Author : Jeffrey Kim
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (967 download)
Book Synopsis Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates by : Jeffrey Kim
Download or read book Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates written by Jeffrey Kim and published by . This book was released on 2016 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial resistance (AMR) has become a central topic as it is a growing threat in human and animal health. Major surveillance systems, such as the National Antimicrobial Resistance Monitoring System (NARMS), are now established to monitor AMR and provide physicians, veterinarians, and scientists with valuable information to make informed decisions on policy and therapeutic treatment. However, there is a lack of comprehensive literature on AMR among nonhuman primates (NHP). This study aims to provide data on current antimicrobial use strategies and on the prevalence of AMR in zoonotic bacteria recovered from NHPs within biomedical research institutions. We focused on four zoonotic enteric bacteria: Shigella flexneri, Yersinia enterocolitica, Y. pseudotuberculosis, and Campylobacter jejuni. Fifteen veterinarians, seven biomedical research institutions, and four diagnostic laboratories participated, providing susceptibility test results across three years (1/2012 – 4/2015). Veterinarians primarily treated cases caused by S. flexneri, Y. enterocolitica, and Y. pseudotuberculosis with enrofloxacin, but treated C. jejuni cases with azithromycin and tylosin. All isolates were susceptible to their associated primary antimicrobials. However, high proportions of AMR was observed to other antimicrobials. S flexneri isolates were resistant to erythromycin (87.5%, 21/24), doxycycline (73.7%, 14/19), and tetracycline (38.2%, 157/411). Y. enterocolitica isolates were resistant to ampicillin (100%, 49/49) and cefazolin (93.6%, 44/47). No Y. pseudotuberculosis isolate (0/58) was resistant to any tested antimicrobial. C. jejuni isolates were resistant to methicillin (99.5%, 569/572) and cephalothin (97.5%, 557/571). Notably, resistance patterns were not shared between this study’s NHP isolates and human isolates presented by NARMS. This study demonstrates that zoonotic bacteria recovered from NHP diagnostic samples are broadly susceptible to the antimicrobials used to treat the clinical infections. These results can help veterinarians ensure effective antimicrobial therapy and protect staff by minimizing occupational risk.