A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease

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Author :
Publisher : Academic Press
ISBN 13 : 012812797X
Total Pages : 162 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease by : Paul J. Marangos

Download or read book A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease written by Paul J. Marangos and published by Academic Press. This book was released on 2017-04-25 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society – splitting the atom, space travel, telecommunications, and the Internet – but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity. This work contains the views and opinions of the author and are in no way intended to harm the reputation of any person, agency, organization, or commercial entity discussed herein. www.cureterminaldisease.com - First comprehensive analysis of the failures in curing cancer, Alzheimer's, and cardiovascular disease with solutions proposed - Defines deficiencies in academic life science research, including conflicting incentives, QA/QC issues, and how to fix them - Provides a rationale for FDA reform especially as it relates to terminal disease drugs - Details how a reformed NIH, regulators, and industry can partner to form a NASA-type effort to speed cures of terminal diseases - Provides the first detailed roadmap for life science researchers to conquer terminal disease

Alzheimer's Disease Drug Development

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Publisher : Cambridge University Press
ISBN 13 : 1108838669
Total Pages : 575 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Alzheimer's Disease Drug Development by : Jeffrey Cummings

Download or read book Alzheimer's Disease Drug Development written by Jeffrey Cummings and published by Cambridge University Press. This book was released on 2022-03-31 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Prevention and Treatment of Atherosclerosis

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Publisher : Springer Nature
ISBN 13 : 3030860760
Total Pages : 537 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Prevention and Treatment of Atherosclerosis by : Arnold von Eckardstein

Download or read book Prevention and Treatment of Atherosclerosis written by Arnold von Eckardstein and published by Springer Nature. This book was released on 2022 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

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Publisher : Academic Press
ISBN 13 : 012823122X
Total Pages : 322 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases by :

Download or read book Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases written by and published by Academic Press. This book was released on 2020-08-25 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more. - Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases - Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases

Early Diagnosis of Alzheimer's Disease

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Author :
Publisher : Springer Science & Business Media
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Early Diagnosis of Alzheimer's Disease by : Leonard F. M. Scinto

Download or read book Early Diagnosis of Alzheimer's Disease written by Leonard F. M. Scinto and published by Springer Science & Business Media. This book was released on 2000-02-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three major approaches to diagnosis of AD -- radiological, biological, and neurophysiological -- are discussed in detail with chapters highlighting the most promising technologies within these approaches. The leading authors, all of whom are intimately involved with these emerging technologies, have developed this as an essential reference for neuropathologists, clinicians and researchers of Alzheimer's disease.

The Alzheimer's Solution

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Publisher : HarperCollins
ISBN 13 : 0062666495
Total Pages : 218 pages
Book Rating : 4.0/5 (626 download)

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Book Synopsis The Alzheimer's Solution by : Dean Sherzai

Download or read book The Alzheimer's Solution written by Dean Sherzai and published by HarperCollins. This book was released on 2017-09-12 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: A revolutionary, proven program for reversing the symptoms of Alzheimer's disease and cognitive decline from award winning neurologists and codirectors of the Brain Health and Alzheimer's Prevention Program at Loma Linda University Medical Center Over 47 million people are currently living with Alzheimer’s disease worldwide. While all other major diseases are in decline, deaths from Alzheimer’s have increased radically. What you or your loved ones don’t yet know is that 90 percent of Alzheimer’s cases can be prevented. Based on the largest clinical and observational study to date, neurologists and codirectors of the Brain Health and Alzheimer’s Prevention Program at Loma Linda University Medical Center, Drs. Dean and Ayesha Sherzai, offer in The Alzheimer’s Solution the first comprehensive program for preventing Alzheimer’s disease and improving cognitive function. Alzheimer’s disease isn’t a genetic inevitability, and a diagnosis does not need to come with a death sentence. Ninety percent of grandparents, parents, husbands, and wives can be spared. Ninety percent of us can avoid ever getting Alzheimer’s, and for the 10 percent with strong genetic risk for cognitive decline, the disease can be delayed by ten to fifteen years. This isn’t an estimate or wishful thinking; it’s a percentage based on rigorous science and the remarkable results the Sherzais have seen firsthand in their clinic. This much-needed revolutionary book reveals how the brain is a living universe, directly influenced by nutrition, exercise, stress, sleep, and engagement. In other words: what you feed it, how you treat it, when you challenge it, and the ways in which you allow it to rest. These factors are the pillars of the groundbreaking program you’ll find in these pages, which features a personalized assessment for evaluating risk, a five-part program for prevention and symptom-reversal, and day-by-day guides for optimizing cognitive function. You can prevent Alzheimer’s disease from affecting you, your family, friends, and loved ones. Even with a diagnosis, you can reverse cognitive decline and add vibrant years to your life. The future of your brain is finally within your control.

Reducing the Impact of Dementia in America

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Publisher :
ISBN 13 : 9780309495035
Total Pages : pages
Book Rating : 4.4/5 (95 download)

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Book Synopsis Reducing the Impact of Dementia in America by : National Academies of Sciences Engineering and Medicine

Download or read book Reducing the Impact of Dementia in America written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2022-04-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As the largest generation in U.S. history - the population born in the two decades immediately following World War II - enters the age of risk for cognitive impairment, growing numbers of people will experience dementia (including Alzheimer's disease and related dementias). By one estimate, nearly 14 million people in the United States will be living with dementia by 2060. Like other hardships, the experience of living with dementia can bring unexpected moments of intimacy, growth, and compassion, but these diseases also affect people's capacity to work and carry out other activities and alter their relationships with loved ones, friends, and coworkers. Those who live with and care for individuals experiencing these diseases face challenges that include physical and emotional stress, difficult changes and losses in their relationships with life partners, loss of income, and interrupted connections to other activities and friends. From a societal perspective, these diseases place substantial demands on communities and on the institutions and government entities that support people living with dementia and their families, including the health care system, the providers of direct care, and others. Nevertheless, research in the social and behavioral sciences points to possibilities for preventing or slowing the development of dementia and for substantially reducing its social and economic impacts. At the request of the National Institute on Aging of the U.S. Department of Health and Human Services, Reducing the Impact of Dementia in America assesses the contributions of research in the social and behavioral sciences and identifies a research agenda for the coming decade. This report offers a blueprint for the next decade of behavioral and social science research to reduce the negative impact of dementia for America's diverse population. Reducing the Impact of Dementia in America calls for research that addresses the causes and solutions for disparities in both developing dementia and receiving adequate treatment and support. It calls for research that sets goals meaningful not just for scientists but for people living with dementia and those who support them as well. By 2030, an estimated 8.5 million Americans will have Alzheimer's disease and many more will have other forms of dementia. Through identifying priorities social and behavioral science research and recommending ways in which they can be pursued in a coordinated fashion, Reducing the Impact of Dementia in America will help produce research that improves the lives of all those affected by dementia.

Translational Research in Biomedical Sciences: Recent Progress and Future Prospects

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Author :
Publisher : Springer Nature
ISBN 13 : 9819717779
Total Pages : 385 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Translational Research in Biomedical Sciences: Recent Progress and Future Prospects by : Krupakar Parthasarathy

Download or read book Translational Research in Biomedical Sciences: Recent Progress and Future Prospects written by Krupakar Parthasarathy and published by Springer Nature. This book was released on with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Healthy lives, healthy people

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Author :
Publisher : The Stationery Office
ISBN 13 : 9780101798525
Total Pages : 104 pages
Book Rating : 4.7/5 (985 download)

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Book Synopsis Healthy lives, healthy people by : Great Britain: Department of Health

Download or read book Healthy lives, healthy people written by Great Britain: Department of Health and published by The Stationery Office. This book was released on 2010-11-30 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Government recognises that many lifestyle-driven health problems are at alarming levels: obesity; high rates of sexually transmitted infections; a relatively large population of drug users; rising levels of harm from alcohol; 80,000 deaths a year from smoking; poor mental health; health inequalities between rich and poor. This white paper outlines the Government's proposals to protect the population from serious health threats; help people live longer, healthier and more fulfilling lives; and improve the health of the poorest. It aims to empower individuals to make healthy choices and give communities and local government the freedom, responsibility and funding to innovate and develop ways of improving public health in their area. The paper responds to Sir Michael Marmot's strategic review of health inequalities in England post 2010 - "Fair society, healthy lives" (available at http://www.marmotreview.org/AssetLibrary/pdfs/Reports/FairSocietyHealthyLives.pdf) and adopts its life course framework for tackling the wider social determinants of health. A new dedicated public health service - Public Health England - will be created to ensure excellence, expertise and responsiveness, particularly on health protection where a national response is vital. The paper gives a timetable showing how the proposals will be implemented and an annex sets out a vision of the role of the Director of Public Health. The Department is also publishing a fuller story on the health of England in "Our health and wellbeing today" (http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/@ps/documents/digitalasset/dh_122238.pdf), detailing the challenges and opportunities, and in 2011 will issue documents on major public health issues.

Global Status Report on Noncommunicable Diseases 2014

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Publisher :
ISBN 13 : 9789241564854
Total Pages : 0 pages
Book Rating : 4.5/5 (648 download)

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Book Synopsis Global Status Report on Noncommunicable Diseases 2014 by : World Health Organization

Download or read book Global Status Report on Noncommunicable Diseases 2014 written by World Health Organization and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This global status report on prevention and control of NCDs (2014), is framed around the nine voluntary global targets. The report provides data on the current situation, identifying bottlenecks as well as opportunities and priority actions for attaining the targets. The 2010 baseline estimates on NCD mortality and risk factors are provided so that countries can report on progress, starting in 2015. In addition, the report also provides the latest available estimates on NCD mortality (2012) and risk factors, 2010-2012. All ministries of health need to set national NCD targets and lead the development and implementation of policies and interventions to attain them. There is no single pathway to attain NCD targets that fits all countries, as they are at different points in their progress in the prevention and control of NCDs and at different levels of socioeconomic development. However all countries can benefit from the comprehensive response to attaining the voluntary global targets presented in this report.--Publisher description.

Keeping Love Alive as Memories Fade

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Publisher : Moody Publishers
ISBN 13 : 0802494412
Total Pages : 275 pages
Book Rating : 4.8/5 (24 download)

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Book Synopsis Keeping Love Alive as Memories Fade by : Gary Chapman

Download or read book Keeping Love Alive as Memories Fade written by Gary Chapman and published by Moody Publishers. This book was released on 2016-09-16 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Across America and around the world, the five love languages have revitalized relationships and saved marriages from the brink of disaster. Can they also help individuals, couples, and families cope with the devastating diagnosis of Alzheimer's disease (AD)? Coauthors Chapman, Shaw, and Barr give a resounding yes. Their innovative application of the five love languages creates an entirely new way to touch the lives of the five million Americans who have Alzheimer’s, as well as their fifteen million caregivers. At its heart, this book is about how love gently lifts a corner of dementia’s dark curtain to cultivate an emotional connection amid memory loss. This collaborative, groundbreaking work between a healthcare professional, caregiver, and relationship expert will: Provide an overview of the love languages and Alzheimer’s disease, correlate the love languages with the developments of the stages of AD, discuss how both the caregiver and care receiver can apply the love languages, address the challenges and stresses of the caregiver journey, offer personal stories and case studies about maintaining emotional intimacy amidst AD. Keeping Love Alive as Memories Fade is heartfelt and easy to apply, providing gentle, focused help for those feeling overwhelmed by the relational toll of Alzheimer’s. Its principles have already helped hundreds of families, and it can help yours, too.

Diet and Cognitive Decline

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Publisher : Nova Publishers
ISBN 13 : 9781594541216
Total Pages : 188 pages
Book Rating : 4.5/5 (412 download)

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Book Synopsis Diet and Cognitive Decline by : Francesco Panza

Download or read book Diet and Cognitive Decline written by Francesco Panza and published by Nova Publishers. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The progressive ageing of the general population and the consequent increase of the number of old people has made the typical medical problems of aged people more frequently observed, and particularly the problems related to the ageing brain. This new book is an updated overview of relevant aspects of cognitive decline associated with ageing. Within the wide landscape of brain ageing the authors reconsider the role of the main predisposing factors and risk factors on the development of various form of mental decline, from mild cognitive impairment to dementia. The strength of this book is the large, updated overview of the most recent data of scientific literature regarding the role of genetic, metabolic and environmental factors on the predisposition and onset of cognitive decline. Particular attention is paid to the dietary micro- and macronutrients and to their possible role in the pathogenesis of the various form of dementigen disorders.

The Role of NIH in Drug Development Innovation and Its Impact on Patient Access

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Author :
Publisher : National Academies Press
ISBN 13 : 0309498511
Total Pages : 103 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Role of NIH in Drug Development Innovation and Its Impact on Patient Access by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Role of NIH in Drug Development Innovation and Its Impact on Patient Access written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.

The XX Brain

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Publisher : Penguin
ISBN 13 : 0593542134
Total Pages : 369 pages
Book Rating : 4.5/5 (935 download)

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Book Synopsis The XX Brain by : Lisa Mosconi PhD

Download or read book The XX Brain written by Lisa Mosconi PhD and published by Penguin. This book was released on 2022-11-08 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times bestseller! "In The XX Brain, Lisa meticulously guides us in the ways we can both nourish and protect ourselves, body and mind, to ensure our brains remain resilient throughout our lives." --from the foreword by Maria Shriver The first book to address cognitive enhancement and Alzheimer's prevention specifically in women--and to frame brain health as an essential component of Women's Health. In this revolutionary book, Dr. Lisa Mosconi, director of the Women's Brain Initiative at Weill Cornell Medical College, provides women with the first plan to address the unique risks of the female brain. Until now, medical research has focused on "bikini medicine," assuming that women are essentially men with breasts and tubes. Yet women are far more likely than men to suffer from anxiety, depression, migraines, brain injuries, and strokes. They are also twice as likely to end their lives suffering from Alzheimer's disease, even when their longer lifespans are taken into account. But in the past, the female brain has received astonishingly little attention and was rarely studied by medical researchers-- resulting in a wealth of misinformation about women's health. The XX Brain confronts this crisis by revealing how the two powerful X chromosomes that distinguish women from men impact the brain first and foremost and by focusing on a key brain-protective hormone: estrogen. Taking on all aspects of women's health, including brain fog, memory lapses, depression, stress, insomnia, hormonal imbalances, and the increased risk of dementia, Dr. Mosconi introduces cutting-edge, evidence-based approaches to protecting the female brain, including a specific diet proven to work for women, strategies to reduce stress, and useful tips for restorative sleep. She also examines the controversy about soy and hormonal replacement therapy, takes on the perils of environmental toxins, and examines the role of our microbiome. Perhaps best of all, she makes clear that it is never too late to take care of yourself. The XX Brain is a rallying cry for women to have full access to information regarding what is going on in their brains and bodies as well as a roadmap for the path to optimal, lifelong brain health.

A Human Health Perspective on Climate Change

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Author :
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis A Human Health Perspective on Climate Change by : Interagency Working Group on Climate Change and Health (U.S.)

Download or read book A Human Health Perspective on Climate Change written by Interagency Working Group on Climate Change and Health (U.S.) and published by . This book was released on 2010 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Jan's Story

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Publisher : Behler Publications
ISBN 13 : 1933016442
Total Pages : 226 pages
Book Rating : 4.9/5 (33 download)

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Book Synopsis Jan's Story by : Barry Rex Petersen

Download or read book Jan's Story written by Barry Rex Petersen and published by Behler Publications. This book was released on 2010 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: CBS News correspondent Barry Petersen tells the tender story of his wife's battle with Early Onset Alzheimer's.

On Pluto: Inside the Mind of Alzheimer's

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Author :
Publisher : Good Night books
ISBN 13 : 0991340191
Total Pages : 332 pages
Book Rating : 4.9/5 (913 download)

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Book Synopsis On Pluto: Inside the Mind of Alzheimer's by : Greg O'Brien

Download or read book On Pluto: Inside the Mind of Alzheimer's written by Greg O'Brien and published by Good Night books. This book was released on 2018-02-27 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about living with Alzheimer’s, not dying with it. It is a book about hope, faith, and humor—a prescription far more powerful than the conventional medication available today to fight this disease. Alzheimer’s is the sixth leading cause of death in the US—and the only one of these diseases on the rise. More than 5 million Americans have been diagnosed with Alzheimer’s or a related dementia; about 35 million people worldwide. Greg O’Brien, an award-winning investigative reporter, has been diagnosed with early-onset Alzheimer's and is one of those faceless numbers. Acting on long-term memory and skill coupled with well-developed journalistic grit, O’Brien decided to tackle the disease and his imminent decline by writing frankly about the journey. O’Brien is a master storyteller. His story is naked, wrenching, and soul searching for a generation and their loved ones about to cross the threshold of this death in slow motion. On Pluto: Inside the Mind of Alzheimer’s is a trail-blazing roadmap for a generation—both a “how to” for fighting a disease, and a “how not” to give up!