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Author : Kimberly Sue Best
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.:/5 (34 download)
Download or read book An Optical Study of K+ Channel Inactivation written by Kimberly Sue Best and published by . This book was released on 2003 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Albert Cha
Publisher :
ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.:/5 ( download)
Download or read book Using Optical Probes to Study the Behavior of Voltage-gated Ion Channels written by Albert Cha and published by . This book was released on 1999 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frances M. Ashcroft
Publisher : Academic Press
ISBN 13 : 0080535216
Total Pages : 505 pages
Book Rating : 4.0/5 (85 download)
Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. - Introduces the relevant aspects of molecular biology and biophysics - Describes the principal methods used to study channelopathies - Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function - Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Author : Stephen G. Waxman
Publisher :
ISBN 13 : 0195082931
Total Pages : 710 pages
Book Rating : 4.1/5 (95 download)
Download or read book The Axon written by Stephen G. Waxman and published by . This book was released on 1995 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapterson the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecularneurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods,are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Author : Shin-Ho Chung
Publisher : Springer Science & Business Media
ISBN 13 : 0387689192
Total Pages : 657 pages
Book Rating : 4.3/5 (876 download)
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Author :
Publisher :
ISBN 13 :
Total Pages : 840 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2009 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 032313890X
Total Pages : 615 pages
Book Rating : 4.3/5 (231 download)
Download or read book Handbook of Membrane Channels written by and published by Academic Press. This book was released on 2012-12-02 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481683284
Total Pages : 903 pages
Book Rating : 4.4/5 (816 download)
Download or read book Advances in Molecular Nanotechnology Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Molecular Nanotechnology Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Molecular Motors. The editors have built Advances in Molecular Nanotechnology Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Motors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Molecular Nanotechnology Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author :
Publisher : Academic Press
ISBN 13 : 0080857728
Total Pages : 385 pages
Book Rating : 4.0/5 (88 download)
Download or read book International Review of Neurobiology written by and published by Academic Press. This book was released on 1995-11-22 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1959, this serial stays up-to-date with current topics in neuroscience; the contributors are first-class experts in their fields. Volume 38 of International Review of Neurobiology presents in-depth reviews on GABAA and other transmitter systems and mechanisms, the genetics of the basal ganglia, the Bergmann glial cell, and the modes of action of monoamines at the cellular level. Neuroscientists will find particularly useful the recent studies on the molecular biology of neurotransmitter transporters.Key Features* Structure, pharmacology, and regulation of GABAA* Bergmann glial cell physiology* Abnormalities of transmitter systems in schizophrenia* Research in genetic influences on the basal ganglia* Presynaptic electrophysiology measurementsMonoamines as stimulators and inhibitors of cellular mechanisms* Molecular biology of neurotransmitter transporters
Author : Simone Furini
Publisher : Springer Nature
ISBN 13 : 1071638181
Total Pages : 298 pages
Book Rating : 4.0/5 (716 download)
Download or read book Potassium Channels written by Simone Furini and published by Springer Nature. This book was released on with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 654 pages
Book Rating : 4.3/5 (129 download)
Download or read book Energy Research Abstracts written by and published by . This book was released on 1993 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Osei Kwame Asamoah
Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 ( download)
Download or read book An Optical Approach to Structure-function Relationships in Voltage-gated Ion Channels written by Osei Kwame Asamoah and published by . This book was released on 2004 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christopher Ahern
Publisher : Springer
ISBN 13 : 1493928457
Total Pages : 159 pages
Book Rating : 4.4/5 (939 download)
Download or read book Novel Chemical Tools to Study Ion Channel Biology written by Christopher Ahern and published by Springer. This book was released on 2015-09-17 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology. Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology. .
Author : Dieter Wicher
Publisher : Frontiers E-books
ISBN 13 : 2889191133
Total Pages : 147 pages
Book Rating : 4.8/5 (891 download)
Download or read book Design principles of sensory receptors written by Dieter Wicher and published by Frontiers E-books. This book was released on 2013-04-23 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} This Research Topic is aimed towards collecting the present knowledge of structure and function of sensory receptors in the animal kingdom, as well as the mechanisms of signal transduction and downstream signal amplification. The term sensory receptor applies for sensory modalities reflecting the outer world (vision, audition, olfaction etc.), the inner world (pH, osmolarity, glucose level etc.) or both such as temperature and pain.
Author : Francisco Sepulveda
Publisher : Springer Science & Business Media
ISBN 13 : 0387274243
Total Pages : 175 pages
Book Rating : 4.3/5 (872 download)
Download or read book Pumps, Transporters, and Ion Channels written by Francisco Sepulveda and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N.I.H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described.
Author : Ramakrishna Seethala
Publisher : CRC Press
ISBN 13 : 0824741447
Total Pages : 619 pages
Book Rating : 4.8/5 (247 download)
Download or read book Handbook of Drug Screening written by Ramakrishna Seethala and published by CRC Press. This book was released on 2001-07-24 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.
Author : James N. C. Kew
Publisher :
ISBN 13 : 0199296758
Total Pages : 586 pages
Book Rating : 4.1/5 (992 download)
Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
