A Study Of The Chemistry Of Quinone Methides

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Quinone Methides

Author : S. E. Rokita
Publisher : John Wiley & Sons
ISBN 13 : 9780470452875
Total Pages : 456 pages
Book Rating : 4.4/5 (528 download)

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Book Synopsis Quinone Methides by : S. E. Rokita

Download or read book Quinone Methides written by S. E. Rokita and published by John Wiley & Sons. This book was released on 2009-02-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidisciplinary perspectives and approaches to quinone methides research The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. This inaugural volume in the series, Quinone Methides, represents the first book devoted to this fascinating and useful intermediate. The authors of this work reflect the many disciplines and approaches to quinone methides research. The volume therefore covers a broad range of topics, including theoretical treatments, generation and detection of intermediates, characterization and applications in chemistry and biochemistry, and biological reactivity. Among the chapters are: Photochemical generation and characterization of quinone methides Quinone methide stabilization by metal complexation Self-immolative dendrimers based on quinone methides Characterization of quinone methides by spectral global fitting and 13C labeling Formation and reactions of xenobiotic quinone methides in biology Quinone methides in lignification With this collection of topics, readers already familiar with quinone methides have the opportunity to advance their own research by discovering new inspiration and opportunities in allied areas. Moreover, the range of topics and perspectives covered make this volume accessible to readers with a broad range of interests, including organic and physical chemistry, biochemistry, biotechnology, and pharmaceutics.

A study of the chemistry of quinone methides

Author : Stanley Bruce Cavitt
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (443 download)

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Book Synopsis A study of the chemistry of quinone methides by : Stanley Bruce Cavitt

Download or read book A study of the chemistry of quinone methides written by Stanley Bruce Cavitt and published by . This book was released on 1961 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies in quinone methide chemistry

Author : Ashot Merijan
Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.:/5 (446 download)

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Book Synopsis Studies in quinone methide chemistry by : Ashot Merijan

Download or read book Studies in quinone methide chemistry written by Ashot Merijan and published by . This book was released on 1962 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Study of the Synthesis and Chemistry of Iron Complexed Aromatic Annulated 5-membered Quinone Methide Analogs

Author : Steven Ryan Neal
Publisher :
ISBN 13 : 9781109827453
Total Pages : 111 pages
Book Rating : 4.8/5 (274 download)

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Book Synopsis A Study of the Synthesis and Chemistry of Iron Complexed Aromatic Annulated 5-membered Quinone Methide Analogs by : Steven Ryan Neal

Download or read book A Study of the Synthesis and Chemistry of Iron Complexed Aromatic Annulated 5-membered Quinone Methide Analogs written by Steven Ryan Neal and published by . This book was released on 2006 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study of the synthesis and chemistry of iron complexed 5-membered ring analogs of a class of compounds known as quinone methides, more specifically ortho-quinone methides, is reported. Ortho-quinone methide intermediates are synthetically and biologically important. They are believed to be a key moiety in selected antitumor drugs during their metabolism processes. We report on the study of the synthesis of iron complexed aromatic annulated vinylallene sigma complexes from the treatment of CpFe(CO)2I and the respective lithiovinylallene, as well as their conversion to iron complexed 5-membered ring quinone methide analogs. We also report on the study of the chemistry of an iron complexed benzene annulated 5-membered ring quinone methide analog with tetrafluoroboric acid, diethylamine, N-methylmaleimide, tetracyanoethylene, dihydropyran, N-methylmorpholine-N-oxide, and ceric ammonium nitrate.

The chemistry of quinone methides and quinodimethanes

Author : Hossein Sarrafizadeh Rafsanjani
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (378 download)

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Book Synopsis The chemistry of quinone methides and quinodimethanes by : Hossein Sarrafizadeh Rafsanjani

Download or read book The chemistry of quinone methides and quinodimethanes written by Hossein Sarrafizadeh Rafsanjani and published by . This book was released on 1960 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies of Lightly Substituted Ortho Quinone Methides

Author : Richard William Morrison
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (215 download)

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Book Synopsis Studies of Lightly Substituted Ortho Quinone Methides by : Richard William Morrison

Download or read book Studies of Lightly Substituted Ortho Quinone Methides written by Richard William Morrison and published by . This book was released on 1990 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chemistry of Some Quinone Methides

Author : Gavin MacNicol Buchan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (646 download)

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Book Synopsis The Chemistry of Some Quinone Methides by : Gavin MacNicol Buchan

Download or read book The Chemistry of Some Quinone Methides written by Gavin MacNicol Buchan and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quinone Methides

Author : Wenjin Yang
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Quinone Methides by : Wenjin Yang

Download or read book Quinone Methides written by Wenjin Yang and published by . This book was released on 1991 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chemistry of the Quinonoid Compounds

Author : Saul Patai
Publisher :
ISBN 13 :
Total Pages : 680 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis The Chemistry of the Quinonoid Compounds by : Saul Patai

Download or read book The Chemistry of the Quinonoid Compounds written by Saul Patai and published by . This book was released on 1974 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Biological Chemistry of Quinone Methides and Benzisoxazoles

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis The Biological Chemistry of Quinone Methides and Benzisoxazoles by :

Download or read book The Biological Chemistry of Quinone Methides and Benzisoxazoles written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quinone Methides

Author : Mariia Vladimirovna Sutton
Publisher :
ISBN 13 :
Total Pages : 54 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Quinone Methides by : Mariia Vladimirovna Sutton

Download or read book Quinone Methides written by Mariia Vladimirovna Sutton and published by . This book was released on 2019 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Efficient generation of quinone methides (QMs) from quinone methide precursors (QMPs) under mild conditions, such as reagent free UV-light irradiation, and exceptional reactivity of QMs towards nucleophiles and, in case of o-QMs, towards dienophiles have attracted a lot of attention to these compounds in computation, chemical, biological and engineering spheres. Our research group has demonstrated successful application of o-napthoquinone methide precursors (o-NQMPs) as photolabile protecting groups (PPGs) and linkers, that can be employed in the design of multifunctional surfaces, used as PPGs for biological molecules that carry different functional groups and as a linker for peptide and protein reversible modification. o-QMs and p-QMs demonstrate different chemical properties and different reactivity. However, to the best of our knowledge, the molecules containing competing o-NQM and p-QM moieties, have not been studied. Thus, the major goal of the first project was to develop and synthesize novel QMPs with ability to generate o-NQM and p-QM under light irradiation. Physical properties, chemical properties, such as ability to react with nucleophiles and undergo inter- and intra-molecular Diels-Alder reaction, as well as kinetic behavior of new QM-system have been studied. We were also interested in investigating the ability of o-NQMPs decorated with thiol moieties to form "smart" polymers, that could be generated upon UV-light irradiation. The photo-induced degradation of the polymers could be achieved on demand upon light irradiation in the presence of vinyl ethers. Unfortunately, light-induced polymerization of the synthesized monomers resulted in exclusive formation of oligomers. Another project has been focused on the development of a novel photocleavable analog of calcium-selective chelating ligand, which was based on the combination of properties of photolabile 3-(hydroxymethyl)-2-naphthol core and high calcium affinity of 1,2-bis(o-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid (BAPTA). Finally, we have worked towards the design of a new fluorogenic PPG that could also serve as an intracellular pH indicator. 9H-xanthene-1,8,9-triol derivatives can be considered as photoactivatable fluorophores and fluorogenic PPGs, as 9H-xanthen-1,8,9-triols are expected to generate relatively stable quinone methide upon UV-light irradiation. Due to its structural similarity with fluorescein derivatives, we expected 8-hydroxy-1H-xanthen-1-one to be highly fluorescent. However, attempted synthesis resulted in the formation of a different unexpected product.

Studies on the Novel Condensation Reactions of Photochemically Generated O̲-quinone Methide

Author : Tom Livinghouse
Publisher :
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Studies on the Novel Condensation Reactions of Photochemically Generated O̲-quinone Methide by : Tom Livinghouse

Download or read book Studies on the Novel Condensation Reactions of Photochemically Generated O̲-quinone Methide written by Tom Livinghouse and published by . This book was released on 1977 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Photogeneration and Chemistry of Quinone Methides from Hydroxybenzyl Alcohols

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Photogeneration and Chemistry of Quinone Methides from Hydroxybenzyl Alcohols by :

Download or read book Photogeneration and Chemistry of Quinone Methides from Hydroxybenzyl Alcohols written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies on New Aspects of Quinone Chemistry

Author : Sanjay S
Publisher : Independent Author
ISBN 13 : 9781805247951
Total Pages : 0 pages
Book Rating : 4.2/5 (479 download)

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Book Synopsis Studies on New Aspects of Quinone Chemistry by : Sanjay S

Download or read book Studies on New Aspects of Quinone Chemistry written by Sanjay S and published by Independent Author. This book was released on 2023-03-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quinones are organic compounds that are formally derived from aromatic compounds such as benzene or naphthalene. During the conversion, an even number of (CH) groups are oxidised into (C=O) groups and necessary double bonds are rearranged to get fully conjugated cyclic dione structure1. Apart from this, organic molecules such as phenols and catechols having electron donating substituents are easily oxidized to quinones. The electron donating substituents increase the nucleophilicity of the ring and contributes to the large redox potential needed to break the aromaticity (quinones are conjugated but not aromatic). Many natural and artificial colouring substances (dyes and pigments) are quinone derivatives. They are next to azo dyes in importance as dyestuffs with particular emphasis on blue colours. Alizarin {1,2-dihydroxy-9,10-anthraquinone} (8), extracted from the madder plant, was the first natural dye to be synthesized from anthracene. This was used as the prominent red dye for dyeing textile fabrics.

Metabolism of Drugs and Other Xenobiotics

Author : Pavel Anzenbacher
Publisher : John Wiley & Sons
ISBN 13 : 352732903X
Total Pages : 755 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Metabolism of Drugs and Other Xenobiotics by : Pavel Anzenbacher

Download or read book Metabolism of Drugs and Other Xenobiotics written by Pavel Anzenbacher and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.

Highlights in Bioorganic Chemistry

Author : Carsten Schmuck
Publisher : John Wiley & Sons
ISBN 13 : 3527604081
Total Pages : 600 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Highlights in Bioorganic Chemistry by : Carsten Schmuck

Download or read book Highlights in Bioorganic Chemistry written by Carsten Schmuck and published by John Wiley & Sons. This book was released on 2006-01-24 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a fascinating introduction to the topic. Spanning the spectrum of nucleic acid chemistry, carbohydrates, peptides, molecular recognition, biosynthesis and natural biosynthesis, right up to medical and biophysical chemistry, the book provides advanced students and those already working in the field with a balanced overview. In more than 30 contributions, a new generation of recognized scientists gives an account of the latest research in such areas as * Artificial receptors for the stabilization of ß-sheet structures * Carbohydrate recognition by artificial receptors * Combinatorial chemistry as a tool for the discovery of catalysts * The interaction of NO and peroxynitrite with hemoglobin and myoglobin * Inhibitors against human mast-cell-tryptase as a potential approach to conquering asthma * The selectivity of DNA replication. A readily accessible survey for everyone wishing to stay abreast of developments. With a Foreword by Ronald Breslow.

Activity-Based Proteomics

Author : Herman S. Overkleeft
Publisher : Humana Press
ISBN 13 : 9781493982004
Total Pages : 222 pages
Book Rating : 4.9/5 (82 download)

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Book Synopsis Activity-Based Proteomics by : Herman S. Overkleeft

Download or read book Activity-Based Proteomics written by Herman S. Overkleeft and published by Humana Press. This book was released on 2018-07-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Activity-Based Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.