Adaptive Systems in Drug Design

Download Adaptive Systems in Drug Design PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 149871370X
Total Pages : 184 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!


Book Synopsis Adaptive Systems in Drug Design by : Gisbert Schneider

Download or read book Adaptive Systems in Drug Design written by Gisbert Schneider and published by CRC Press. This book was released on 2002-10-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly. This is due in part to the fact that the way that a new paradigm is accepted in a drug company often does not depend on its scientific merit alone.

Adaptive Systems in Drug Design

Download Adaptive Systems in Drug Design PDF Online Free

Author :
Publisher : Eurekah.com
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Adaptive Systems in Drug Design by : Gisbert Schneider

Download or read book Adaptive Systems in Drug Design written by Gisbert Schneider and published by Eurekah.com. This book was released on 2003 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major concepts in the field of drug design are described in this book, with a strong focus on complex adaptive systems. Special emphasis is placed on neural network applications and evolutionary algorithms. The book is meant to complement a text on computational chemistry and bioinformatices and to present some new challenging ideas. A conceptual framework is presented for the use of adaptive systems and evolutionary algorithms, then the concept of chemical space is discussed and numerous examples of algorithms for classical unsupervised projection methods are given. The use of evolutionary algorithms and artificial neural networks in quantitative structure- activity relationships is discussed, and the drug-likeness concepts is explained. A final chapter examines the utility of evolutionary method in de novo molecular design. Schneider teaches cheminformatics at Johann Wolfgang Goethe University in Germany. So is affiliated with F. Hoffman-La Roche, Inc. Annotation copyrighted by Book News, Inc., Portland, OR

Drug-like Properties: Concepts, Structure Design and Methods

Download Drug-like Properties: Concepts, Structure Design and Methods PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!


Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di

Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

Download Handbook of Adaptive Designs in Pharmaceutical and Clinical Development PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1439810176
Total Pages : 475 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!


Book Synopsis Handbook of Adaptive Designs in Pharmaceutical and Clinical Development by : Annpey Pong

Download or read book Handbook of Adaptive Designs in Pharmaceutical and Clinical Development written by Annpey Pong and published by CRC Press. This book was released on 2016-04-19 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip

Lead Generation Approaches in Drug Discovery

Download Lead Generation Approaches in Drug Discovery PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470584165
Total Pages : 310 pages
Book Rating : 4.4/5 (75 download)

DOWNLOAD NOW!


Book Synopsis Lead Generation Approaches in Drug Discovery by : Zoran Rankovic

Download or read book Lead Generation Approaches in Drug Discovery written by Zoran Rankovic and published by John Wiley & Sons. This book was released on 2010-04-07 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Chemogenomics in Drug Discovery

Download Chemogenomics in Drug Discovery PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527604022
Total Pages : 487 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!


Book Synopsis Chemogenomics in Drug Discovery by : Hugo Kubinyi

Download or read book Chemogenomics in Drug Discovery written by Hugo Kubinyi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Molecular Design

Download Molecular Design PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 9783527314324
Total Pages : 284 pages
Book Rating : 4.3/5 (143 download)

DOWNLOAD NOW!


Book Synopsis Molecular Design by : Gisbert Schneider

Download or read book Molecular Design written by Gisbert Schneider and published by John Wiley & Sons. This book was released on 2008-02-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kleine Moleküle für Einsteiger: Dieser für Lehre und Selbststudium gleichermaßen geeignete Band behandelt den computergestützten Entwurf von Wirkstoffen, Enzyminhibitoren, Sonden und Markern für Biomoleküle und führt den Leser bis zum ersten eigenen De-Novo-Design eines funktionellen Moleküls. Gestützt auf lange Erfahrung im Molecular-Modeling-Umfeld erläutern die Autoren, welche Fragen mit den beschriebenen Methoden beantwortet werden können (und welche nicht).

Pharmacogenomics in Drug Discovery and Development

Download Pharmacogenomics in Drug Discovery and Development PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.0/5 (716 download)

DOWNLOAD NOW!


Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

De novo Molecular Design

Download De novo Molecular Design PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527677038
Total Pages : 540 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!


Book Synopsis De novo Molecular Design by : Gisbert Schneider

Download or read book De novo Molecular Design written by Gisbert Schneider and published by John Wiley & Sons. This book was released on 2013-10-10 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development, the approaches are equally applicable for chemical probes and diagnostics, pesticides, and any other molecule designed to interact with a biological system. Numerous images and screenshots illustrate the many examples and method descriptions. With its broad and balanced coverage, this will be the firststop resource not only for medicinal chemists, biochemists and biotechnologists, but equally for bioinformaticians and molecular designers for many years to come. From the content: * Reaction-driven de novo design * Adaptive methods in molecular design * Design of ligands against multitarget profiles * Free energy methods in ligand design * Fragment-based de novo design * Automated design of focused and target family-oriented compound libraries * Molecular de novo design by nature-inspired computing * 3D QSAR approaches to de novo drug design * Bioisosteres in de novo design * De novo design of peptides, proteins and nucleic acid structures, including RNA aptamers and many more.

The Science and Business of Drug Discovery

Download The Science and Business of Drug Discovery PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 3030578143
Total Pages : 401 pages
Book Rating : 4.0/5 (35 download)

DOWNLOAD NOW!


Book Synopsis The Science and Business of Drug Discovery by : Edward D. Zanders

Download or read book The Science and Business of Drug Discovery written by Edward D. Zanders and published by Springer Nature. This book was released on 2020-11-09 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators

Modern Biopharmaceuticals, 4 Volume Set

Download Modern Biopharmaceuticals, 4 Volume Set PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 352731184X
Total Pages : 2074 pages
Book Rating : 4.5/5 (273 download)

DOWNLOAD NOW!


Book Synopsis Modern Biopharmaceuticals, 4 Volume Set by : Jörg Knäblein

Download or read book Modern Biopharmaceuticals, 4 Volume Set written by Jörg Knäblein and published by John Wiley & Sons. This book was released on 2005-10-28 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched. Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years. With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.

Adaptive Design Methods in Clinical Trials

Download Adaptive Design Methods in Clinical Trials PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1439839883
Total Pages : 368 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!


Book Synopsis Adaptive Design Methods in Clinical Trials by : Shein-Chung Chow

Download or read book Adaptive Design Methods in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2011-12-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini

Explainable AI in Health Informatics

Download Explainable AI in Health Informatics PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 9819737052
Total Pages : 287 pages
Book Rating : 4.8/5 (197 download)

DOWNLOAD NOW!


Book Synopsis Explainable AI in Health Informatics by : Rajanikanth Aluvalu

Download or read book Explainable AI in Health Informatics written by Rajanikanth Aluvalu and published by Springer Nature. This book was released on with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intelligent and Adaptive Systems in Medicine

Download Intelligent and Adaptive Systems in Medicine PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1420012088
Total Pages : 402 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!


Book Synopsis Intelligent and Adaptive Systems in Medicine by : Olivier C. L. Haas

Download or read book Intelligent and Adaptive Systems in Medicine written by Olivier C. L. Haas and published by CRC Press. This book was released on 2008-03-19 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intelligent and adaptive techniques are rapidly being used in all stages of medical treatment, from the initial diagnosis to planning delivery and follow-up therapy.To realize the full potential of these techniques, developers and end users must understand both the underlying technology and the specifics of the medical application considered. Focus

Advances in Swarm Intelligence

Download Advances in Swarm Intelligence PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319938185
Total Pages : 589 pages
Book Rating : 4.3/5 (199 download)

DOWNLOAD NOW!


Book Synopsis Advances in Swarm Intelligence by : Ying Tan

Download or read book Advances in Swarm Intelligence written by Ying Tan and published by Springer. This book was released on 2018-06-15 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set of LNCS 10941 and 10942 constitutes the proceedings of the 9th International Conference on Advances in Swarm Intelligence, ICSI 2018, held in Shanghai, China, in June 2018. The total of 113 papers presented in these volumes was carefully reviewed and selected from 197 submissions. The papers were organized in topical sections namely: multi-agent systems; swarm robotics; fuzzy logic approaches; planning and routing problems; recommendation in social media; predication; classification; finding patterns; image enhancement; deep learning; theories and models of swarm intelligence; ant colony optimization; particle swarm optimization; artificial bee colony algorithms; genetic algorithms; differential evolution; fireworks algorithm; bacterial foraging optimization; artificial immune system; hydrologic cycle optimization; other swarm-based optimization algorithms; hybrid optimization algorithms; multi-objective optimization; large-scale global optimization.

Systems Thinking in Medicine and New Drug Discovery

Download Systems Thinking in Medicine and New Drug Discovery PDF Online Free

Author :
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527523667
Total Pages : 632 pages
Book Rating : 4.5/5 (275 download)

DOWNLOAD NOW!


Book Synopsis Systems Thinking in Medicine and New Drug Discovery by : Robert E. Smith

Download or read book Systems Thinking in Medicine and New Drug Discovery written by Robert E. Smith and published by Cambridge Scholars Publishing. This book was released on 2018-12-17 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encourages us to work together to look at the effects of new drugs on entire systems and not just single molecular targets. It also leads us to a better understanding of genetics and epigenetics, as well as the deep ecology of the human body. The healthcare community is developing targeted therapies that stimulate our own bodies to cure ourselves and eliminate the need for animal testing. This book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the important different ways that dietary supplements and prescription drugs are developed, sold and marketed.

Advances in Nervous System Research and Application: 2012 Edition

Download Advances in Nervous System Research and Application: 2012 Edition PDF Online Free

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464992576
Total Pages : 517 pages
Book Rating : 4.4/5 (649 download)

DOWNLOAD NOW!


Book Synopsis Advances in Nervous System Research and Application: 2012 Edition by :

Download or read book Advances in Nervous System Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nervous System Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nervous System in a concise format. The editors have built Advances in Nervous System Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nervous System in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nervous System Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.