A General Strategy For Site Specific Incorporation Of Unnatural Amino Acids Into Proteins

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Non-Natural Amino Acids

Author :
Publisher : Academic Press
ISBN 13 : 0080921639
Total Pages : 334 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Non-Natural Amino Acids by :

Download or read book Non-Natural Amino Acids written by and published by Academic Press. This book was released on 2009-07-24 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. - Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube - Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules - Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods

Noncanonical Amino Acids

Author : Edward A. Lemke
Publisher :
ISBN 13 : 9781493975747
Total Pages : 411 pages
Book Rating : 4.9/5 (757 download)

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Book Synopsis Noncanonical Amino Acids by : Edward A. Lemke

Download or read book Noncanonical Amino Acids written by Edward A. Lemke and published by . This book was released on 2018 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A General Strategy for Site-specific Incorporation of Unnatural Amino Acids Into Proteins

Author : Spencer Jay Anthony-Cahill
Publisher :
ISBN 13 :
Total Pages : 676 pages
Book Rating : 4.:/5 (33 download)

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Book Synopsis A General Strategy for Site-specific Incorporation of Unnatural Amino Acids Into Proteins by : Spencer Jay Anthony-Cahill

Download or read book A General Strategy for Site-specific Incorporation of Unnatural Amino Acids Into Proteins written by Spencer Jay Anthony-Cahill and published by . This book was released on 1990 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Micro and Nanofabrication Using Self-Assembled Biological Nanostructures

Author : Jaime Castillo-León
Publisher : William Andrew
ISBN 13 : 9780323296427
Total Pages : 0 pages
Book Rating : 4.2/5 (964 download)

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Book Synopsis Micro and Nanofabrication Using Self-Assembled Biological Nanostructures by : Jaime Castillo-León

Download or read book Micro and Nanofabrication Using Self-Assembled Biological Nanostructures written by Jaime Castillo-León and published by William Andrew. This book was released on 2014-09-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembled nanostructures based on peptides and proteins have been investigated and presented as biomaterials with an impressive potential for a broad range of applications such as microfabrication, biosensing platforms, drug delivery systems, bioelectronics and tissue reparation. Through self-assembly peptides can give rise to a range of well-defined nanostructures such as nanotubes, nanofibers, nanoparticles, nanotapes, gels and nanorods. However, there are challenges when trying to integrate these biological nanostructures in the development of sensing devices or drug-delivery systems - challenges such as controlling the size during synthesis, the stability in liquid environments and manipulation. In "Micro and Nanofabrication Using Self-assembled Biological Nanostructures" the options and challenges when using self-assembled peptide nanostructures in micro and nanofabrication are discussed. The publication covers different ways to manipulate, deposit and immobilize on specific locations these biological nanostructures in order to use them in the fabrication of new structures or as part of biosensing platforms. Examples where researchers used biological nanostructures for those types of applications are provided. Finally, future applications are discussed as well as parameters to accelerate and expand the use of these biological building blocks in nano- and micro-fabrication processes by taking advantage of their impressive properties such as low-cost and short synthesis time.

Site-Specific Protein Labeling

Author : Arnaud Gautier
Publisher : Humana Press
ISBN 13 : 9781493922710
Total Pages : 0 pages
Book Rating : 4.9/5 (227 download)

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Book Synopsis Site-Specific Protein Labeling by : Arnaud Gautier

Download or read book Site-Specific Protein Labeling written by Arnaud Gautier and published by Humana Press. This book was released on 2015-01-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides in-depth protocols for protein labeling techniques and applications, with an additional focus on general background information on the design and generation of the organic molecules used for the labeling step. Chapters provide protocols for labeling techniques and applications, with an additional focus on general background information on the design and generation of the organic molecules used for the labeling step. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Site-Specific Protein Labeling: Methods and Protocols provides a comprehensive overview on the most relevant and established labeling methodologies, and helps researchers to choose the most appropriate labeling method for their biological question.

Fluorine-containing Amino Acids

Author : Valery P. Kukhar
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Fluorine-containing Amino Acids by : Valery P. Kukhar

Download or read book Fluorine-containing Amino Acids written by Valery P. Kukhar and published by John Wiley & Sons. This book was released on 1995-04-06 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.

Engineering the Genetic Code

Author : Nediljko Budisa
Publisher : John Wiley & Sons
ISBN 13 : 3527607099
Total Pages : 312 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Engineering the Genetic Code by : Nediljko Budisa

Download or read book Engineering the Genetic Code written by Nediljko Budisa and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to introduce non-canonical amino acids in vivo has greatly expanded the repertoire of accessible proteins for basic research and biotechnological application. Here, the different methods and strategies to incorporate new or modified amino acids are explained in detail, including a lot of practical advice for first-time users of this powerful technique. Novel applications in protein biochemistry, genomics, biotechnology and biomedicine made possible by the expansion of the genetic code are discussed and numerous examples are given. Essential reading for all molecular life scientists who want to stay ahead in their research.

Chemical Ligation

Author : Luca D. D'Andrea
Publisher : John Wiley & Sons
ISBN 13 : 1119044103
Total Pages : 578 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Chemical Ligation by : Luca D. D'Andrea

Download or read book Chemical Ligation written by Luca D. D'Andrea and published by John Wiley & Sons. This book was released on 2017-04-03 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a wide array of information on chemical ligation – one of the more powerful tools for protein and peptide synthesis – this book helps readers understand key methodologies and applications that protein therapeutic synthesis, drug discovery, and molecular imaging. • Moves from fundamental to applied aspects, so that novice readers can follow the entire book and apply these reactions in the lab • Presents a wide array of information on chemical ligation reactions, otherwise scattered across the literature, into one source • Features comprehensive and multidisciplinary coverage that goes from basics to advanced topics • Helps researchers choose the right chemical ligation technique for their needs

Enzyme Engineering

Author : James Samuelson
Publisher : Humana Press
ISBN 13 : 9781493962877
Total Pages : 266 pages
Book Rating : 4.9/5 (628 download)

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Book Synopsis Enzyme Engineering by : James Samuelson

Download or read book Enzyme Engineering written by James Samuelson and published by Humana Press. This book was released on 2016-05-01 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides guidance to those wishing to create enzyme variants. It covers such topics as a simple method for generating site-specific mutations within bacterial chromosomes and the engineering of two difference types of rare-cutting endonucleases.

Unnatural Amino Acids

Author : Loredano Pollegioni
Publisher : Humana Press
ISBN 13 : 9781493958887
Total Pages : 409 pages
Book Rating : 4.9/5 (588 download)

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Book Synopsis Unnatural Amino Acids by : Loredano Pollegioni

Download or read book Unnatural Amino Acids written by Loredano Pollegioni and published by Humana Press. This book was released on 2016-08-23 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even though they are present in nature, non-proteinogenic amino acids are usually defined as unnatural or non-natural. Beside their structural diversity, interest in these compounds is due to their occurrence in nature, their biological properties, the analytical aspects, their use as probes, and their incorporation into peptides and proteins, among other reasons. Divided into five convenient sections, Unnatural Amino Acids: Methods and Protocols deals with enzymatic methods used to produce non-natural amino acids, aspects concerning the presence of unnatural amino acids in peptides with antimicrobial properties, genetic incorporation of unnatural amino acids into proteins (yeast and mammalian cells), and detection and quantification of D-amino acids and related enzymes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Unnatural Amino Acids: Methods and Protocols serves as an ideal guide for scientists and contributes to directing the attention of researchers to the many fields of growing scientific interest in non-natural amino acids.

Total Chemical Synthesis of Proteins

Author : Ashraf Brik
Publisher : John Wiley & Sons
ISBN 13 : 3527346600
Total Pages : 626 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Total Chemical Synthesis of Proteins by : Ashraf Brik

Download or read book Total Chemical Synthesis of Proteins written by Ashraf Brik and published by John Wiley & Sons. This book was released on 2021-06-08 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Combinatorial Library

Author : Lisa B. English
Publisher : Springer Science & Business Media
ISBN 13 : 1592592856
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Library by : Lisa B. English

Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

Innovations for Next-Generation Antibody-Drug Conjugates

Author : Marc Damelin
Publisher : Springer
ISBN 13 : 3319781545
Total Pages : 358 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Innovations for Next-Generation Antibody-Drug Conjugates by : Marc Damelin

Download or read book Innovations for Next-Generation Antibody-Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Life Sciences Industry

Author : Basanta Kumara Bahera
Publisher : Springer Nature
ISBN 13 : 9811620512
Total Pages : 221 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Life Sciences Industry by : Basanta Kumara Bahera

Download or read book Life Sciences Industry written by Basanta Kumara Bahera and published by Springer Nature. This book was released on 2021-08-24 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic principles of applied life sciences such as recombinant DNA technology is used in most life sciences industries marketing bio-formulations for designing more effective protein-based drugs, such as erythropoietin and fast-acting insulin etc. In recent times genetically engineered host cells from mammal, animal and plants are also being used in life sciences industries to manufacture biologics. This book discusses the most basic as well advanced issues on biological products for successfully managing a life sciences industry. It elucidates the life cycle of biological molecules, right from the conceptual development of different types of biopolymers, and their subsequent transfer from the conical flasks in laboratory to life sciences industries for large scale production and marketing. It focuses on sustainable longevity in the life cycle of commercial biopolymers. Cumulative facts and figures in this volume would immensely help in inspiring life sciences industry promoters to monitor value chain transfer process of biologics for better profitability. Additionally, it would serve as a perusal document for the students and researchers interested in entrepreneurial ventures or having their own start-up projects for the commercialization of biologics.

Molecular Photoswitches

Author : Zbigniew L. Pianowski
Publisher : John Wiley & Sons
ISBN 13 : 3527827617
Total Pages : 1577 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Molecular Photoswitches by : Zbigniew L. Pianowski

Download or read book Molecular Photoswitches written by Zbigniew L. Pianowski and published by John Wiley & Sons. This book was released on 2022-06-01 with total page 1577 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview about the emerging field of photoswitches and their applications in materials science and biology Molecular Photoswitches guides the reader through the basic molecular structures of photochromic compounds and their applications in the area of photoresponsive materials as well as in the biological context. The initial chapters describe individual classes of molecular photoswitches, introducing their principles of photochromism, typical switching wavelengths, thermal stability of photoisomers and other key information, which is ordinarily spread in the literature. These classes comprise i.a. azobenzenes, diazocines, arylazoheterocycles, arylhydrazones, indigoids, photochromic imines, or acylhydrazones. The book also covers: Catalysis with molecular switches Applications in photochromic porous materials, liquid crystals, or nanoparticles Light-responsive molecular machines, logic devices, and molecular magnets Photomodulation of biological systems: photoswitchable biopolymers, lightmodulated antibiotics, cytotoxins, ion channel inhibitors, light-propelled artificial muscles, and computationally designed photochromic proteins This two-volume work is a valuable guide for researchers and non-experts working in the field of photochemistry, organic chemistry, catalysis, materials science, biology, and medicine.

Photoaffinity Labeling for Structural Probing Within Protein

Author : Yasumaru Hatanaka
Publisher : Springer
ISBN 13 : 4431565698
Total Pages : 268 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Photoaffinity Labeling for Structural Probing Within Protein by : Yasumaru Hatanaka

Download or read book Photoaffinity Labeling for Structural Probing Within Protein written by Yasumaru Hatanaka and published by Springer. This book was released on 2017-09-25 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.

The Limits of Organic Life in Planetary Systems

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309179564
Total Pages : 116 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Limits of Organic Life in Planetary Systems by : National Research Council

Download or read book The Limits of Organic Life in Planetary Systems written by National Research Council and published by National Academies Press. This book was released on 2007-06-26 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search for life in the solar system and beyond has to date been governed by a model based on what we know about life on Earth (terran life). Most of NASA's mission planning is focused on locations where liquid water is possible and emphasizes searches for structures that resemble cells in terran organisms. It is possible, however, that life exists that is based on chemical reactions that do not involve carbon compounds, that occurs in solvents other than water, or that involves oxidation-reduction reactions without oxygen gas. To assist NASA incorporate this possibility in its efforts to search for life, the NRC was asked to carry out a study to evaluate whether nonstandard biochemistry might support life in solar system and conceivable extrasolar environments, and to define areas to guide research in this area. This book presents an exploration of a limited set of hypothetical chemistries of life, a review of current knowledge concerning key questions or hypotheses about nonterran life, and suggestions for future research.