Amiloride And Its Analogs

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Seldin and Giebisch's The Kidney

Author : Robert J. Alpern
Publisher : Elsevier
ISBN 13 : 0080559506
Total Pages : 2922 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Seldin and Giebisch's The Kidney by : Robert J. Alpern

Download or read book Seldin and Giebisch's The Kidney written by Robert J. Alpern and published by Elsevier. This book was released on 2007-10-10 with total page 2922 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch's The Kidney is your number one source for information.* Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic.* Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics.* Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

Amiloride and Epithelial Sodium Transport

Author : Alan William Cuthbert
Publisher : Urban & Schwarzenberg
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Amiloride and Epithelial Sodium Transport by : Alan William Cuthbert

Download or read book Amiloride and Epithelial Sodium Transport written by Alan William Cuthbert and published by Urban & Schwarzenberg. This book was released on 1979 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lead Generation

Author : Jörg Holenz
Publisher : John Wiley & Sons
ISBN 13 : 3527677070
Total Pages : 824 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Lead Generation by : Jörg Holenz

Download or read book Lead Generation written by Jörg Holenz and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the first time. Beginning with a general discussion of the underlying principles and strategies, individual lead generation approaches are described in detail, highlighting their strengths and weaknesses, along with all relevant bordering disciplines like e.g. target identification and validation, predictive methods, molecular recognition or lead quality matrices. Novel lead generation approaches for challenging targets like DNA-encoded library screening or chemical biology approaches are treated here side by side with established methods as high throughput and affinity screening, knowledge- or fragment-based lead generation, and collaborative approaches. Within the entire book, a very strong focus is given to highlight the application of the presented methods, so that the reader will be able to learn from real life examples. The final part of the book presents several lead generation case studies taken from different therapeutic fields, including diabetes, cardiovascular and respiratory diseases, neuroscience, infection and tropical diseases. The result is a prime knowledge resource for medicinal chemists and for every scientist involved in lead generation.

Diuretics

Author : Rainer F. Greger
Publisher : Springer Science & Business Media
ISBN 13 : 364279565X
Total Pages : 535 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Diuretics by : Rainer F. Greger

Download or read book Diuretics written by Rainer F. Greger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: The action of diuretics including cellular mechanisms of action, pharmacokinetics, and clinical usage, with much emphasis placed on the most recent findings on the pharmacodynamics of the respective drugs. During the past twenty-five years since volume 14 on Diuretica was published in the Handbook series, the cellular mechanisms of action of diuretics have slowly been unravelled. Today, the role of action within the target cells is known for most of the substances discussed. This has provided a new basis not only for the understanding of drug action but also for secondary effects and interactions. The book represents a comprehensive reference work on the diverse groups of diuretics which are among the most frequently prescribed medications.

Oxford Textbook of Clinical Nephrology

Author : Neil N. Turner
Publisher : Oxford University Press
ISBN 13 : 0191017655
Total Pages : 3045 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Textbook of Clinical Nephrology by : Neil N. Turner

Download or read book Oxford Textbook of Clinical Nephrology written by Neil N. Turner and published by Oxford University Press. This book was released on 2015-10-29 with total page 3045 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

The Sodium-Hydrogen Exchanger

Author : Morris Karmazyn
Publisher : Springer Science & Business Media
ISBN 13 : 9781402074745
Total Pages : 356 pages
Book Rating : 4.0/5 (747 download)

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Book Synopsis The Sodium-Hydrogen Exchanger by : Morris Karmazyn

Download or read book The Sodium-Hydrogen Exchanger written by Morris Karmazyn and published by Springer Science & Business Media. This book was released on 2003-06-30 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Acute Care Handbook for Physical Therapists - E-Book

Author : Jaime C. Paz
Publisher : Elsevier Health Sciences
ISBN 13 : 0323227538
Total Pages : 529 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Acute Care Handbook for Physical Therapists - E-Book by : Jaime C. Paz

Download or read book Acute Care Handbook for Physical Therapists - E-Book written by Jaime C. Paz and published by Elsevier Health Sciences. This book was released on 2013-10-04 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: - NEW! Restructured table of contents helps you quickly locate information. - NEW! Language from the International Classification of Functioning, Disability, and Health (ICF) model adopted by the American Physical Therapy Association increases your familiarity with terminology. - NEW! New intervention algorithms along with existing algorithms break clinical decision-making into individual steps and sharpens your on-the-spot critical-thinking skills. - NEW! A quick-reference appendix covering abbreviations commonly found in the acute care environment supplies the translation tools you need, while flagging any abbreviations that may be harmful to the patient.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Neutrophil Methods and Protocols

Author : Mark T. Quinn
Publisher : Springer Science & Business Media
ISBN 13 : 1588297888
Total Pages : 1099 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Neutrophil Methods and Protocols by : Mark T. Quinn

Download or read book Neutrophil Methods and Protocols written by Mark T. Quinn and published by Springer Science & Business Media. This book was released on 2007-08-02 with total page 1099 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise set of protocols for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step-by-step diagnostic assays of common neutrophil disorders. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Scientists and clinicians will find this collection an invaluable aid.

Current Topics in Membranes and Transport

Author :
Publisher : Academic Press
ISBN 13 : 0080584918
Total Pages : 347 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Current Topics in Membranes and Transport by :

Download or read book Current Topics in Membranes and Transport written by and published by Academic Press. This book was released on 1984-02-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes and Transport

Mechanisms of Taste Transduction

Author : Sidney A. Simon
Publisher : CRC Press
ISBN 13 : 1498710638
Total Pages : 527 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Mechanisms of Taste Transduction by : Sidney A. Simon

Download or read book Mechanisms of Taste Transduction written by Sidney A. Simon and published by CRC Press. This book was released on 2014-07-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to the

Endocrinology of the Vasculature

Author : J. R. Sowers
Publisher : Springer Science & Business Media
ISBN 13 : 1461202310
Total Pages : 391 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Endocrinology of the Vasculature by : J. R. Sowers

Download or read book Endocrinology of the Vasculature written by J. R. Sowers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key workers in vascular medicine and biology apply state-of-the-art techniques in cell and molecular biology to study the endothelial and vascular smooth muscle cells. The distinguished scientists and clinicians open a new area of endocrinology, which sees the vasculature and kidney as endocrine organs and sheds new light on the hormonal regulation of the cardiovascular system. They also add significantly to our current understanding of the autocrine, paracrine, and endocrine regulation of vascular function in health and in those vascular disease states that accompany diabetes mellitus, dyslipidemia, and hypertension. Endocrinology of the Vasculature is the first book to comprehensively and systematically explore the vasculature as an endocrine organ.

Pharmaceutical Chemistry of Antihypertensive Agents

Author : Gyorgy Szasz
Publisher : CRC Press
ISBN 13 : 9780849347245
Total Pages : 288 pages
Book Rating : 4.3/5 (472 download)

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Book Synopsis Pharmaceutical Chemistry of Antihypertensive Agents by : Gyorgy Szasz

Download or read book Pharmaceutical Chemistry of Antihypertensive Agents written by Gyorgy Szasz and published by CRC Press. This book was released on 1990-12-19 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Chemistry of Antihypertensive Agents, provides the only comprehensive treatment of anti-hypertensive properties (e.g., structure-activity relationship, analytics, and metabolism) of pharmaceutical chemicals. The topics discussed include diuretics, renin inhibitors, angiotensin-converting enzyme inhibitors, a-blocking agents, b-adrenergic antagonists, and vasodilators. Data is supported by more than 1400 references and 300 chemical structures. This book is essential reading for physicians and pharmaceutical researchers, as well as pharmaceutical chemistry students.

The Senses: A Comprehensive Reference

Author :
Publisher : Academic Press
ISBN 13 : 0128054093
Total Pages : 5215 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Senses: A Comprehensive Reference by :

Download or read book The Senses: A Comprehensive Reference written by and published by Academic Press. This book was released on 2020-09-30 with total page 5215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Senses: A Comprehensive Reference, Second Edition, Seven Volume Set is a comprehensive reference work covering the range of topics that constitute current knowledge of the neural mechanisms underlying the different senses. This important work provides the most up-to-date, cutting-edge, comprehensive reference combining volumes on all major sensory modalities in one set. Offering 264 chapters from a distinguished team of international experts, The Senses lays out current knowledge on the anatomy, physiology, and molecular biology of sensory organs, in a collection of comprehensive chapters spanning 4 volumes. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods. Written for a wide audience, this reference work provides students, scholars, medical doctors, as well as anyone interested in neuroscience, a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. As with the first edition, contributions from leading scholars from around the world will ensure The Senses offers a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience and provides the ultimate entry point into the review and original literature in Sensory Neuroscience enabling students and scientists to delve into the subject and deepen their knowledge. All-inclusive coverage of topics: updated edition offers readers the only current reference available covering neurobiology, physiology, anatomy, and molecular biology of sense organs and the processing of sensory information in the brain Authoritative content: world-leading contributors provide readers with a reputable, dynamic and authoritative account of the topics under discussion Comprehensive-style content: in-depth, complex coverage of topics offers students at upper undergraduate level and above full insight into topics under discussion

Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Author : Morris Karmazyn
Publisher : Birkhäuser
ISBN 13 : 3034889887
Total Pages : 508 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Myocardial Ischemia: Mechanisms, Reperfusion, Protection by : Morris Karmazyn

Download or read book Myocardial Ischemia: Mechanisms, Reperfusion, Protection written by Morris Karmazyn and published by Birkhäuser. This book was released on 2013-03-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.

Issues in Neuroscience Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464963614
Total Pages : 3143 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Neuroscience Research and Application: 2011 Edition by :

Download or read book Issues in Neuroscience Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 3143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.