A Concise Review Of Molecular Pathology Of Breast Cancer

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A Concise Review of Molecular Pathology of Breast Cancer

Author : Mehmet Gunduz
Publisher : BoD – Books on Demand
ISBN 13 : 9535120301
Total Pages : 236 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis A Concise Review of Molecular Pathology of Breast Cancer by : Mehmet Gunduz

Download or read book A Concise Review of Molecular Pathology of Breast Cancer written by Mehmet Gunduz and published by BoD – Books on Demand. This book was released on 2015-03-25 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading causes of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed gene expression and DNA abnormalities including methylation in breast cancer. A recent important topic, roles of miRNAs and their potential use in cancer therapy have been discussed in this cancer type as well. Bioinformatics is very important part of recent human genome developments and data mining and thus this topic has also been added for the readers. It is hoped that this book will contribute to development of novel diagnostic as well as therapeutic approaches, which lead to cure of breast cancer.

Precision Molecular Pathology of Breast Cancer

Author : Ashraf Khan
Publisher : Springer
ISBN 13 : 1493928864
Total Pages : 336 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Precision Molecular Pathology of Breast Cancer by : Ashraf Khan

Download or read book Precision Molecular Pathology of Breast Cancer written by Ashraf Khan and published by Springer. This book was released on 2015-08-12 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Basic Concepts of Molecular Pathology

Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 0387896260
Total Pages : 195 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Basic Concepts of Molecular Pathology by : Philip T. Cagle

Download or read book Basic Concepts of Molecular Pathology written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Molecular Surgical Pathology

Author : Liang Cheng
Publisher : Springer Science & Business Media
ISBN 13 : 1461449006
Total Pages : 442 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Molecular Surgical Pathology by : Liang Cheng

Download or read book Molecular Surgical Pathology written by Liang Cheng and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a “first knowledge base” in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.

Molecular Testing in Cancer

Author : George M. Yousef
Publisher : Springer Science & Business
ISBN 13 : 1489980504
Total Pages : 438 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Molecular Testing in Cancer by : George M. Yousef

Download or read book Molecular Testing in Cancer written by George M. Yousef and published by Springer Science & Business. This book was released on 2014-04-21 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Testing in Cancer provides a state of the art review of clinically relevant molecular pathology in cancer. The book provides a brief, easy to read review of commonly employed diagnostic molecular techniques including recently developed "next generation" analytic tools, and offers a system-based run-through of the utility of molecular testing in individual cancer types, as well as reviewing current markers in cancer diagnosis, prognosis, and management. The volume also provides a prospective for the future which includes recently characterized and emerging biomarkers. Written by experts in the field, Molecular Testing in Cancer serves as a useful and comprehensive resource for pathologists, hematologists, laboratory technicians and molecular scientists.

Breast Cancer

Author : Daniel F. Roses
Publisher : Churchill Livingstone
ISBN 13 :
Total Pages : 840 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Breast Cancer by : Daniel F. Roses

Download or read book Breast Cancer written by Daniel F. Roses and published by Churchill Livingstone. This book was released on 2005 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated New Edition provides a complete yet concise understanding of breast cancer-from biology, pathology, and screening through diagnosis, treatment, long-term follow-up, and adjuvant care. Its practical, multidisciplinary focus addresses the concerns of every member of the health care team. A unique question-and-answer format offers clear answers to clinical questions, enhancing communication among physicians, nurses, and patients. Considers the full range of management options, including radiation therapy, chemotherapy, hormone therapy, and monoclonal antibody therapy. Uses a question-and-answer format to make reference easy. Saves time by examining only well-established, proven diagnostic and therapeutic strategies. Incorporates new chapters on needle biopsy, lymph node pathology, sonography, new diagnostic imaging modalities, MRI, emerging surgical approaches (such as radiofrequency and cryoablative techniques), and medicolegal issues. Offers new coverage of lymphatic mapping and sentinel node biopsy, molecular pathology, and the latest chemotherapeutic options. Presents 50% new contributors who are international leaders in molecular biology, genetics, radiology, pathology, surgery, and oncology. Delivers nearly 300 new clinical photographs and line illustrations.

Molecular Pathology of Breast Cancer

Author : Sunil Badve
Publisher : Springer
ISBN 13 : 9783319417592
Total Pages : 0 pages
Book Rating : 4.4/5 (175 download)

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Book Synopsis Molecular Pathology of Breast Cancer by : Sunil Badve

Download or read book Molecular Pathology of Breast Cancer written by Sunil Badve and published by Springer. This book was released on 2016-12-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Cell and Molecular Biology of Breast Cancer

Author : Heide Schatten
Publisher : Springer Science & Business Media
ISBN 13 : 1627036342
Total Pages : 382 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Cell and Molecular Biology of Breast Cancer by : Heide Schatten

Download or read book Cell and Molecular Biology of Breast Cancer written by Heide Schatten and published by Springer Science & Business Media. This book was released on 2013-09-27 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

WHO Classification of Tumours of the Breast

Author : Sunil R. Lakhani
Publisher : World Health Organization
ISBN 13 : 9789283224334
Total Pages : 240 pages
Book Rating : 4.2/5 (243 download)

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Book Synopsis WHO Classification of Tumours of the Breast by : Sunil R. Lakhani

Download or read book WHO Classification of Tumours of the Breast written by Sunil R. Lakhani and published by World Health Organization. This book was released on 2012 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Breast is the fourth volume of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 90 authors from 24 countries, contains more than 340 colour photographs, tables and figures, and more than 1600 references.

Essential Concepts in Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128132582
Total Pages : 634 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Essential Concepts in Molecular Pathology by : William B. Coleman

Download or read book Essential Concepts in Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2019-11-23 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today’s advances in pathology and medicine. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology

Pathology and Epidemiology of Cancer

Author : Massimo Loda
Publisher : Springer
ISBN 13 : 3319351532
Total Pages : 664 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Pathology and Epidemiology of Cancer by : Massimo Loda

Download or read book Pathology and Epidemiology of Cancer written by Massimo Loda and published by Springer. This book was released on 2016-09-01 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.

Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128027878
Total Pages : 805 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Pathology by : William B. Coleman

Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2017-11-09 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Practical Breast Pathology

Author : Tibor Tot
Publisher : Thieme
ISBN 13 : 3131607815
Total Pages : 184 pages
Book Rating : 4.1/5 (316 download)

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Book Synopsis Practical Breast Pathology by : Tibor Tot

Download or read book Practical Breast Pathology written by Tibor Tot and published by Thieme. This book was released on 2011-01-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Review By AuntMinnie.comIdeal for general pathologists who may not be familiar with breast examinations, here is the first book to correlate breast pathology and mammography. This outstanding new book provides all the basic facts needed for pathologic examinations, with hundreds of diagrams, slides, and histological illustrations to demonstrate the process. A strong emphasis is placed on the teamwork philosophy, teaching specialists from different fields how to function together.Key features: Extensively illustrated with hundreds of diagrams, radiographs, and full-color illustrations to guide you through the pathologic process Valuable information on understanding the connection between radiologic appearance and the underlying pathology Concise text providing the relevant information specialists need The first text to focus on the team approach to treating breast cancersCovering topics such as hyperplastic changes, benign and malignant lesions, invasive breast carcinoma, preoperative diagnostic criteria, and more, Practical Breast Pathology is essential for all radiologists, pathologists, surgeons and oncologists involved in breast cancer detection. Stay on the cutting edge of the field with this state-of-the-art guide, order today!

Molecular Diagnosis of Cancer

Author : Joseph E. Roulston
Publisher : Springer Science & Business Media
ISBN 13 : 1592597602
Total Pages : 389 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Molecular Diagnosis of Cancer by : Joseph E. Roulston

Download or read book Molecular Diagnosis of Cancer written by Joseph E. Roulston and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are currently experiencing a fundamental shift in the way in which we approach the characterization of cancer. Never before has the make up of cancer tissues and individual cells been so exhaustively researched and char- terized. We are now capable of producing molecular “fingerprints” that ch- acterize the expression of all known and unknown genes within tumors and their surrounding tissues. More than 30,000 different genes may be measured in each patient’s tumor in a single experiment. Simultaneously, novel therapies that exploit the molecular roadmap have been developed and are now being offered to patients. These novel agents, such as Glivec, Herceptin, Iressa, and others, specifically target individual genes within tumors and can produce d- matic responses in some patients. These drugs are only the forerunners of a coming tidal wave of novel therapeutics that individually target specific m- ecules within cancer cells—more than 300 such agents are currently in phase I or II clinical trials. This is an exciting time for cancer specialists and patients alike. However, if we have learned anything from the past 50 or more years of research into cancer, it is that Lord Beaverbrook, in founding the British national health service in the 1950s, was frighteningly prescient when he defined the primary goal of health care to be “Diagnosis, Diagnosis, Diag- sis. ” Now, more than ever, it is essential that appropriate diagnostic methods and approaches are applied to the selection of patients for treatment.

Practical Oncologic Molecular Pathology

Author : Yi Ding
Publisher : Springer Nature
ISBN 13 : 3030732274
Total Pages : 449 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Practical Oncologic Molecular Pathology by : Yi Ding

Download or read book Practical Oncologic Molecular Pathology written by Yi Ding and published by Springer Nature. This book was released on 2021-07-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.

Pathology and Genetics of Tumours of the Breast and Female Genital Organs

Author : World Health Organization
Publisher : IARC
ISBN 13 : 9789283224129
Total Pages : 436 pages
Book Rating : 4.2/5 (241 download)

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Book Synopsis Pathology and Genetics of Tumours of the Breast and Female Genital Organs by : World Health Organization

Download or read book Pathology and Genetics of Tumours of the Breast and Female Genital Organs written by World Health Organization and published by IARC. This book was released on 2003 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 5th volume in a WHO series on histological and genetic typing of human tumours. This edition focuses on cancers of the breast and female genital organs, and describes diagnostic criteria, pathological features, associated genetic alterations and gene expression patterns in a disease-oriented manner. Sections on all recognised neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics and predictive factors. It contains colour photographs, X-rays, computed tomography (CT) and magnetic resonance (MR) images, charts and over 3,200 references. The classifications presented reflect the views of WHO working group conferences held in France in January and March 2002, and the volume was produced in collaboration with the International Academy of Pathology.

Biomarkers in Breast Cancer

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.