Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Anti Obesity Targeting Brown And Beige Adipocytes full books in PDF, epub, and Kindle. Read online Anti Obesity Targeting Brown And Beige Adipocytes ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Jiqiu Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889743411
Total Pages : 160 pages
Book Rating : 4.8/5 (897 download)
Download or read book Anti-obesity: Targeting Brown and Beige Adipocytes written by Jiqiu Wang and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Takeshi Yoneshiro
Publisher : Frontiers Media SA
ISBN 13 : 2889662829
Total Pages : 187 pages
Book Rating : 4.8/5 (896 download)
Download or read book Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity written by Takeshi Yoneshiro and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Saverio Cinti
Publisher :
ISBN 13 : 9788885030329
Total Pages : 94 pages
Book Rating : 4.0/5 (33 download)
Download or read book The Adipose Organ written by Saverio Cinti and published by . This book was released on 1999 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alexander Pfeifer
Publisher : Springer
ISBN 13 : 303010513X
Total Pages : 424 pages
Book Rating : 4.0/5 (31 download)
Download or read book Brown Adipose Tissue written by Alexander Pfeifer and published by Springer. This book was released on 2019-04-02 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.
Author : Jiyoung Bae
Publisher :
ISBN 13 :
Total Pages : 177 pages
Book Rating : 4.:/5 (14 download)
Download or read book Brown and Beige Adipocytes written by Jiyoung Bae and published by . This book was released on 2015 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent findings of brown adipocytes and brown-like or beige adipocytes, capable of dissipating energy as heat, in adult humans have promised new hope for obesity treatment and prevention. Understanding of the regulation of brown and beige adipocytes will provide novel strategies to reach the goal. Pattern recognition receptors (PRR) are responsible for inflammation in adipose tissue, which leads to adipose dysfunction and obesity associated chronic diseases. It has been shown that PRR activation induces inflammation, leading to insulin resistance in white adipocytes and white adipose tissue (WAT). However, the roles of PRR activation in brown adipocytes and brown adipose tissue (BAT) have not been studied. In addition, in vitro and in vivo studies have shown that bioactive food components can contribute to obesity prevention; however, very few bioactive food components have been studied for their beneficial effects in promoting development and function of brown and beige adipocytes. This dissertation reports that (1) mRNA of PRRs and inflammatory cytokines/chemokines are upregulated in the BAT of both diet induced obesity mice model and ob/ob mice model; (2) activation of PRRs induces activation of NF-kB and MAPK signaling pathways, leading to upregulation of the proinflammatory genes, MCP- 1, IL-6, RANTES, and TNF-[alpha], in mature brown adipocytes; (3) activation of PRRs suppresses UCP-1 expression, leading to decreased mitochondrial respiration and thermogenesis in mature brown adipocytes; (4) chronic activation of PRRs reduces adipogenesis and suppresses expression of brown-specific genes in both classic brown adipocytes and multipotent stem cells. This dissertation further demonstrates that naringenin, a flavanone mainly found in citrus fruits, enhances thermogenic activation in isoproterenol-stimulated 3T3-L1 adipocytes through PKA/p38 MAPK pathways. The results suggest that PRR-mediated inflammation in brown adipocytes may be a potential target for regulating BAT development and function for obesity treatment and prevention. Dietary bioactive compounds, such as naringenin, could be beneficial in promoting functional BAT, thereby contributing to energy expenditure.
Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681085585
Total Pages : 245 pages
Book Rating : 4.6/5 (81 download)
Download or read book Anti-obesity Drug Discovery and Development written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2018-12-14 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs. The fourth volume of this series covers 6 reviews on anti-obesity treatment strategies including updates on obesity and cancer prevention through dietary modulation, the role of anti-obesity medications in polycystic ovary syndrome, potential anti-obesity strategies targeting mitochondria, calcium silicate based formulations for anti-obesity therapy, and the identification of obesity medications from natural products and plants.
Author : Carsten Carlberg
Publisher : Springer
ISBN 13 : 3319304151
Total Pages : 237 pages
Book Rating : 4.3/5 (193 download)
Download or read book Nutrigenomics written by Carsten Carlberg and published by Springer. This book was released on 2016-06-11 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fascinating area of Nutrigenomics describes this daily communication between diet, food and nutrients, their metabolites and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannas of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life, and our life-long “chat” with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. We are not aiming to compete with more comprehensive textbooks on molecular nutrition, evolutionary biology, genomics, gene regulation or metabolic diseases, but rather will focus on the essentials and will combine, in a compact form, elements from different disciplines. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of this book is based on the lecture course “Nutrigenomics”, which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book is subdivided into three sections and twelve chapters. Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively. Besides its value as a textbook, Nutrigenomics will be a usefull reference for individuals working in biomedicine.
Author : Carsten Carlberg
Publisher : Springer Nature
ISBN 13 : 303036948X
Total Pages : 195 pages
Book Rating : 4.0/5 (33 download)
Download or read book Nutrigenomics: How Science Works written by Carsten Carlberg and published by Springer Nature. This book was released on 2020-02-14 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fascinating area of Nutrigenomics describes this daily communication between our diet and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannahs of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life and our life-long “chat” with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. The content of this book is based on the lecture course “Nutrigenomics”, which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book represents an updated but simplified version of our textbook “Nutrigenomics” (ISBN 978-3-319-30413-7). Besides its value as a textbook, “Nutrigenomics: how science works” will be a useful reference for individuals working in biomedicine
Author : Rubén Cereijo
Publisher : Frontiers Media SA
ISBN 13 : 2832534007
Total Pages : 139 pages
Book Rating : 4.8/5 (325 download)
Download or read book Novel regulatory mechanisms behind thermogenesis of brown and beige adipocytes written by Rubén Cereijo and published by Frontiers Media SA. This book was released on 2023-09-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joana Vieira Silva
Publisher : Springer Nature
ISBN 13 : 3030444368
Total Pages : 444 pages
Book Rating : 4.0/5 (34 download)
Download or read book Tissue-Specific Cell Signaling written by Joana Vieira Silva and published by Springer Nature. This book was released on 2020-05-29 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Hyung Sun Yoo
Publisher :
ISBN 13 : 9781303439483
Total Pages : 59 pages
Book Rating : 4.4/5 (394 download)
Download or read book Intermittent Cold Exposure Induces Fat Deposition in Mice written by Hyung Sun Yoo and published by . This book was released on 2013 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brown adipose tissue (BAT) is the most essential thermogenic organ in homeotherms. In mice, brown adipocytes like cells (beige adipocytes) appear in subcutaneous fat depot after prolonged cold exposure. Fully-functioning BAT and beige adipocytes in subcutaneous fat depot drive a sharp increase in energy expenditure. In fact, cold-elicited BAT activation and beige cell recruitment in subcutaneous adipose tissue have shown anti-obesity effect, making them a promising target for obesity treatment. Due to the practice reasons, intermittent cold exposure may be an effective approach to activate BAT and to treat obesity and type 2 diabetes. However, cold exposure is known to induce various physiological changes and therefore warrants a comprehensive study looking at the effects of cold exposure on the whole body energy homeostasis. We found that intermittent cold exposure (ICE) leads to mild adaptive hyperphagia and fat accumulation in mice. Fat accumulation was mostly observed in subcutaneous adipose tissue with increased lipogenesis genes expression. ICE also increased fat accumulation in liver. Interestingly, pair-feeding and restrain studies ruled out the causal role of hyperphagia and stress on ICE-induced fat accumulation. In conclusion, intermittent cold exposure shifts energy homeostasis favoring fat accumulation in mice, although ICE stimulates BAT activation and beige cell recruitment in inguinal fat.
Author : Joel Faintuch
Publisher : Springer Nature
ISBN 13 : 3030533700
Total Pages : 994 pages
Book Rating : 4.0/5 (35 download)
Download or read book Obesity and Diabetes written by Joel Faintuch and published by Springer Nature. This book was released on 2020-12-14 with total page 994 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.
Author : Rita De Matteis
Publisher : Frontiers Media SA
ISBN 13 : 2889636577
Total Pages : 212 pages
Book Rating : 4.8/5 (896 download)
Download or read book Insights Into Brown Adipose Tissue Functions and Browning Phenomenon written by Rita De Matteis and published by Frontiers Media SA. This book was released on 2020-04-20 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shamim I. Ahmad
Publisher : Springer
ISBN 13 : 3319198211
Total Pages : 375 pages
Book Rating : 4.3/5 (191 download)
Download or read book Obesity written by Shamim I. Ahmad and published by Springer. This book was released on 2015-10-19 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings a comprehensive treatise about obesity, examining the measures that can be taken to stop and even reduce obesity if these right measures are taken in time. Recent studies show that obesity is on the increase at an alarming rate, especially in the industrialized and affluent countries. A number of reasons have been put forward for this increase, including life style choices, over-eating, over-use of commercially processed food, addiction for fast food, high caloric diet specially containing high levels of sugar and fat, lack of exercise and sedentary life style. Also genetic make up has been associated with obesity. Obesity can lead to a variety of lethal diseases, notably coronary heart disease, cancer and diabetes. These diseases account for the highest number of human death amongst all other causes. There are also a number of other side effects associated with obesity including increased stress, loss of intelligentsia, pancreatitis, premature birth and osteoarthritis. In recent years media have been playing important roles in highlighting the lethality and damage caused by obesity, nevertheless no significant effects can be seen in the population and obesity remains on the increase, especially amongst children. The editors believe that it is important that more education, campaign and research are used to stop this increasing disease.
Author : Atta-ur Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1681081873
Total Pages : 245 pages
Book Rating : 4.6/5 (81 download)
Download or read book Anti-Obesity Drug Discovery and Development written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2017-06-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. The third volume of this series is dedicated to anti-obesity treatments including updates on new therapeutics for obesity, Nesfatin-1 and its therapeutic uses, the role of proteomics in pediatric anti-obesity treatment, the role of oxidative stress in childhood obesity and a review of data on gut microbiota as a treatment option for obesity.
Author : Meghan Elizabeth McDonald
Publisher :
ISBN 13 :
Total Pages : 372 pages
Book Rating : 4.:/5 (95 download)
Download or read book Identification of Novel Regulators of Mesenchymal Stem Cell Commitment to the Brown Adipocyte Lineage written by Meghan Elizabeth McDonald and published by . This book was released on 2013 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Obesity is associated with an imbalance resulting from increased caloric intake and decreased energy expenditure. Humans have two types of adipose tissue: white adipose tissue (WAT), specialized for the storage of excess energy as lipid; and brown adipose tissue (BAT), which catabolizes lipid, releasing heat. Enhancing the development and/or activity of brown adipose tissue (BAT) or brown-like (beige) adipocytes within WAT is proposed as a means to enhance energy expenditure in obese individuals. Brown adipocyte progenitors share common origins with vascular cells; however, the mechanisms regulating commitment to these lineages are not understood. Bone Morphogenic Protein 7 (BMP7), a member of the Transforming Growth Factor B (TGFB) superfamily, promotes the development of brown adipocytes. The goal of this study was to identify novel mechanisms regulating the commitment of mesenchymal stem cells (MSCs) to the brown adipocyte lineage, and to characterize the contrasting effects of BMP7 and TGFB1 on cell fate.To address these questions, we used MSC culture models and identified several genes that are selectively regulated by BMP7 during BAT lineage commitment. These include the transcription factor Zinc Finger Protein of the Cerebellum 1 (Zic1 ), Gremlin1, a secreted BMP antagonist, and regulators of cell shape, the Rho-associated protein kinases, Rock1/2. Repression of Gremlin1 and Zic1 expression are necessary for MSCs to undergo brown adipogenesis. It is well-established that TGFB1 activates ROCK, and induces elongated, myofibroblast morphology in MSCs. We demonstrate that BMP7, in contrast, represses ROCK activity, altering actin dynamics and promoting a broadened morphology. Consistent with these findings, inhibition of ROCK activity or the downstream transcription factor Serum Response Factor (SRF), promotes brown adipocyte development. We conclude from these results that changes in cell shape and gene expression programs that are responsive to the status of the actin cytoskeleton are critical mediators of BAT lineage commitment.Our study has identified multiple genes involved in a brown fat/myofibroblast phenotypic switch. Modulation of ROCK or SRF activity may provide a novel means of promoting the development of brown/beige adipocytes in obese individuals. Further delineation of mechanisms regulating BAT development will lead to the identification of novel targets for anti-obesity therapeutics.
Author : Todd Leff
Publisher : John Wiley & Sons
ISBN 13 : 9783527629534
Total Pages : 530 pages
Book Rating : 4.6/5 (295 download)
Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
