potential clinical usefulness has also been carried out.
Book Synopsis The Chemistry of Antitumor Antibiotics by : William A. Remers
Download or read book The Chemistry of Antitumor Antibiotics written by William A. Remers and published by John Wiley & Sons. This book was released on 1979-03-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Chemistry of Antitumor Antibiotics by : William Alan Remers
Download or read book The Chemistry of Antitumor Antibiotics written by William Alan Remers and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heterocyclic Antitumor Antibiotics by : Moses Lee
Download or read book Heterocyclic Antitumor Antibiotics written by Moses Lee and published by . This book was released on 2006-05-22 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series "Topics in Heterocyclic Chemistry" will present critical reviews on "Heterocyclic Compounds" within topic related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Book Synopsis Mechanism of Action of Antimicrobial and Antitumor Agents by : J. F. Snell
Download or read book Mechanism of Action of Antimicrobial and Antitumor Agents written by J. F. Snell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
Book Synopsis Structures and Possible Modes of Action of Two Antitumor Antibiotics by : Edward Van Dyke Arnold
Download or read book Structures and Possible Modes of Action of Two Antitumor Antibiotics written by Edward Van Dyke Arnold and published by . This book was released on 1982 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Book Synopsis Anthracycline Antibiotics in Cancer Therapy by : Franco M. Muggia
Download or read book Anthracycline Antibiotics in Cancer Therapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical application of these two compounds heralded a decade of excitement among oncologists dealing with pediatric tumors, breast cancer, leukemias, and lymphomas, and opened new hope for patients afflicted with sar comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with the occurrence of alopecia and other acute toxicities. This record of past achievements and problems has slowly given way to a present increasingly illuminated by our ability to modify the distressing toxicities of these agents. Detailed clinical studies supplemented by ingenious laboratory models have gradually elucidated mechanisms and risk factors im plicated in the cardiomyopathy.
Book Synopsis ANTITUMOR ANTIBIOTICS- PAPERS PRESENTED- U.S. JAPAN JOINT AGREEMENT ON CANCER RESEARCH 3RD ANNUAL PROGRAM REVIEW SYMPOSIUM- NORTHERN CALIFORNIA CANCER PROGRAM. by :
Download or read book ANTITUMOR ANTIBIOTICS- PAPERS PRESENTED- U.S. JAPAN JOINT AGREEMENT ON CANCER RESEARCH 3RD ANNUAL PROGRAM REVIEW SYMPOSIUM- NORTHERN CALIFORNIA CANCER PROGRAM. written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanism of Action Studies on the FR-9000482 Class of Antitumor Antibiotics by : Scott Raymond Rajski
Download or read book Mechanism of Action Studies on the FR-9000482 Class of Antitumor Antibiotics written by Scott Raymond Rajski and published by . This book was released on 1997 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Aspects of Anticancer Drug DNA Interactions by : Stephen Neidle
Download or read book Molecular Aspects of Anticancer Drug DNA Interactions written by Stephen Neidle and published by CRC Press. This book was released on 1994-05-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
Book Synopsis Handbook of Brain Tumor Chemotherapy by : Herbert B. Newton
Download or read book Handbook of Brain Tumor Chemotherapy written by Herbert B. Newton and published by Elsevier. This book was released on 2005-12-19 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy. - Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors - Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors - Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors
Book Synopsis Studies Toward the Synthesis of Antitumor Antibiotics FR-900482 and FR-66979 by : Hee-Jong Lim
Download or read book Studies Toward the Synthesis of Antitumor Antibiotics FR-900482 and FR-66979 written by Hee-Jong Lim and published by . This book was released on 1996 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecuarbiological mechanisms of antitumor antibiotics action by : Hermann Berg
Download or read book Molecuarbiological mechanisms of antitumor antibiotics action written by Hermann Berg and published by . This book was released on 1985 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Chemistry of Antitumor Antibiotics by : William A. Remers
Download or read book The Chemistry of Antitumor Antibiotics written by William A. Remers and published by John Wiley & Sons. This book was released on 1979-03-12 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
