Advances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agents

Download Advances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agents full books in PDF, epub, and Kindle. Read online Advances And Avenues In The Development Of Novel Carriers For Bioactives And Biological Agents ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Author : Manju Rawat Singh
Publisher : Academic Press
ISBN 13 : 0128199180
Total Pages : 657 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by : Manju Rawat Singh

Download or read book Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents written by Manju Rawat Singh and published by Academic Press. This book was released on 2020-04-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Phytopharmaceuticals and Herbal Drugs

Author : Manju Rawat Singh
Publisher : Elsevier
ISBN 13 : 0323993699
Total Pages : 488 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Phytopharmaceuticals and Herbal Drugs by : Manju Rawat Singh

Download or read book Phytopharmaceuticals and Herbal Drugs written by Manju Rawat Singh and published by Elsevier. This book was released on 2023-07-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource. This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity. Includes perspectives from academic and industry research Provides information on the safety, regulatory aspects and clinical aspects related to plant-based drugs Introduces developments of new targeted drug delivery systems

Applications of Nanovesicular Drug Delivery

Author : Amit Kumar Nayak
Publisher : Academic Press
ISBN 13 : 0323919537
Total Pages : 525 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Applications of Nanovesicular Drug Delivery by : Amit Kumar Nayak

Download or read book Applications of Nanovesicular Drug Delivery written by Amit Kumar Nayak and published by Academic Press. This book was released on 2022-07-22 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables

Pharmaceutical Nanobiotechnology for Targeted Therapy

Author : Hamed Barabadi
Publisher : Springer Nature
ISBN 13 : 3031126580
Total Pages : 641 pages
Book Rating : 4.0/5 (311 download)

DOWNLOAD NOW!

Book Synopsis Pharmaceutical Nanobiotechnology for Targeted Therapy by : Hamed Barabadi

Download or read book Pharmaceutical Nanobiotechnology for Targeted Therapy written by Hamed Barabadi and published by Springer Nature. This book was released on 2022-10-18 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of nanotechnology for targeted therapy initiated more than decade ago has grown fast and interest is increasing. Given the importance of the field for targeted drug and gene delivery systems, there are a large number of laboratory investigations today researching nanobiomaterials for diagnostic and therapeutic applications. Because of the ability of scientists to load nanoparticles with any agent, interest continues to grow and technology in this arena is rapidly evolving. These emerging nanobiomaterials-based medicines can overcome the disadvantages of traditional medicines by target-oriented and site-specific delivery of precise medicines (immunotherapeutic agents, chemotherapeutic agents, diagnostic agents, and so on). Pharmaceutical Nanobiotechnology for Targeted Therapy presents an updated overview of recent advancements in the field of pharmaceutical nanobiotechnology and nano-based drug and gene delivery systems. This comprehensive knowledge will allow researchers to discover innovative nanobiomaterials for targeted therapeutics. The chapters deal with various emerging nanobiomaterials for targeted therapeutic delivery systems and the writing is in a style that is easily disseminated and in a manner that can be readily adopted as sources for new and further studies. This book should be useful for researchers and professionals from academia and industry working in the field of nanotechnology, nanobiotechnology, as well as in the field of pharmaceutical nanotechnology. It should also be useful to those interested in a range of disciplines from material science, chemistry, molecular biology, polymer chemistry, and many more interdisciplinary areas.

Alternative Medicine

Author : Muhammad Akram
Publisher : BoD – Books on Demand
ISBN 13 : 1839623322
Total Pages : 388 pages
Book Rating : 4.8/5 (396 download)

DOWNLOAD NOW!

Book Synopsis Alternative Medicine by : Muhammad Akram

Download or read book Alternative Medicine written by Muhammad Akram and published by BoD – Books on Demand. This book was released on 2021-10-27 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Edited Volume “Alternative Medicine - Update” is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of alternative medicine. The book comprises single chapters authored by various researchers and edited by an expert active in the alternative medicine research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on alternative medicine, and open new possible research paths for further novel developments.

New Insights into Glioblastoma

Author : Carla Vitorino
Publisher : Elsevier
ISBN 13 : 0323999425
Total Pages : 788 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis New Insights into Glioblastoma by : Carla Vitorino

Download or read book New Insights into Glioblastoma written by Carla Vitorino and published by Elsevier. This book was released on 2023-05-17 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment. Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma Includes overviews to help readers apply information in their research Encompasses summarizing diagrams and real-world examples to facilitate comprehension and enhance the applicability of the content

Recent Advances in Novel Drug Carrier Systems

Author : Ali Demir Sezer
Publisher : IntechOpen
ISBN 13 : 9789535108108
Total Pages : 514 pages
Book Rating : 4.1/5 (81 download)

DOWNLOAD NOW!

Book Synopsis Recent Advances in Novel Drug Carrier Systems by : Ali Demir Sezer

Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by IntechOpen. This book was released on 2012-10-31 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Novel Drug Delivery Systems for Phytoconstituents

Author : Madhu Gupta
Publisher : CRC Press
ISBN 13 : 1351057618
Total Pages : 375 pages
Book Rating : 4.3/5 (51 download)

DOWNLOAD NOW!

Book Synopsis Novel Drug Delivery Systems for Phytoconstituents by : Madhu Gupta

Download or read book Novel Drug Delivery Systems for Phytoconstituents written by Madhu Gupta and published by CRC Press. This book was released on 2019-07-23 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.

Innovation in Pharmacy: Advances and Perspectives. September 2018

Author : Organizer Committee IPAP18 – Salamanca
Publisher : Ediciones Universidad de Salamanca
ISBN 13 : 8490129762
Total Pages : 358 pages
Book Rating : 4.4/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Innovation in Pharmacy: Advances and Perspectives. September 2018 by : Organizer Committee IPAP18 – Salamanca

Download or read book Innovation in Pharmacy: Advances and Perspectives. September 2018 written by Organizer Committee IPAP18 – Salamanca and published by Ediciones Universidad de Salamanca. This book was released on 2018-09-21 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.

Drug Delivery

Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 1118833368
Total Pages : 740 pages
Book Rating : 4.1/5 (188 download)

DOWNLOAD NOW!

Book Synopsis Drug Delivery by : Binghe Wang

Download or read book Drug Delivery written by Binghe Wang and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Targeted Drug Delivery : Concepts and Design

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 788 pages
Book Rating : 4.3/5 (191 download)

DOWNLOAD NOW!

Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan

Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Author : Lisa C. du Toit
Publisher : Elsevier
ISBN 13 : 0128184728
Total Pages : 318 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering by : Lisa C. du Toit

Download or read book Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering written by Lisa C. du Toit and published by Elsevier. This book was released on 2020-03-08 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Carbon Nanotubes for Biomedical Applications

Author : Rüdiger Klingeler
Publisher : Springer Science & Business Media
ISBN 13 : 3642148026
Total Pages : 286 pages
Book Rating : 4.6/5 (421 download)

DOWNLOAD NOW!

Book Synopsis Carbon Nanotubes for Biomedical Applications by : Rüdiger Klingeler

Download or read book Carbon Nanotubes for Biomedical Applications written by Rüdiger Klingeler and published by Springer Science & Business Media. This book was released on 2011-02-09 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

Evidence-Based Validation of Herbal Medicine

Author : Pulok K. Mukherjee
Publisher : Elsevier
ISBN 13 : 0323984568
Total Pages : 858 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Evidence-Based Validation of Herbal Medicine by : Pulok K. Mukherjee

Download or read book Evidence-Based Validation of Herbal Medicine written by Pulok K. Mukherjee and published by Elsevier. This book was released on 2022-07-12 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more

Nanostructures for Oral Medicine

Author : Ecaterina Andronescu
Publisher : Elsevier
ISBN 13 : 0323477216
Total Pages : 1034 pages
Book Rating : 4.3/5 (234 download)

DOWNLOAD NOW!

Book Synopsis Nanostructures for Oral Medicine by : Ecaterina Andronescu

Download or read book Nanostructures for Oral Medicine written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-04-11 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 340 pages
Book Rating : 4.0/5 (34 download)

DOWNLOAD NOW!

Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Targeted Drug Strategies for Cancer and Inflammation

Author : Ann L. Jackman
Publisher : Springer Science & Business Media
ISBN 13 : 1441984178
Total Pages : 262 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Targeted Drug Strategies for Cancer and Inflammation by : Ann L. Jackman

Download or read book Targeted Drug Strategies for Cancer and Inflammation written by Ann L. Jackman and published by Springer Science & Business Media. This book was released on 2011-05-05 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.