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An Approach To The Total Synthesis Of Rhyncophylline
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Book Synopsis Formal Syntheses of Hirsutine and Rhynchophylline and Progress Toward the Enantioselective Total Synthesis of Citrinadin A by : Martin Youngjin Pettersson
Download or read book Formal Syntheses of Hirsutine and Rhynchophylline and Progress Toward the Enantioselective Total Synthesis of Citrinadin A written by Martin Youngjin Pettersson and published by . This book was released on 2007 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diastereoselective formal syntheses of the corynanthe alkaloid hirsutine and oxindole alkaloid rhynchophylline are described. The general approach features the use of ring-closing metathesis (RCM) to construct an [alpha], [beta]-unsaturated lactam, which is subjected to 1,4-addition. The lithium enolate of ethyl-1,3-dithiolane-2-carboxylate was identified as the optimal nucleophile in these systems. A key feature of this approach is that the stereochemical outcome of the 1,4-addition can be effectively controlled by appropriately sequencing the indole Boc-protection step to give either the C(3)-H/C(15)-H cis or C(3)-H/C(15)-H trans stereochemical relationship. As a result, we have developed a unified approach to both the "normal" and "pseudo" corynanthe alkaloids. This finding was highlighted through the synthesis of the complete carbon skeleton of the archetypal normal corynanthe alkaloid dihydrocorynantheol. An efficient synthesis of the tricyclic spiroindolinone ABC-fragment of the marine alkaloid citrinadin A has been achieved. The synthesis relies on a novel asymmetric oxidative rearrangement of an indole to an oxindole using a chiral auxiliary on the indole nitrogen to achieve facial selectivity. The transformation proceeds via the epoxidation of the indole C(2), C(3) double bond using DMDO, followed by a silica gelmediated 1,2-epoxide rearrangement. Using this tactic, the spirooxindole of citrinadin A, which contains two adjacent quaternary centers, was formed in high yield and excellent diastereoselectivity. Efforts toward the fragment coupling of the tricyclic spiroindolinone with a 2,4,6-trisubstituted piperidine coupling partner are described.
Book Synopsis Total Synthesis of Isorhynchophylline, Rhynchophylline, Isocorynoxeine and Corynoxeine by : Zhihong Zhang
Download or read book Total Synthesis of Isorhynchophylline, Rhynchophylline, Isocorynoxeine and Corynoxeine written by Zhihong Zhang and published by . This book was released on 2020 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Total Synthesis of Natural Products, Volume 3 by : John ApSimon
Download or read book The Total Synthesis of Natural Products, Volume 3 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Book Synopsis The Total Synthesis of Natural Products by : John ApSimon
Download or read book The Total Synthesis of Natural Products written by John ApSimon and published by Wiley-Interscience. This book was released on 1973 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Book Synopsis The logic of chemical synthesis by : E.J. Corey
Download or read book The logic of chemical synthesis written by E.J. Corey and published by Рипол Классик. This book was released on 1991 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis 5-Membered Heterocycle Synthesis Using Iodine by : Navjeet Kaur
Download or read book 5-Membered Heterocycle Synthesis Using Iodine written by Navjeet Kaur and published by Elsevier. This book was released on 2023-01-24 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: 5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols. This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine. - Covers the applications of five-membered heterocycles - Highlights methodologies for the synthesis of five-membered heterocycles using iodine - Contains the most up-to-date information in this fast-moving field
Book Synopsis Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products by : N. H. Andersen
Download or read book Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by N. H. Andersen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mit Beiträgen zahlreicher Fachwissenschaftler
Download or read book Spirooxindole written by Gautam Patel and published by Elsevier. This book was released on 2024-06-12 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern advances in organic synthesis require compouds having attractive properties with high percentage of yield. Spirooxindole examines the current state of the art, recent progress and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in vaious fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book. - Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents - Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds - Highlights green synthesis and nanocatalysis - Describes in-depth various medicinal applications - Covers both synthesis and applications
Book Synopsis WHO Expert Committee on Drug Dependence by :
Download or read book WHO Expert Committee on Drug Dependence written by and published by World Health Organization. This book was released on 2022-03-15 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Iodine Catalysis in Organic Synthesis by : Kazuaki Ishihara
Download or read book Iodine Catalysis in Organic Synthesis written by Kazuaki Ishihara and published by John Wiley & Sons. This book was released on 2022-05-16 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iodine Catalysis in Organic Synthesis The first book of its kind to highlight iodine as a sustainable alternative to conventional transition metal catalysis Iodine Catalysis in Organic Synthesis provides detailed coverage of recent advances in iodine chemistry and catalysis, focusing on the utilization of various iodine-containing compounds as oxidative catalysts. Featuring contributions by an international panel of leading research chemists, this authoritative volume explores the development of environmentally benign organic reactions and summarizes catalytic transformations of molecular iodine and iodine compounds such as hypervalent organoiodine and inorganic iodine salts. Readers are first introduced to the history of iodine chemistry, the conceptual background of homogeneous catalysis, and the benefits of iodine catalysis in comparison with transition metals. Next, chapters organized by reaction type examine enantioselective transformations, catalytic reactions involving iodine, catalyst states, oxidation in iodine and iodine catalyses, and catalytic reactions based on halogen bonding. Practical case studies and real-world examples of different applications in organic synthesis and industry are incorporated throughout the text. An invaluable guide for synthetic chemists in both academic and industrial laboratories, Iodine Catalysis in Organic Synthesis: Provides a thorough overview of typical iodine-catalyzed reactions, catalyst systems, structures, and reactivity Explores promising industrial applications of iodine-based reagents for organic synthesis Highlights the advantages iodine catalysis has over classical metal-catalyzed reactions Discusses sustainable and eco-friendly methods in hypervalent iodine chemistry Edited by two world authorities on the catalytic applications of organoiodine compounds, Iodine Catalysis in Organic Synthesis is required reading for catalytic, organic, and organometallic chemists, medicinal and pharmaceutical chemists, industrial chemists, and academic researchers and advanced students in relevant fields.
Book Synopsis Research Methodology in Chemical Sciences by : Tanmoy Chakraborty
Download or read book Research Methodology in Chemical Sciences written by Tanmoy Chakraborty and published by CRC Press. This book was released on 2017-03-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Methodology in Chemical Sciences provides an eclectic survey of contemporary problems in experimental, theoretical, and applied chemistry. This book covers recent trends in research with the different domain of the chemical sciences. The chapters, written by knowledgeable researchers, provide different insights to the modern-day research in the domain of spectroscopy, plasma modification, and theoretical and computational analysis of chemical problems. It covers descriptions of experimental techniques, discussions on theoretical modeling, and much more.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cooperative Catalysis by : René Peters
Download or read book Cooperative Catalysis written by René Peters and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the field, this is a much-needed overview of the rapidly emerging field of cooperative catalysis. The authors focus on the design and development of novel high-performance catalysts for applications in organic synthesis (particularly asymmetric synthesis), covering a broad range of topics, from the latest progress in Lewis acid / Br?nsted base catalysis to e.g. metal-assisted organo catalysis, cooperative metal/enzyme catalysis, and cooperative catalysis in polymerization reactions and on solid surfaces. The chapters are classified according to the type of cooperating activating groups, and describe in detail the different strategies of cooperative activation, highlighting their respective advantages and pitfalls. As a result, readers will learn about the different concepts of cooperative catalysis, their corresponding modes of operation and their applications, thus helping to find a solution to a specific synthetic catalysis problem.
Book Synopsis Naturally Occurring Chemicals against Alzheimer's Disease by : Tarun Belwal
Download or read book Naturally Occurring Chemicals against Alzheimer's Disease written by Tarun Belwal and published by Academic Press. This book was released on 2020-11-19 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally Occurring Chemicals against Alzheimer's Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer's disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations. - Provides information on phytochemistry, pharmacology, toxicology, clinical trials, and advancement in formulations specific to Alzheimer's Disease in a single source - Explores natural compounds, which can be more affordable to the majority of Alzheimer's Disease patients, who will increasingly be in developing countries - Covers a wide array of specific chemical compounds
Book Synopsis Microwave Assisted Organic Synthesis by : Jason Tierney
Download or read book Microwave Assisted Organic Synthesis written by Jason Tierney and published by John Wiley & Sons. This book was released on 2009-02-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first reports on the application of microwaves in organicsynthesis date back to 1986, but it was not until the recentintroduction of specifically designed and constructed equipment,which countered the safety and reproducibility concerns, thatsynthetic application of microwaves has become established as alaboratory technique. Microwave assisted synthesis is now beingadopted in many industrial and academic laboratories to takeadvantage of the novel chemistry that can be carried out using avariety of organic reaction types. This book demonstrates the underlying principles of microwavedielectric heating and, by reference to a range of organic reactiontypes, it's effective use in synthetic organic chemistry. Toillustrate the impact microwave assisted organic synthesis can haveon chemical research, case studies drawn mainly from thepharmaceutical industry are presented.
Book Synopsis Asymmetric Organocatalysis Combined with Metal Catalysis by : Bruce A. Arndtsen
Download or read book Asymmetric Organocatalysis Combined with Metal Catalysis written by Bruce A. Arndtsen and published by Springer Nature. This book was released on 2020-04-24 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.
Download or read book Alkaloids written by Margaret F. Roberts and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not since the late 1970s has a single work presented the biology of this heterogenous group of secondary alkaloids in such depth. Alkaloids, a unique treatise featuring leaders in the field, presents both the historical use of alkaloids and the latest discoveries in the biochemistry of alkaloid production in plants alkaloid ecology, including marine invertebrates, animal and plant parasites, and alkaloids as antimicrobial and current medicinal use . Highlights include chapters on the chemical ecology of alkaloids in host-predator interactions, and on the compartmentation of alkaloids synthesis, transport, and storage. Extensive cross-referencing in tabular format makes this volume an excellent reference.
