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Advances On The Gametocyte Biology Host Immunity And Vector Stages To Interrupt The Transmission Of Malaria
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Book Synopsis Advances on the Gametocyte Biology, Host Immunity and Vector Stages to interrupt the Transmission of Malaria by : Linda Reiling
Download or read book Advances on the Gametocyte Biology, Host Immunity and Vector Stages to interrupt the Transmission of Malaria written by Linda Reiling and published by Frontiers Media SA. This book was released on 2022-06-14 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Malaria Transmission Biology by : Rhoel Dinglasan
Download or read book Malaria Transmission Biology written by Rhoel Dinglasan and published by Frontiers Media SA. This book was released on 2021-01-22 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The malaria parasite life cycle is complex and includes an obligatory developmental stage in its mosquito vector host. This transition from human-host to mosquito-host to human-host involves multiple developmental stages and divergent host tissues. Over the years, the research focus on the asexual stage parasites, which causes the symptoms of the disease, has transitioned towards a renewed focus on the transmission forms (or gametocytes), the only stages transmittable to the mosquito vector through ingestion of an infected blood meal. Analysis of sporozoite-liver interactions that result in the establishment of parasitic infection in the mammalian host has become an important research focus, and we now have a greater appreciation of the fascinating development of the sporozoites of the mosquito midgut wall and its travel to the salivary glands prior to inoculation into the mammalian dermis. This Research Topic embraces the full transition of the malaria parasite between its two obligatory hosts in what is termed as “malaria transmission biology”. Of note are the critical, enabling technologies and experimental systems that have been developed over the recent decade and have opened up significant new avenues for exploring the multi-stage, and multi-step processes that comprise malaria transmission biology. From uncovering that gametocyte development occurs in the bone marrow to quantifying the influence of both human host metabolism and parasite genetics on mosquito infection, it is clear that malaria transmission biology has entered an exciting era of discovery. Importantly, recent maturation of humanized liver mice and more sophisticated in vitro platforms have allowed more accurate recapitulations of the mosquito-to-skin-to-liver stages of human malaria infection. This allows both observation and study of the biological nuances of parasite vector-to-mammalian host transmission as well as interventions which can inhibit or block this stage of transmission. Paired with observations from clinical trials and the field, we can better understand exactly which parameters in which systems are most relevant for translation and biology.
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Book Synopsis Current Topics in Malaria by : Alfonso J. Rodriguez-Morales
Download or read book Current Topics in Malaria written by Alfonso J. Rodriguez-Morales and published by . This book was released on 2016-11-30 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria written by Dyann Fergus Wirth and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is a mosquito-borne disease caused by parasitic protozoa that belong to the genus Plasmodium. This disease imposes a significant global health burden, claiming the lives of several thousand children and pregnant women each day. Increasing antimalarial drug resistance and the complexity of the Plasmodium life cycle, among other factors, have made eradication difficult. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biology, pathology, and epidemiology of malaria, as well as ongoing efforts to treat infections and manage their spread. Contributors discuss the Plasmodium life cycle, focusing on the molecular mechanisms by which the various parasitic stages induce clinical symptoms, interact with the immune system, and lead to further transmission of malaria. They also explore topics such as the interaction between mosquito reproduction and Plasmodium development, epigenetic regulation of malaria-associated genes, and unique features of malaria in pregnant women (e.g., parity-dependent susceptibility) and describe how an improved understanding of these phenomena may lead to novel intervention strategies. The driving forces behind antimalarial drug resistance are covered, as is progress in developing an effective vaccine and controlling mosquito populations. This volume is therefore an essential reference for all scientists, clinicians, and public health professionals interested in understanding malaria and reducing its devastating effects.
Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
Book Synopsis Towards Malaria Elimination by : Sylvie Manguin
Download or read book Towards Malaria Elimination written by Sylvie Manguin and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.
Book Synopsis Host Manipulation by Parasites by : David P. Hughes
Download or read book Host Manipulation by Parasites written by David P. Hughes and published by Oxford University Press. This book was released on 2012-06-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasites that manipulate the behaviour of their hosts represent striking examples of adaptation by natural selection. This text provides an authoritative review of host manipulation by parasites that assesses developments in the field and lays out a framework for future research.
Book Synopsis World Malaria Report 2015 by : World Health Organization
Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.
Book Synopsis A Textbook of Malaria Eradication by : Emilio Pampana
Download or read book A Textbook of Malaria Eradication written by Emilio Pampana and published by Oxford University Press, USA. This book was released on 1969 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunity to Malaria and Vaccine Strategies by : Kevin N. Couper
Download or read book Immunity to Malaria and Vaccine Strategies written by Kevin N. Couper and published by Frontiers Media SA. This book was released on 2019-10-10 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at increased risk of severe malarial disease when protection wanes. Thus, to define new ways to combat malaria, there remains an urgent requirement to identify the immune mechanisms that promote resistance to malarial disease and to understand why these so often fail. The review and primary research articles in this Research Topic illustrate the breadth of research performed worldwide aimed to understand the biology of the Plasmodium parasite, the roles of the various cell types that act within the immune response against the parasite, and the parasitological and immunological basis of severe malarial disease. The articles in section 1 exemplify the different vaccination strategies being developed and tested by the research community in the fight against malaria. The articles in section 2 review important overarching aspects of malaria immunology and the use of models to study human malaria. The articles in section 3 describe the ways through which the Plasmodium parasite is initially recognised by the immune system during infection, how the parasite can directly impact this critical event to restrict anti-Plasmodial immunity, and resolve the roles of key innate cell populations, such as dendritic cells, in coordinating malarial immunity. The articles in sections 4-6 outline the roles T and B cell populations play during malaria, highlighting the activation, diversification and regulation of the crucial cell types during malaria, and discuss some of the reasons adaptive immunity to malaria is often considered so poor compared with other diseases. The articles in section 7 provide up to date information on the pathogenesis of cerebral malaria, bridging our understanding of the syndrome in humans with information learned from animal models. Overall, the articles in this research, many of which are published by leaders in the malaria field, emphasize the imagination and technical advances being employed by researchers against malaria. We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Book Synopsis Guidelines for the Treatment of Malaria. Third Edition by : World Health Organization
Download or read book Guidelines for the Treatment of Malaria. Third Edition written by World Health Organization and published by World Health Organization. This book was released on 2015-08-13 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.
Book Synopsis The Biology and Identification of the Coccidia (Apicomplexa) of Carnivores of the World by : Donald W. Duszynski
Download or read book The Biology and Identification of the Coccidia (Apicomplexa) of Carnivores of the World written by Donald W. Duszynski and published by Academic Press. This book was released on 2018-06-29 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental concept of The Biology and Identification of the Coccidia (Apicomplexa) of Carnivores of the World is to provide an up-to-date reference guide to the identification, taxonomy, and known biology of apicomplexan intestinal and tissue parasites of carnivores including, but not limited to, geographic distribution, prevalence, sporulation, prepatent and patent periods, site(s) of infection in the definitive and (if known) intermediate hosts, endogenous development, cross-transmission, pathology, phylogeny, and (if known) their treatments. These data will allow easy parasite recognition with a summation of virtually everything now known about the biology of each parasite species covered. The last (very modest) and only treatise published on this subject was in 1981 so this book fills a fundamental gap in our knowledge of what is now known, and what is not, about the coccidian parasites that infect and sometimes kill carnivores and/or their prey that can harbor intermediate stages, including many domestic and game animals. Offers line drawings and photomicrographs of many parasite species that will allow easy diagnosis and identification by both laypersons and professionals (veterinarians, wildlife biologists, etc.) Presents a complete historical rendition of all known publications on carnivore coccidia for all carnivore families and evaluates the scientific and scholarly merit of each apicomplexan species relative to the current body of knowledge Provides a complete species analysis and their known biology of all coccidia described from each carnivore lineage and species Reviews the most current taxonomy of carnivores and their phylogenetic relationships to help assess host-specificity patterns that may be apparent Evaluates what little cross-transmission work is available to help understand the complexities of those coccidians that use two hosts (e.g., Sarcocystis, Besnoitia, and others) Provides known treatments for the various parasite genera/species
Book Synopsis Skin and Arthropod Vectors by : Nathalie Boulanger
Download or read book Skin and Arthropod Vectors written by Nathalie Boulanger and published by Academic Press. This book was released on 2018-01-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity
Book Synopsis Medical and Veterinary Entomology by : Gary R. Mullen
Download or read book Medical and Veterinary Entomology written by Gary R. Mullen and published by Academic Press. This book was released on 2009-04-22 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical and Veterinary Entomology, Second Edition, has been fully updated and revised to provide the latest information on developments in entomology relating to public health and veterinary importance. Each chapter is structured with the student in mind, organized by the major headings of Taxonomy, Morphology, Life History, Behavior and Ecology, Public Health and Veterinary Importance, and Prevention and Control. This second edition includes separate chapters devoted to each of the taxonomic groups of insects and arachnids of medical or veterinary concern, including spiders, scorpions, mites, and ticks. Internationally recognized editors Mullen and Durden include extensive coverage of both medical and veterinary entomological importance. This book is designed for teaching and research faculty in medical and veterinary schools that provide a course in vector borne diseases and medical entomology; parasitologists, entomologists, and government scientists responsible for oversight and monitoring of insect vector borne diseases; and medical and veterinary school libraries and libraries at institutions with strong programs in entomology. Follows in the tradition of Herm's Medical and Veterinary Entomology The latest information on developments in entomology relating to public health and veterinary importance Two separate indexes for enhanced searchability: Taxonomic and Subject New to this edition: Three new chapters Morphological Adaptations of Parasitic Arthropods Forensic Entomology Molecular Tools in Medical and Veterinary Entomology 1700 word glossary Appendix of Arthropod-Related Viruses of Medical-Veterinary Importance Numerous new full-color images, illustrations and maps throughout
Book Synopsis Regulation of Immunity to Parasitic Infections Endemic to Africa by : Faith H. A. Osier
Download or read book Regulation of Immunity to Parasitic Infections Endemic to Africa written by Faith H. A. Osier and published by Frontiers Media SA. This book was released on 2020-07-24 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Download or read book The Garki Project written by L. Molineaux and published by . This book was released on 1980 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
