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Author : Richard C. Lewit
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)
Download or read book A total synthesis of ellipticine written by Richard C. Lewit and published by . This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard Newhall Stillwell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (769 download)
Download or read book Total Synthesis of Ellipticine and 5-norellipticine written by Richard Newhall Stillwell and published by . This book was released on 1964 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph Gregory Stowell
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (15 download)
Download or read book The Total Synthesis of Ellipticine, a Pyridocarbazole Alkaloid from Ochrosia Elliptica, Labill written by Joseph Gregory Stowell and published by . This book was released on 1982 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James Martin Frincke
Publisher :
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.:/5 (13 download)
Download or read book The Total Synthesis of Natural Products written by James Martin Frincke and published by . This book was released on 1979 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fiona Deane
Publisher :
ISBN 13 :
Total Pages : 308 pages
Book Rating : 4.:/5 (795 download)
Download or read book Design, Synthesis and Evaluation of Ellipticine Derivatives as Potential Anti-cancer Agents written by Fiona Deane and published by . This book was released on 2009 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is focused on the design and investigation of ellipticine derivatives as potential anti-cancer agents. Using a modified synthetic route, the total synthesis of the natural product ellipticine was improved leading to overall yields of 14% compared with previous yields of 3%. Furthermore, of the twenty eight novel ellipticine derivatives synthesized for biological evaluation, ten were found to inhibit the topoisomerase II enzyme with a greater potency than that of the parent ellipticines. The inhibition of topoisomerase enzymes is a significant target for cancer chemotherapy. As part of this research, the complex mechanisms of topoisomerase I were investigated. Through the use of molecular modeling, the mechanistic duality surrounding certain benzo[c]phenanthridines is explained. Chapters one and two summarize the literature background regarding the total synthesis and derivatisation of ellipticine along with the anti-cancer mechanisms of action. The third chapter lists the aims and objectives regarding both the chemical synthesis and biological evaluation of this project. The fourth chapter provides a detailed discussion of the total synthesis of ellipticine, ellipticine derivatives and ellipticinium salts undertaken during the course of this research. The improvement of the Vilsmeier-Haack reaction of 3-formyl-1,4,-dimethylcarbazole is central in obtaining improved overall yields of ellipticine. Formation of ellipticinium salts is also discussed along with a comprehensive investigation of the 1H NMR spectra relating to these compounds. The ability of 9 formylellipticine to form adducts with biological nucleophiles was also studied by MS and LCMS analysis, leading to the identification of adduct formation with the amino acid cysteine. Chapter five discusses the biological evaluation of ellipticine derivatives synthesized during the course of this research. Dual topoisomerase inhibition was one of the key aims of this project. Investigation of these compounds was achieved using topoisomerase relaxation, cleavage and decatenation assays. Chapter six provides full experimental details relating to the total synthesis of these compounds, many of which have previously been unreported. Chapter seven describes the molecular modeling of the interaction of benzo[c]phenanthridines, fagaronine and ethoxidine, on topoisomerase I. The ternary complex of drug-DNA-enzyme is comprehensively investigated leading to a reasonable hypothesis as to why fagaronine acts as a DNA poison and ethoxidine is a DNA suppressor.
Author : Johannes Petrus Marinus Plug
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (461 download)
Download or read book Synthesis of New Ellipticine Derivatives by Regioselective Functionalization written by Johannes Petrus Marinus Plug and published by . This book was released on 1992 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John ApSimon
Publisher : John Wiley & Sons
ISBN 13 : 0470129522
Total Pages : 579 pages
Book Rating : 4.4/5 (71 download)
Download or read book The Total Synthesis of Natural Products, Volume 3 written by John ApSimon and published by John Wiley & Sons. This book was released on 2009-09-22 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Author : Krishna C. Majumdar
Publisher : John Wiley & Sons
ISBN 13 : 3527634894
Total Pages : 648 pages
Book Rating : 4.5/5 (276 download)
Download or read book Heterocycles in Natural Product Synthesis written by Krishna C. Majumdar and published by John Wiley & Sons. This book was released on 2011-06-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.
Author : Kengadarane Anebouselvy
Publisher : Royal Society of Chemistry
ISBN 13 : 1782620907
Total Pages : 220 pages
Book Rating : 4.7/5 (826 download)
Download or read book Dienamine Catalysis for Organic Synthesis written by Kengadarane Anebouselvy and published by Royal Society of Chemistry. This book was released on 2018-03-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade a new era in asymmetric catalysis has been realised by the discovery of L-proline induced chiral enamines from carbonyls. Inspired by this, researchers have developed many other primary catalytic species in situ, more recently secondary catalytic species such as aminals have been identified for use in asymmetric synthesis. High-yielding asymmetric synthesis of bioactive and natural products through mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the synthesis of complex molecules, with less attention on the reaction efficiency and eco-friendly conditions. Recent investigations have been directed towards the development of atom economy, eco-friendly and enantioselective synthesis for more targeted and efficient synthesis. Building on the momentum of this rapidly expanding research area, Dienamine catalysis for organic synthesis will provide a comprehensive introduction, from the preformed species, in situ generation and onto their applications in the synthesis of bioactive molecules and natural products.
Author : Steven Craig Farmer
Publisher :
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.:/5 (64 download)
Download or read book A Synthesis Route for Ellipticine Via Sulfur Extrusion & Synthesis of Organic/inorganic Composite Nanoparticles written by Steven Craig Farmer and published by . This book was released on 2002 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carmen Avendaño
Publisher : Elsevier
ISBN 13 : 0444626670
Total Pages : 767 pages
Book Rating : 4.4/5 (446 download)
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Author : Gordon W. Gribble
Publisher : John Wiley & Sons
ISBN 13 : 0470512180
Total Pages : 704 pages
Book Rating : 4.4/5 (75 download)
Download or read book Indole Ring Synthesis written by Gordon W. Gribble and published by John Wiley & Sons. This book was released on 2016-08-08 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Author : Bimal Krishna Banik
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110735814
Total Pages : 1185 pages
Book Rating : 4.1/5 (17 download)
Download or read book Heterocyclic Anticancer Agents written by Bimal Krishna Banik and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-06-21 with total page 1185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Author : Navjeet Kaur
Publisher : Elsevier
ISBN 13 : 0323994938
Total Pages : 232 pages
Book Rating : 4.3/5 (239 download)
Download or read book Raney Nickel-Assisted Synthesis of Heterocycles written by Navjeet Kaur and published by Elsevier. This book was released on 2022-04-04 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raney Nickel-Assisted Synthesis of Heterocycles covers the synthesis of heterocycles using Raney nickel. The book focuses on the use of Raney-Ni, a common catalyst in hydrogenation reaction and its uses in the synthesis and preparation of heterocycles. Furthermore, it explains how the development of new approaches and strategic deployments in known approaches for the formation of complex heterocyclic compounds continue to drive the field of synthetic organic chemistry, along with updates on efforts to prepare heterocycles through the development of new and efficient synthetic transformations. Heterocyclic chemistry is an inexhaustible source of novel compounds, providing the most diverse chemical, physical and biological properties through the design of a wide range of combinations of carbon, hydrogen and heteroatoms. Significant focus has been paid to novel approaches to the formation of heterocyclic compounds, which are of practical use acting as modifiers and additives in a wide range of industries such as reprography, plastics, cosmetics, vulcanization accelerators, solvents, antioxidants and information storage. - Presents complete coverage of Raney Nickel assisted reactions - Includes the discovery, reactivities, advantages, disadvantages and other characteristics of Raney nickel - Presents new methodologies for the synthesis of heterocycles
Author : John ApSimon
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 582 pages
Book Rating : 4.:/5 ( download)
Download or read book The Total Synthesis of Natural Products written by John ApSimon and published by Wiley-Interscience. This book was released on 1973 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.
Author : Jie Jack Li
Publisher : John Wiley & Sons
ISBN 13 : 0470085088
Total Pages : 704 pages
Book Rating : 4.4/5 (7 download)
Download or read book Name Reactions in Heterocyclic Chemistry II written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2011-09-13 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: The up-to-DATE guide to name reactions in heterocyclic chemistry Name Reactions in Heterocyclic Chemistry II presents a comprehensive treatise on name reactions in heterocyclic chemistry, one of the most exciting and important fields within organic chemistry today. The book not only covers fresh ground, but also provides extensive information on new and/or expanded reactions in: Three- and four-membered heterocycles Five-membered heterocycles (pyrroles and pyrrolidines, indoles, furans, thiophenes, and oxazoles) Six-membered heterocycles, including pyridines, quinolines, and isoquinolines Featuring contributions from the leading authorities in heterocyclic chemistry. Each section includes a description of the given reaction, as well as the relevant historical perspective, mechanism, variations and improvements, synthetic utilities, experimental details, and references to the current primary literature. The reactions covered in Name Reactions in Heterocyclic Chemistry have been widely adopted in all areas of organic synthesis, from the medicinal/pharmaceutical field, to agriculture, to fine chemicals, and the book brings the most cutting-edge knowledge to practicing synthetic chemists and students, along with the tools needed to synthesize new and useful molecules.
Author : Otto Theodor Benfey
Publisher : Chemical Heritage Foundation
ISBN 13 : 9780941901253
Total Pages : 508 pages
Book Rating : 4.9/5 (12 download)
Download or read book Robert Burns Woodward written by Otto Theodor Benfey and published by Chemical Heritage Foundation. This book was released on 2001 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Burns Woodward was the star of 20th-century organic chemistry. An MIT graduate by age 19, Woodward's ingenious notions about organic synthesis and his artful methodology were astounding. He is most famed for his synthesis of vitamin B12,which he undertook with Albert Eschenmoser, and for the orbital symmetry rules he developed with Roald Hoffmann. This volume presents Woodward's most celebrated papers and lectures--including the famous Cope lecture. Insightful commentaries and rarely seen photographs are also included.
