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Analysis Of Noncovalent And Covalent Protein Ligand Complexes By Electrospray Ionisation Mass Spectrometry
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Book Synopsis Mass Spectrometry of Non-Covalent Complexes by : Christoph A. Schalley
Download or read book Mass Spectrometry of Non-Covalent Complexes written by Christoph A. Schalley and published by John Wiley & Sons. This book was released on 2009-09-08 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the many benefits of applying mass spectrometry to supramolecular chemistry Except as a method for the most basic measurements, mass spectrometry (MS) has long been considered incompatible with supramolecular chemistry. Yet, with today's methods, the disconnect between these two fields is not warranted. Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes provides a convincing look at how modern MS techniques offer supramolecular chemists a powerful investigatory toolset. Bringing the two fields together in an interdisciplinary manner, this reference details the many different topics associated with the study of non-covalent complexes in the gas phase. The text begins with brief introductions to supramolecular chemistry and such relevant mass spectrometric methods as ionization techniques, analyzers, and tandem MS experiments. The coverage continues with: How the analyte's transition into the gas phase changes covalent bonding How limitations and pitfalls in analytical methods may produce data misinterpretations Artificial supramolecular aggregates and their examination Biomolecules, their complexes, and their examination After the general remarks making up the first section of the book, the following sections describe specific experimental procedures and are illustrated with numerous examples and short tutorials. Detailed citations end each chapter. Mass spectrometrists, supramolecular chemists, students in these fields, and interested readers from other disciplines involving the study of non-covalent bonds will all value Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes as an innovative and practical resource.
Book Synopsis Avidin-biotin Technology by : Meir Wilchek
Download or read book Avidin-biotin Technology written by Meir Wilchek and published by . This book was released on 1990 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: The avidin-biotin complex has been used for isolation (affinity chromatography), localization (affinity cytochemistry, cell cytometry, and blotting technology), and diagnostics (immunoassay, histopathology, and gene probes). Recently, usage of the system has been extended to include other areas. This volume covers these new applications and methodologies including hybridoma technology, bioaffinity sensors, affinity targeting, and drug delivery, as well as cross-linking, immobilization, and fusogenic studies.
Book Synopsis Applied Electrospray Mass Spectrometry by : Birendra N. Pramanik
Download or read book Applied Electrospray Mass Spectrometry written by Birendra N. Pramanik and published by CRC Press. This book was released on 2002-02-28 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, pr
Book Synopsis Mass Spectrometry of Nucleosides and Nucleic Acids by : Joseph H. Banoub
Download or read book Mass Spectrometry of Nucleosides and Nucleic Acids written by Joseph H. Banoub and published by CRC Press. This book was released on 2009-12-21 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustra
Book Synopsis Biophysical Approaches Determining Ligand Binding to Biomolecular Targets by : Alberto Podjarny
Download or read book Biophysical Approaches Determining Ligand Binding to Biomolecular Targets written by Alberto Podjarny and published by Royal Society of Chemistry. This book was released on 2011 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete overview of current techniques to identify ligands, characterize their binding sites, and understand binding mechanisms. Suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry.
Download or read book Protein Misassembly written by and published by Academic Press. This book was released on 1997-10-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role that primary amino acid sequences plays in influencing the partitioning of polypeptides between productive folding and irreversible aggregation pathways has introduced a whole new dimension to the folding problem. The volume deals with the structures of the products of protein misassembly and the role of amino acid sequences in favoring these structures.
Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner
Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner and published by John Wiley & Sons. This book was released on 2007-04-09 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Book Synopsis Advances in Bioanalytical Methods for Probing Ligand-Target Interactions by : Quezia B. Cass
Download or read book Advances in Bioanalytical Methods for Probing Ligand-Target Interactions written by Quezia B. Cass and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Plasma Chromatography by : T.W. Carr
Download or read book Plasma Chromatography written by T.W. Carr and published by Springer. This book was released on 1984-03-31 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mass Spectrometry in Chemical Biology by : Norberto Peporine Lopes
Download or read book Mass Spectrometry in Chemical Biology written by Norberto Peporine Lopes and published by Royal Society of Chemistry. This book was released on 2017-11-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.
Book Synopsis Reactive Intermediates by : Leonardo S. Santos
Download or read book Reactive Intermediates written by Leonardo S. Santos and published by John Wiley & Sons. This book was released on 2009-11-04 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades there has been considerable growth in the development of electrospray ionization mass spectrometry (ESI-MS) as a practical method in the study of reaction mechanisms. This method allows the interception and characterization of key intermediates, either as transient species or as protonated/deprotonated forms of neutral species by API-MS. The outstanding features and advantages of ESI-MS make it one of the most suitable tools for the fast screening of intermediates directly from solution, providing hitherto unavailable chemical information to organic chemists. This monograph provides an overview of the mechanisms involved in ESI-MS, the historical perspectives before looking further in-depth at specific reactions and intermediates. Written by researchers in the field, this book is an unique resource for the understanding of this cutting-edge technique.
Book Synopsis Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics by : M. Chance
Download or read book Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics written by M. Chance and published by John Wiley & Sons. This book was released on 2008-09-22 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a wide variety of mass spectrometry methods used to explore structural mechanisms, protein dynamics and interactions between proteins. Preliminary chapters cover mass spectrometry methods for examining proteins and are then followed by chapters devoted to presenting very practical, how-to methods in a detailed way. Includes footprinting and plistex specifically, setting this book apart from the competition.
Book Synopsis Structure-based Drug Discovery by : Harren Jhoti
Download or read book Structure-based Drug Discovery written by Harren Jhoti and published by Springer Science & Business Media. This book was released on 2007-05-24 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.
Book Synopsis Mass Spectrometry in Biopharmaceutical Analysis by : Igor A. Kaltashov
Download or read book Mass Spectrometry in Biopharmaceutical Analysis written by Igor A. Kaltashov and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-11-22 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceuticals are a unique class of compounds due to their extreme structural complexity. The current text puts together a variety of the state‐of‐the art approaches that use mass spectrometry to evaluate various aspects of biopharmaceutical products ranging from monitoring stress‐related structural changes to their quantitation in pharmacokinetic studies.
Book Synopsis Mass Spectrometry of Biological Materials by : Barbara S. Larsen
Download or read book Mass Spectrometry of Biological Materials written by Barbara S. Larsen and published by CRC Press. This book was released on 1998-03-02 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.
Book Synopsis Principles of Mass Spectrometry Applied to Biomolecules by : Chava Lifshitz
Download or read book Principles of Mass Spectrometry Applied to Biomolecules written by Chava Lifshitz and published by John Wiley & Sons. This book was released on 2006-10-27 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.
Download or read book Flavor Chemistry written by Roy Teranishi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating the founding of the Flavor Subdivision of the Agriculture and Food Chemistry Division of the American Chemical Society, this book provides an overview of progress made during the past 30-40 years in various aspects of flavor chemistry as seen by internationally renowned scientists in the forefront of their respective fields. In addition, it presents up-to-date findings in the areas of flavor chemistry, analytical methods, thermally produced flavors and precursors, enzymatically produced flavors and precursors, and sensory methods and results.
