Protein Structure, Stability, and Folding

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Publisher : Springer Science & Business Media
ISBN 13 : 1592591930
Total Pages : 258 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Protein Structure, Stability, and Folding by : Kenneth P. Murphy

Download or read book Protein Structure, Stability, and Folding written by Kenneth P. Murphy and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

Biological Water

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Publisher : Springer Nature
ISBN 13 : 3030825035
Total Pages : 523 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Biological Water by : Gertz I. Likhtenshtein

Download or read book Biological Water written by Gertz I. Likhtenshtein and published by Springer Nature. This book was released on 2021-10-21 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book embraces all physiochemical aspects of the structure and molecular dynamics of water, focusing on its role in biological objects, e.g. living cells and tissue, and in the formation of functionally active structures of biological molecules and their ensembles. Water is the single most abundant chemical found in all living things. It offers a detailed look into the latest modern physical methods for studying the molecular structure and dynamics of the water and provides a critical analysis of the existing literature data on the properties of water in biological objects. Water as a chemical reagent and as a medium for the formation of conditions for enzymatic catalysis is a core focus of this book. Although well suited for active researchers, the book as a whole, as well as each chapter on its own, can be used as fundamental reference material for graduate and undergraduate students throughout chemistry, physics, biophysics and biomedicine.

Concepts and Methods of 2D Infrared Spectroscopy

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Publisher : Cambridge University Press
ISBN 13 : 1139497073
Total Pages : 297 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Concepts and Methods of 2D Infrared Spectroscopy by : Peter Hamm

Download or read book Concepts and Methods of 2D Infrared Spectroscopy written by Peter Hamm and published by Cambridge University Press. This book was released on 2011-02-24 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2D infrared (IR) spectroscopy is a cutting-edge technique, with applications in subjects as diverse as the energy sciences, biophysics and physical chemistry. This book introduces the essential concepts of 2D IR spectroscopy step-by-step to build an intuitive and in-depth understanding of the method. This unique book introduces the mathematical formalism in a simple manner, examines the design considerations for implementing the methods in the laboratory, and contains working computer code to simulate 2D IR spectra and exercises to illustrate involved concepts. Readers will learn how to accurately interpret 2D IR spectra, design their own spectrometer and invent their own pulse sequences. It is an excellent starting point for graduate students and researchers new to this exciting field. Computer codes and answers to the exercises can be downloaded from the authors' website, available at www.cambridge.org/9781107000056.

Dynamics in Enzyme Catalysis

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Publisher : Springer
ISBN 13 : 3642389627
Total Pages : 217 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Dynamics in Enzyme Catalysis by : Judith Klinman

Download or read book Dynamics in Enzyme Catalysis written by Judith Klinman and published by Springer. This book was released on 2013-09-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christopher M. Cheatum and Amnon Kohen, Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer. Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole, A Surprising Role for Conformational Entropy in Protein Function. Travis P. Schrank, James O. Wrabl and Vincent J. Hilser, Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations. Buyong Ma and Ruth Nussinov, Structured Crowding and Its Effects on Enzyme Catalysis. Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui, Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations. Karunesh Arora and Charles L. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase. Steven D. Schwartz, Protein Dynamics and the Enzymatic Reaction Coordinate.

Ultrafast Infrared Vibrational Spectroscopy

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Publisher : CRC Press
ISBN 13 : 1466510137
Total Pages : 491 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Ultrafast Infrared Vibrational Spectroscopy by : Michael D. Fayer

Download or read book Ultrafast Infrared Vibrational Spectroscopy written by Michael D. Fayer and published by CRC Press. This book was released on 2013-03-04 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of laser-based sources of ultrafast infrared pulses has extended the study of very fast molecular dynamics to the observation of processes manifested through their effects on the vibrations of molecules. In addition, non-linear infrared spectroscopic techniques make it possible to examine intra- and intermolecular interactions and how such interactions evolve on very fast time scales, but also in some instances on very slow time scales. Ultrafast Infrared Vibrational Spectroscopy is an advanced overview of the field of ultrafast infrared vibrational spectroscopy based on the scientific research of the leading figures in the field. The book discusses experimental and theoretical topics reflecting the latest accomplishments and understanding of ultrafast infrared vibrational spectroscopy. Each chapter provides background, details of methods, and explication of a topic of current research interest. Experimental and theoretical studies cover topics as diverse as the dynamics of water and the dynamics and structure of biological molecules. Methods covered include vibrational echo chemical exchange spectroscopy, IR-Raman spectroscopy, time resolved sum frequency generation, and 2D IR spectroscopy. Edited by a recognized leader in the field and with contributions from top researchers, including experimentalists and theoreticians, this book presents the latest research methods and results. It will serve as an excellent resource for those new to the field, experts in the field, and individuals who want to gain an understanding of particular methods and research topics.

Organic Optoelectronic Materials

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Publisher : Springer
ISBN 13 : 3319168622
Total Pages : 402 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Organic Optoelectronic Materials by : Yongfang Li

Download or read book Organic Optoelectronic Materials written by Yongfang Li and published by Springer. This book was released on 2015-05-30 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the latest trends in organic optoelectronic materials. Each comprehensive chapter allows graduate students and newcomers to the field to grasp the basics, whilst also ensuring that they have the most up-to-date overview of the latest research. Topics include: organic conductors and semiconductors; conducting polymers and conjugated polymer semiconductors, as well as their applications in organic field-effect-transistors; organic light-emitting diodes; and organic photovoltaics and transparent conducting electrodes. The molecular structures, synthesis methods, physicochemical and optoelectronic properties of the organic optoelectronic materials are also introduced and described in detail. The authors also elucidate the structures and working mechanisms of organic optoelectronic devices and outline fundamental scientific problems and future research directions. This volume is invaluable to all those interested in organic optoelectronic materials.

Two-Dimensional Optical Spectroscopy

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Publisher : CRC Press
ISBN 13 : 1420084305
Total Pages : 396 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Two-Dimensional Optical Spectroscopy by : Minhaeng Cho

Download or read book Two-Dimensional Optical Spectroscopy written by Minhaeng Cho and published by CRC Press. This book was released on 2009-06-16 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two-Dimensional Optical Spectroscopy discusses the principles and applications of newly emerging two-dimensional vibrational and optical spectroscopy techniques. It provides a detailed account of basic theory required for an understanding of two-dimensional vibrational and electronic spectroscopy. It also bridges the gap between the formal developm

Biointerface Characterization by Advanced IR Spectroscopy

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Publisher : Elsevier
ISBN 13 : 0444535594
Total Pages : 344 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Biointerface Characterization by Advanced IR Spectroscopy by : C.-M. Pradier

Download or read book Biointerface Characterization by Advanced IR Spectroscopy written by C.-M. Pradier and published by Elsevier. This book was released on 2011-07-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: IR spectroscopy has become without any doubt a key technique to answer questions raised when studying the interaction of proteins or peptides with solid surfaces for a fundamental point of view as well as for technological applications. Principle, experimental set ups, parameters and interpretation rules of several advanced IR-based techniques; application to biointerface characterisation through the presentation of recent examples, will be given in this book. It will describe how to characterise amino acids, protein or bacterial strain interactions with metal and oxide surfaces, by using infrared spectroscopy, in vacuum, in the air or in an aqueous medium. Results will highlight the performances and perspectives of the technique. - Description of the principles, expermental setups and parameter interpretation, and the theory for several advanced IR-based techniques for interface characterisation - Contains examples which demonstrate the capacity, potential and limits of the IR techniques - Helps finding the most adequate mode of analysis - Contains examples - Contains a glossary by techniques and by keywords

Dynamics of Soft Matter

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Publisher : Springer Science & Business Media
ISBN 13 : 1461407265
Total Pages : 455 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Dynamics of Soft Matter by : VICTORIA GARCIA SAKAI

Download or read book Dynamics of Soft Matter written by VICTORIA GARCIA SAKAI and published by Springer Science & Business Media. This book was released on 2011-12-19 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamics of Soft Matter: Neutron Applications provides an overview of neutron scattering techniques that measure temporal and spatial correlations simultaneously, at the microscopic and/or mesoscopic scale. These techniques offer answers to new questions arising at the interface of physics, chemistry, and biology. Knowledge of the dynamics at these levels is crucial to understanding the soft matter field, which includes colloids, polymers, membranes, biological macromolecules, foams, emulsions towards biological & biomimetic systems, and phenomena involving wetting, friction, adhesion, or microfluidics. Emphasizing the complementarities of scattering techniques with other spectroscopic ones, this volume also highlights the potential gain in combining techniques such as rheology, NMR, light scattering, dielectric spectroscopy, as well as synchrotron radiation experiments. Key areas covered include polymer science, biological materials, complex fluids and surface science.

Analysis and Control of Ultrafast Photoinduced Reactions

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Publisher : Springer Science & Business Media
ISBN 13 : 3540680381
Total Pages : 854 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Analysis and Control of Ultrafast Photoinduced Reactions by : Oliver Kühn

Download or read book Analysis and Control of Ultrafast Photoinduced Reactions written by Oliver Kühn and published by Springer Science & Business Media. This book was released on 2007-07-05 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes several years of research carried out by a collaboration of many groups on ultrafast photochemical reactions. It emphasizes the analysis and characterization of the nuclear dynamics within molecular systems in various environments induced by optical excitations and the study of the resulting molecular dynamics by further interaction with an optical field.

Copper Coordination Chemistry

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Publisher :
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Copper Coordination Chemistry by : Kenneth D. Karlin

Download or read book Copper Coordination Chemistry written by Kenneth D. Karlin and published by . This book was released on 1983 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Measles Virus Nucleoprotein

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Publisher : Nova Publishers
ISBN 13 : 9781600216299
Total Pages : 180 pages
Book Rating : 4.2/5 (162 download)

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Book Synopsis Measles Virus Nucleoprotein by : Sonia Longhi

Download or read book Measles Virus Nucleoprotein written by Sonia Longhi and published by Nova Publishers. This book was released on 2007 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.

Reviews in Computational Chemistry, Volume 31

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Publisher : John Wiley & Sons
ISBN 13 : 1119518024
Total Pages : 368 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Reviews in Computational Chemistry, Volume 31 by : Abby L. Parrill

Download or read book Reviews in Computational Chemistry, Volume 31 written by Abby L. Parrill and published by John Wiley & Sons. This book was released on 2018-11-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered on molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 31 include: Lattice-Boltzmann Modeling of Multicomponent Systems: An Introduction Modeling Mechanochemistry from First Principles Mapping Energy Transport Networks in Proteins The Role of Computations in Catalysis The Construction of Ab Initio Based Potential Energy Surfaces Uncertainty Quantification for Molecular Dynamics

Protein Conformational Dynamics

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Publisher : Springer Science & Business Media
ISBN 13 : 3319029703
Total Pages : 488 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Protein Conformational Dynamics by : Ke-li Han

Download or read book Protein Conformational Dynamics written by Ke-li Han and published by Springer Science & Business Media. This book was released on 2014-01-20 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.

Coherent Vibrational Dynamics

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Publisher : CRC Press
ISBN 13 : 1420017519
Total Pages : 286 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Coherent Vibrational Dynamics by : Guglielmo Lanzani

Download or read book Coherent Vibrational Dynamics written by Guglielmo Lanzani and published by CRC Press. This book was released on 2007-11-29 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable developments in the spectroscopy field regarding ultrashort pulse generation have led to the possibility of producing light pulses ranging from 50 to5 fs and frequency tunable from the near infrared to the ultraviolet range. Such pulses enable us to follow the coupling of vibrational motion to the electronic transitions in molecules and

Modern Techniques of Spectroscopy

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Publisher : Springer Nature
ISBN 13 : 9813360844
Total Pages : 663 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Modern Techniques of Spectroscopy by : Dheeraj Kumar Singh

Download or read book Modern Techniques of Spectroscopy written by Dheeraj Kumar Singh and published by Springer Nature. This book was released on 2021-04-01 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights recent developments in the field of spectroscopy by providing the readers with an updated and high-level of overview. The focus of this book is on the introduction to concepts of modern spectroscopic techniques, recent technological innovations in this field, and current examples of applications to molecules and materials relevant for academia and industry. The book will be beneficial to researchers from various branches of science and technology, and is intended to point them to modern techniques, which might be useful for their specific problems. Spectroscopic techniques, that are discussed include, UV-Visible absorption spectroscopy, XPS, Raman spectroscopy, SERS, TERS, CARS, IR absorption spectroscopy, SFG, LIBS, Quantum cascade laser (QCL) spectroscopy, fluorescence spectroscopy, ellipsometry, cavity-enhanced absorption spectroscopy, such as cavity ring-down spectroscopy (CRDS) and evanescent wave-CRDS both in gas and condensed phases, time-resolved spectroscopy etc. Applications introduced in the different chapters demonstrates the usefulness of the spectroscopic techniques for the characterization of fundamental properties of molecules, e.g. in connection with environmental impact, bio-activity, or usefulness for pharmaceutical drugs, and materials important e.g. for nano-science, nuclear chemistry, or bio-applications. The book presents how spectroscopic techniques can help to better understand substances, which have also great impact on questions of social and economic relevance (environment, alternative energy, etc.).

The Plasma Proteins

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Publisher : Elsevier
ISBN 13 : 032313808X
Total Pages : 498 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Plasma Proteins by : Frank W Putnam

Download or read book The Plasma Proteins written by Frank W Putnam and published by Elsevier. This book was released on 2012-12-02 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such as serum albumin, lipoproteins, and immunoglobulins. Subsequent chapters deal with protease inhibitors in plasma; purification, physical properties, chemical composition, and molecular structure of transferrin; biosynthesis and metabolism of serum lipoproteins; and physical, chemical, and functional properties of the proteins of the complement system. The final chapter is devoted to ?2-microglobulin, with particular reference to its purification and physical properties; chemical composition and structure; physiological function, biosynthesis, and catabolism; and presence and function in cell membranes. This monograph will be of interest to molecular biologists and biochemists.