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Analysis Of Nuclear Transport Signals
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Book Synopsis Analysis of Nuclear Transport Signals by : Silvana Wolf
Download or read book Analysis of Nuclear Transport Signals written by Silvana Wolf and published by GRIN Verlag. This book was released on 2017-05-09 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bachelor Thesis from the year 2015 in the subject Computer Science - Bioinformatics, Technical University of Munich, language: English, abstract: Nuclear transport of proteins is a basic cellular mechanism preceding a lot of biological processes. The classical transport mechanism for nuclear proteins involves karyopherins importing and exporting the proteins. The karyopherins recognize typically nuclear transport signals in the protein sequence. Three main types of nuclear localization signals (NLS) are focused in the scientific field of nuclear protein transport: monopartite, bipartite and PY-NLS. In studies on nuclear export signals (NES) the specific type of leucine-rich signals is often investigated. The first goal of this thesis was to update NLSdb, a database containing 114 experimental and 194 potential NLS, to the current state of available data. Towards this end, a set of 2452 novel signals with published experimental evidence was extracted from the literature and used as development set. An in silico mutagenesis approach was applied to this set to detect 4301 novel potential NLS in nuclear proteins. We matched these potential NLS in protein sequences of unannotated subcellular localization to identify nuclear proteins. We were able to confirm the predicted localization using our potential NLS in literature. Additional to the collection of data, an extensive analysis on protein sequences containing NLS and NES was performed to provide insights into subcellular localization of proteins and their occurrence in various organisms. A clustering of sequences of NLS led to the separation of signals into distinct sub-groups with a clear definition of a consensus sequence for each sub-group. Aligning potential NLS against the sub-groups resulted in a refinement of the consensus sequences. The results from this study reflect the scientific progress, lead to further knowledge in the field of nuclear transport and highlight the usability of bioinformatics methods for the discovery of new insights in biology. Nuclear transport is related to many interesting researches, for example allergic reactions, cancer and other diseases. The outcome of this work provides a good fundament for other studies with nuclear transport signals.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Transport written by Karsten Weis and published by Springer Science & Business Media. This book was released on 2002 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Book Synopsis Identification of Nuclear Export Signals and Structural Analysis of Transport Complexes by :
Download or read book Identification of Nuclear Export Signals and Structural Analysis of Transport Complexes written by and published by . This book was released on 2012 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and controlled process. Facilitated transport processes are executed by Nuclear Transport Receptors (NTR). The goals of my doctoral work have been divided in two broad themes, which have been summarized below. Identification of Nuclear Export Signals for CRM1 mediated export: The nucleus is specialised in transcription and the cytosol is specialised in translation. Nuclear translatio...
Book Synopsis Nucleocytoplasmic Transport by : Reiner Peters
Download or read book Nucleocytoplasmic Transport written by Reiner Peters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nuclear Import and Export in Plants and Animals by : Tzvi Tzfira
Download or read book Nuclear Import and Export in Plants and Animals written by Tzvi Tzfira and published by Springer Science & Business Media. This book was released on 2007-02-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Download or read book Bioinformatics written by Pierre Baldi and published by MIT Press (MA). This book was released on 1998 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: An unprecedented wealth of data is being generated by genome sequencing projects and other experimental efforts to determine the structure and function of biological molecules. The demands and opportunities for interpreting these data are expanding more than ever. Biotechnology, pharmacology, and medicine will be particularly affected by the new results and the increased understanding of life at the molecular level. Bioinformatics is the development and application of computer methods for analysis, interpretation, and prediction, as well as for the design of experiments. It has emerged as a strategic frontier between biology and computer science. Machine learning approaches (e.g., neural networks, hidden Markov models, and belief networks) are ideally suited for areas where there is a lot of data but little theory—and this is exactly the situation in molecular biology. As with its predecessor, statistical model fitting, the goal in machine learning is to extract useful information from a body of data by building good probabilistic models. The particular twist behind machine learning, however, is to automate the process as much as possible. In this book, Pierre Baldi and Soren Brunak present the key machine learning approaches and apply them to the computational problems encountered in the analysis of biological data. The book is aimed at two types of researchers and students. First are the biologists and biochemists who need to understand new data-driven algorithms, such as neural networks and hidden Markov models, in the context of biological sequences and their molecular structure and function. Second are those with a primary background in physics, mathematics, statistics, or computer science who need to know more about specific applications in molecular biology.
Book Synopsis Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods by :
Download or read book Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods written by and published by Elsevier. This book was released on 2014-05-20 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) Chapters are written by experts in the field Cutting-edge material
Book Synopsis Small-signal stability, control and dynamic performance of power systems by : M.J Gibbard
Download or read book Small-signal stability, control and dynamic performance of power systems written by M.J Gibbard and published by University of Adelaide Press. This book was released on 2015-07-15 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough and exhaustive presentation of theoretical analysis and practical techniques for the small-signal analysis and control of large modern electric power systems as well as an assessment of their stability and damping performance.
Book Synopsis Nuclear-Cytoplasmic Transport by : Weidong Yang
Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang and published by Springer. This book was released on 2018-07-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Book Synopsis Passive Nondestructive Assay of Nuclear Materials by : Doug Reilly
Download or read book Passive Nondestructive Assay of Nuclear Materials written by Doug Reilly and published by . This book was released on 1991 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bulk Collection of Signals Intelligence by : National Research Council
Download or read book Bulk Collection of Signals Intelligence written by National Research Council and published by National Academies Press. This book was released on 2015-03-24 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bulk Collection of Signals Intelligence: Technical Options study is a result of an activity called for in Presidential Policy Directive 28 (PPD-28), issued by President Obama in January 2014, to evaluate U.S. signals intelligence practices. The directive instructed the Office of the Director of National Intelligence (ODNI) to produce a report within one year "assessing the feasibility of creating software that would allow the intelligence community more easily to conduct targeted information acquisition rather than bulk collection." ODNI asked the National Research Council (NRC)-the operating arm of the National Academy of Sciences and National Academy of Engineering-to conduct a study, which began in June 2014, to assist in preparing a response to the President. Over the ensuing months, a committee of experts appointed by the Research Council produced the report.
Book Synopsis Condition Monitoring with Vibration Signals by : Hosameldin Ahmed
Download or read book Condition Monitoring with Vibration Signals written by Hosameldin Ahmed and published by John Wiley & Sons. This book was released on 2020-01-07 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an extensive, up-to-date treatment of techniques used for machine condition monitoring Clear and concise throughout, this accessible book is the first to be wholly devoted to the field of condition monitoring for rotating machines using vibration signals. It covers various feature extraction, feature selection, and classification methods as well as their applications to machine vibration datasets. It also presents new methods including machine learning and compressive sampling, which help to improve safety, reliability, and performance. Condition Monitoring with Vibration Signals: Compressive Sampling and Learning Algorithms for Rotating Machines starts by introducing readers to Vibration Analysis Techniques and Machine Condition Monitoring (MCM). It then offers readers sections covering: Rotating Machine Condition Monitoring using Learning Algorithms; Classification Algorithms; and New Fault Diagnosis Frameworks designed for MCM. Readers will learn signal processing in the time-frequency domain, methods for linear subspace learning, and the basic principles of the learning method Artificial Neural Network (ANN). They will also discover recent trends of deep learning in the field of machine condition monitoring, new feature learning frameworks based on compressive sampling, subspace learning techniques for machine condition monitoring, and much more. Covers the fundamental as well as the state-of-the-art approaches to machine condition monitoringguiding readers from the basics of rotating machines to the generation of knowledge using vibration signals Provides new methods, including machine learning and compressive sampling, which offer significant improvements in accuracy with reduced computational costs Features learning algorithms that can be used for fault diagnosis and prognosis Includes previously and recently developed dimensionality reduction techniques and classification algorithms Condition Monitoring with Vibration Signals: Compressive Sampling and Learning Algorithms for Rotating Machines is an excellent book for research students, postgraduate students, industrial practitioners, and researchers.
Book Synopsis Uranium Enrichment and Nuclear Weapon Proliferation by : Allan S. Krass
Download or read book Uranium Enrichment and Nuclear Weapon Proliferation written by Allan S. Krass and published by Routledge. This book was released on 2020-11-20 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1983, this book presents both the technical and political information necessary to evaluate the emerging threat to world security posed by recent advances in uranium enrichment technology. Uranium enrichment has played a relatively quiet but important role in the history of efforts by a number of nations to acquire nuclear weapons and by a number of others to prevent the proliferation of nuclear weapons. For many years the uranium enrichment industry was dominated by a single method, gaseous diffusion, which was technically complex, extremely capital-intensive, and highly inefficient in its use of energy. As long as this remained true, only the richest and most technically advanced nations could afford to pursue the enrichment route to weapon acquisition. But during the 1970s this situation changed dramatically. Several new and far more accessible enrichment techniques were developed, stimulated largely by the anticipation of a rapidly growing demand for enrichment services by the world-wide nuclear power industry. This proliferation of new techniques, coupled with the subsequent contraction of the commercial market for enriched uranium, has created a situation in which uranium enrichment technology might well become the most important contributor to further nuclear weapon proliferation. Some of the issues addressed in this book are: A technical analysis of the most important enrichment techniques in a form that is relevant to analysis of proliferation risks; A detailed projection of the world demand for uranium enrichment services; A summary and critique of present institutional non-proliferation arrangements in the world enrichment industry, and An identification of the states most likely to pursue the enrichment route to acquisition of nuclear weapons.
Book Synopsis Cytochromes P450 by : Costas Ioannides
Download or read book Cytochromes P450 written by Costas Ioannides and published by CRC Press. This book was released on 1996-09-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicity Anticipate drug interactions Modify doses to fit the needs of patients Contributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest. This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.
Book Synopsis Strengthening Forensic Science in the United States by : National Research Council
Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.
Book Synopsis Love and Other Dangerous Chemicals by : Anthony Capella
Download or read book Love and Other Dangerous Chemicals written by Anthony Capella and published by Atlantic Books. This book was released on 2012-10-01 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Steven J. Fisher is a young and brilliant biochemist (special subject: the female orgasm). He's invented a Viagra-like pill for women—now he just needs his results to be perfect. Annie is an orgasmically-challenged arts student (special subject: Victorian semicolons). She's just volunteered to be one of Fisher's case studies—but for some reason his miracle treatment isn't working. As scientist and subject bond over romantic meals lit by the flickering glow of a Bunsen burner, Dr. Fisher is surprised to find his feelings taking a most unscientifc turn. . . What if love is one thing science can't explain?
