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Alternate Fractionation In Radiotherapy
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Book Synopsis Alternate Fractionation in Radiotherapy by : Mark Trombetta
Download or read book Alternate Fractionation in Radiotherapy written by Mark Trombetta and published by Springer. This book was released on 2018-09-25 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice. Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide.
Book Synopsis Practical Radiation Oncology by : Supriya Mallick
Download or read book Practical Radiation Oncology written by Supriya Mallick and published by Springer Nature. This book was released on 2019-11-25 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the most relevant aspects of radiation oncology in terms of technical integrity, dose parameters, machine and software specifications, as well as regulatory requirements. Radiation oncology is a unique field that combines physics and biology. As a result, it has not only a clinical aspect, but also a physics aspect and biology aspect, all three of which are inter-related and critical to optimal radiation treatment planning. In addition, radiation oncology involves a host of machines/software. One needs to have a firm command of these machines and their specifications to deliver comprehensive treatment. However, this information is not readily available, which poses serious challenges for students learning the planning aspect of radiation therapy. In response, this book compiles these relevant aspects in a single source. Radiation oncology is a dynamic field, and is continuously evolving. However, tracking down the latest findings is both difficult and time-consuming. Consequently, the book also comprehensively covers the most important trials. Offering an essential ready reference work, it represents a value asset for all radiation oncology practitioners, trainees and students.
Book Synopsis Fractionation in Radiotherapy by : Howard D. Thames
Download or read book Fractionation in Radiotherapy written by Howard D. Thames and published by CRC Press. This book was released on 1987-07-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereotactic Body Radiation Therapy by : Simon S. Lo
Download or read book Stereotactic Body Radiation Therapy written by Simon S. Lo and published by Springer Science & Business Media. This book was released on 2012-08-28 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Book Synopsis Radiobiology for the Radiologist by : Eric J. Hall
Download or read book Radiobiology for the Radiologist written by Eric J. Hall and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: In print since 1972, this seventh edition of Radiobiology for the Radiologist is the most extensively revised to date. It consists of two sections, one for those studying or practicing diagnostic radiolo, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia. Now in full color, this lavishly illustrated new edition is replete with tables and figures that underscore essential concepts. Each chapter concludes with a "summary of pertinent conclusions" to facilitate quick review and help readers retain important information.
Book Synopsis Basic Clinical Radiobiology by : Michael C. Joiner
Download or read book Basic Clinical Radiobiology written by Michael C. Joiner and published by CRC Press. This book was released on 2018-08-28 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Builds on success and reputation of previous editions Draws on the considerable teaching experience of an international author team, most notably the US and European Editors The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US Highly illustrated with new, 2 colour illustrations Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics
Book Synopsis Robust, Non-stationary, and Adaptive Fractionation in Radiotherapy by : Ali Ajdari
Download or read book Robust, Non-stationary, and Adaptive Fractionation in Radiotherapy written by Ali Ajdari and published by . This book was released on 2017 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: In external beam radiotherapy for cancer, high-energy radiation is passed through the pa- tient’s body from an outside source to kill tumor cells. The challenge is that radiation also damages healthy tissue and organs-at-risk (OAR) in its path. The objective therefore is to devise treatment plans that maximize tumor-damage while protecting healthy anatomies. Treatment planners attempt two separate methods to attain this goal: spatial and biological. The spatial side focuses on the geometry and physics of the problem. The key consider- ation here is the location of the tumor relative to the nearby healthy regions as seen in an anatomical image, and the dose (energy absorbed per unit mass) deposition properties of the radiation beam. The treatment planner prescribes a high dose to the tumor and puts upper limits on the doses delivered to the healthy regions. Intensity Modulated Radiation Therapy (IMRT) technology is then employed to tune the profile (fluence-map) of the radiation beam to administer a dose that is as close as possible to this tumor-conforming prescription. Sev- eral mathematical optimization models and solution algorithms for this problem have been developed and embedded into treatment planning systems. The biological side of planning exploits the difference between the dose-response charac- teristics of tumors and healthy anatomies. For example, healthy cells are believed to possess better damage repair capabilities than tumor cells. Thus, treatment is delivered over mul- tiple sessions to give healthy tissue some time to recover between sessions. This is called fractionation. Fractionation also gives the tumor some time to re-oxygenate, which increases its sensitivity to radiation. Tumors, however, proliferate during the treatment course, and hence, too long a treatment course may not be ideal. One key question on this biological side is to determine the optimal number of treatment sessions. This is called the fraction- ation problem. Existing optimization research on the fractionation problem relies on the linear-quadratic (LQ) model of dose-response with tumor- and OAR-specific parameters to approximately capture the behavior of the complex biological system involved. Recent studies have suggested that an integrated approach that simultaneously tackles the spatial and biological sides of the problem may lead to a higher tumor-damage as com- pared to tackling the two aspects separately. The goal in such integrated formulations is to simultaneously find the fluence-map and the number of sessions that maximize tumor- damage while limiting toxic effects of dose on the healthy anatomies. Emerging advances in quantitative functional imaging technologies are enabling planners to observe the tumor’s actual dose-response over the treatment course. This provides additional opportunities for better-utilizing the LQ model by dynamically adapting treatment plans to further improve outcomes. The challenge, however, is that spatiobiologically integrated formulations based on the LQ model typically yield nonconvex quadratically constrained quadratic programming problems, which are computationally difficult to solve exactly. The research objective of this dissertation is to develop efficient convex, robust, and dynamic optimization methods to formulate and approximately solve different nonadaptive and adaptive versions of the spatiobiologically integrated fractionation problem within the LQ framework. Chapter 1 briefly describes state-of-the-art literature on spatiobiologically integrated fractionation. Each subsequent chapter is motivated by a distinct limitation of an existing formulation of the spatiobiologically integrated fractionation problem from this literature. Chapter 2: The solutions offered by existing formulations of the fractionation problem crucially depend on the assumed values of the dose-response parameters of the LQ model. Unfortunately, “true” values of these parameters are unknown. Consequently, a solution of the fractionation problem may not be feasible in practice. This concern is addressed in Chapter 2 via a robust formulation, whose solution remains feasible as long as the dose- response parameters belong to an interval. An efficient solution method rooted in a convex, finite-dimensional reformulation of the resulting infinite-dimensional problem is proposed. The price of robustness and feasibility properties of the robust solution are quantified via numerical experiments. Chapter 3: Existing spatiobiologically integrated formulations of the fractionation problem assume that the fluence-map is not changed across treatment sessions. From a computational viewpoint, this simplifies the problem significantly. Chapter 3 relaxes this assumption, and proposes an efficient solution method that allows the fluence-maps to vary across sessions. The quality of the time-variant solutions produced by this method is compared against traditional time-invariant solutions via numerical experiments. Chapter 4: Adaptive spatiobiologically integrated fractionation attempts to alter fluence- maps according to the observed evolution of tumor cell density in functional images. Chapter 4 proposes a formulation and solution method that also determine the length of the remaining treatment course adaptively. Potential benefits of such adaptive treatment-length planning are investigated through numerical experiments. Chapter 5: Adaptive fluence-map planning methods assume that the treatment planner knows the probability distribution of the uncertainty in the tumor’s dose-response parame- ters. In contrast to this “clairvoyant” approach, Chapter 5 proposes an alternative formula- tion, where the treatment planner learns this distribution from tumor-response information observed in functional images over the treatment course while also adaptively optimizing fluence-maps. This yields a Bayesian stochastic control formulation whose exact solution is impossible to derive. The chapter proposes a simple approximate solution method rooted in certainty equivalent control, and compares its performance agains a clairvoyant certainty equivalent control scheme and a “no learning” approach via numerical experiments. Finally, Chapter 6 outlines limitations of this dissertation work and describes two direc- tions for future research.
Book Synopsis Accelerated Partial Breast Irradiation by : Douglas W. Arthur
Download or read book Accelerated Partial Breast Irradiation written by Douglas W. Arthur and published by Springer. This book was released on 2006-05-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a concise handbook designed to assist the clinician in the implementation of Accelerated Partial Breast Irradiation (APBI). It includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications. The book encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation.
Book Synopsis Clinical Equine Oncology by : Derek C. Knottenbelt
Download or read book Clinical Equine Oncology written by Derek C. Knottenbelt and published by Saunders. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnose common equine tumors accurately and find clinical information quickly! Clinical Equine Oncology describes the cellular basis of cancer and its etiopathogenesis, along with the principles of diagnosis, treatment, and management of cancer cases. This comprehensive resource offers more than just facts and diagrams - hundreds of detailed photographs make it easier to recognize and evaluate more than 50 types of tumors. It's useful to anyone working in the equine field, whether you're a veterinary surgeon, a practicing vet, equine dentist, or veterinary student. Written by a recognized expert on equine medicine, Derek Knottenbelt, this is the only book on the market that is completely dedicated to coverage of cancer in horses! More than 50 different types of tumor are covered, including tumors that occur in each of the 10 body systems. Over 800 excellent-quality photographs show the appearance of pathologies and cancerous conditions both before and after treatment. More than 80 full-color diagrams summarize key information. Detailed Pathology section describes common neoplasms in horses, cites research literature, and describes what is generally known about each condition. Authoritative, inclusive, and unique coverage is likely to remain the standard reference for years to come. Expert authors are recognized as the top experts in the field of equine oncology. Practical, colorful design includes icon-based references for quick appraisal of prevalence and prognosis.
Book Synopsis Textbook of Radiation Oncology by : Steven A. Leibel
Download or read book Textbook of Radiation Oncology written by Steven A. Leibel and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.
Book Synopsis IASLC Thoracic Oncology E-Book by : Harvey Pass
Download or read book IASLC Thoracic Oncology E-Book written by Harvey Pass and published by Elsevier Health Sciences. This book was released on 2017-04-21 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. Features a new full-color design throughout, as well as updated diagnostic algorithms.
Book Synopsis Hypofractionated and Stereotactic Radiation Therapy by : Orit Kaidar-Person
Download or read book Hypofractionated and Stereotactic Radiation Therapy written by Orit Kaidar-Person and published by Springer Nature. This book was released on with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lung Cancer written by Henry S. Park and published by BoD – Books on Demand. This book was released on 2021-06-02 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.
Book Synopsis Re-Irradiation: New Frontiers by : Carsten Nieder
Download or read book Re-Irradiation: New Frontiers written by Carsten Nieder and published by Springer. This book was released on 2016-10-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Book Synopsis Radiation Source Use and Replacement by : National Research Council
Download or read book Radiation Source Use and Replacement written by National Research Council and published by National Academies Press. This book was released on 2008-05-25 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States there are several thousand devices containing high-activity radiation sources licensed for use in areas ranging from medical uses such as cancer therapy to safety uses such as testing of structures and industrial equipment. Those radiation sources are licensed by the U.S. Nuclear Regulatory Commission and state agencies. Concerns have been raised about the safety and security of the radiation sources, particularly amid fears that they could be used to create dirty bombs, or radiological dispersal device (RDD). In response to a request from Congress, the U.S. Nuclear Regulatory Commission asked the National Research Council to conduct a study to review the uses of high-risk radiation sources and the feasibility of replacing them with lower risk alternatives. The study concludes that the U.S. government should consider factors such as potential economic consequences of misuse of the radiation sources into its assessments of risk. Although the committee found that replacements of most sources are possible, it is not economically feasible in some cases. The committee recommends that the U.S. government take steps to in the near term to replace radioactive cesium chloride radiation sources, a potential "dirty bomb" ingredient used in some medical and research equipment, with lower-risk alternatives. The committee further recommends that longer term efforts be undertaken to replace other sources. The book presents a number of options for making those replacements.
Book Synopsis Systemic Drug Delivery Strategies by : Mansoor M. Amiji
Download or read book Systemic Drug Delivery Strategies written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-21 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
