Advanced Wound Repair Therapies

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Advanced Wound Repair Therapies

Author : David Farrar
Publisher : Elsevier
ISBN 13 : 0857093304
Total Pages : 672 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Advanced Wound Repair Therapies by : David Farrar

Download or read book Advanced Wound Repair Therapies written by David Farrar and published by Elsevier. This book was released on 2011-06-21 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds. Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices. With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Microcurrent: Advanced Wound Healing

Author : John Hache
Publisher :
ISBN 13 : 9781726477079
Total Pages : 186 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Microcurrent: Advanced Wound Healing by : John Hache

Download or read book Microcurrent: Advanced Wound Healing written by John Hache and published by . This book was released on 2018-09 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The care and treatment of wounds has long been attributed to the western medical system, which has developed within itself a method for treating wounds that can in effect extend the duration of the wound, and cause excruciating pain in the process. Wounds or pain can become such a detriment on people's lives that they have all but given up. Dr. John Hache has spent years of his life helping patients in these situations find relief from this pain. With Microcurrent technology we have the power to restore that life to them.This illustrated book aims to examine the current epidemic in the prescription of harmful medications for the management of acute and chronic pain as well as the reasons behind delayed wound healing. We will consider why wounds take so long to heal, and why a lot of them do not heal at all; furthermore, we will show you a non-invasive way to accelerate their repair. The prevalence of prescription medications and surgical intervention within the medical field has prevented, and still prevents, medical professionals from seeing the advantages that alternative methods can produce. Within this book we will go over individual cases, a full case study with over 100 participants, and reveal specific step-by-step protocols for a variety of types of wounds, both basic, and severe that you can do with your microcurrent technology.These studies presented within reveal remarkable evidence that correct use of microcurrent technology, could-right now-replace a portion of the current medical practices in the treatment of wound healing. Dr. John Hache earned a PhD in Integrative Medicine from Quantum University. His thesis focused on research and practice in the healing of wounds using microcurrent technology.

Therapeutic Dressings and Wound Healing Applications

Author : Joshua Boateng
Publisher : John Wiley & Sons
ISBN 13 : 1119433266
Total Pages : 444 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Therapeutic Dressings and Wound Healing Applications by : Joshua Boateng

Download or read book Therapeutic Dressings and Wound Healing Applications written by Joshua Boateng and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest research on techniques for effective healing of chronic and difficult to heal wounds The healing of chronic wounds is a global medical concern, specifically for patients suffering from obesity and type II diabetes. Therapeutic Dressing and Wound Healing Applications is an essential text for research labs, industry professionals, and general clinical practitioners that want to make the shift towards advanced therapeutic dressing and groundbreaking wound application for better healing. This book takes a clinical and scientific approach to wound healing, and includes recent case studies to highlight key points and areas of improvement. It is divided into two key sections that include insight into the biochemical basis of wounds, as well as techniques and recent advancements. Chapters include information on: ● Debridement and disinfection properties of wound dressing ● Biofilms, silver nanoparticles, and honey dressings ● Clinical perspectives for treating diabetic wounds ● Treating mixed infections ● Wound healing and tissue regeneration treatments ● Gene based therapy, 3D bioprinting and freeze-dried wafers Anyone looking to update and improve the treatment of chronic wounds for patients will find the latest pertinent information in Therapeutic Dressing and Wound Healing Applications.

Advanced Textiles for Wound Care

Author : S. Rajendran
Publisher : Elsevier
ISBN 13 : 1845696301
Total Pages : 360 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Advanced Textiles for Wound Care by : S. Rajendran

Download or read book Advanced Textiles for Wound Care written by S. Rajendran and published by Elsevier. This book was released on 2009-04-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important and growing area of the textile industry is the medical sector. The extent of this growth is due to constant improvements in both textile technology and medical procedures. This collection provides a detailed review of how textiles are incorporated into wound care applications, explaining the importance and suitability of using textiles on different wound types. Part one of the book provides an overview of the use of textiles in particular aspects of wound care, providing details of wound management and the importance of laboratory testing in relation to wound care. Further chapters cover minor wounds, moist wound management and bioactive dressings to promote healing. Given their increasing importance, part two describes how advanced textiles, such as smart temperature controlled textiles and composites, can be used for wound care products. The final chapter gives an interesting insight into the use of fibrous scaffolds for tissue engineering. Advanced textiles for wound care is essential reading for any manufacturers, designers, scientists and producers of wound care materials. It is a valuable resource for professionals within the medical sector, as well as those in academia. Provides a comprehensive introduction to wound care from types of wound and wound healing mechanisms to the importance of testing in relation to wound care Analyses the application of textiles to wound healing covering minor wounds, burns, ulcers and other deep skin wounds Reviews the current use of smart textiles for wound care including drug delivery dressings and textile-based scaffolds for tissue engineering as well as future trends

Advances in Wound Healing Materials

Author : Willi Paul
Publisher : Smithers Rapra
ISBN 13 : 1909030384
Total Pages : 208 pages
Book Rating : 4.9/5 (9 download)

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Book Synopsis Advances in Wound Healing Materials by : Willi Paul

Download or read book Advances in Wound Healing Materials written by Willi Paul and published by Smithers Rapra. This book was released on 2015-06-11 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wound healing and wound care technologies are an ever expanding field with the advancement of materials science, biomedicine and tissue engineering. In the year 2011 the global wound care market generated US$ 6,500 million with an annual growth rate of 7.5%. The global advanced wound care products market share in 2023 is predicted to be approximately US$ 16,300 million.This book discusses the evolution of wound care devices and protocol over the years and different technologies being used in the present day wound care treatment. New strategies involving engineered tissues and drug delivery to mimic the natural wound healing milieu are discussed. The use of cytokine growth factors enhances chronic wound healing particularly for burn wound healing. Prevention of scarring, keloid formation or contractures and a cosmetically acceptable healing is a challenge even now.Skin tissue engineering was the first successfully clinically applied product in regenerative medicine. Bioengineered skin seeded with fibroblast and keratinocyte cells could form a permanent solution that do not require skin grafting or as a temporary cover for burns prior to grafting. Cell attachment, proliferation and tissue formation in a three-dimensional porous scaffold can be engineered for specific application. These cell based skin substitutes had significant wound healing and scar reducing effect on patients.Gene-activated dermal equivalent is another emerging approach for the healing of full thickness incision wounds with good remodelling of the skin. The book also describes similar latest developments on wound healing science and research.The target audiences are wound care professionals, researchers working on wound healing technology and skin tissue engineering; as well as graduate students and industries that need to understand the aspects of wound healing and technological orientation towards successful commercialisation.

Wound Care

Author : Carrie Sussman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781774444
Total Pages : 786 pages
Book Rating : 4.7/5 (744 download)

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Book Synopsis Wound Care by : Carrie Sussman

Download or read book Wound Care written by Carrie Sussman and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for health care professionals in multiple disciplines and clinical settings, this comprehensive, evidence-based wound care text provides basic and advanced information on wound healing and therapies and emphasizes clinical decision-making. The text integrates the latest scientific findings with principles of good wound care and provides a complete set of current, evidence-based practices. This edition features a new chapter on wound pain management and a chapter showing how to use negative pressure therapy on many types of hard-to-heal wounds. Technological advances covered include ultrasound for wound debridement, laser treatments, and a single-patient-use disposable device for delivering pulsed radio frequency.

Innovations and Advances in Wound Healing

Author : Seung-Kyu Han
Publisher : Springer Nature
ISBN 13 : 9811998051
Total Pages : 414 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Innovations and Advances in Wound Healing by : Seung-Kyu Han

Download or read book Innovations and Advances in Wound Healing written by Seung-Kyu Han and published by Springer Nature. This book was released on 2023-03-27 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state of the art knowledge on new techniques and materials that can improve functional and aesthetic results in wound healing while reducing invasiveness, based on the author's extensive personal experience. The aim is to equip the practitioner with all the information required in order to select a strategy that will accelerate wound healing and minimize both the risk of complications and scar formation after the wound has fully healed. The opening chapters set the stage by providing an overview of wound healing, including brief descriptions of the anatomy of the skin, the wound healing process, and advanced wound dressings. A full description follows of the various methodologies employed in repairing acute wounds with the goal of achieving optimal functional and cosmetic outcomes while utilizing the safest and least invasive method. Treatment protocols that have proven successful in closing nonhealing and/or delayed healing chronic wounds are then presented. In addition, a chapter addresses aesthetic procedures using advanced technology in wound healing. The closing chapter presents author’s experience with the establishment a hospital wound dressing team. The text is supported by 1,411 full color photos. Since the publication of the second edition, there have been many notable advances in wound healing research. The third edition is expanded and updated to reflect the advancements and new information. Key revisions include new chapters and/or sections on recently developed dressings such as a bioelectric dressing, a fluorescence imaging device of bacteria, usefulness of fibrin glue to support wound healing, graft of 3D-printed micronized adipose tissue, significance of skin hydration level for wound healing, novel staged excision technique to reduce scar length, newly developed risk scoring system to predict wound healing outcomes in diabetic patients, expanded coverage of cell therapy, new devices such as extracorporeal shock wave therapy, and automated SVF cell isolation system.

Wound Management for the Advanced Practitioner

Author : Terry Swanson
Publisher : IP Communications
ISBN 13 : 0987290533
Total Pages : 593 pages
Book Rating : 4.9/5 (872 download)

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Book Synopsis Wound Management for the Advanced Practitioner by : Terry Swanson

Download or read book Wound Management for the Advanced Practitioner written by Terry Swanson and published by IP Communications. This book was released on 2014-10-21 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasingly, wound management is recognised as a specialised area of practice. Advances in wound-care products, surgical interventions, and social-support options create an often bewildering array of knowledge for healthcare practitioners. This textbook opens with a focus on the core elements of effective wound management: an understanding of how wounds heal and what inhibits wound healing, rigorous assessment, use of outcome measures, evidence-based approaches to practice, and an understanding of how clinical research is done. Key aspects of wound-bed preparation and management - diagnostic investigations, assessment and management of non-viable tissue, infected wounds, dressings and technology, pharmacological therapy, and acute wounds – are then elucidated. Optimal management of commonly-encountered wounds (venous leg ulceration, arterial and mixed arterial-venous ulceration, inflammatory ulcers, pressure injury, and the high-risk foot) and unusual wounds is described. The path to professionalisation of wound management in Australia is charted. The book ends with a list of wound care products (types, properties, uses, distributor-contact details). The editors of and specialist contributors to this text have aimed to build on the foundations provided by the numerous basic, introductory-level textbooks in the field to provide an authoritative, comprehensive, and up-to-date textbook for wound managers who wish to further develop their knowledge and skills.

Science of Wound Healing and Dressing Materials

Author : Vibhakar Vachhrajani
Publisher : Springer Nature
ISBN 13 : 9813292369
Total Pages : 180 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Science of Wound Healing and Dressing Materials by : Vibhakar Vachhrajani

Download or read book Science of Wound Healing and Dressing Materials written by Vibhakar Vachhrajani and published by Springer Nature. This book was released on 2019-11-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines, from a surgeon’s standpoint, how physicians and mid-level providers working at wound care centres can expeditiously and effectively manage wounds. It comprehensively addresses the concept of wound healing, from the healing process to debridement concepts, and various antiseptics and local antibiotics used in dressing materials to facilitate healing. The book also discusses the latest inventions and treatment options that have revolutionized wound healing, such as: oxygen therapy, ozone therapy, hyperbaric oxygen therapy, electric therapy and ultrasonic wound therapy. In closing, it examines the latest regenerative therapies based on stem cell therapy, cellular therapy and gene therapy. Given its scope, the book offers a valuable resource for medical students and physicians dealing with wound management, as well as a reference guide for nurses in primary and tertiary wound care settings.

Wound Healing Research

Author : Prasun Kumar
Publisher : Springer Nature
ISBN 13 : 9811626774
Total Pages : 694 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Wound Healing Research by : Prasun Kumar

Download or read book Wound Healing Research written by Prasun Kumar and published by Springer Nature. This book was released on 2021-07-20 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge on both the physiological and the microbiological aspects of wound healing. Fresh insights into the process of cutaneous wound healing are described, which involves tissue regeneration and repair processes consisting of a sequence of molecular and cellular events. The management of infected wounds is then discussed in detail, covering the roles of traditional medicine practices, novel anti-infective formulations, non-antibiotic approaches, and probiotic bacteria. A section devoted to the interdisciplinary approach to wound care addresses topics including in vitro and in vivo research models, the development of advanced wound dressings, tissue engineering, and the potential applications of bioscaffolds. The authors are all leading researchers in the field. This book is an attempt to showcase current research status and future directions in the area of wound-healing research, which must be of interest to a large group of readers and researchers interested in this field.

Local Wound Care for Dermatologists

Author : Afsaneh Alavi
Publisher : Springer Nature
ISBN 13 : 3030288722
Total Pages : 211 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Local Wound Care for Dermatologists by : Afsaneh Alavi

Download or read book Local Wound Care for Dermatologists written by Afsaneh Alavi and published by Springer Nature. This book was released on 2020-03-26 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on local wound care specifically for the dermatologist, this concise text provides a go-to source for practitioners looking for a quick solution for many of the most common wounds as well as an update on what's new in the field. From the most basic principles of local wound care to a look at what upcoming therapies like stem cells and lasers can do, this text is comprehensive and informed. Providing quality local wound care requires an ample knowledge of available products, their cost effectiveness, and the principles for the optimal interventions; Local Wound Care for Dermatologists includes these three guiding points in each chapter that focuses on a specific therapy. Expertly written text is accompanied by multiple tables of drug-specific names, current price points, and comparable products. Chapters include many color images, thereby providing insight to a given wound and the various therapies available to treat it. While the basics are reviewed in the opening chapters, later chapters feature updates in therapies including discussions on what's new in skin substitutes, negative pressure wound therapy, oxygen therapy, and an update in cell based therapy. Written with the dermatologist in mind, Local Wound Care for Dermatologists is an indispensable reference for students, residents, and practicing doctors alike. General practitioners and plastic surgeons will also find this title a useful refresher.

Dressings for Advanced Wound Care

Author : Sharon Lam Po Tang
Publisher : CRC Press
ISBN 13 : 0429523610
Total Pages : 255 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Dressings for Advanced Wound Care by : Sharon Lam Po Tang

Download or read book Dressings for Advanced Wound Care written by Sharon Lam Po Tang and published by CRC Press. This book was released on 2021-07-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dressings for Advanced Wound Care focuses on helping the reader better understand advanced wound care and relevant technologies. It explains how different types of wounds may require different environments to heal and how dressings can help in creating the right environment. It gives an overview of the various dressing technologies that are available to help manage wounds that are difficult to heal. Finally, this book highlights the current trends that may be directing the future of the advanced wound dressing sector. FEATURES: Relates technologies with commercially available end-products, giving the reader a more specific overview of the advanced wound dressing sector Provides a realistic overview of the process of developing an advanced wound care dressing Summarises recent clinical evidence on advanced wound dressings Explains how dressings differ and what works best for which wound type Examines clinical evidence on technologies and on-market products Describes the requirements for launching a new advanced wound dressing This book is aimed at medical clinicians and professionals in the fields of biomedical engineering, textile science, and materials engineering.

Wound Care

Author : Zena Moore
Publisher : MDPI
ISBN 13 : 3038420441
Total Pages : 188 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Wound Care by : Zena Moore

Download or read book Wound Care written by Zena Moore and published by MDPI. This book was released on 2018-10-08 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Wound Care" that was published in Healthcare

Surgical Wound Healing and Management

Author : Mark S. Granick
Publisher : Thieme
ISBN 13 : 162623941X
Total Pages : 250 pages
Book Rating : 4.6/5 (262 download)

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Book Synopsis Surgical Wound Healing and Management by : Mark S. Granick

Download or read book Surgical Wound Healing and Management written by Mark S. Granick and published by Thieme. This book was released on 2012-09-24 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgical Wound Healing and Management, Second Edition explores the critical role of surgery in wound bed preparation and management, and provides a sound knowledge of wound mechanisms, physiology, and metabolic control. Founded on the expertise of internationally recognized authorities, this source illustrates the many techniques utilized by surgeons to design optimal healing environments, maximize the efficacy of existing treatment modalities, and extract bacteria from a variety of wound situations resulting from burns, trauma, and disease. This new edition includes: In-depth examinations of a variety of clinical situations Full colour photographs New approaches to treat difficult-to-heal wounds, now including the open abdomen and SSIs New chapters on "Advanced Therapies," "The Role of Negative Pressure on Wound Therapy," "Wound Dressings for Surgeons," and "The Impact of Telemedicine in Wound Management."

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Wound Healing Biomaterials - Volume 1

Author : Magnus Ågren
Publisher : Woodhead Publishing
ISBN 13 : 0081006055
Total Pages : 318 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Wound Healing Biomaterials - Volume 1 by : Magnus Ågren

Download or read book Wound Healing Biomaterials - Volume 1 written by Magnus Ågren and published by Woodhead Publishing. This book was released on 2016-06-03 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wound Healing Biomaterials: Volume One, Therapies and Regeneration discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal these types of wounds, with science increasingly turning towards biomaterials to address these challenges. Much research is now concerned with new therapies, regeneration methods, and biomaterials to assist in wound healing and healing response. This book provides readers with a comprehensive review of the fundamentals and advances in the field of wound healing with regard to therapies and tissue regeneration. Chapters in Part One discuss fundamentals and strategies of wound healing, while Part Two reviews gene, stem cell, and drug delivery therapies for wound healing. Final chapters look at tissue regeneration strategies, making this an all-encompassing book on the topic of wound care and biomaterials. Provides more systematic and comprehensive coverage of specific therapies and biomaterials for wound healing Highlights research that is concerned with new therapies, regeneration methods, and the use of biomaterials to assist in wound healing and healing response Presents an organized layout of the material that is carefully arranged with clear titles and comprehensive section headings Looks at tissue regeneration strategies, making this an all encompassing book on the topic of wound care

Advanced Wound Care Therapies for Non-Healing Diabetic, Venous, and Arterial Ulcers

Author : U. S. Department of Veterans Affairs
Publisher : Createspace Independent Pub
ISBN 13 : 9781484893586
Total Pages : 184 pages
Book Rating : 4.8/5 (935 download)

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Book Synopsis Advanced Wound Care Therapies for Non-Healing Diabetic, Venous, and Arterial Ulcers by : U. S. Department of Veterans Affairs

Download or read book Advanced Wound Care Therapies for Non-Healing Diabetic, Venous, and Arterial Ulcers written by U. S. Department of Veterans Affairs and published by Createspace Independent Pub. This book was released on 2013-05-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic ulcers (i.e., ulcers that are unresponsive to initial therapy or that persist despite appropriate care) are estimated to affect over 6 million people in the United States. The incidence is expected to increase as the population ages and as the number of individuals with diabetes increases. Chronic ulcers negatively affect the quality of life and productivity of the patient and represent a substantial financial burden to the health care system. Lower extremity ulcers, especially those attributed to either diabetes, venous disease, or arterial disease comprise a substantial proportion of chronic ulcers. Approximately 15% to 25% of individuals with diabetes develop a foot ulcer at some point in their lifetime and an estimated 12% of those patients require lower extremity amputation. Healing is complicated by diabetic neuropathy and susceptibility to infection. Venous disease accounts for the majority of chronic lower extremity ulcers. Venous hypertension secondary to various causes results in damage to vessel walls and ultimately leads to skin breakdown. Arterial ulcers are less common and are a result of impaired circulation which can affect healing lead to ulceration. Standard treatment for diabetic ulcers includes debridement of necrotic tissue, infection control, local ulcer care, mechanical off-loading, management of blood glucose levels, and education on foot care. For venous ulcers, standard treatment typically includes the use of mechanical compression and limb elevation to reverse tissue edema and improve venous blood flow. Care for ulcers caused by arterial insufficiency is centered on reestablishing blood flow and minimizing further loss of tissue perfusion. If ulcers do not adequately heal with standard treatment, additional modalities may be required – these are often termed “advanced wound care therapies.” Lower extremity ulcers are frequently classified etiologically as diabetic, venous or arterial, though overlap may exist. Treatment modalities and wound care therapies are often selected based on the ulcer characteristics as well as patient factors, past treatment, and provider preference. A large and growing array of advanced wound care therapies of different composition and indications have been developed though their efficacy, comparative effectiveness and harm is not well established. The purpose of this review is to synthesize the evidence on therapies for non-healing diabetic, venous, and arterial lower extremity ulcers and is intended to provide an evidence base to guide clinical practice and policy needs within the VA. We recognize that a non-healing ulcer is likely a result of multiple factors and comorbid conditions. We group studies in the review according to the study authors' description of the included ulcer type. The review focuses on FDA-approved therapies and examines clinically relevant outcomes. We address the following key questions: Key Question #1. What are the efficacy and harms of therapies for diabetic ulcers? Is efficacy dependent on ancillary therapies? Does efficacy differ according to patient demographics, comorbid conditions, treatment compliance, or activity level? Key Question #2. What are the efficacy and harms of therapies for venous ulcers? Is efficacy dependent on ancillary therapies? Does efficacy differ according to patient demographics, comorbid conditions, treatment compliance, or activity level? Key Question #3. What are the efficacy and harms of therapies for arterial ulcers? Is efficacy dependent on ancillary therapies? Does efficacy differ according to patient demographics, comorbid conditions, treatment compliance, or activity level?