Acid Proteases Structure Function And Biology

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Acid Proteases: Structure, Function, and Biology

Author : Jordan Tang
Publisher : Springer Science & Business Media
ISBN 13 : 1475707193
Total Pages : 350 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Acid Proteases: Structure, Function, and Biology by : Jordan Tang

Download or read book Acid Proteases: Structure, Function, and Biology written by Jordan Tang and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past ten years, a number of proceedings of symposia on the structure and function of proteolytic enzymes have been pub lished. Their coverage of acid proteases has been limited, mainly due to the lack of significant new information on the structure of these enzymes. In the last four years, however, the primary and tertiary structures of a number of acid proteases have been deter mined, prompting the need to discuss the meanings of the old data and the possibilities for new experimentations. It was for this purpose that the "Conference on Acid Proteases: Structure, Function, and Biology" was organized. It took place at the University of Oklahoma on November 21-24, 1976. This book is a collection of the main lectures delivered at the Conference. Acid Proteases, by definition refers to a group of proteases having an optimal pH in acidic solutions. The classic examples are pepsin and chymosin. Some catalytic features are obviously shared by these proteases, most notably, their inhibition by pepstatin. The use of active center-directed inactivators such as diazoacetyl norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane has shown that two catalytic aspartyl residues are present in most of these enzymes. These apparent cornmon features have prompted the suggestion by several investigators to name this group of enzymes "aspartyl proteases" or "carboxyl proteases".

Acid Proteases

Author : Jordan Tang
Publisher :
ISBN 13 : 9781475707205
Total Pages : 370 pages
Book Rating : 4.7/5 (72 download)

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Book Synopsis Acid Proteases by : Jordan Tang

Download or read book Acid Proteases written by Jordan Tang and published by . This book was released on 2014-01-15 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:

ACID PROTEASES: STRUCTURE, FUNCTION, AND BIOLOGY- SELECTED PAPERS PRESENTED AT A CONFERENCE- OKLAHOMA MEDICAL RESEARCH FOUNDATION.

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (846 download)

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Book Synopsis ACID PROTEASES: STRUCTURE, FUNCTION, AND BIOLOGY- SELECTED PAPERS PRESENTED AT A CONFERENCE- OKLAHOMA MEDICAL RESEARCH FOUNDATION. by :

Download or read book ACID PROTEASES: STRUCTURE, FUNCTION, AND BIOLOGY- SELECTED PAPERS PRESENTED AT A CONFERENCE- OKLAHOMA MEDICAL RESEARCH FOUNDATION. written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Acid Proteases

Author : Jordan Tang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (472 download)

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Book Synopsis Acid Proteases by : Jordan Tang

Download or read book Acid Proteases written by Jordan Tang and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structure–Function Relationships of Proteolytic Enzymes

Author : P. Desnuelle
Publisher : Elsevier
ISBN 13 : 1483261174
Total Pages : 310 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Structure–Function Relationships of Proteolytic Enzymes by : P. Desnuelle

Download or read book Structure–Function Relationships of Proteolytic Enzymes written by P. Desnuelle and published by Elsevier. This book was released on 2014-05-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure–Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.

Proteases: Structure and Function

Author : Klaudia Brix
Publisher : Springer Science & Business Media
ISBN 13 : 3709108853
Total Pages : 568 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Proteases: Structure and Function by : Klaudia Brix

Download or read book Proteases: Structure and Function written by Klaudia Brix and published by Springer Science & Business Media. This book was released on 2014-01-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aspartic Proteinases

Author : Kenji Takahashi
Publisher : Springer Science & Business Media
ISBN 13 : 1461518717
Total Pages : 614 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Aspartic Proteinases by : Kenji Takahashi

Download or read book Aspartic Proteinases written by Kenji Takahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 5th International Conference on Aspartic Proteinases was held on September 19 through 24, 1993, at Naito Museum of Pharmaceutical Science and Industry, Kawashima cho, Gifu Prefecture, Japan, about 15 miles northwest of Nagoya City. About 100 scientists attended the conference, including 52 from 14 countries outside Japan, and 32 papers were presented by invited speakers, and 58 papers as posters. The purpose of this conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic proteinases, and this book is a collec tion of nearly all the papers presented at the meeting. Aspartic proteinases belong to one of the four major classes of proteinases, the others being serine, cysteine, and metalloproteinases, and are so called since they have two catalytic aspartic acid residues in common in their active sites. Most of them are optimally active at acidic pH, hence the long-used name "acid proteinases," which, indeed, was the major title of the first conference of this series. However, some of them are active at around neutral pH, indicating their physiological roles in a wider range of pH than hitherto considered.

Mechanisms of Catalysis

Author :
Publisher : Academic Press
ISBN 13 : 0080865968
Total Pages : 471 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Mechanisms of Catalysis by :

Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Structure and Function of the Aspartic Proteinases

Author : Ben M. Dunn
Publisher : Springer Science & Business Media
ISBN 13 : 1468460129
Total Pages : 561 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Structure and Function of the Aspartic Proteinases by : Ben M. Dunn

Download or read book Structure and Function of the Aspartic Proteinases written by Ben M. Dunn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Mechanisms of Protease Action

Author : Laszlo Polgar
Publisher : CRC Press
ISBN 13 : 9780849369018
Total Pages : 236 pages
Book Rating : 4.3/5 (69 download)

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Book Synopsis Mechanisms of Protease Action by : Laszlo Polgar

Download or read book Mechanisms of Protease Action written by Laszlo Polgar and published by CRC Press. This book was released on 1989-01-31 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.

Plant Proteases

Author : Mercedes Diaz-Mendoza
Publisher : Frontiers Media SA
ISBN 13 : 2889633993
Total Pages : 157 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Plant Proteases by : Mercedes Diaz-Mendoza

Download or read book Plant Proteases written by Mercedes Diaz-Mendoza and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Proteases New Perspectives

Author : Vito Turk
Publisher : Birkhäuser
ISBN 13 : 303488737X
Total Pages : 238 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Proteases New Perspectives by : Vito Turk

Download or read book Proteases New Perspectives written by Vito Turk and published by Birkhäuser. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

Structure-function Relationships of Proteolytic Enzymes

Author : Pierre Desnuelle
Publisher :
ISBN 13 :
Total Pages : 309 pages
Book Rating : 4.:/5 (79 download)

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Book Synopsis Structure-function Relationships of Proteolytic Enzymes by : Pierre Desnuelle

Download or read book Structure-function Relationships of Proteolytic Enzymes written by Pierre Desnuelle and published by . This book was released on 1970 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic proteases. Microbial proteases. Pepsin and related enzymes. Sulfhydryl proteases.

Handbook of Proteolytic Enzymes

Author : Alan J. Barrett
Publisher : Academic Press
ISBN 13 : 0123822203
Total Pages : 4097 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Handbook of Proteolytic Enzymes by : Alan J. Barrett

Download or read book Handbook of Proteolytic Enzymes written by Alan J. Barrett and published by Academic Press. This book was released on 2012-10-30 with total page 4097 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. - The only comprehensive book on proteolytic enzymes - Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research - Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases - Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features - Over 1000 peptidases included

Proteases in Health and Disease

Author : Sajal Chakraborti
Publisher : Springer Science & Business Media
ISBN 13 : 1461492335
Total Pages : 407 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Proteases in Health and Disease by : Sajal Chakraborti

Download or read book Proteases in Health and Disease written by Sajal Chakraborti and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Proteinases and Their Inhibitors

Author : V. Turk
Publisher : Elsevier
ISBN 13 : 1483153118
Total Pages : 405 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Proteinases and Their Inhibitors by : V. Turk

Download or read book Proteinases and Their Inhibitors written by V. Turk and published by Elsevier. This book was released on 2014-05-23 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.