Zinc Biochemistry Physiology And Homeostasis

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Zinc Biochemistry, Physiology, and Homeostasis

Author : W. Maret
Publisher : Springer Science & Business Media
ISBN 13 : 9401737282
Total Pages : 232 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Zinc Biochemistry, Physiology, and Homeostasis by : W. Maret

Download or read book Zinc Biochemistry, Physiology, and Homeostasis written by W. Maret and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapters in this book review the remarkable advances in the field of zinc biology over the last decade. Zinc is essential for life, in particular for growth and development, through its role in hundreds of zinc enzymes and thousands of zinc proteins. Its catalytic, structural, and regulatory functions in these proteins impact metabolism, gene expression, and signal transduction, including neurotransmission. Among the micronutrients, zinc may rank with iron as to its importance for public health. The topics covered range from single molecules to cells and to whole organisms: the chemistry, design, and application of fluorophores for the determination of cellular zinc; the role of zinc in proliferation, differentiation, and apoptosis of cells; proteins that transport, sense, and distribute zinc and together form a cellular homeostatic system; the coordination chemistry of zinc in metalloproteins; the role of zinc in the brain as a neuromodulator/transmitter; the dependence of the immune system on zinc; zinc homeostasis in the whole human body.

Zinc Signaling in Physiology and Pathogenesis

Author : Toshiyuki Fukada
Publisher : MDPI
ISBN 13 : 3038428213
Total Pages : 293 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Zinc Signaling in Physiology and Pathogenesis by : Toshiyuki Fukada

Download or read book Zinc Signaling in Physiology and Pathogenesis written by Toshiyuki Fukada and published by MDPI. This book was released on 2018-05-04 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS

Zinc in Human Biology

Author : Colin F. Mills
Publisher : Springer Science & Business Media
ISBN 13 : 1447138791
Total Pages : 394 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Zinc in Human Biology by : Colin F. Mills

Download or read book Zinc in Human Biology written by Colin F. Mills and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume is one of a series concerned with topics considered to be of growing interest to those whose ultimate aim is the understanding of the nutrition of man. Volumes on Sweetness, Calcium in Human Biology and Sucrose: Nutritional and Safety Aspects, have already been published, and another, on Dietary Starches and Sugars in Man: A Comparison, is in preparation. Written for workers in the nutritional and allied sciences rather than for the specialist, they aim to fill the gap between the textbook on the one hand and the many publications addressed to the expert on the other. The target readership spans medicine, nutrition and the biological sciences generally and includes those in the food, chemical and allied industries who need to take account of advances in these fields relevant to their products. Funded by industry but with an independent status, the Inter national Life Sciences Institute (ILSI) is a non-profit organization founded to deal objectively with the numerous health and safety issues that today concern industry internationally. ILSI sponsors scientific research, organizes conferences and publishes monographs relative to these problems. London Ian Macdonald March 1988 Series Editor Preface This volume has been prepared at a time when interest in both the biological roles of zinc and its nutritional significance is growing rapidly.

Zinc Signals in Cellular Functions and Disorders

Author : Toshiyuki Fukada
Publisher : Springer
ISBN 13 : 443155114X
Total Pages : 345 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Zinc Signals in Cellular Functions and Disorders by : Toshiyuki Fukada

Download or read book Zinc Signals in Cellular Functions and Disorders written by Toshiyuki Fukada and published by Springer. This book was released on 2014-09-25 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the crucial role of "zinc signals" in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon. To accomplish this, a group of worldwide leaders in the field, who have made outstanding contributions, overview zinc signals from a professional standpoint. Zinc plays an indispensable role in various cellular processes. It regulates a great number of protein functions including transcription factors, enzymes, adapters, and growth factors as a structural or catalytic factor or both. Recently, another function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an intracellular and extracellular signaling factor and thus regulates cellular signaling pathways, which enables communication between cells, conversion of extracellular stimuli to intracellular signals, and control of various intracellular events. These functions of zinc have become recognized as “zinc signals,” which play critical roles in physiology, and therefore their imbalance can cause a variety of problems with regard to human health. Because the notion of zinc signals is quite new and no integrative review books focusing on them have yet been published, we believe this book will provide very timely information on the subject and thus should be of importance and interest to a wide range of readers.

Zinc Signaling

Author : Toshiyuki Fukada
Publisher : Springer Nature
ISBN 13 : 9811505578
Total Pages : 412 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Zinc Signaling by : Toshiyuki Fukada

Download or read book Zinc Signaling written by Toshiyuki Fukada and published by Springer Nature. This book was released on 2019-12-13 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Zinc in Human Health

Author : Lothar Rink
Publisher :
ISBN 13 : 9781607508151
Total Pages : 0 pages
Book Rating : 4.5/5 (81 download)

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Book Synopsis Zinc in Human Health by : Lothar Rink

Download or read book Zinc in Human Health written by Lothar Rink and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This comprehensive book provides a state of the art overview of the role of zinc as an essential trace element in human diet and its effect on human health."--P. 4 of cover.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Download Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc PDF Online Free

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309072905
Total Pages : 798 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

Metal Transporters

Author : Jose M. Arguello
Publisher : Academic Press
ISBN 13 : 0123943906
Total Pages : 478 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Metal Transporters by : Jose M. Arguello

Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise

Molecular Mechanisms of Zinc Homeostasis in Bacillus Subtilis Mediated by Zur, a Fur Family Member

Author : Scott Edward Gabriel
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (46 download)

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Book Synopsis Molecular Mechanisms of Zinc Homeostasis in Bacillus Subtilis Mediated by Zur, a Fur Family Member by : Scott Edward Gabriel

Download or read book Molecular Mechanisms of Zinc Homeostasis in Bacillus Subtilis Mediated by Zur, a Fur Family Member written by Scott Edward Gabriel and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zinc is an essential nutrient due to its role as a structural co-factor for protein folding and as a catalytic co-factor for many enzymes. However, if this nutrient accumulates over a given threshold, it can become toxic to the cell. For these reasons, it is absolutely critical for cell survival that zinc homeostasis be tightly controlled. In Bacillus subtilis, a model Gram positive organism, the response to zinc limitation is mediated by Zur which acts as a classical repressor when Zinc is present. The Zur regulon has been characterized and currently contains ten genes all suspected or known to contribute to the zinc starvation response. Classically this response was thought of in terms of obtaining external zinc by high affinity pumps. In part, the work presented within will show that our understanding bacterial metal ion homeostasis is expanding. We now understand that in addition to uptake as a metal limitation response, cells also create duplicates of zinc requiring proteins which have altered metal co-factor specificity, a mechanism we classify as substitution. Finally, bacteria use mobilization as a response mechanism by creating conditions in which zinc containing proteins are replaced and the zinc which they contained is used for continued growth in zinc limiting conditions. The work presented here shows a cross-section of the molecular mechanisms Zur employs to achieve zinc homeostasis in Bacillus subtilis. Starting at the protein biochemistry level, I will present studies aimed at addressing how Zur senses zinc. This work uses a site directed mutagenesis approach to identify amino acid residues which make up the three conserved zinc binding pockets within the Zur protein and how each contributes to Zur's function. Second, after understanding how the protein senses zinc, I sought to understand how Zur regulated one of the uncharacterized members of its regulon, the yciC gene. In addition to elucidating the regulation of the unique promoter structure of yciC, I also show that Zur binds a consensus 9-1-9 inverted repeat. Finally at a physiological level, I studied the three ribosomal genes under the control of Zur to understand their contribution towards the zinc starvation response.

Zinc Metabolism

Author : Ananda Shiva Prasad
Publisher :
ISBN 13 :
Total Pages : 498 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Zinc Metabolism by : Ananda Shiva Prasad

Download or read book Zinc Metabolism written by Ananda Shiva Prasad and published by . This book was released on 1966 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Zinc Homeostasis in E. Coli

Author : Mart Patrick Hensley
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (973 download)

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Book Synopsis Zinc Homeostasis in E. Coli by : Mart Patrick Hensley

Download or read book Zinc Homeostasis in E. Coli written by Mart Patrick Hensley and published by . This book was released on 2012 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: The homeostasis of transition metal ions is critical to the survival of all organisms. Zinc (Zn(II)) is one of the most important transition metals found in biological systems; however, the homeostasis of this metal is poorly understood. Previous studies have shown that intracellular Zn(II) levels in E. coli are in the low millimolar range, yet there is less than one "free" (unbound) Zn(II) ion per cell. There must exist in the E. coli cell a mechanism for the delivery and insertion of Zn(II) into proteins. The cytoplasmic transport of other transitions metals, such as copper, iron, nickel, manganese, and arsenic, is accomplished by a group of proteins called metallochaperones. No such metallochaperone has been identified for Zn(II). Since none of the available models for intracellular Zn(II) transport are able to explain adequately Zn(II) homeostasis in E. coli, we hypothesized a new model. This model proposes that Zn(II) is delivered to Zn(II) metalloproteins as the proteins are translated and exiting the ribosome. In the co-translational model for Zn(II) homeostasis, the first datum that must be accounted for is the constant presence of 0.2 mM Zn(II) in E. coli. In Chapter 2 it is shown that the ribosome binds significant amounts of Zn(II). This ribosomal storage accounts for millimolar amounts of intracellular Zn(II). In Chapters 3 and 4 studies on several ribosomal proteins (L31, L13, L22, L24, and L29) are presented in an effort to identify Zn(II) binding proteins that could transfer Zn(II) to nascent proteins. Our data show that soluble L31 adopts a unique Zn(II) binding motif containing one cysteine and histidine. This Zn(II) binding site is reminiscent of the Cu(I) binding site of ATX1, a copper metallochaperone. Close examination of the E. coli ribosome crystal structures shows that L31 does not bind Zn(II) with the same binding site as in solution. By accounting for all known data about Zn(II) homeostasis in E. coli, it is hypothesized that ribosomal protein L31, while in solution and not bound to the ribosome, acts as a Zn(II) metallochaperone, delivering Zn(II) to nascent proteins as they exit the ribosome.

Diet and Health

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Protein Nutrition and Mineral Absorption

Author : Raul A. Wapnir
Publisher : CRC Press
ISBN 13 : 9780849352270
Total Pages : 360 pages
Book Rating : 4.3/5 (522 download)

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Book Synopsis Protein Nutrition and Mineral Absorption by : Raul A. Wapnir

Download or read book Protein Nutrition and Mineral Absorption written by Raul A. Wapnir and published by CRC Press. This book was released on 1990-09-25 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, plus 25 tables. Nutritionists and physicians will find this book to be an invaluable reference source for rationalizing nutritional interventions and diet modifications for their patients.

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Microbial Biofertilizers and Micronutrient Availability

Author : Shams Tabrez, Khan
Publisher : Springer Nature
ISBN 13 : 3030766098
Total Pages : 468 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Microbial Biofertilizers and Micronutrient Availability by : Shams Tabrez, Khan

Download or read book Microbial Biofertilizers and Micronutrient Availability written by Shams Tabrez, Khan and published by Springer Nature. This book was released on 2021-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses various issues related to micronutrient deficiency, especially zinc, and discusses the possible approaches for combating mineral deficiency among humans and plants. The book mainly focuses on the zinc biofortification of vegetable and cereal crops and highlights the consequences of zinc deficiency and the health risks associated with zinc deficiency, especially in children and expecting mothers. The authors discuss different types of food that are rich in zinc and other minerals, how diets can be designed to meet the daily zinc requirements, and the impact of zinc deficiency on plant health and quality of agricultural products and the role of micronutrients in abiotic stress tolerance. The book also covers sustainable approaches to zinc biofortification in crops, such as the microbial solubilization of zinc in soil to improve zinc uptake by plants, and the formulation of these microbes into biofertilizers. The book will be of interest to dieticians, agricultural scientists, students and microbiologists.

Molecular Biology of Metal Homeostasis and Detoxification

Author : Markus J. Tamás
Publisher : Springer Science & Business Media
ISBN 13 : 3540317198
Total Pages : 519 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Molecular Biology of Metal Homeostasis and Detoxification by : Markus J. Tamás

Download or read book Molecular Biology of Metal Homeostasis and Detoxification written by Markus J. Tamás and published by Springer Science & Business Media. This book was released on 2006-07-07 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

Protective Chemical Agents in the Amelioration of Plant Abiotic Stress

Author : Aryadeep Roychoudhury
Publisher : John Wiley & Sons
ISBN 13 : 1119551633
Total Pages : 698 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Protective Chemical Agents in the Amelioration of Plant Abiotic Stress by : Aryadeep Roychoudhury

Download or read book Protective Chemical Agents in the Amelioration of Plant Abiotic Stress written by Aryadeep Roychoudhury and published by John Wiley & Sons. This book was released on 2020-07-07 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the chemical agents that protect plants from various environmental stressors Protective Chemical Agents in the Amelioration of Plant Abiotic Stress offers a guide to the diverse chemical agents that have the potential to mitigate different forms of abiotic stresses in plants. Edited by two experts on the topic, the book explores the role of novel chemicals and shows how using such unique chemical agents can tackle the oxidative damages caused by environmental stresses. Exogenous application of different chemical agents or chemical priming of seeds presents opportunities for crop stress management. The use of chemical compounds as protective agents has been found to improve plant tolerance significantly in various crop and non-crop species against a range of different individually applied abiotic stresses by regulating the endogenous levels of the protective agents within plants. This important book: Explores the efficacy of various chemical agents to eliminate abiotic stress Offers a groundbreaking look at the topic and reviews the most recent advances in the field Includes information from noted authorities on the subject Promises to benefit agriculture under stress conditions at the ground level Written for researchers, academicians, and scientists, Protective Chemical Agents in the Amelioration of Plant Abiotic Stress details the wide range of protective chemical agents, their applications, and their intricate biochemical and molecular mechanism of action within the plant systems during adverse situations.