A Text Book Of Practical Medicine Vol 2

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Davidson's Principles and Practice of Medicine E-Book

Author : Stuart H. Ralston
Publisher : Elsevier Health Sciences
ISBN 13 : 0702070262
Total Pages : 1440 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Davidson's Principles and Practice of Medicine E-Book by : Stuart H. Ralston

Download or read book Davidson's Principles and Practice of Medicine E-Book written by Stuart H. Ralston and published by Elsevier Health Sciences. This book was released on 2018-02-02 with total page 1440 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than two million medical students, doctors and other health professionals around the globe have owned a copy of Davidson's Principles and Practice of Medicine since it was first published. Now in its 23rd Edition, this textbook describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine and explains how to recognise, investigate, diagnose and manage them. Taking its origins from Sir Stanley Davidson's much-admired lecture notes, Davidson's has endured because it keeps pace with how modern medicine is taught and provides a wealth of information in an easy-to-read, concise and beautifully illustrated format. This book will serve readers everywhere as a core text that integrates medical science with clinical medicine, conveying key knowledge and practical advice in a highly accessible and readable format. - The opening section describes the fundamentals of genetics, immunology, infectious diseases and population health, and discusses the core principles of clinical decision-making and good prescribing. - A new second section on emergency and critical care medicine encompasses poisoning, envenomation and environmental medicine, and introduces a new chapter on acute medicine and critical illness. - The third section covers the major medical specialties, each thoroughly revised and brought fully up to date. Two new chapters on maternal and adolescent/transition medicine complement the one on ageing and disease. A new chapter on medical ophthalmology has been included. - Clinical Examination overviews summarise the main elements for each system and now feature in the biochemistry, nutrition and dermatology chapters. - Presenting Problems sections provide a clear pathway for the assessment of and approach to the most common complaints in each specialty. - Practice Point summaries detail the practical skills that medical students and junior doctors must acquire. - Emergency boxes emphasise the core knowledge needed to manage acutely ill patients. - In Old Age, In Pregnancy and In Adolescence boxes highlight differences in the practice of medicine in these patient groups, and illustrate the interfaces between medical, obstetric and paediatric services. - The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images. - The global perspective is enhanced by an International Advisory Board of experts from 17 countries, and by authors from around the world.

Manual of Practical Medicine

Author : R Alagappan
Publisher : JP Medical Ltd
ISBN 13 : 9351523160
Total Pages : 1024 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis Manual of Practical Medicine by : R Alagappan

Download or read book Manual of Practical Medicine written by R Alagappan and published by JP Medical Ltd. This book was released on 2014-08-31 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual emphasizes the practical features of clinical diagnosis and patient management.

Religion in Medicine Volume I

Author : John B. Dawson
Publisher : Xlibris Corporation
ISBN 13 : 1465368310
Total Pages : 215 pages
Book Rating : 4.4/5 (653 download)

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Book Synopsis Religion in Medicine Volume I by : John B. Dawson

Download or read book Religion in Medicine Volume I written by John B. Dawson and published by Xlibris Corporation. This book was released on 2011-12 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this treatise is: 1) to draw attention to the presence of situations arising within medical practice in which religious beliefs play an important role. 2) to emphasize the fact that most students and many doctors are given insufficient training in such matters, which are of considerable import to a fair percentage of the public. 3) to provide a few examples of what is meant by a religio-medical situation, and a bibliography for further exploration by the initiate in such matters. The stimulus to think along these lines stemmed from the examples set me by my erstwhile 'chiefs', Sir James Patterson-Ross, Professor Sir E. F. Scowen and Sir Stanley Davidson. Further encouragement came while I was in Edinburgh from the Reverend Dr. H.C. Whitley of St. Giles and his brother counterparts Msgr. Quill and the Reverend A. Brysh-White. In Australia, Bishop E.H. Burgmann of Canberra gave me the benefit of his legendary experience and passed me on to Father Michael Scott of Newman College, Professor D. McCaughey of Ormond College and Mr. Ben Gurewicz in Melbourne. The Reverend Granger Westberg of the Lutheran ministry in the United States infused his enthusiasm into the venture and this, with an intellectual commentary from Professor B. Hamnett of the State University of New York, along with the constructive critique volunteered by members of the local Baha'i community, tidied up many loose ends. In respect to the actual page-by-page construction I must mention my wife and Professor G. Bolton of the University of Western Australia who turned my thoughts into reality. My gratitude to these and many other people of distinction and industry can never be satisfactorily expressed. I hope they will accept my efforts to interpret or to pass on their humane counsel as part payment.

Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2)

Author : Joseph Loscalzo
Publisher : McGraw Hill Professional
ISBN 13 : 1264268513
Total Pages : 4132 pages
Book Rating : 4.2/5 (642 download)

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Book Synopsis Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2) by : Joseph Loscalzo

Download or read book Harrison's Principles of Internal Medicine, Twenty-First Edition (Vol.1 & Vol.2) written by Joseph Loscalzo and published by McGraw Hill Professional. This book was released on 2022-04-05 with total page 4132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Voice of Clinical ReasonHarrison’s Principles of Internal Medicine is the world's most trusted clinical medicine text—and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world’s top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison’s is world-renowned as the most authoritative source for: • Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases • Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases • The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow • Updated clinical trial results and recommended guidelines • Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings • Coverage of both therapeutic approaches and specific treatment regimens • Practical clinical decision trees and algorithms • Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison’s remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world’s top experts are featured in the 21st edition: • Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer • Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries • More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes • More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management • Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials • Clinical reasoning resources and helpful disease/presentation schemas • Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

A Text-book of Practical Medicine

Author : Felix von Niemeyer
Publisher :
ISBN 13 :
Total Pages : 894 pages
Book Rating : 4.A/5 ( download)

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Book Synopsis A Text-book of Practical Medicine by : Felix von Niemeyer

Download or read book A Text-book of Practical Medicine written by Felix von Niemeyer and published by . This book was released on 1883 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Text-book of practical medicine, with particular reference to physiology and pathological anatomy v. 1

Author : Felix von Niemeyer
Publisher :
ISBN 13 :
Total Pages : 814 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis A Text-book of practical medicine, with particular reference to physiology and pathological anatomy v. 1 by : Felix von Niemeyer

Download or read book A Text-book of practical medicine, with particular reference to physiology and pathological anatomy v. 1 written by Felix von Niemeyer and published by . This book was released on 1883 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles and Practice of Hospital Medicine

Author : Sylvia McKean
Publisher : McGraw Hill Professional
ISBN 13 : 0071603905
Total Pages : 2351 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Principles and Practice of Hospital Medicine by : Sylvia McKean

Download or read book Principles and Practice of Hospital Medicine written by Sylvia McKean and published by McGraw Hill Professional. This book was released on 2011-12-30 with total page 2351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to the knowledge and skills necessary to practice Hospital Medicine Presented in full color and enhanced by more than 700 illustrations, this authoritative text provides a background in all the important clinical, organizational, and administrative areas now required for the practice of hospital medicine. The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Each chapter opens with boxed Key Clinical Questions that are addressed in the text and hundreds of tables encapsulate important information. Case studies demonstrate how to apply the concepts covered in the text directly to the hospitalized patient. Principles and Practice of Hospital Medicine is divided into six parts: Systems of Care: Introduces key issues in Hospital Medicine, patient safety, quality improvement, leadership and practice management, professionalism and medical ethics, medical legal issues and risk management, teaching and development. Medical Consultation and Co-Management: Reviews core tenets of medical consultation, preoperative assessment and management of post-operative medical problems. Clinical Problem-Solving in Hospital Medicine: Introduces principles of evidence-based medicine, quality of evidence, interpretation of diagnostic tests, systemic reviews and meta-analysis, and knowledge translations to clinical practice. Approach to the Patient at the Bedside: Details the diagnosis, testing, and initial management of common complaints that may either precipitate admission or arise during hospitalization. Hospitalist Skills: Covers the interpretation of common “low tech” tests that are routinely accessible on admission, how to optimize the use of radiology services, and the standardization of the execution of procedures routinely performed by some hospitalists. Clinical Conditions: Reflects the expanding scope of Hospital Medicine by including sections of Emergency Medicine, Critical Care, Geriatrics, Neurology, Palliative Care, Pregnancy, Psychiatry and Addiction, and Wartime Medicine.

Practical Psychopharmacology

Author : Joseph F. Goldberg
Publisher : Cambridge University Press
ISBN 13 : 1108450741
Total Pages : 611 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Practical Psychopharmacology by : Joseph F. Goldberg

Download or read book Practical Psychopharmacology written by Joseph F. Goldberg and published by Cambridge University Press. This book was released on 2021-04-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.

Clinical Small Animal Internal Medicine

Author : David Bruyette
Publisher : John Wiley & Sons
ISBN 13 : 1118497031
Total Pages : 5143 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Clinical Small Animal Internal Medicine by : David Bruyette

Download or read book Clinical Small Animal Internal Medicine written by David Bruyette and published by John Wiley & Sons. This book was released on 2020-03-25 with total page 5143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Small Animal Internal Medicine is a comprehensive, practical reference designed to meet the needs of veterinary practitioners and students alike. Covering all aspects of small animal internal medicine, this innovative guide provides clinically relevant material, plus podcasts and continual updates online. Concise, identically-formatted chapters allow readers to quickly find the most essential information for clinical veterinary practice. Contributions from academic and clinical experts cover general medicine subjects, including patient evaluation and management, critical care medicine, preventative care, and diagnostic and therapeutic considerations. Topics relevant to daily clinical practice are examined in detail, ranging from endocrine, cardiovascular, respiratory, and infectious disease to oncology, dermatology, metabolic orthopedic disease, gastroenterology, and hepatology. A companion website features podcasts and updated information. An important addition to the library of any practice, this clinically-oriented text: Presents complete, practical information on small animal internal medicine Provides the background physiology required to understand normal versus abnormal in real-world clinical settings Includes general medicine topics not covered in other internal medicine books Focuses on information that is directly applicable to daily practice Features podcasts and continual updates on a companion website Carefully tailored for the needs of small animal practitioners and veterinary students, Clinical Small Animal Internal Medicine is an invaluable, reader-friendly reference on internal medicine of the dog and cat.

Veterinary Medicine

Author : Peter D. Constable
Publisher : Elsevier Health Sciences
ISBN 13 : 0702070580
Total Pages : 2358 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Veterinary Medicine by : Peter D. Constable

Download or read book Veterinary Medicine written by Peter D. Constable and published by Elsevier Health Sciences. This book was released on 2016-10-25 with total page 2358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treat the diseases affecting large animals! Veterinary Medicine, 11th Edition provides up-to-date information on the diseases of horses, cattle, sheep, goats, and pigs. Comprehensive coverage includes the principles of clinical examination and making a diagnosis, along with specific therapy recommendations. For easier use, this edition has been divided into two volumes and restructured into a logical, anatomically based approach to disease. From internationally known veterinary experts Peter Constable, Kenneth Hinchcliff, Stanley Done, and Walter Grünberg, this book is the definitive, one-stop reference for farm animal and equine care. Comprehensive coverage includes information essential to any large-animal veterinarian, especially those working with horses, cattle, sheep, goats, or pigs. Coverage of diseases addresses major large-animal diseases of all countries, including foreign animal and emerging diseases. User-friendly format makes it easier to quickly absorb key information. Quick review/synopsis sections make important information on complex diseases easy to find. NEW! Convenient, easy-access format is organized by organ systems, and divides the content into two compact volumes with the same authoritative coverage. Nearly 200 new color photographs and line drawings are included in this edition. NEW full-color design improves navigation, clarifies subject headings, and includes more boxes, tables, and charts for faster reference. New Diseases Primarily Affecting the Reproductive System chapter is added. Updated and expanded chapter on pharmacotherapy lists therapeutic interventions and offers treatment boxes and principles of antibiotic use. Expanded sections on herd health include biosecurity and infection control, and valuable Strength of Evidence boxes. NEW or extensively revised sections include topics such as the Schmallenberg and Bluetongue viral epidemics of ruminants in Europe, Wesselbron disease in cattle, hypokalemia in adult cattle, equine multinodular pulmonary fibrosis, Hendra virus infection, porcine reproductive and respiratory syndrome, torque teno virus, and numerous recently identified congenital and inherited disorders of large animals. Additional content is provided on lameness in cattle and the diseases of cervids.

Practical Guide to Traditional Chinese Veterinary Medicine Vol. 2 Small Animal Practice

Author : Huisheng Xie
Publisher :
ISBN 13 : 9781934786451
Total Pages : 1001 pages
Book Rating : 4.7/5 (864 download)

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Book Synopsis Practical Guide to Traditional Chinese Veterinary Medicine Vol. 2 Small Animal Practice by : Huisheng Xie

Download or read book Practical Guide to Traditional Chinese Veterinary Medicine Vol. 2 Small Animal Practice written by Huisheng Xie and published by . This book was released on 2014-11-01 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analytic Cyclopedia of Practical Medicine

Author : Charles Eucharist de Medicis Sajous
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (147 download)

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Book Synopsis Analytic Cyclopedia of Practical Medicine by : Charles Eucharist de Medicis Sajous

Download or read book Analytic Cyclopedia of Practical Medicine written by Charles Eucharist de Medicis Sajous and published by . This book was released on 1927 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)

Author : J. Larry Jameson
Publisher : McGraw-Hill Education / Medical
ISBN 13 : 9781259644030
Total Pages : 4048 pages
Book Rating : 4.6/5 (44 download)

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Book Synopsis Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) by : J. Larry Jameson

Download or read book Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) written by J. Larry Jameson and published by McGraw-Hill Education / Medical. This book was released on 2018-08-13 with total page 4048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms A Doody's Core Title for 2019! Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patien

Foundations of Orientation and Mobility

Author : William R. Wiener
Publisher : American Foundation for the Blind
ISBN 13 : 0891284486
Total Pages : 722 pages
Book Rating : 4.8/5 (912 download)

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Book Synopsis Foundations of Orientation and Mobility by : William R. Wiener

Download or read book Foundations of Orientation and Mobility written by William R. Wiener and published by American Foundation for the Blind. This book was released on 2010 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundations of Orientation and Mobility, the classic professional reference and textbook has been completely revised and expanded to two volumes by the most knowledgeable experts in the field. The new third edition includes both the latest research in O&M and expanded information on practice and teaching strategies. Volume 1, History and Theory, includes the bases of O&M knowledge, including perception, orientation, low vision, audition, kinesiology, psychosocial issues, and learning theories, as well as chapters on technology, dog guides, orientation aids, and environmental accessibility. A section on the profession of O&M includes its international history; administration, assessment and program planning; and a chapter on research in O&M. No O&M student or professional can afford to be without this essential resource.

Harrisons Manual of Medicine, 20th Edition

Author : Dennis L. Kasper
Publisher : McGraw Hill Professional
ISBN 13 : 1260455351
Total Pages : 1277 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Harrisons Manual of Medicine, 20th Edition by : Dennis L. Kasper

Download or read book Harrisons Manual of Medicine, 20th Edition written by Dennis L. Kasper and published by McGraw Hill Professional. This book was released on 2019-10-22 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the authority of the most trusted brand in medical content in a convenient, portable guide A Doody's Core Titles for 2023! The Harrison’s Manual, derived from most clinically salient content featured in Harrison's Principles of Internal Medicine, 20th Edition, delivers numerous clinical algorithms in one practical, portable resource. The Manual also includes abundant quick reference tables, plus concise text—providing rapid access to bedside information when decisions need to be made quickly. This full color summary guide covers all diseases and conditions commonly seen in inpatient general medicine, so you can be sure to find invaluable content directly to your workflow and practice. The 20th edition has been updated to reflect the latest clinical developments in medicine. The Manual truly makes it easy to find what you need at the point of care. The easy-to-navigate chapters cover symptoms/signs, medical emergencies, specific diseases, and care of the hospitalized patient, with a particular focus on: Etiology and Epidemiology Clinically Relevant Pathophysiology Signs and Symptoms Differential Diagnosis Physical and Laboratory Findings Therapeutics Practice Guidelines, and more

A System of Theoretical and Practical Chemistry

Author : Friedrich Christian Accum
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (334 download)

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Book Synopsis A System of Theoretical and Practical Chemistry by : Friedrich Christian Accum

Download or read book A System of Theoretical and Practical Chemistry written by Friedrich Christian Accum and published by . This book was released on 1803 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Prediction Models

Author : Ewout W. Steyerberg
Publisher : Springer
ISBN 13 : 3030163997
Total Pages : 574 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Clinical Prediction Models by : Ewout W. Steyerberg

Download or read book Clinical Prediction Models written by Ewout W. Steyerberg and published by Springer. This book was released on 2019-07-22 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice. There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include: • A discussion of Big Data and its implications for the design of prediction models • Machine learning issues • More simulations with missing ‘y’ values • Extended discussion on between-cohort heterogeneity • Description of ShinyApp • Updated LASSO illustration • New case studies