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Advances In Vasopressin And Oxytocin From Genes To Behaviour To Disease
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Book Synopsis Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease by : Rainer Landgraf
Download or read book Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease written by Rainer Landgraf and published by Elsevier. This book was released on 2008-09-10 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohypophysial system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike. Comprehensive review of OXT and AVP physiology and behaviour Each chapter covers a novel aspect of OXT and AVP research and is written by a leading expert Review articles are ideal for experts and newcomers to the field alike Discusses fascinating behavioural effects of oxytocin and vasopressin Summarizes the recent explosion of neuropeptide research, physiology and behaviour, is in one location
Book Synopsis Vasopressin and Oxytocin: From Genes to Clinical Applications by : D. Poulain
Download or read book Vasopressin and Oxytocin: From Genes to Clinical Applications written by D. Poulain and published by Elsevier. This book was released on 2002-10-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system. Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.
Book Synopsis Vasopressin and Oxytocin by : Hans H. Zingg
Download or read book Vasopressin and Oxytocin written by Hans H. Zingg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph provides a comprehensive overview of recent advances in the field of vasopressin and oxytocin. In the summer of 1997, scientists from over 20 countries congregated in Montreal for the 1997 World Congress of Neurohypophysial Hormones, a conference that united the fields of vasopressin, neurohypophysis and oxytocin in a single joint meeting that gave rise to the present book. The organization of a joint meeting was prompted by several recent developments. Specifically the molecular characterization of the vasopressin/oxytocin receptor family made it mandatory to adopt an integrated view and to discuss the vasopressin/oxytocin ligand/receptor family as a whole. To ensure em phasis on novelty, the conference focused on advances made over the last two years and also included important contributions by scientists that had not previously been associated with the vasopressin/oxytocin field. Vasopressin and oxytocin are two neurohormones that exert a wide spectrum of cen tral and peripheral actions. Accordingly, the vasopressin/oxytocin field embraces a large number of different domains, ranging from neuroscience, endocrinology, and oncology to renal, reproductive, and cardiovascular physiology and pathology.
Book Synopsis Oxytocin's routes in social behavior: into the 21st century. “Precision Medicine” approach for Oxytocin by : Alaine Keebaugh
Download or read book Oxytocin's routes in social behavior: into the 21st century. “Precision Medicine” approach for Oxytocin written by Alaine Keebaugh and published by Frontiers Media SA. This book was released on 2015-12-21 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our brain is endowed with an incredible capacity to be social, to trust, to cooperate, to be altruistic, to feel empathy and love. Nevertheless, the biological underpinnings of such behaviors remain partially hardwired. Seminal research in rodents has provided important insights on the identification of specific genes in modulating social behaviors, in particular, the arginine vasopressin receptor and the oxytocin receptor genes. These genes are involved in regulating a wide range of social behaviors, mother-infant interactions, social recognition, aggression and socio-sexual behavior. Remarkably, we now know that these genes contribute to social behavior in a broad range of species from voles to humans. Indeed, advances in human non-invasive neuroimaging techniques and genetics have enabled scientists to begin to elucidate the neurobiological basis of the complexity of human social behaviors using "pharmacological fMRI" and "imaging genetics". Over the past few years, there has been a strong interest focused on the role of oxytocin in modulating human social behaviors with translational relevance for understanding neuropsychiatric disorders, such as autism, schizophrenia and depression, in which deficits in social perception and social recognition are key phenotypes. The convergence of this interdisciplinary research is beginning to reveal the complex nature of oxytocin’s actions. For instance, the way that oxytocin does influence social functioning is highly related to individual differences in social experiences, but also to the inter-individual variability in the receptor distribution of this molecule in the brain. Remarkably, despite the increasing evidence that oxytocin has a key role in regulating human social behavior, we still lack of knowledge on the core mechanisms of action of this molecule. Understanding its fundamental actions is a crucial need in order to target optimal therapeutic strategies for human social disorders. The originality of this Research Topic stands on its translational focus on bridging the gap between fundamental knowledge acquired from oxytocin research in voles and monkeys and recent clinical investigations in humans. For instance, what are the key animal findings that can import further knowledge on the mechanisms of actions of this molecule in humans? What are the key experiences that can be performed in the animal model in order to answer significant science gaps in the treatment of neuropsychiatric disorders? Hence, within this Research Topic, we will review the current state of the field, identify where the gaps in knowledge are, and propose directions for future research. This issue will begin with a comparative review that examines the role of this peptide in diverse animal models, which highlights the adaptive value of oxytocin’s function across multiple species. Then, a series of reviews will examine the role of oxytocin in voles, primates, and humans with an eye toward revealing commonalities in the underlying brain circuits mediating oxytocin’s effects on social behavior. Next, there will be a translational review highlighting the evidence for oxytocin’s role in clinical applications in psychopathology. Hence, via the continuum of basic to translational research areas, we will try to address the important gaps in our understanding of the neurobiological routes of social cognition and the mechanisms of action of the neuropeptides that guide our behaviors and decisions.
Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Ramon Lim
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Ramon Lim and published by Springer Science & Business Media. This book was released on 2006-09-18 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.
Book Synopsis Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior by : Elena Choleris
Download or read book Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior written by Elena Choleris and published by Cambridge University Press. This book was released on 2013-04-11 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian neurohypophyseal peptide hormones oxytocin and vasopressin act to mediate human social behavior - they affect trust and social relationships and have an influence on avoidance responses. Describing the evolutionary roots of the effects that these neuropeptides have on behavior, this book examines remarkable parallel findings in both humans and non-human animals. The chapters are structured around three key issues: the molecular and neurohormonal mechanisms of peptides; phylogenetic considerations of their role in vertebrates; and their related effects on human behavior, social cognition and clinical applications involving psychiatric disorders such as autism. A final chapter summarizes current research perspectives and reflects on the outlook for future developments. Providing a comparative overview and featuring contributions from leading researchers, this is a valuable resource for graduate students, researchers and clinicians in this rapidly developing field.
Book Synopsis Oxytocin's Routes in Social Behavior: Into the 21st Century by :
Download or read book Oxytocin's Routes in Social Behavior: Into the 21st Century written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our brain is endowed with an incredible capacity to be social, to trust, to cooperate, to be altruistic, to feel empathy and love. Nevertheless, the biological underpinnings of such behaviors remain partially hardwired. Seminal research in rodents has provided important insights on the identification of specific genes in modulating social behaviors, in particular, the arginine vasopressin receptor and the oxytocin receptor genes. These genes are involved in regulating a wide range of social behaviors, mother-infant interactions, social recognition, aggression and socio-sexual behavior. Remarkably, we now know that these genes contribute to social behavior in a broad range of species from voles to humans. Indeed, advances in human non-invasive neuroimaging techniques and genetics have enabled scientists to begin to elucidate the neurobiological basis of the complexity of human social behaviors using "pharmacological fMRI" and "imaging genetics". Over the past few years, there has been a strong interest focused on the role of oxytocin in modulating human social behaviors with translational relevance for understanding neuropsychiatric disorders, such as autism, schizophrenia and depression, in which deficits in social perception and social recognition are key phenotypes. The convergence of this interdisciplinary research is beginning to reveal the complex nature of oxytocin's actions. For instance, the way that oxytocin does influence social functioning is highly related to individual differences in social experiences, but also to the inter-individual variability in the receptor distribution of this molecule in the brain. Remarkably, despite the increasing evidence that oxytocin has a key role in regulating human social behavior, we still lack of knowledge on the core mechanisms of action of this molecule. Understanding its fundamental actions is a crucial need in order to target optimal therapeutic strategies for human social disorders. The originality of this Research Topic stands on its translational focus on bridging the gap between fundamental knowledge acquired from oxytocin research in voles and monkeys and recent clinical investigations in humans. For instance, what are the key animal findings that can import further knowledge on the mechanisms of actions of this molecule in humans? What are the key experiences that can be performed in the animal model in order to answer significant science gaps in the treatment of neuropsychiatric disorders? Hence, within this Research Topic, we will review the current state of the field, identify where the gaps in knowledge are, and propose directions for future research. This issue will begin with a comparative review that examines the role of this peptide in diverse animal models, which highlights the adaptive value of oxytocin's function across multiple species. Then, a series of reviews will examine the role of oxytocin in voles, primates, and humans with an eye toward revealing commonalities in the underlying brain circuits mediating oxytocin's effects on social behavior. Next, there will be a translational review highlighting the evidence for oxytocin's role in clinical applications in psychopathology. Hence, via the continuum of basic to translational research areas, we will try to address the important gaps in our understanding of the neurobiological routes of social cognition and the mechanisms of action of the neuropeptides that guide our behaviors and decisions.
Book Synopsis Behavioral Pharmacology of Neuropeptides: Oxytocin by : Rene Hurlemann
Download or read book Behavioral Pharmacology of Neuropeptides: Oxytocin written by Rene Hurlemann and published by Springer. This book was released on 2018-07-09 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects cutting-edge expert reviews in the oxytocin field and will be of interest to a broad scientific audience ranging from social neuroscience to clinical psychiatry. The role of the neuropeptide oxytocin in social behaviors is one of the earliest and most significant discoveries in social neuroscience. Influential studies in animal models have delineated many of the neural circuits and genetic components that underlie these behaviors. These discoveries have inspired researchers to investigate the effects of oxytocin on brain and behavior in humans and its potential relevance as a treatment for psychiatric disorders including borderline personality disorder and autism and schizophrenia spectrum disorders. In fact, there is no established social psychopharmacology in Psychiatry, and oxytocin can be seen as the first endogenous agent specifically addressing social-cognitive impairment in psychiatric disorders, with animal research suggesting that it could be especially efficient in the early postnatal period. From a human perspective, it is crucial to understand more precisely who can benefit from potential oxytocin-related treatments, which outcome measures will best represent their effects, how they should be administered, and what brain mechanisms are likely involved in mediating their effects. This type of “precision medicine” approach is in line with the research domain criteria defined by the U.S. National Institute of Mental Health.
Book Synopsis Neuropsychiatric Disorders by : Koho Miyoshi
Download or read book Neuropsychiatric Disorders written by Koho Miyoshi and published by Springer Science & Business Media. This book was released on 2010-08-09 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around the world societies are facing growing aging populations with the concomitant increase in neuropsychiatric disorders. Neuropsychiatric disorders are organic brain diseases with psychiatric symptoms, as in Alzheimer’s and Parkinson’s diseases, that cause cognitive impairment, including dementia, amnesic syndrome, and personality–behavioral changes. As a clinical science, neuropsychiatry aims to explore the complex interrelationship between behavior and brain function from a variety of perspectives, including those of psychology, neurology, and psychiatry. This concise and updated monograph comprises the latest findings in the field and includes chapters on delusional symptoms, mood disorders and neurotic symptoms, cognitive impairment, behavioral and personality changes, and recently, cerebral alterations revealed in PTSD patients and in endogenous psychoses through neuroimaging and neuropathology. These findings will certainly widen the realm of neuropsychiatry going forward and will prove of great value to specialists as well as to academics and trainees in neurology, psychiatry, neuropsychology, neuroradiology, neuropathology, neurophysiology, neurochemistry, and clinical genetics. Ultimately, neuropsychiatry aims to prevent and reduce the suffering of individuals with the psychiatric symptoms of cerebral disorders.
Book Synopsis Genes and Behaviour by : David J. Hosken
Download or read book Genes and Behaviour written by David J. Hosken and published by John Wiley & Sons. This book was released on 2019-04-15 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad snapshot of recent findings showing how the environment and genes influence behavior The great debate of nature versus nurture rages on — but our understanding of the genetic basis of many behaviors has expanded over the last decade, and there is now very good evidence showing that seemingly complex behaviours can have relatively simple genetic underpinnings, but also that most behaviours have very complicated genetic and environmental architecture. Studies have also clearly shown that behaviors, and other traits, are influenced not just by genes and the environment, but also by the statistical interaction between the two. This book aims to end the nature versus nurture argument by showing that behaviors are nature and nurture and the interaction between the two, and by illustrating how single genes can explain some of the variation in behaviors even when they are seemingly complex. Genes and Behaviour: Beyond Nature-Nurture puts to rest the nature versus nurture dichotomy, providing an up-to-date synopsis of where we are, how far we've come and where we are headed. It considers the effects of a dual-inheritance of genes and culture, and genes and social environment, and highlights how indirect genetic effects can affect the evolution of behavior. It also examines the effect of non-self genes on the behavior of hosts, shines a light on the nature and nurturing of animal minds and invites us to embrace all the complexity nature and nurture generates, and more. Explores exciting new findings about behavior and where we go from here Features contributions by top scholars of the subject Seeks to end the nature versus nurture debate forever Genes and Behaviour: Beyond Nature-Nurture is a unique, and eye-opening read that will appeal to Ph.D. Students, post-doctoral fellows, and researchers in evolution and behavior. Additionally, the book will also be of interest to geneticists, sociologists and philosophers.
Book Synopsis Psychobiological Approaches for Anxiety Disorders by : Stefan G. Hofmann
Download or read book Psychobiological Approaches for Anxiety Disorders written by Stefan G. Hofmann and published by John Wiley & Sons. This book was released on 2012-04-09 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychobiological Approaches for Anxiety Disorders presents a comprehensive overview of the latest empirical evidence and research results on combining pharmacological agents and CBT techniques for the treatment of anxiety disorders. The first book to focus on the issue of enhancing CBT with pharmacological agents Features chapters from leading authors in the fields of psychiatry, pharmacology, clinical psychology, neuroscience, and emotion research Contributes significantly to the field by summarizing the contemporary research in combination treatments in anxiety disorders A valuable resource for clinicians in training, as well as experienced clinicians seeking to help patients with anxiety disorders
Book Synopsis Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management by : M. Mohamed Essa
Download or read book Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management written by M. Mohamed Essa and published by Springer Nature. This book was released on 2020-01-31 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.
Book Synopsis Hormones, Regulators and Hippocampus by : Gerald Litwack
Download or read book Hormones, Regulators and Hippocampus written by Gerald Litwack and published by Academic Press. This book was released on 2022-02-16 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones serials Updated release includes the latest information on Hormones, Regulators and Hippocampus
Download or read book Binge Eating written by Guido K.W. Frank and published by Springer Nature. This book was released on 2020-06-01 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of our current understanding of binge eating, which is characterized by the uncontrollable consumption of large amounts of food in a discrete time period. Written by experts on eating disorders, it first introduces the phenotype of binge eating, including its epidemiology and assessment. It then describes the underlying neurobiological alterations, drawing on cutting-edge animal models and human studies to do so. In addition, it extensively discusses current treatment models, including medication, psychotherapy, self-interventions and disease prevention. Lastly, an outlook on the future research agenda rounds out the coverage. Given binge eating’s current status as an under-researched symptom, but one shared across many eating disorders, this book provides an up-to-date, integrative and comprehensive synthesis of recent research and offers a valuable reference for scientists and clinicians alike.
Book Synopsis Brain Extracellular Matrix in Health and Disease by :
Download or read book Brain Extracellular Matrix in Health and Disease written by and published by Elsevier. This book was released on 2014-10-30 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. Authors are the leading experts in the field of brain extracellular matrix in health and disease Book covers the most important aspects of brain extracellular matrix in health and disease Interesting for both scientists and clinicians
Book Synopsis New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System by :
Download or read book New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System written by and published by Elsevier. This book was released on 2015-11-16 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields. This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields
Book Synopsis New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System – by :
Download or read book New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System – written by and published by Elsevier. This book was released on 2015-11-16 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System - Part B is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields. This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields
