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Angptl4 And Omega 3 Polyunsaturated Fatty Acids As Mediators Of Lipid Homeostasis In Different Metabolic States
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Book Synopsis ANGPTL4 and Omega-3 Polyunsaturated Fatty Acids as Mediators of Lipid Homeostasis in Different Metabolic States by : Alexander Rajna
Download or read book ANGPTL4 and Omega-3 Polyunsaturated Fatty Acids as Mediators of Lipid Homeostasis in Different Metabolic States written by Alexander Rajna and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis investigated the relationship between omega-3 polyunsaturated fatty acids (n-3 PUFA), white adipose tissue (WAT) angiopoietin-like 4 (ANGPTL4) expression, and metabolic state-dependent lipid homeostasis. C57BL/6J mice fed low-fat diets containing n-3 PUFA had reduced plasma NEFA and liver TAG accumulation in the fasted state, while in WAT, markers of lipogenesis were reduced, and markers of lipolysis were increased. Additionally, n-3 PUFA increased WAT Angptl4 gene expression. In contrast, n-3 PUFA reduced plasma TAG in the fed state but had no effect on Angptl4 gene expression. Collectively, this thesis suggests that n-3 PUFA regulate lipid metabolism in a metabolic-state dependent manner, and that these important fatty acids may work via differential regulation of Angptl4 in WAT.
Book Synopsis Omega-3 Fatty Acids in Health and Disease by : Lindsay Brown
Download or read book Omega-3 Fatty Acids in Health and Disease written by Lindsay Brown and published by MDPI. This book was released on 2018-09-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Omega-3 Fatty Acids in Health and Disease" that was published in JCM
Book Synopsis Latest Findings Of Omega-3 Long Chain Polyunsaturated Fatty Acids: From Molecular Mechanisms To New Applications In Health And Diseases by : Maricela Rodriguez Cruz
Download or read book Latest Findings Of Omega-3 Long Chain Polyunsaturated Fatty Acids: From Molecular Mechanisms To New Applications In Health And Diseases written by Maricela Rodriguez Cruz and published by Bentham Science Publishers. This book was released on 2011 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. The knowledge of physiological effects of LC-PUFAs at different levels is constantly expanding. Topics covered over 10 chapters thoroughly detail the role of omega-3 LCPUFAs in nutrition (gene regulation) and disease (clinical applications); information about food sources and recent intake recommendations is also explained. This book also discusses current data concerning the role of LC-PUFAs during pregnancy and lactation, in cognitive function, immune response.
Book Synopsis The Role of Polyunsaturated Fatty Acids in Metabolic Phenotypes and Genetic Associations with Cardiovascular Health by : Carmen Arrington
Download or read book The Role of Polyunsaturated Fatty Acids in Metabolic Phenotypes and Genetic Associations with Cardiovascular Health written by Carmen Arrington and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart disease continues to be the leading cause of death in the United States, killing about 695,000 people in 2021, ahead of cancer and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)1. In the United States, the average annual direct and indirect cost of cardiovascular disease (CVD) was an estimated $378.0 billion in 2017-2018; the estimated direct costs have more than doubled in the last two decades2. Fatty acids (FAs), which can be obtained exogenously through the diet or produced endogenously through de novo lipogenesis (DNL), play a critical role in heart health by helping maintain lipid balance and regulate inflammatory processes. FAs can be oxygenated to produce oxylipins which are bioactive, act as lipid mediators, and are thought to be a potential explanation for the diverse effects of polyunsaturated FAs (PUFAs)3, 4. FA and oxylipin synthesis are highly regulated processes in which genes exert substantial influence. Genetic variation contributes to the activity and efficiency of enzymes responsible for FA and oxylipin metabolism as well as the functionality of receptors specific to FAs and oxylipins. The field of precision nutrition has developed to understand how one's diet and their genes interact to affect the way the body responds to food. This dissertation aims to address how a person's genes affect the way the body responds to food, specifically fats and FAs, to provide individualized nutrition guidance in CVD prevention and treatment. In Study 1, we explore the pivotal role of free fatty acid receptor 4 (FFAR4 (human); Ffar4 (mouse)) in the context of myocardial infarction (MI), focusing particularly on its impact on the early oxylipin response to cardiac ischemia/reperfusion (I/R) injury. Previous research has established the relevance of Ffar4 in metabolic and inflammatory pathways and found cardiac function improves 7 days after ischemic insult, prompting an in-depth analysis of the complex milieu of cardiac ischemia. To unravel the intricate connections, a murine model was employed, subjecting mice to cardiac ischemia followed by only 3 days of reperfusion while scrutinizing the influence of Ffar4 on oxylipin dynamics. The study was designed to meticulously assess the response to I/R injury, unraveling gene- and sex-specific variations in the oxylipin response. Additionally, to bridge the translational gap, the analysis extended to the UK Biobank (UKB) cohort. This human component aimed to elucidate the association of FFAR4 single nucleotide polymorphisms (SNPs) with MI and ischemic CVDs. The murine experimentation uncovered a Ffar4-dependent response, particularly concerning LA-derived oxylipins, to I/R injury. While animals with systemic deletion of Ffar4 had higher LA alcohols and epoxides than wildtype prior to injury, I/R injury ablated the differences in oxylipin profile. Sex-specific differences also emerged from the analysis, shedding light on distinct molecular mechanisms operating in male and female mice. However, the human analysis found FFAR4-dependent higher risk for stroke in women; no other FFAR4-dependent differences in disease incidence were found which may suggest genetic variation is not the cause of downstream differences due implicating FFAR4. In essence, this research underscores the intricate involvement of FFAR4 in the oxylipin responses to cardiac ischemia. The study provides valuable insights into potential sex-specific mechanisms of oxylipin response while acknowledging the inherent disparities between murine and human response to cardiovascular (CV) challenges. These complexities emphasize the multifaceted role of the FFAR4 in CVD. In Study 2, we investigate substrate competition between saturated FAs (SFAs) and PUFAs as ligands for FFAR4 and the downstream impact on metabolic outcomes, specifically related to metabolic syndrome (MetSyn), MI, and death. The study utilizes data from the UKB cohort including various demographic and health-related variables as well as FA measurements. The statistical methods involve linear regression models and Cox-proportional hazard models to explore the relationships between SFAs and PUFAs, as well as their interaction on MetSyn risk factors, MI, and death. The study reveals that the association of PUFAs with lower triglycerides (TG), higher high-density lipoprotein cholesterol (HDL-c), lower waist circumference (WC), and lower blood pressure (BP) depends on the levels of SFAs. Unexpectedly, when stratified by PUFA level higher SFAs are associated with metabolically beneficial outcomes, contrary to common perceptions. The study also uncovers differences by racial/ethnic group membership, showing distinct responses to SFAs and PUFAs among White, Black, and Asian participants. The findings challenge the simplistic view that reducing SFAs and increasing PUFAs uniformly benefit metabolic health. Instead, the findings suggest that individual differences in participant characteristics, including in racial/ethnic group membership, play a crucial role in how SFAs and PUFAs influence metabolic outcomes. A more nuanced approach to dietary recommendations that considers the intricate interplay between specific FAs and their impact on diverse populations may allow researchers to better address the risks for CVD. In Study 3, we focus on the fatty acid desaturase (FADS) genes, which play a regulatory role in PUFA metabolism. The FADS genes (FADS1 and FADS2) have two major haplotypes (haplotype D and haplotype A) which vary in prevalence across populations. Functional analyses indicate that haplotype D is more efficient in synthesis of longer chain PUFA in both the omega-3 ([omega]3) and omega-6 ([omega]6) pathways. The study specifically examines variant rs174547 in FADS1 as a proxy for the FADS genes. This variant has been associated with CV health outcomes leading to the hypothesis that 1) the association between FADS and lipid outcomes depends on FAs (moderation) and 2) the effect of FADS on outcomes occurs through FAs (mediation). The analysis uses the UKB dataset to explore the interplay between FADS and FAs on lipid outcomes including total cholesterol (TC), HDL-c, low-density lipoprotein cholesterol (LDL-c), and TGs. The research employs a statistical framework to quantify the extent to which FAs mediate or moderate the relationship between FADS and lipid biomarkers. Results reveal evidence of moderation and/or mediation (or suppression) effects. For instance, out of the 28 tests of moderation, 19 models have evidence that a FA modifies the effect of FADS on lipid outcomes. Additionally, there are 12 models with evidence of mediation; for example, DHA acts as a mediator for the association between FADS and HDL-c, indicating that the influence of FADS on HDL-c is explained by the level of DHA, and non-LA [omega]6-PUFA suppresses the association between FADS and LDL-c. The study provides valuable insights into the complex interactions between FADS, FAs, and CV health. By analyzing FADS as a case study, the research demonstrates an analytical framework that can be applied to understand similar relationships in other genetic contexts. The findings underscore the need to consider individual variations in FA metabolism to optimize dietary recommendations for CV health. Collectively, this research sheds light on the multifaceted interplay between PUFAs, genetic factors, and CV health. The conditional associations based on FA profiles emphasize the potential for dietary modifications to address health disparities rooted in individual genotypes, as well as social and environmental factors. These findings challenge broad dietary recommendations and advocate for a more personalized approach to disease prevention and treatment strategies. The implications extend beyond CV health, prompting a reevaluation of how individualized nutrition guidance can be integrated into broader public health initiatives.
Author :Artemis P. Simopoulos Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805590199 Total Pages :177 pages Book Rating :4.8/5 (55 download)
Book Synopsis Omega-3 Fatty Acids, the Brain and Retina by : Artemis P. Simopoulos
Download or read book Omega-3 Fatty Acids, the Brain and Retina written by Artemis P. Simopoulos and published by Karger Medical and Scientific Publishers. This book was released on 2009-01-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on omega-3 fatty acids has come a long way since its beginnings in the middle 70's. Starting with studies on the role of omega-3 fatty acids in the secondary prevention of cardiovascular disease, interest soon turned to the mechanisms of and the need to balance the omega-6 to the omega-3 ratio for homeostasis and normal development. Today, it is widely accepted that docosahexaenoic acid (DHA) and arachidonic acid are essential for brain development during pregnancy, lactation and throughout the life cycle. It is also no longer controversial that DHA can affect brain function, mental health and behavior, and studies on supplemental DHA in age-related macular degeneration have revealed significant Interactions between DHA and genetic variants. Featuring contributions by leading scientists in the field, this publication discusses not only the role of omega-3 fatty acids in maintaining homeostasis, but also their importance in the prevention and management of neurodegenerative diseases associated with the aging process or genetic predisposition. It is thus not only of interest to nutritionists, dieticians or policy makers, but also to psychologists, physiologists, neuroscientists, psychiatrists, ophthalmologists, geneticists, neurologists, pedlatrlclans, obstetricians and geriatricians.
Book Synopsis Omega-6/3 Fatty Acids by : Fabien De Meester
Download or read book Omega-6/3 Fatty Acids written by Fabien De Meester and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several years developing human research suggests that a component of omega-3 fatty acids, long chain ones, contribute particularly to health benefits. Omega-6/3 Fatty Acids: Functions, Sustainability Strategies and Perspectives focuses on developing information on this newly recognized key component. This volume uniquely, and for the first time, focuses on sustainability of natural sources of omega-3 fatty acids variants including long chain ones, and on ways to increase their use and availability to reduce major diseases. The authors review cardiovascular disease, neurological changes and mental health and other diseases like diabetes where long chain omega-3 fatty acids play protective roles from recent human trials. Each chapter evaluates developing information on the possible mechanistic role of long chain omega-3 fatty acids. After showing their requirement and involvement in health promotion there are reviews of various sources and ways to protect and promote them. Authors provide support for the benefits and sources of long chain omega-3 fatty acids and their increased dietary intake that reduce various physical and mental illnesses. Omega-6/3 Fatty Acids: Functions, Sustainability and Perspectives is a unique and important new volume that provides the latest data and reviews to physicians who need to assess serum omega-6/3 and fatty acids to help diagnose risks and change diets and to inform industry and the scientific community with reviews of research for actions including new studies and therapies.
Author :International Society for the Study of Fatty Acids and Lipids. Congress Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805571828 Total Pages :271 pages Book Rating :4.8/5 (55 download)
Book Synopsis Fatty Acids and Lipids by : International Society for the Study of Fatty Acids and Lipids. Congress
Download or read book Fatty Acids and Lipids written by International Society for the Study of Fatty Acids and Lipids. Congress and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication at hand gives an outline of recent advances in both of these topics, including a general discussion on fatty acid nutrition amd metabolism. Moreover, issues such as vascular functions, inflammation, bone metabolism, cancer, obesity and lipoprotein metabolism are dealt with in this context. Finally, the book also contains new findings on bioactive lipids such as anandamide and related compounds, as well as on conjugated linoleic acid. Scientists interested in nutrition, cardiovascular disease, behavior and psychiatry as well as fatty acid metabolism and lipids in general will find this publication a most welcome source of information.
Book Synopsis The Role of Angiopoietin-like 4 in Lipid Homeostasis by : Nora Gray
Download or read book The Role of Angiopoietin-like 4 in Lipid Homeostasis written by Nora Gray and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract The Role of Angiopoietin-like 4 in Lipid Homeostasis by Nora Elizabeth Forbes Gray Doctor of Philosophy in Molecular and Biochemical Nutrition University of California, Berkeley Professor Jen-Chywan Wang, Chair Alterations in the regulation of lipid homeostasis are major causes of metabolic diseases like obesity, insulin resistance and the metabolic syndrome. These diseases affect millions of people and therefore constitute a pressing public health concern. The mobilization of lipids is a key regulatory step in lipid homeostasis and the proteins that mobilize lipids from adipocytes to other tissues are therefore potential targets for therapeutic interventions. One such protein is angiopoietin-like 4 (Angptl4), a secreted protein induced by fasting and glucocorticoid treatment that inhibits lipoprotein lipase (LPL) and induces intracellular adipocyte lipolysis. These studies seek to characterize the role of Angptl4 in modulating lipid homeostasis. We found that Angptl4 is involved in the lipolytic response to fasting, glucocorticoids and catecholamines and in each case it modulates intracellular cAMP levels. We further discovered that purified Angptl4 can directly increase cAMP and lipolysis in adipocytes in a dose-dependent manner. We were also able to dissociate ability of Angptl4 to inhibit LPL from its ability to induce lipolysis by determining that just the C-terminal domain, which cannot inhibit LPL, can induce adipocyte lipolysis. Initial attempts to uncover the mechanism by which Angptl4 modulates cAMP showed that soluble adenylate cyclase is important for the lipolytic response to Angptl4. Additionally, Angptl4 treatment increases activation of focal adhesion kinase (FAK) and inhibition of FAK attenuates the lipolytic response to Angptl4, suggesting the potential involvement of integrins in Angptl4 signaling in adipocytes although more research is needed to confirm this possibility. In addition to its expression in white adipose tissue, Angptl4 levels are also high in the liver where its expression is regulated by glucocorticoids. Because mice lacking Angptl4 are protected from glucocorticoid-induced fatty liver and hyperlipidemia we wanted to investigate the lipogenic role of Angptl4 in the liver. Using stable isotope labeling and gene expression analysis we found that glucocorticoids increase the rate of triglyceride synthesis as well as de novo lipogenesis but this effect is blunted in mice that lack Angptl4. There was also differential hepatic expression of genes involved in lipogenesis in the mice without Angptl4. Treatment of hepatocytes with purified Angptl4 revealed that the increase in triglyceride synthesis is not a direct effect of the protein, nor are the alterations in the expression of most lipogenic genes. Two notable exceptions, however, are Agpat1 and Agpat2, the expression of which was induced by Angptl4 treatment. This is a previously undescribed role of Angptl4 and further research is necessary to understand the mechanism by which it could be modulating transcription. A third tissue with high expression of Angptl4 is brown adipose tissue. Because of its role in lipolysis and the fact that lipolysis is critical for adaptive thermogenesis, we investigated the how Angptl4 might be involved in thermoregulation. We found that mice lacking Angptl4 maintained a consistently lower body temperature during cold exposure. We further determined that lipolysis in brown adipose tissue was impaired in these mice and the induction of thermogenic genes was compromised relative to wild types. We also found that mice without Angptl4 maintain a lower body temperature during fasting than WT mice. These results indicate a potential role of Angptl4 in thermogenesis, which could have important implications for obesity. These studies confirm that Angptl4 is important for the regulation of lipid homeostasis. A more complete understanding of its mechanism, including the identification of a receptor that can mediate its intracellular effects, will be crucial for evaluating the potential of Angptl4 as a therapeutic target for diseases of deregulated lipid metabolism.
Book Synopsis Health Effects of [omega]3 Polyunsaturated Fatty Acids in Seafoods by : Artemis P. Simopoulos
Download or read book Health Effects of [omega]3 Polyunsaturated Fatty Acids in Seafoods written by Artemis P. Simopoulos and published by S. Karger AG (Switzerland). This book was released on 1991 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Omega 3 Fatty Acids in Clinical Nutrition by : Axel R. Heller
Download or read book Omega 3 Fatty Acids in Clinical Nutrition written by Axel R. Heller and published by Nova Biomedical Books. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, intensive collaborative research in the fields of chronic and acute inflammatory disorders has resulted in a better understanding of the pathophysiology and diagnosis of these diseases. Modern therapeutic approaches remain unsatisfactory and shock, sepsis and multiple organ failure (MOF) are still a great challenge in intensive care medicine. Furthermore, treatment of inflammatory diseases like rheumatoid arthritis, ulcerative colitis or psoriasis represents an unresolved problem as well. Many factors contribute to the complex course of inflammatory reactions. Microbiological, immunological and toxic agents are able to initiate the inflammatory response by activating a variety of humoural and cellular mediators. In the early phase of inflammation interleukins and lipid-mediators are excessively released and play a crucial role in the pathogenesis of organ dysfunction. Cellular lipid membranes represent a dynamic high turnover barrier system, which separate the intracellular from the extracellular space and easily adapt to respective demands. In addition to this barrier function membrane lipids (arachidonic acid) can be oxygenized to biologically active lipid mediators (eicosanoids). These function as "local mediators" which can quickly reach considerable concentrations and, due to their short half life, act in intercellular microenvironments.Two omega-3 polyunsaturated fatty acids (omega-3 FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are mainly found in maritime sources, as opposed to omega-6 polyunsaturated fatty acids found in terrestrial sources (the typical western diet). Contemporary nutritional habits, emphasising industrially produced vegetable oils and animal fats, have disturbed this balance, resulting in a proportional decrease of omega-3 FA. This book presents an update of the pathophysiological impact of lipid mediators in inflammatory disorders and summarises the recent development of therapeutic approaches.
Book Synopsis Lipid Signaling and Metabolism by : James M. Ntambi
Download or read book Lipid Signaling and Metabolism written by James M. Ntambi and published by Academic Press. This book was released on 2020-08-09 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others
Book Synopsis Prevention and Treatment of Atherosclerosis by : Arnold von Eckardstein
Download or read book Prevention and Treatment of Atherosclerosis written by Arnold von Eckardstein and published by Springer Nature. This book was released on 2022 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.
Book Synopsis Polyunsaturated Fatty Acid Metabolism by : Graham C. Burdge
Download or read book Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and published by Elsevier. This book was released on 2018-05-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. Provides a comprehensive view of polyunsaturated fatty acid metabolism Describes underlying metabolism on lipids that include polyunsaturated fatty acids Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism
Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Book Synopsis The Vascular Endothelium I by : Salvador Moncada
Download or read book The Vascular Endothelium I written by Salvador Moncada and published by Springer Science & Business Media. This book was released on 2006-12-22 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Book Synopsis Textbook of Diabetes by : Richard I. G. Holt
Download or read book Textbook of Diabetes written by Richard I. G. Holt and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.
Book Synopsis Energy Balance and Obesity by : Isabelle Romieu
Download or read book Energy Balance and Obesity written by Isabelle Romieu and published by IARC Working Group Report. This book was released on 2018-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the relationship between energy balance and obesity is essential to develop effective prevention programs and policies. The International Agency for Research on Cancer convened a Working Group of world-leading experts in December 2015 to review the evidence regarding energy balance and obesity, with a focus on low- and middle-income countries, and to consider the following scientific questions: (i) Are the drivers of the obesity epidemic related only to energy excess and/or do specific foods or nutrients play a major role in this epidemic? (ii) What are the factors that modulate these associations? (iii) Which types of data and/or studies will further improve our understanding? This book provides summaries of the evidence from the literature as well as the Working Group's conclusions and recommendations to tackle the global epidemic of obesity.
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