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Author : T. W. Stone
Publisher : Taylor & Francis
ISBN 13 : 9780748400638
Total Pages : 272 pages
Book Rating : 4.4/5 (6 download)
Download or read book Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins written by T. W. Stone and published by Taylor & Francis. This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ezio Giacobini
Publisher : Springer Science & Business Media
ISBN 13 : 1461581494
Total Pages : 673 pages
Book Rating : 4.4/5 (615 download)
Download or read book Alzheimer Disease written by Ezio Giacobini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Author : Chris Carter
Publisher : Academic Press
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.3/5 (91 download)
Download or read book Neuropharmacology of Polyamines written by Chris Carter and published by Academic Press. This book was released on 1994-09-16 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields of life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effects in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridine) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to lay a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain. Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts to group the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
Author : British Council
Publisher :
ISBN 13 :
Total Pages : 868 pages
Book Rating : 4.3/5 (91 download)
Download or read book British Book News written by British Council and published by . This book was released on 1993 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes no. 53a: British wartime books for young people.
Author : British Library. Document Supply Centre
Publisher :
ISBN 13 :
Total Pages : 990 pages
Book Rating : 4.3/5 (91 download)
Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 1993 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1022 pages
Book Rating : 4.3/5 (555 download)
Download or read book The Journal of Neuroscience written by and published by . This book was released on 1995 with total page 1022 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 2954 pages
Book Rating : 4.3/5 (91 download)
Download or read book Whitaker's Books in Print written by and published by . This book was released on 1998 with total page 2954 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rae R. Matsumoto
Publisher : Springer Science & Business Media
ISBN 13 : 0387365141
Total Pages : 416 pages
Book Rating : 4.3/5 (873 download)
Download or read book Sigma Receptors written by Rae R. Matsumoto and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Author : Raymond S. Sinatra
Publisher : Cambridge University Press
ISBN 13 : 0521874912
Total Pages : 729 pages
Book Rating : 4.5/5 (218 download)
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author : Peter M. Haddad
Publisher :
ISBN 13 : 9781911623465
Total Pages : pages
Book Rating : 4.6/5 (234 download)
Download or read book Seminars in Clinical Psychopharmacology written by Peter M. Haddad and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The 2nd edition of this book was edited by David King and published in 2004. Since then there have been major advances in psychopharmacology in terms of new medications coming to the market, increased understanding of the mechanisms of drug action and new data on the efficacy, tolerability, safety and clinical effectiveness of a range of medications. Partly as a result, clinical guidelines for many psychiatric disorders have altered. As such, a new edition of this textbook was essential and we were delighted when the College approached us to edit the 3rd edition. This was a major endeavor that was only possible with the commitment and expertise of the authors"--
Author : Arthur James Wells
Publisher :
ISBN 13 :
Total Pages : 1656 pages
Book Rating : 4.3/5 (91 download)
Download or read book The British National Bibliography written by Arthur James Wells and published by . This book was released on 1993 with total page 1656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pragya Mishra
Publisher : Springer Nature
ISBN 13 : 9811561214
Total Pages : 522 pages
Book Rating : 4.8/5 (115 download)
Download or read book Innovations in Food Technology written by Pragya Mishra and published by Springer Nature. This book was released on 2020-10-12 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers a collection of essays that describe recent innovations in food technology including food processing, packaging, food safety, and novel ingredients. By 2050, the world will face the challenge of having to feed an estimated 9 billion people. In order to meet that challenge, innovations in food research are of the utmost importance. The book is divided into four sections, each of which explores an important aspect like food processing, food microbiology, and nutritional security. Written by respected scholars in the field, the respective chapters discuss a range of new and enhanced food materials, as well as processing innovations to extend shelf life and reduce toxic effects. The book also addresses the health potential of various nutraceuticals, bio-absorption of metals and their positive impacts on living systems, as well as methods for reducing food wastage, preventing the loss of nutritive value, and preserving or enhancing palatability. Given its scope, the book will be highly interesting for food scientists, both in academia and the food industry. It will also benefit advanced graduate students and senior researchers.
Author : Adlkofer
Publisher : Birkhäuser
ISBN 13 : 303487457X
Total Pages : 608 pages
Book Rating : 4.0/5 (348 download)
Download or read book Effects of Nicotine on Biological Systems written by Adlkofer and published by Birkhäuser. This book was released on 2013-03-08 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: As part of its scientific activities, the German Research Council on Smoking and Health regularly provides opportunities for scientists to discuss progress in the field of nicotine research. In this context, the Research Council sponsored a Satellite Symposium in Hamburg, June 28-30, 1990 entitled "Effects of Nicotine on Biological Systems". This meeting was held in conjunction with the XIth International Congress of Pharmacology in Amsterdam and follows the first Satellite Symposium on Nicotine which was convened in Brisbane, Australia in 1987. The aim of these conferences has been to discuss state of the art research on the pharmacology and toxicology of nicotine and its metabolites and to integrate this information to help define nicotinic actions on the central and peripheral nervous system as well as to evaluate health or behavioral effects associated with use of this alkaloid. Furthermore, at this conference, potential therapeutic benefits of nicotine for certain disease states were discussed. Smoking and the health effects of smoking were dealt with only as far as they could not be separated from the effects of nicotine. This volume contains the lectures presented at the symposium and illustrates that knowledge of nicotine has advanced considerably in recent years with regard to mechanisms of its actions. Despite such progress however, it is apparent that a' large number of questions remain unanswered, especially in the light of new insight into cellular and molecular mechanisms which can be affected by nicotine.
Author : Hans G. Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)
Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
Author : Daniel Pedro Cardinali
Publisher : Springer
ISBN 13 : 3319575716
Total Pages : 393 pages
Book Rating : 4.3/5 (195 download)
Download or read book Autonomic Nervous System written by Daniel Pedro Cardinali and published by Springer. This book was released on 2017-08-04 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A traditional view of the Autonomic Nervous System (ANS) considers only its peripheral part: the sympathetic and parasympathetic systems. However, this view misses to consider the most important ANS function: the maintenance of homeostasis. This term is used today to define not only the strategies that allow the body proper response to changes in the environment (reactive homeostasis), but also temporal mechanisms that allow the body to predict the most likely timing of environmental stimuli (predictive homeostasis based on biological rhythms). This book discusses the ANS from both an enlarged and a timed perspective. First, it presents how the organization of the ANS is hierarchical into different levels. Following that, the book discusses how the ANS changes functionally in the three-body configurations (wakefulness, slow sleep, rapid eye movement sleep) found in a 24-hour cycle. Finally, the most important clinical implications of this enlarged and timed vision of ANS will be discussed. Autonomic Nervous System – Basic and Clinical Aspects is a comprehensive text intended for medical students and health professionals who are interested in a deeper approach to this important part of the nervous system. It provides a detailed and complete understanding of the neuroscience behind the ANS, allowing a proper clinical applicability of this knowledge.
Author : Theophile Theophanides
Publisher : Springer Science & Business Media
ISBN 13 : 9780792348214
Total Pages : 448 pages
Book Rating : 4.3/5 (482 download)
Download or read book Magnesium: Current Status and New Developments written by Theophile Theophanides and published by Springer Science & Business Media. This book was released on 1997-09-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the 8th International Symposium on Magnesium. It presents research and applications in order to interface between medical doctors, clinicians and scientists responsible for magnesium involvement in the pathogenesis of diseases, its biological significance, metabolism and many other utilizations which are associated with membranes and cells. The topics which are discussed concern mechanisms of the mode of action of free magnesium cations, hydrated cations and magnesium-linked cations.
Author : William F. Ganong
Publisher :
ISBN 13 :
Total Pages : 870 pages
Book Rating : 4.:/5 (124 download)
Download or read book Review of Medical Physiology written by William F. Ganong and published by . This book was released on 2001 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review presents anatomic considerations, physiology and clinical examples. Ganong begins with an introduction to the cellular basis of medical physiology, and cell physiology is interwoven into the text where applicable.
