A Guide To Sample Size For Animal Based Studies

Download A Guide To Sample Size For Animal Based Studies full books in PDF, epub, and Kindle. Read online A Guide To Sample Size For Animal Based Studies ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

A Guide to Sample Size for Animal-based Studies

Author : Penny S. Reynolds
Publisher : John Wiley & Sons
ISBN 13 : 111979997X
Total Pages : 294 pages
Book Rating : 4.1/5 (197 download)

DOWNLOAD NOW!

Book Synopsis A Guide to Sample Size for Animal-based Studies by : Penny S. Reynolds

Download or read book A Guide to Sample Size for Animal-based Studies written by Penny S. Reynolds and published by John Wiley & Sons. This book was released on 2023-12-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs Replacement, Reduction and Refinement the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-Based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "right-sizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data binary, continuous, ordinal, time to event and different study types description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-Based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Statistical Principles for the Design of Experiments

Author : R. Mead
Publisher : Cambridge University Press
ISBN 13 : 113957664X
Total Pages : 587 pages
Book Rating : 4.1/5 (395 download)

DOWNLOAD NOW!

Book Synopsis Statistical Principles for the Design of Experiments by : R. Mead

Download or read book Statistical Principles for the Design of Experiments written by R. Mead and published by Cambridge University Press. This book was released on 2012-09-13 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.

Guidance for the Description of Animal Research in Scientific Publications

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030921954X
Total Pages : 42 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!

Book Synopsis Guidance for the Description of Animal Research in Scientific Publications by : National Research Council

Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

Institutional Animal Care and Use Committee Guidebook

Author :
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (327 download)

DOWNLOAD NOW!

Book Synopsis Institutional Animal Care and Use Committee Guidebook by :

Download or read book Institutional Animal Care and Use Committee Guidebook written by and published by . This book was released on 2002 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Design of Animal Experiments

Author : Michael Festing
Publisher : SAGE Publications Limited
ISBN 13 : 9781473974630
Total Pages : 0 pages
Book Rating : 4.9/5 (746 download)

DOWNLOAD NOW!

Book Synopsis The Design of Animal Experiments by : Michael Festing

Download or read book The Design of Animal Experiments written by Michael Festing and published by SAGE Publications Limited. This book was released on 2016-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.

The Design and Statistical Analysis of Animal Experiments

Author : Simon T. Bate
Publisher : Cambridge University Press
ISBN 13 : 1107030781
Total Pages : 327 pages
Book Rating : 4.1/5 (7 download)

DOWNLOAD NOW!

Book Synopsis The Design and Statistical Analysis of Animal Experiments by : Simon T. Bate

Download or read book The Design and Statistical Analysis of Animal Experiments written by Simon T. Bate and published by Cambridge University Press. This book was released on 2014-03-13 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.

Guide for the Care and Use of Laboratory Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

ANOVA

Author : Ellen R. Girden
Publisher : SAGE
ISBN 13 : 9780803942578
Total Pages : 88 pages
Book Rating : 4.9/5 (425 download)

DOWNLOAD NOW!

Book Synopsis ANOVA by : Ellen R. Girden

Download or read book ANOVA written by Ellen R. Girden and published by SAGE. This book was released on 1992 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on situations in which analysis of variance (ANOVA) involving the repeated measurement of separate groups of individuals is needed, Girden reveals the advantages, disadvantages, and counterbalancing issues of repeated measures situations. Using additive and nonadditive models to guide the analysis in each chapter, the book covers such topics as the rationale for partitioning the sum of squares, detailed analyses to facilitate the interpretation of computer printouts, the rationale for the F ratios in terms of expected means squares, validity assumptions for sphericity or circularity and approximate tests to perform when sphericity is not met.

Statistical Power Analysis for the Behavioral Sciences

Author : Jacob Cohen
Publisher : Routledge
ISBN 13 : 1134742770
Total Pages : 625 pages
Book Rating : 4.1/5 (347 download)

DOWNLOAD NOW!

Book Synopsis Statistical Power Analysis for the Behavioral Sciences by : Jacob Cohen

Download or read book Statistical Power Analysis for the Behavioral Sciences written by Jacob Cohen and published by Routledge. This book was released on 2013-05-13 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Power Analysis is a nontechnical guide to power analysis in research planning that provides users of applied statistics with the tools they need for more effective analysis. The Second Edition includes: * a chapter covering power analysis in set correlation and multivariate methods; * a chapter considering effect size, psychometric reliability, and the efficacy of "qualifying" dependent variables and; * expanded power and sample size tables for multiple regression/correlation.

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Author : Anton Bespalov
Publisher : Springer Nature
ISBN 13 : 3030336565
Total Pages : 424 pages
Book Rating : 4.0/5 (33 download)

DOWNLOAD NOW!

Book Synopsis Good Research Practice in Non-Clinical Pharmacology and Biomedicine by : Anton Bespalov

Download or read book Good Research Practice in Non-Clinical Pharmacology and Biomedicine written by Anton Bespalov and published by Springer Nature. This book was released on 2020-01-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

The Theory of the Design of Experiments

Author : D.R. Cox
Publisher : CRC Press
ISBN 13 : 1420035835
Total Pages : 337 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis The Theory of the Design of Experiments by : D.R. Cox

Download or read book The Theory of the Design of Experiments written by D.R. Cox and published by CRC Press. This book was released on 2000-06-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why study the theory of experiment design? Although it can be useful to know about special designs for specific purposes, experience suggests that a particular design can rarely be used directly. It needs adaptation to accommodate the circumstances of the experiment. Successful designs depend upon adapting general theoretical principles to the spec

Observing Animal Behaviour

Author : Marian Stamp Dawkins
Publisher : OUP Oxford
ISBN 13 : 0191037443
Total Pages : 176 pages
Book Rating : 4.1/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Observing Animal Behaviour by : Marian Stamp Dawkins

Download or read book Observing Animal Behaviour written by Marian Stamp Dawkins and published by OUP Oxford. This book was released on 2007-10-18 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the reader to the power of observation before, and sometimes instead of, experimental manipulation in the study of animal behaviour. It starts with simple and easily accessible methods suitable for student projects, before going on to demonstrate the possibilities that now exist for far more sophisticated analyses of observational data. At a time when animal welfare considerations are attracting political as well as scientific debate, the potential for non-intrusive studies on animals is being increasingly recognized. Observation emerges as a valuable alternative approach, often yielding highly informative results in situations (such as on zoos, farms or for wild animals) where more invasive experimental techniques would be undesirable, unethical or just plain impossible. However, to justify its place alongside experimentation as a rigorous scientific method, observation needs to be just as disciplined and systematic and have just as much attention paid to project design in the way that observations are made and recorded. Observing Animal Behaviour takes the reader through all these stages: from the initial observations, to the formulation of hypotheses, and their subsequent testing with further systematic observations. Although designed principally as a companion text for advanced undergraduate and students taking courses in animal behaviour, this accessible text will be essential reading for anyone wanting to study animal behaviour using observational methods rather than experimentation, and assumes no previous knowledge of animals, statistics or scientific method. It will be of particular relevance and use to those professional researchers and consultants in the behavioural sciences who seek a compact but comprehensive introduction to the quantitative observation of animal behaviour.

The Principles of Humane Experimental Technique

Author : William Moy Stratton Russell
Publisher : Hyperion Books
ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.U/5 (183 download)

DOWNLOAD NOW!

Book Synopsis The Principles of Humane Experimental Technique by : William Moy Stratton Russell

Download or read book The Principles of Humane Experimental Technique written by William Moy Stratton Russell and published by Hyperion Books. This book was released on 1992 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Step-by-step Programming with Base SAS Software

Author :
Publisher : SAS Press
ISBN 13 : 9781580257916
Total Pages : 0 pages
Book Rating : 4.2/5 (579 download)

DOWNLOAD NOW!

Book Synopsis Step-by-step Programming with Base SAS Software by :

Download or read book Step-by-step Programming with Base SAS Software written by and published by SAS Press. This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Step-by-Step Programming with Base SAS Software provides conceptual information about Base SAS software along with step-by-step examples that illustrate the concepts. This title is also available online.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309266335
Total Pages : 111 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!

Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine

Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2013-04-25 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

A Guide to Sample Size for Animal-based Studies

Author : Penny S. Reynolds
Publisher : John Wiley & Sons
ISBN 13 : 1119799988
Total Pages : 294 pages
Book Rating : 4.1/5 (197 download)

DOWNLOAD NOW!

Book Synopsis A Guide to Sample Size for Animal-based Studies by : Penny S. Reynolds

Download or read book A Guide to Sample Size for Animal-based Studies written by Penny S. Reynolds and published by John Wiley & Sons. This book was released on 2023-08-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Guide to Sample Size for Animal-based Studies Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.