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Advances In The Treatment Of Myelodysplastic Syndromes
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Book Synopsis Myelodysplastic Syndromes by : Peter L. Greenberg
Download or read book Myelodysplastic Syndromes written by Peter L. Greenberg and published by Cambridge University Press. This book was released on 2011-02-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelodysplastic Syndromes was first published in 2006, and continues to stand out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. It remains a major reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes. Authored by international experts, the book provides an assessment of the subject's status and a variety of advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.
Book Synopsis Advances in the Treatment of Myelodysplastic Syndromes by : Guillermo Garcia-Manero
Download or read book Advances in the Treatment of Myelodysplastic Syndromes written by Guillermo Garcia-Manero and published by . This book was released on 2008 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Developments in Myelodysplastic Syndromes by : Ota Fuchs
Download or read book Recent Developments in Myelodysplastic Syndromes written by Ota Fuchs and published by BoD – Books on Demand. This book was released on 2019-02-20 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
Book Synopsis Myelodysplastic Syndromes—Advances in Research and Treatment: 2012 Edition by :
Download or read book Myelodysplastic Syndromes—Advances in Research and Treatment: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelodysplastic Syndromes—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Myelodysplastic Syndromes in a compact format. The editors have built Myelodysplastic Syndromes—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Myelodysplastic Syndromes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myelodysplastic Syndromes—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Myelodysplastic Syndromes by : Uwe Platzbecker
Download or read book Myelodysplastic Syndromes written by Uwe Platzbecker and published by Springer. This book was released on 2018-06-05 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the standard diagnostic and therapeutic management of patients with myelodysplastic syndromes (MDS) and examines ongoing research developments in the field. The importance of appropriate prognostic stratification, taking into account recent advances in understanding of the molecular pathogenesis of MDS, is explained, and both established and novel treatment approaches are discussed in depth. The coverage includes, for example, the use of erythropoietic stimulating agents, iron chelation therapy, the immunomodulator lenalidomide, hypomethylating agents such as azacitidine, and allogeneic hematopoietic stem cell transplantation. Myelodysplastic syndromes are heterogeneous and complex hematologic disorders ranging from indolent conditions to forms approaching the aggressiveness of acute myeloid leukemia. The diversity of MDS gives rise to challenges in diagnosis and clinical decision making, and the highly variable clinical course necessitates a risk-adapted treatment strategy and the application of disease-specific therapies. Hematologists, oncologists, and other interested clinicians will find this book to be an invaluable source of information on diagnostic and prognostic evaluation and treatment selection.
Book Synopsis Recent Advances in the Treatment of Myelodysplastic Syndromes by :
Download or read book Recent Advances in the Treatment of Myelodysplastic Syndromes written by and published by . This book was released on 2009 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology and Treatment of Leukemia and Bone Marrow Neoplasms by : Vinod Pullarkat
Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Download or read book Cancer and Aging written by M. Extermann and published by Karger Medical and Scientific Publishers. This book was released on 2013-01-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
Download or read book Hematology written by Ronald Hoffman and published by . This book was released on 2005 with total page 2821 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Manual of Blood and Bone Marrow Transplantation by : Syed A. Abutalib
Download or read book Clinical Manual of Blood and Bone Marrow Transplantation written by Syed A. Abutalib and published by John Wiley & Sons. This book was released on 2017-04-19 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship
Book Synopsis Recent Advances in the Treatment of MDS by :
Download or read book Recent Advances in the Treatment of MDS written by and published by . This book was released on 2007 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Allogeneic Stem Cell Transplantation by : Hillard M. Lazarus
Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Book Synopsis Myelodysplastic Syndromes (MDS) by : Deanna Rodgers
Download or read book Myelodysplastic Syndromes (MDS) written by Deanna Rodgers and published by . This book was released on 2016 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelodysplastic syndrome (MDS) is a family of clonal haematopoietic stem cells disorders characterized by dysplasia, ineffective hematopoiesis and susceptibility to transformation to Acute Myeloblastic Leukaemia (AML) that are shown to be strikingly refractory to current therapeutic modalities. The first chapter of this book provides a detailed review of the risk factors, treatment options and prognosis of MDS. Chapter two studies the inflammatory and autoimmune nature of MDS. Chapter three discusses the pathogenesis of 5q-syndrome. Chapter four examines the genetic mutations identified in MDS and their significance. Chapter five reviews different prognostic factors and stratifications of risk in Argentinean patients with MDS. Chapter six discusses epigenetics and epigenetic therapy. Chapter seven introduces mild oral chemotherapy treatments for elderly patients with a higher-risk myelodyspastic syndrome. Chapter eight discusses lenalidomide treatment in lower risk myelodysplastic syndromes. Chapter nine analyzes the old and new-integrating prognostic models and mutational advances with epigenetic and cellular therapies for MDS. The last chapter studies the entropy evaluation of bone marrow biopsies in MDS.
Book Synopsis Myelodysplastic Syndrome (MDS) by : Arthur Hadley
Download or read book Myelodysplastic Syndrome (MDS) written by Arthur Hadley and published by . This book was released on 2019-09-23 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being diagnosed with Myelodysplastic syndrome can be daunting and unexpected. Many people have never heard of the blood/ bone marrow disorder MDS. I have written this short MDS book to help you quickly understand some of the jargon and medical issues relating to Myelodysplastic syndromes. This book will cover diagnosis, symptoms, treatments and more. If you have any of the following questions then this guide may help you understand some aspect of MDS what does MDS stand for? What is Myelodysplastic Syndrome? How MDS is diagnosed? How does MDS typically affect the body? What MDS treatments are available? Is MDS cancer? Does MDS turn into AML? Is MDS genetic? There is also a section which covers how to maintain a healthy lifestyle and understanding a person's limitations when living with MDS. The effects of common symptoms of anaemia, low blood cell counts (white blood cell types and red blood cells) and low platelets and how to counter their effects with growth factors and blood transfusions. Ideal for MDS sufferers and their caregivers / family. Also included are references to sites that you may find useful. Please note, I am not a medical professional, but have had a family member with this condition and help care for them over many years. All the best, Arthur Hadley
Book Synopsis Myelodysplastic Syndromes by : David Steensma
Download or read book Myelodysplastic Syndromes written by David Steensma and published by CRC Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and cancer researchers, this Second Edition features: a new eight-page color insert 200 color and black-and-white illustrations reworked content organized into three sections: MDS epidemiology and biology; diagnosis, classification, and prognosis; and MDS therapy thoroughly updated chapters reflecting a shift from the topical focus as dictated by the evolution of the field New topics in Myelodysplastic Syndrome include: del(5q) and 5q-syndrome, CMML, and MDS-MPD overlap syndrome the reborn DNA methyltransferase inhibiting nucleoside analogs the diagnosis of chronic myelomonocytic leukemia and other MDS cases with myeloproliferative features the role of mitochondria and the potential importance of iron overload in MDS global genomics approaches, such as cDNA expression arrays, array-based comparative genomic hybridization, and single nucleotide polymorphism array the role of abnormal mitochondrial ferritin accumulation and other mitochondrial metabolic anomalies in MD other disease-associated alterations, such as abnormalities of B lymphocyte populations in MD three recently approved drugs: azacitidine, lenalidomide, and decitabine
Book Synopsis Myelodysplastic Syndrome by : Emma E. Steffensen
Download or read book Myelodysplastic Syndrome written by Emma E. Steffensen and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this compilation, the authors review the biological aspects of myelodysplastic syndrome disease, diagnosis, and treatment, as well as innovations involving genetics and new treatment perspectives.Myelodysplastic syndromes are a heterogeneous group of clonal haematopoietic stem cells disorders characterized by dysplasia, as well as peripheral blood cytopenias with a hypercellular marrow and ineffective hematopoiesis.Myelodysplastic syndromes are frequently associated with acute and chronic inflammation, and autoimmune disorders such as: rheumatoid arthritis, bowel disease, diverse types of vasculitis, autoimmune anemias, several rheumatic and skin disorders, and certain thyroid disorders.Spliceosome mutations are the most frequent mutations found in blood and bone marrow cells of myelodysplastic syndromes patients. As such, the authors explore the four predominant splicing factor genes: SF3B1, SFRS2, U2AF1, ZRSR2.Subsequently, this collection discusses the CSNK1A1 gene in the context of myelodysplastic syndromes. It is located at 5q32 within the deleted region, which encodes for casein kinase 1α (CK1α). CK1α is a component of a multiprotein β-catenin destruction complex that regulates Wnt/β-catenin and p53 pathways.The concluding study focuses on the mutations in epigenetic modifiers occur which myelodysplastic syndromes and drive this disease, such as: DNA methylation, histone acetylation, and RNA interference that alters gene expression.
Book Synopsis Myelodysplastic Syndromes by : Hamid Sayar
Download or read book Myelodysplastic Syndromes written by Hamid Sayar and published by Nova Science Publishers. This book was released on 2013-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of tremendous advances in the field, the current understanding of pathogenesis of myelodysplastic syndromes (MDS) remains limited. Furthermore, the correct diagnosis and effective therapy of this heterogeneous group of clonal haematological disorders represent a common challenge in daily practice of haematology. This book provides a thorough, up-to-date, and comprehensive review of different aspects of MDS. Chapters are written by selected investigators and clinicians with specific expertise and track record of research in the field. Of particular interest, the clinical chapters provide a practical approach to the treatment of patients with different manifestations of the disease. This book would be a useful asset to researchers in the field as well as haematologists in practice. Other health care members such as haematology fellows in training, residents, medical students and nurses will also find this book helpful for better understanding of the disease and clinical management of patients with MDS.
