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Author : Scott S. Harried
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.:/5 (418 download)
Download or read book A Total Synthesis of ( - )-discodermolide written by Scott S. Harried and published by . This book was released on 1998 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jennie Beth Nerenberg
Publisher :
ISBN 13 :
Total Pages : 400 pages
Book Rating : 4.:/5 (4 download)
Download or read book The Total Synthesis of Discodermolide written by Jennie Beth Nerenberg and published by . This book was released on 1993 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ge Yang
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (327 download)
Download or read book Studies Toward the Total Synthesis of Discodermolide written by Ge Yang and published by . This book was released on 1994 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gordon John Florence
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (894 download)
Download or read book The Total Synthesis of (+)-discodermolide written by Gordon John Florence and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Isabelle Lyothier
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)
Download or read book An Improved Total Synthesis of (+)-discodermolide written by Isabelle Lyothier and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Patrick Halstead
Publisher :
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.:/5 (45 download)
Download or read book I. Total Synthesis of (+)-miyakolide written by David Patrick Halstead and published by . This book was released on 1998 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Louis Clark
Publisher :
ISBN 13 :
Total Pages : 338 pages
Book Rating : 4.:/5 (34 download)
Download or read book Synthetic Studies Towards Discodermolide and a Total Synthesis of Didehydrodiscodermolide written by David Louis Clark and published by . This book was released on 1996 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yuping Qiu
Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 (187 download)
Download or read book The Total Synthesis of (-)-discodermolide written by Yuping Qiu and published by . This book was released on 1997 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alexander Arefolov
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.:/5 (32 download)
Download or read book Total Synthesis of (+)-discodermolide written by Alexander Arefolov and published by . This book was released on 2006 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: An enantioselective total synthesis of the marine natural product (+)-discodermolide has been accomplished utilizing a highly convergent and stereocontrolled strategy. The C1-C24 fragment was constructed via a palladium-mediated sp 2 -sp 3 cross-coupling reaction between the C1-C14 vinyl iodide and the C15-C24 alkyl iodide subunits. The C1-C14 subunit was obtained using an acetate aldol reaction to construct the C6-C7 bond and install the C7 stereocenter with high levels of 1,5- anti stereoinduction. The key C13-C14 trisubstituted (Z)-olefin was prepared applying a novel hydrozirconation-cross-coupling methodology. The C1-C6, C7-C14 and C15-C24 subunits were synthesized using chiral silane-based asymmetric C-C bond construction methodology to introduce eight out of thirteen molecule's stereogenic centers. This synthesis illustrates the application of chiral crotylsilane bond construction methodology for the enantioselective synthesis of natural products and offers complementary approach to the aldol-based methodology. A highly flexible and stereoselective protocol for the synthesis of functionalized (Z)- and (E)-trisubstituted alkenes has been developed. The key steps are hydrozirconation-iodination of (1-alkynyl)trimethylsilane followed by Negishi-type cross-coupling. The resultant (Z)-vinyl silane is iododesilylated and subjected to the second cross-coupling to give the trisubstituted olefin. Model studies aimed at the construction of C13-C14 trisubstituted olefin of (+)-discodermolide are described.
Author : Stephen P. Wren
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (62 download)
Download or read book Studies Towards the Total Synthesis of the Marine-derived Immunosuppressant Discodermolide written by Stephen P. Wren and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Application of the [2,3] Wittig Rearrangement to Synthetic Studies Toward the Total Synthesis of (+)-discodermolide PDF Online Free](https://books.google.com/books/content/images/frontcover/N3SwuAAACAAJ?fife=w200-h370)
Author : Guohua Liang
Publisher :
ISBN 13 : 9780549042266
Total Pages : 154 pages
Book Rating : 4.0/5 (422 download)
Download or read book Application of the [2,3] Wittig Rearrangement to Synthetic Studies Toward the Total Synthesis of (+)-discodermolide written by Guohua Liang and published by . This book was released on 2007 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background information and stereochemical consequences of the [2,3] Wittig rearrangement are discussed. Examples of the application of the [2,3] Wittig rearrangement to the total synthesis of natural products are described, as are previous total syntheses of (+)-discodermolide also presented.
Author : K. C. Nicolaou
Publisher : John Wiley & Sons
ISBN 13 : 3527329579
Total Pages : 788 pages
Book Rating : 4.5/5 (273 download)
Download or read book Classics in Total Synthesis III written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 2011-03-14 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists.
Author : Elizabeth G. L. Williams
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)
Download or read book Total Synthesis of Novel Analogues and Hybrids of the Anti-cancer Agents Dictyostatin and Discodermolide written by Elizabeth G. L. Williams and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Huanyan Cao
Publisher :
ISBN 13 :
Total Pages : 494 pages
Book Rating : 4.:/5 (166 download)
Download or read book Catalytic Asymmetric Synthesis of the Chiral Tetraene Acyl Side Chain of Papulacandins written by Huanyan Cao and published by . This book was released on 2005 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gordon M. Cragg
Publisher : CRC Press
ISBN 13 : 1420039652
Total Pages : 610 pages
Book Rating : 4.4/5 (2 download)
Download or read book Anticancer Agents from Natural Products written by Gordon M. Cragg and published by CRC Press. This book was released on 2005-06-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Author : Sandra Ann Filla
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.:/5 (31 download)
Download or read book Discodermolide Synthesis written by Sandra Ann Filla and published by . This book was released on 1994 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiao-Yu Sun
Publisher : Springer Science & Business Media
ISBN 13 : 3642271952
Total Pages : 232 pages
Book Rating : 4.6/5 (422 download)
Download or read book Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B written by Xiao-Yu Sun and published by Springer Science & Business Media. This book was released on 2012-01-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery.
