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An Optical Approach To Structure Function Relationships In Voltage Gated Ion Channels
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Book Synopsis An Optical Approach to Structure-function Relationships in Voltage-gated Ion Channels by : Osei Kwame Asamoah
Download or read book An Optical Approach to Structure-function Relationships in Voltage-gated Ion Channels written by Osei Kwame Asamoah and published by . This book was released on 2004 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels by : Valentin K. Gribkoff
Download or read book Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels written by Valentin K. Gribkoff and published by John Wiley & Sons. This book was released on 2008-12-09 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Book Synopsis Ion Channels: Channel Production and Optical Methods by :
Download or read book Ion Channels: Channel Production and Optical Methods written by and published by Academic Press. This book was released on 2021-06-05 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels Part B, Volume 652 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including NMDAR, Pannexin, and CALHM, Making NaV1.4 and NaV1.7, TRPVs, Purification native nAChRs, GABAR Radu Aricescu, TRPV5/2, NaV1.5, KATP, TRPA1, TREK-1, SARS-CoV-2 3a ion channel, Ion channel conformational dynamics by encoded unnatural amino acid, Fluorescence lifetime measurement of absolute membrane potential, Fluorescent Toxins as Activity Sensors, FRET Analyses of Ion Channel Protein-Protein Interactions, Control of Ion Channel Gating with Photo-Switchable Tweezers, and Counting Subunits in Kv Channel Complexes. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series
Book Synopsis Simulation Approaches to Ion Channel Structure-function Relationships by : D. Peter Tieleman
Download or read book Simulation Approaches to Ion Channel Structure-function Relationships written by D. Peter Tieleman and published by . This book was released on 2001 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.
Book Synopsis Structure-function Relationships in Biological Ion Channels by : Guy M. P. Coates
Download or read book Structure-function Relationships in Biological Ion Channels written by Guy M. P. Coates and published by . This book was released on 2001 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression and Analysis of Recombinant Ion Channels by : Jeffrey J. Clare
Download or read book Expression and Analysis of Recombinant Ion Channels written by Jeffrey J. Clare and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. These latest developments are covered here for the first time, contributed by editors and authors working for major pharmaceutical companies and who routinely apply these techniques in their daily work. The first three chapters cover the use of the Xenopus oocyte expression system for structure-function studies, from basic approaches for manipulating ion channel cDNAs to more specialized but powerful techniques. This is followed by reviews of strategies and methodologies available for expressing channels in mammalian cells and for their analysis by patch-clamp electrophysiology. Chapters 6 to 8 review the latest methodologies for ion channel drug discovery, including high throughput screening using fluorescence and luminescence, as well as automated planar array electrophysiology. The remaining two chapters focus on approaches for determining ion channel crystal structures and on computational approaches to understanding channel mechanisms at atomic resolution. Rather than provide detailed protocols, indicated by references in each chapter, the authors provide a comprehensive and easily accessible overview of the techniques involved, reviewing underlying principles and providing working guidelines as well as an understanding of the key theoretical and practical considerations associated with each topic. In each case, this practical advice is illustrated by real life examples, taken either from the author's own experience or from key examples in the literature, providing valuable practical hints not found elsewhere. The result is a compendium of practical ion channel information that will prove a valuable resource to academic and industrial workers alike.
Book Synopsis Mechanisms of Mode Shift and Gating Polarity in Voltage-dependent Ion Channels by : John Cowgill
Download or read book Mechanisms of Mode Shift and Gating Polarity in Voltage-dependent Ion Channels written by John Cowgill and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical signaling is one of the most essential processes to the survival of higher organisms. This is mediated by the regulated flow of ions through the cell membrane catalyzed by a diverse set of membrane proteins known as ion channels. An important channel type opens and closes in response to changes in the membrane potential. These voltage-gated ion channels (VGICs) thus regulate the very stimulus which governs their activity, enabling them to generate and regulate electrical excitability in cells. In this thesis, I examine the structural and thermodynamic aspects of voltage-dependent regulation of channel function. In Chapter Three, I used a hierarchical approach based on recently-solved cryoEM structures of two VGICs to examine the role of various structural elements in voltage sensing, opening the pore, and coupling these processes. I localized discrete elements in hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels that are responsible for conferring an inverted gating response in these channels compared to virtually all other VGICs which activate on depolarization. Surprisingly, the HCN voltage sensor can gate the same pore open in both hyperpolarizing and depolarizing directions suggesting that these channels use a unique voltage sensing mechanism. In Chapter Four, long-timescale molecular dynamics simulations from collaborators revealed a new atomic model of voltage sensing in HCN channels that sheds light on the mechanism of inverted gating polarity. We experimentally validated this novel mechanism using cysteine accessibility measurements and utilized our bipolar constructs to demonstrate that this mechanism underlies the inverted gating polarity of HCN channels. Finally, in Chapter Five I examined the origin mode shift in VGIC gating, a widely observed phenomenon whereby longterm changes in membrane potential alter gating properties. By improving the protocols for recording gating currents, I demonstrated that the hysteresis in gating charge-voltage relationship that is commonly attributed to mode shift stems from non-equilibrium measurement conditions. Throughout these works, my findings are discussed in terms of structural, functional, and thermodynamic implications.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling Structure-Function Relations in Ion Channels by : Rob D. Coalson
Download or read book Modeling Structure-Function Relations in Ion Channels written by Rob D. Coalson and published by . This book was released on with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Book Synopsis Investigations of Ion Channel Structure-function Relationships Using Molecular Modeling and Experimental Biochemistry by : Donald Eugene Elmore
Download or read book Investigations of Ion Channel Structure-function Relationships Using Molecular Modeling and Experimental Biochemistry written by Donald Eugene Elmore and published by . This book was released on 2004 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel by :
Download or read book Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Caged Compounds by : Gerard Marriott
Download or read book Caged Compounds written by Gerard Marriott and published by Academic Press. This book was released on 1998-06-22 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.
Book Synopsis Carpenter's Neurophysiology by : Dunecan Massey
Download or read book Carpenter's Neurophysiology written by Dunecan Massey and published by CRC Press. This book was released on 2022-02-14 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurophysiology: A Conceptual Approach offers a refreshing alternative to ‘learning by rote’. Under new authorship, the sixth edition preserves the legacy of the original author, the late Roger Carpenter, retaining the concise approach and readable style so central to its predecessors. Integrating the disciplines of neurology and neuroscience with an emphasis on principles and functional concepts, this comprehensive textbook covers the entire subject of neurophysiology, from the conduction of nerve impulses to the higher functions of the brain, within a single accessible volume. Key Features: Everything the student of medicine or physiology needs to understand neurophysiology. Blends successfully the principles of neuroscience with clinical manifestations in line with modern undergraduate curriculums. Revised and updated, with a particular focus on proprioception, skin sense and hearing, including developments in cochlear implants, and functional MRI Over 500 illustrations, accompanied by full figure legends, also available as a download for use in presentations. Choice of PB with bundled ebook, durable HB or ebook only for complete flexibility Full of explanatory colour diagrams, the book remains an unrivalled ‘one-stop shop’ for students of medicine, physiology and applied physiology, neurophysiology, neuroscience, and other bioscience disciplines seeking an integrated introduction to the challenging disciplines of neuroscience and neurology.
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:
