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Analysis Of The Function And Transcriptional Regulation Of The Recombination Activating Genes 1 And 2
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Book Synopsis Analysis of the Function and Transcriptional Regulation of the Recombination Activating Genes-1 and -2 by : Zoran Galic
Download or read book Analysis of the Function and Transcriptional Regulation of the Recombination Activating Genes-1 and -2 written by Zoran Galic and published by . This book was released on 1999 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Human Recombination Activating Gene 1 (RAG1) and RAG2 Promoter Regions by : Ali Akbar Zarrin
Download or read book Characterization of the Human Recombination Activating Gene 1 (RAG1) and RAG2 Promoter Regions written by Ali Akbar Zarrin and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In all vertebrates, the genes encoding Antigen Receptor (AgR) variable (V) regions are assembled during B and T cell development from gene segments termed V, (D), and J through the process of V(D)J recombination. V(D)J recombination is central for the successful function and development of B and T cell lymphocytes. Recombination Activating Gene 1 (RAG1) and RAG2 are the essential and tissue specific components of V(D)J recombination. Their precise pattern of expression during B and T cell development determines where and when V(D)J recombination occurs. This thesis describes studies on the regulation of RAG1 and RAG2 at the transcription level. In chapter 2, I have characterized the exon 1 and promoter region of human RAG1. I show that a single promoter region is used for RAG1 transcription. In chapter 3, I describe the isolation and characterization of the human RAG2 promoter regions. The major transcription initiation site (exon 1A) of human RAG2 is located 3.9 kb upstream of the coding exon while the less frequently used transcription initiation site (exon 1B) is only 0.7 kb upstream of the coding exon. Two alternate promoters upstream of exon1A or 1B drive the transcription of RAG2 gene. Using transient assays, I show that promoter regions of human RAG1 and RAG2 are active in both lymphoid and non-lymphoid cell lines. Chapter 4 describes an approach that I took to study the tissue-specific regulation of RAG genes. I stably transfected a 65 kb P1 phage genomic clone containing RAG1, RAG2 and their surrounding sequences, into the human cervical carcinoma cell line, HeLa (RAG1-, RAG2-) and the mouse pre-B cell line, NFS-70 (RAG1+, RAG2+). I found consistent expression of the human RAG1 gene in multiple clones of NFS-70 cell line while no RAG1 expression was detected in HeLa clones suggesting that this genomic clone contains some of the sequences required for the tissue-specific regulation of RAG1. In chapter 5, I describe the second approach to isolate the potential regulatory elements by subcloning fragments of the P1 phage into the RAG1 promoter construct and subsequently looking for enhancer or silencer activity. I located a 1425 bp within the 3' untranslated region of the RAG1 gene with enhancer activity. In chapter 6, I describe the subcloning and sequencing a 7.3 kilobase of the 5' flanking region of human RAG2 to look for potential conserved regulatory elements between human and mouse species. In Chapter 7, models of RAG1/RAG2 promoters, and their tissue-specific transcriptional regulation are discussed.
Book Synopsis Transcriptional Regulation of the Human Recombination Activating Gene-1 (RAG-1) by : Haitao Zhang
Download or read book Transcriptional Regulation of the Human Recombination Activating Gene-1 (RAG-1) written by Haitao Zhang and published by . This book was released on 2000 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation Studies of the Human Recombination Activating Genes, RAG-1 and RAG-2 by : Laurent Karl Verkoczy
Download or read book Regulation Studies of the Human Recombination Activating Genes, RAG-1 and RAG-2 written by Laurent Karl Verkoczy and published by . This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been suggested that a signal transduced through the B-cell antigen receptor complex (BCR) may be required for regulating the expression of the recombination activating genes. To study this possibility, we utilized a unique set of cell variants from the human mature B cell line OCI LY8 which vary in expression of both the BCR and of the RAG-1 and RAG-2 genes. Two forms of stimulation were employed to generate a signal: either a soluble F(ab) '2 anti-[mu] fragment or the combination of PMA and ionomycin. The finding that RAG expression can be upregulated by BCR ligation may be relevant in the context of its potential role in situations where BCR + B cells may undergo secondary rearrangements for the purpose of "editing" their sIg receptors. To better understand the molecular mechanisms that may be involved in this inducible upregulation as well as in the constitutively expressed increases in RAG gene expression in RAGhi OCI LY8 variants (as compared to the parental RAGlo clone), we determined to what extent various levels of regulation were contributing to these effects. (Abstract shortened by UMI.).
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Author :Ivan Chek-Fuan Fong Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 :9780612784161 Total Pages :382 pages Book Rating :4.7/5 (841 download)
Book Synopsis Transcriptional Regulation of the Human Recombination-activating Gene 2 [microform] by : Ivan Chek-Fuan Fong
Download or read book Transcriptional Regulation of the Human Recombination-activating Gene 2 [microform] written by Ivan Chek-Fuan Fong and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2003 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Functional Analysis of the Recombination Activating Gene 1 (RAG-1) by : Navin Rao
Download or read book A Functional Analysis of the Recombination Activating Gene 1 (RAG-1) written by Navin Rao and published by . This book was released on 1996 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunoglobulin Genes by : Tasuku Honjo
Download or read book Immunoglobulin Genes written by Tasuku Honjo and published by Elsevier. This book was released on 1995-09-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse."For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes.The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response.* Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues* Contains invaluable information for clinicians and research scientists with an interest in the immune response* For the Immunologist* Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them* For the Molecular Biologist* Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Handbook of Vertebrate Immunology by : Paul-Pierre Pastoret
Download or read book Handbook of Vertebrate Immunology written by Paul-Pierre Pastoret and published by Academic Press. This book was released on 1998-05-21 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species.This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology.Each section, devoted to a major animal group covers: - Lymphoid organs and their anatomical disposition - Leukocytes and their markers - Leukocyte traffic and associated molecules - Cytokines - T cell receptors - Immunoglobulins - MHC antigens - Ontogeny of the immune system - Passive transfer of immunity - Neonatal immune responses - Non-specific immunity - Complement system - Mucosal immunity - Immunodeficiencies - Tumours of the immune system - Autoimmunity
Book Synopsis Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci by :
Download or read book Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci written by and published by Academic Press. This book was released on 2015-11-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes. Focuses on the generation of an effective immune response to invading pathogens Contains contributions from leading authorities Informs and updates on all the latest developments in the field of immunology
Book Synopsis Stiehm's Immune Deficiencies by : Kathleen E. Sullivan
Download or read book Stiehm's Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians Fills an increasingly deep gap in the information available to clinicians Presents both clinical management and scientific advances for immune deficiencies Provides a primary resource for physicians in the field of immunodeficiencies Includes website access to a range of videos relevant to the topics discussed
Book Synopsis Primer to the Immune Response by : Tak W. Mak
Download or read book Primer to the Immune Response written by Tak W. Mak and published by Newnes. This book was released on 2013-12-23 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject's fascinating appeal. The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections. - Complete yet concise coverage of the basic and clinical principles of immunology - Engaging conversational writing style that is to the point and very readable - Over 200 clear, elegant color illustrations - Comprehensive glossary and list of abbreviations
Book Synopsis The CRISPR/Cas System by : Muhammad Jamal
Download or read book The CRISPR/Cas System written by Muhammad Jamal and published by Caister Academic Press Limited. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of CRISPR/Cas technology for genome editing suggests many potential applications, including the alteration of the germline of humans, animals and food crops. The speed and efficiency of the CRISPR/Cas system make it a potentially useful system for gene therapy. In this volume expert international authors provide a useful and timely review of the applications of the CRISPR/Cas system across diverse fields and explore further avenues and research directions of this novel and powerful editing technology. The technology and its application are reviewed with respect to reproduction and development, immunity and genetic diseases, system structure and system specificity. Some of the potential problems of the CRISPR/Cas system are also discussed, in particular the specificity of the system: this remains an important topic as improvement could lead to the more direct and efficient use of the CRISPR/Cas system in clinical settings. The authors also debate ethical concerns associated with this powerful new technology. This volume is a rigorous review of the applications and new opportunities for the CRISPR/Cas system and provides a stimulus for current and future research. An invaluable guide for all scientists working in the fields of genome editing and gene therapy the book is also recommended for all life sciences libraries.
Book Synopsis Regulation of Gene Expression by Small RNAs by : Rajesh K. Gaur
Download or read book Regulation of Gene Expression by Small RNAs written by Rajesh K. Gaur and published by CRC Press. This book was released on 2009-04-27 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Findings Revolutionize Concepts of Gene FunctionEndogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 p
Book Synopsis Genome Stability by : Igor Kovalchuk
Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
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