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Author : Bibiana Garcia Bailo
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book 25-hydroxyvitamin D and Biomarkers of Cardiometabolic Disease written by Bibiana Garcia Bailo and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jin Xia
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (114 download)
Download or read book Associations Between Vitamin D Biomarkers and Cardiometabolic Outcomes Among Women written by Jin Xia and published by . This book was released on 2020 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing evidence that vitamin D endocrine system may be associated with multiple cardiometabolic outcomes, such as gestational diabetes mellitus (GDM), type 2 diabetes, and other relevant cardiometabolic comorbidities, as well as some intermediate cardiometabolic biomarkers. African Americans tend to have lower 25-hydroxyvitamin D[25(OH)D] levels and higher cardiometabolic risk than whites. However, the temporal relation between vitamin D status and cardiometabolic outcomes remains unclear due to the lack of longitudinal data. Further, whether adding information on parathyroid hormone (PTH) can explain black-white disparities in cardiometabolic health is unknown. In this dissertation, I first prospectively and longitudinally investigated vitamin D status during early to mid-pregnancy in relation to GDM risk in a multiracial cohort of women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singleton cohort. I also analyzed the data from the Women's Health Initiative-Observational Study to 1) cross-sectionally examine race (black-white)-specific linear and non-linear relations of 25(OH)D and PTH with a panel of cardiometabolic biomarkers, including high-sensitive C-reactive protein, estimated glomerular filtration rate, and homeostatic model assessment of insulin resistance and beta-cell function, and 2) cross-sectionally and prospectively evaluate the combined associations of 25(OH)D and PTH with risk of diabetes and related cardiometabolic comorbidities (obesity, hypertension, chronic kidney disease, and cardiovascular disease) in U.S. white and black postmenopausal women. This research provides evidence of the temporal association between vitamin D status and cardiometabolic risk among women from racially/ethnically diverse groups, and possible black-white differences in these associations. The findings enhance our understanding of the contribution of vitamin D-PTH endocrine system to racial disparities in cardiometabolic health.
Author : May Cheung
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)
Download or read book The Role of Magnesium and Vitamin D on Cardiometabolic Risk Factors in Overweight and Obese Adults written by May Cheung and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Obesity is an epidemic in the United States, and it is associated with the pathogenesis of many chronic diseases. Individuals who are overweight or obese (Owt/Ob) are at a higher risk of developing cardiometabolic diseases and have a higher prevalence of micronutrient deficiencies when compared to individuals with a healthy weight. Vitamin D and magnesium are two micronutrients that are commonly found to be deficient in the Owt/Ob population, and deficiencies in both nutrients are independently associated with poor cardiometabolic health. Furthermore, magnesium is an essential cofactor that aids in vitamin D metabolism. We theorized that a poor magnesium status may lead to improper vitamin D metabolism, and therefore, leading to an increase of parathyroid hormone (PTH), a hormone that is an independent predictor for elevated systemic inflammation, hypertension, and cardiovascular disease. Parathyroid hormone and vitamin D exhibit a negative relationship in healthy weight individuals. However, this expected negative relationship between vitamin D and parathyroid hormone can potentially be altered in Owt/Ob individuals with magnesium deficiency. This dissertation focused on investigating the role magnesium plays in vitamin D metabolism and the effects of a combined vitamin D and magnesium treatment in the Owt/Ob population and its effect on protecting cardiometabolic health. Methods: A cross-sectional study was first conducted to determine the relationship between magnesium status, serum 25-hydroxyvitamin D (25OHD) concentrations, and serum PTH concentrations. Secondly, we conducted a 12-week double-blinded controlled supplementation trial to determine whether a combined magnesium and vitamin D would increase serum concentrations of 25OHD, and lower serum concentrations of PTH, markers of inflammation and blood pressure. This study had three treatment arms - magnesium + vitamin D (MagD) group, vitamin D only (VitD) group, and a placebo group. Participants in the MagD Group received 360 mg magnesium glycinate + 1000 IU vitamin D3 daily, VitD Group received 1000 IU vitamin D3 daily, and Placebo Group received 10 mg of cellulose. Information such as body composition measurements was collected using Dual-energy X-ray Absorptiometry, systolic and diastolic blood pressures were collected using the American Heart Association In-clinic Guideline for Blood Pressure Measurements, blood biomarkers (serum concentrations of 25-hydroxyvitamin D, parathyroid hormone, markers of inflammation) were assessed through fasting blood samples analyses. Additional information such as anthropometry measurements and diet records were also collected. Results: In our cross-sectional study, a total of 57 Owt/Ob participants were divided into three groups according to dietary magnesium intake percentiles (Low Mg Group = 33 percentile, Medium Mg Group = 33 to 66 percentile, High Mg Group = 66 percentile). Higher serum concentrations of 25OHD were negatively associated with lower serum concentrations of PTH only in the High Mg Intake group (r=-0.472, p=0.041), but not in other groups. For the 12-week double-blinded supplementation trial, a total of 83 Owt/Ob participants were randomized into one of the three study arms. Participants in the MagD Group had a greater increase in serum 25OHD compared to participants in VitD Group, but only for those whose baseline 25OHD were less than 23.49 ng/mL. There were no statistically significant effects on PTH concentrations and markers of inflammation between and within groups. Conclusion: A low dietary magnesium intake may alter PTH response to 25OHD. Furthermore, a combined magnesium and vitamin D treatment may be more effective in raising serum 25OHD concentrations compared to vitamin D supplements alone for individuals whose 25OHD level were insufficient at baseline. However, increase in serum 25OHD concentrations may not influence systemic inflammation and blood pressure.
Author : D. J. Berry
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (829 download)
Download or read book Analysing the Association of Vitamin D Status on Selected Cardiovascular Risk Markers Using Seasonal and Genetic Variations written by D. J. Berry and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is common and has been proposed as a risk factor for cardiovascular disease (CVD), but much of this evidence is inconsistent. The aim of the thesis was to explore the associations between vitamin D status (25(OH)D) and selected risk biomarkers of CVD, in participants of the British 1958 birth cohort free from CVD. Different methodologies were used in an attempt to avoid confounded associations. Mediation analysis was used to infer an association between 25(OH)D and biomarkers from seasonal variations. A genome-wide association study (GWAS) was done to find single nucleotide polymorphisms (SNPs) associated with 25(OH)D. SNPs found by the GWAS and SNPs in candidate genes were evaluated as proxy markers for 25(OH)D, and used in Mendelian randomisation (MR) analysis with the biomarkers. Higher 25(OH)D concentrations were associated with lower levels of tissue plasminogen activator (tPA), after adjusting for lifestyle, socio-economic and adiposity covariates. An association between 25(OH)D and tPA was inferred using mediation analysis. In the GWAS, SNPs from genes involved in the synthesis, hydroxylation and transportation of vitamin D were associated with 25(OH)D. SNPs passing evaluation as proxy markers for 25(OH)D were classified as "synthesis" and "metabolism" based on gene function, with the former considered to be a more robust proxy than the latter. Statistical power to detect an association was limited in MR analysis. However, there was some evidence that 25(OH)D had a protective association with tPA, when metabolism SNPs were used as proxy for 25(OH)D in MR analysis. Findings from the different analyses were inconsistent for CRP, D-dimer and fibrinogen. In conclusion, the findings tentatively suggest that vitamin D has a beneficial influence on CVD through the mechanism of fibrinolysis. However, more evidence is required from large MR studies and randomised controlled trials before the role of vitamin D in CVD is conclusively understood.
Author : Sivakumar Joghi Thatha Gowder
Publisher : BoD – Books on Demand
ISBN 13 : 9535130854
Total Pages : 262 pages
Book Rating : 4.5/5 (351 download)
Download or read book A Critical Evaluation of Vitamin D written by Sivakumar Joghi Thatha Gowder and published by BoD – Books on Demand. This book was released on 2017-04-26 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D, a fat-soluble vitamin, also called as "sunshine vitamin" is derived mostly from sun exposure and food, and for normal activation, it has to undergo two hydroxylation reactions. Vitamin D affects more than 2000 genes in the body. Serum level of 25(OH) D is an ideal indicator of vitamin D status in our body. Vitamin D deficiency leads to various diseases. On a therapeutic point of view, vitamin D helps to treat many diseases. The book "A Critical Evaluation of Vitamin D - Clinical Overview" targets the principles, mechanisms, and clinical significance of vitamin D. This book covers four sections: "Vitamin D in Cardiovascular and Renal Diseases", "Vitamin D in Age and Neurological Diseases", "Vitamin D and Cancer" and "Therapeutic Measurements of Vitamin D". Each of these sections is interwoven with the theoretical aspects and experimental techniques of basic and clinical sciences. This book will be a significant source to students, scientists, physicians, healthcare professionals and also other members of this society who are interested in exploring the role of vitamin D in human life. [Vitamin D can be considered as vitamin of "defense" since it cures several diseases. - Sivakumar Gowder]
Author : Vinood B. Patel
Publisher : Springer Nature
ISBN 13 : 3031073894
Total Pages : 1173 pages
Book Rating : 4.0/5 (31 download)
Download or read book Biomarkers in Nutrition written by Vinood B. Patel and published by Springer Nature. This book was released on 2022-10-14 with total page 1173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides an all-inclusive insight into biomarkers assessing the impact of nutrition on human health. The reader will gain insight into the area of circulating body fluid biomarkers, from cardiovascular related markers to liver functional tests. Various biomarkers related to the intake of micronutrient and macronutrients are presented, and the effects of different diets, pesticide exposure and dietary supplements are discussed, so are changes of genetic, cellular and histological variables. This systematic handbook is a must have for biomedical researchers as well as clinicians and pharmacologists, who wish to gain extensive understanding on the analysis of effects of various nutritional and dietary effects on human health, ageing and longevity.
Author : Emilia Pauline Liao
Publisher : Humana Press
ISBN 13 : 3319737422
Total Pages : 258 pages
Book Rating : 4.3/5 (197 download)
Download or read book Extraskeletal Effects of Vitamin D written by Emilia Pauline Liao and published by Humana Press. This book was released on 2018-04-23 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
Author : Malcolm K Robinson
Publisher : CRC Press
ISBN 13 : 1420018906
Total Pages : 475 pages
Book Rating : 4.4/5 (2 download)
Download or read book Obesity and Cardiovascular Disease written by Malcolm K Robinson and published by CRC Press. This book was released on 2006-03-07 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although cardiovascular disease remains the leading proximate cause of death in the United States, it is now estimated that obesity may be equivalent to smoking as the leading cause of preventable death in America. In light of these statistics, this reference presents our current understanding of the epidemiology, pathology, and genetics of the obe
Author : Yulong Li
Publisher : Frontiers Media SA
ISBN 13 : 2832531849
Total Pages : 344 pages
Book Rating : 4.8/5 (325 download)
Download or read book Biomarkers: Precision Nutrition in Chronic Diseases written by Yulong Li and published by Frontiers Media SA. This book was released on 2023-08-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic diseases such as obesity, diabetes, and cardiovascular disease are major causes of morbidity and mortality worldwide with increasing prevalence in all age groups, genders, and ethnicities. Emerging evidence suggests that precision nutrition plays a pivotal role in the prevention and management of chronic diseases and has been recognized as a key focus for the next ten years of health research. Currently, one of the major challenges in precision nutrition is the valid and reliable assessment of foods and nutrients intake, especially whole foods (e.g., fermented foods) and macromolecules (e.g., polysaccharides), as well as their impact on host health and disease. Strong evidence has supported that the biomarkers (e.g., metabolites) as an intermediate bridge can effectively link precision nutrition and chronic diseases, which can contribute to objectively assessing food consumption and precisely determining the biological effects of complex foods (ingredients). However, still we are at the very beginning to understand how precision nutrition regulates biomarkers to prevent chronic diseases with individual differences. The molecular mechanisms of key biomarkers in chronic diseases have not been fully elucidated and extensive studies are crucially warranted.
Author : Mu Wang
Publisher : BoD – Books on Demand
ISBN 13 : 9535125052
Total Pages : 262 pages
Book Rating : 4.5/5 (351 download)
Download or read book Role of Biomarkers in Medicine written by Mu Wang and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.
Author : Juan Antonio Vílchez
Publisher : Bentham Science Publishers
ISBN 13 : 1681084953
Total Pages : 568 pages
Book Rating : 4.6/5 (81 download)
Download or read book New Trends in Biomarkers and Diseases: An Overview written by Juan Antonio Vílchez and published by Bentham Science Publishers. This book was released on 2017-09-29 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are any measurable biochemical characteristics of an organism that reflect a particular physiological state. Biomarkers can take many different forms including particular proteins or peptides, antibodies, cell types, metabolites, hormones, enzyme levels, compounds related to genomics, etc. A biomarker can also be a substance introduced into a patient to assess the internal organ systems role. In medicine, biomarkers considered as compounds isolated from serum, urine, or other fluids, can be used as an indicator of the presence or severity of a particular disease state. The use of biomarkers is becoming a fundamental practice in medicine, Biomarker research involves a significantly greater scope of laboratory medicine. This monograph presents information on several types of biomarkers for general pathologies (preeclampsia, metabolic syndrome, iron metabolism, bone disease, liver function, renal function), cardiovascular pathology (including atrial fibrillation, peripheral artery disease, thrombotic disorders) and sepsis. Additional information on endocrine and salivary biomarkers is also presented. New Trends in Biomarkers and Diseases: An Overview is an ideal reference for medical students, pathology trainees and clinical researchers seeking information on biomarkers in medicine.
Author : Martin Hewison
Publisher : Elsevier
ISBN 13 : 0323913903
Total Pages : 1232 pages
Book Rating : 4.3/5 (239 download)
Download or read book Feldman and Pike's Vitamin D written by Martin Hewison and published by Elsevier. This book was released on 2023-10-28 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike's Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. • A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles • Chapters written by the most prominent and well-published names in the field
Author : Jasmina Debeljak Martacic
Publisher : Frontiers Media SA
ISBN 13 : 2832523684
Total Pages : 168 pages
Book Rating : 4.8/5 (325 download)
Download or read book The role of vitamin D in metabolic and cardiovascular health written by Jasmina Debeljak Martacic and published by Frontiers Media SA. This book was released on 2023-05-16 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael J. Wilkinson
Publisher : Springer Nature
ISBN 13 : 3030781771
Total Pages : 279 pages
Book Rating : 4.0/5 (37 download)
Download or read book Prevention and Treatment of Cardiovascular Disease written by Michael J. Wilkinson and published by Springer Nature. This book was released on 2021-08-13 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention. It highlights the strength of evidence for particular diet styles in CVD prevention, including plant-based diets, the Mediterranean diet, the DASH diet, and low-carbohydrate diets. Chapters present evidence and future directions for diet and nutrition in diseases related to CVD, such as dyslipidemia, cardiometabolic disease (pre-diabetes, the metabolic syndrome, type-2 diabetes mellitus), and obesity. Finally, the book reviews novel and emerging aspects of dietary intervention in CVD prevention, such as dietary approaches to inflammation and the role of the microbiome in CVD. Up-to-date, evidence-based, and clinically oriented, Prevention and Treatment of Cardiovascular Disease: Nutritional and Dietary Approaches is an essential resource for physicians, residents, fellows, and medical students in cardiology, clinical nutrition, family medicine, endocrinology, and lipidology.
Author : Murray J. Favus
Publisher :
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 (91 download)
Download or read book Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism written by Murray J. Favus and published by . This book was released on 1999 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anatomy and biology of bone matrix and cellular elements; Skeletal physiology; Mineral homeostasis; Clinical evaluation of bone and mineral disorders; Disorders of serum minerals; Metabolic bone diseases; Genetic, developmenal, and dysplastic skeletal disorders; Acquired disorders of cartilage and bone; Paget's disease; Extraskeletal (ectopic) calcification and ossification; Nephrolithiasis; Dentistry.
Author : Julia Fedotova
Publisher : BoD – Books on Demand
ISBN 13 : 1838807756
Total Pages : 284 pages
Book Rating : 4.8/5 (388 download)
Download or read book Vitamin D Deficiency written by Julia Fedotova and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D is the topic for many discussions in the scientific community. Nowadays, a different interpretation of this secosteroid hormone is needed. Today the term "vitamin" may be considered outdated. This compound may be correctly be called a vitamin only when it is administered to humans or animals that suffer from its deficiency. This book attempts to clarify the role of Vitamin D deficiency in many pathological processes in the whole organism. Chapters in this book cover such issues as the earliest clinical and preclinical investigations of the consequences of Vitamin D deficiency for cognitive, cardiovascular, metabolic, immune, and renal disorders.
Author : Suks Minhas
Publisher : John Wiley & Sons
ISBN 13 : 1118746554
Total Pages : 340 pages
Book Rating : 4.1/5 (187 download)
Download or read book Male Sexual Dysfunction written by Suks Minhas and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sexual dysfunction affects men of all ages and incidence rates are expected to double by 2025 resulting in a major health burden. Though normal sexual function is an important aspect of health and well-being, sadly, this common condition still carries an associated stigma. As a result, affected men are often reluctant to approach their doctor and, instead, may live for many years with sexual dysfunction, often to the detriment of their personal lives. Male Sexual Dysfunction: A Clinical Guide covers all the common problems encountered by the clinician in this rapidly expanding and developing field. With full color throughout, this easy to read guide provides a comprehensive and systematic approach to patient management. Packed with key features, every chapter will contain flow diagrams and algorithms, key points, clinical pearls, what to avoid boxes, and numerous tables, graphs and photographs . This book provides: Comprehensive focus on the core clinical areas of physiology/pharmacology, investigation, diagnosis, management and surgical options Coverage of all treatment pathways, including psychological, pharmacologic and surgical A straightforward, logical approach to clinical management An experienced and international editor and contributor team Expertly-written, this book is the perfect resource for urologists and general practitioners with an interest in this highly topical area, as well as those about to undergo their urology trainee examinations.
