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Download or read book X-Ray Crystallographic Studies Of Designed Peptides written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book X-Ray Crystallographic Studies Of Designed Peptides And Protected Omega Amino Acids written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book X-ray Crystallographic Studies Of Designed Peptides, Self Assembling Pseudopeptides And Molecular Modeling written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural studies of peptides has relevance for various applications, like, in de novo design of proteins, in designing better catalysts for organic synthesis, in structure based drug design, in the design and construction of synthetic protein mimics and in building novel materials via supramolecular self assembly. Crystal structure determination of peptides is expected to provide information about their static structure, mode of aggregation, solvation and hydrogen bond interactions of the sequences in the solid state. Comparison and analysis of the related structures from the database analysis could provide information about sequence dependent conformational features, which eventually would act as precursor for de novo protein design. Self assembling processes are common throughout nature and technology. Living cells self assemble, and understanding life will therefore require an understanding of self assembly. Supramolecular chemistry has become an area of intense research, partly inspired by biological ensembles in nature, such as collagen and enzymes or protein assemblies in general. Understanding, inducing, and directing such self assembling processes are key to unraveling the progressive emergence of complex matter. Most of the drugs available today have a broad spectrum of action in that they can act on more than one receptor and the mechanism of action of these drugs are poorly understood. Homology modeling of receptors and docking studies with drug molecules (both peptides and non-peptides) would result in a better understanding of the mechanism of drug-receptor binding thus resulting in the design of more specific and effective drugs. This thesis reports the results of X-ray crystallographic studies of ten molecules listed below (Ter: terephthalic acid) and the molecular model of cholecystokinin type 1 receptor (CCK1R). The abbreviations used for the sequences are given in parenthesis. Boc-Gly-Dpg-Gly-Leu-OMe (GDGL), C24H44N4O7 Boc-Val-Ala-Leu-Dpg-Val-Ala.
Author : Jan Drenth
Publisher : Springer Science & Business Media
ISBN 13 : 1475730926
Total Pages : 355 pages
Book Rating : 4.4/5 (757 download)
Download or read book Principles of Protein X-ray Crystallography written by Jan Drenth and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.
Author : Pauline May Cowan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book X-Ray Crystallographic Studies in Some Peptides and Proteins written by Pauline May Cowan and published by . This book was released on 1952 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ryan K. Spencer
Publisher :
ISBN 13 : 9781321646443
Total Pages : 221 pages
Book Rating : 4.6/5 (464 download)
Download or read book X-ray Crystallographic Studies of Oligomers Derived from Amyloidogenic Peptides and Proteins written by Ryan K. Spencer and published by . This book was released on 2015 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert E. Babine
Publisher : John Wiley & Sons
ISBN 13 : 9783527306787
Total Pages : 284 pages
Book Rating : 4.3/5 (67 download)
Download or read book Protein Crystallography in Drug Discovery, Volume 20 written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2004-02-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
Author : Rachel Zoe Kramer
Publisher :
ISBN 13 :
Total Pages : 496 pages
Book Rating : 4.:/5 (838 download)
Download or read book X-ray Crystallographic Structural Studies of Three Collagen-like Peptides written by Rachel Zoe Kramer and published by . This book was released on 1998 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sukarno Ferreira
Publisher : BoD – Books on Demand
ISBN 13 : 9535110101
Total Pages : 436 pages
Book Rating : 4.5/5 (351 download)
Download or read book Advanced Topics on Crystal Growth written by Sukarno Ferreira and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystal growth is the key step of a great number of very important applications. The development of new devices and products, from the traditional microelectronic industry to pharmaceutical industry and many others, depends on crystallization processes. The objective of this book is not to cover all areas of crystal growth but just present, as specified in the title, important selected topics, as applied to organic and inorganic systems. All authors have been selected for being key researchers in their field of specialization, working in important universities and research labs around the world. The first section is mainly devoted to biological systems and covers topics like proteins, bone and ice crystallization. The second section brings some applications to inorganic systems and describes more general growth techniques like chemical vapor crystallization and electrodeposition. This book is mostly recommended for students working in the field of crystal growth and for scientists and engineers in the fields of crystalline materials, crystal engineering and the industrial applications of crystallization processes.
Author : M. N. G. James
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (944 download)
Download or read book X-ray Crystallographic Studies of Some Antibiotic Peptides written by M. N. G. James and published by . This book was released on 1966 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiaofei Jia
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (129 download)
Download or read book X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics written by Xiaofei Jia and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : T. L. Blundell
Publisher : Academic Press
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.:/5 ( download)
Download or read book Protein Crystallography written by T. L. Blundell and published by Academic Press. This book was released on 1976-01-28 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : W Laver
Publisher : Elsevier
ISBN 13 : 0323152457
Total Pages : 415 pages
Book Rating : 4.3/5 (231 download)
Download or read book Use of X-Ray Crystallography in the Design of Antiviral Agents written by W Laver and published by Elsevier. This book was released on 2012-12-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use of X-Ray Crystallography in the Design of Antiviral Agents describes materials presented at an International Workshop held in Kona, Hawaii on February 6-8, 1989, which discussed the use of X-ray crystallography in the design of antiviral agents. This book focuses on the approach that determines the three-dimensional structures of viruses and virus proteins with biological activity, such as computer molecular modeling. The three-dimensional structures of a number of immune complexes that involve complexes of antigen with antibodies or peptide antigens complexed with an MHC molecule are also deliberated. This text emphasizes that the three-dimensional structures allow the rational design of virus replication inhibitors that control virus infections in man and economically important domestic animals. This publication is a good reference for pharmacists, biochemists, and clinicians researching on the design of antiviral agents.
Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
ISBN 13 : 0081007426
Total Pages : 655 pages
Book Rating : 4.0/5 (81 download)
Download or read book Peptide Applications in Biomedicine, Biotechnology and Bioengineering written by Sotirios Koutsopoulos and published by Woodhead Publishing. This book was released on 2017-11-16 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides
![Download X-ray Crystallography as a Tool for the Structural Study and Design of [alpha]/[beta]-peptides PDF Online Free](https://books.google.com/books/content/images/frontcover/G2ZlzQEACAAJ?fife=w200-h370)
Author : Nicole Christine Thomas
Publisher :
ISBN 13 :
Total Pages : 173 pages
Book Rating : 4.:/5 (113 download)
Download or read book X-ray Crystallography as a Tool for the Structural Study and Design of [alpha]/[beta]-peptides written by Nicole Christine Thomas and published by . This book was released on 2018 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: My thesis focuses on the use of X-ray crystallography as a tool to study the structure of alpha/beta-peptides. First, I describe my efforts to solve and interpret two quasiracemic crystal structures of magainin 2 derivatives in an attempt to identify biologically relevant association modes. Chapter 3 details my work in solving the first co-crystal structure of a nonhelical alpha/beta-peptide bound to its protein target, VEGF8-109, and comparing the binding interactions observed in the co-crystal structure with those of a related alpha-peptide bound to VEGF8-109 in a published NMR structure. Chapter 4 summarizes how I used the co-crystal structure from chapter 3 in an attempt to develop alpha/beta-peptides with tighter binding to VEGF8-109.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (915 download)
Download or read book X-ray Crystallographic Methods for the Study of Native and Non-native Protein Structure written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diverse functions that proteins carry out are intimately connected with the three-dimensional shapes that these molecules adopt in solution. Our understanding of the various biological roles that proteins play depends critically on our ability to probe their underlying structural parameters. Among the various experimental methods that have been used to interrogate protein structure, X-ray crystallography is unrivaled in its capacity to provide high-resolution structural information. In spite of its advantages as a tool for protein structural analysis, X-ray crystallography suffers a critical drawback in that it requires that a single crystal of the protein of interest be grown. The racemic crystallization method, which involves the combination of enantiomeric proteins in a crystallization experiment, has attracted significant interest because it is believed to facilitate crystal growth from proteins that are recalcitrant to conventional crystallization techniques. The majority of the work described in this dissertation centers on the application of racemic crystallization to the structural characterization of several different peptides and proteins. Through our studies, we have found that the racemic method can provide insights into how non-canonical amino acid subunits are accommodated within an otherwise native protein context; these findings are relevant to design efforts involving non-natural subunits. Additionally, we used the racemic method to explore interactions between enantiomeric (i.e., L- and D-) polypeptides. These studies provide a starting point for efforts to design protease-resistant D-peptide inhibitors of protein-protein interactions of therapeutic interest. Chapter Two of this dissertation describes our efforts to assess the impact of incorporating a highly fluorinated amino acid into the hydrophobic core of a model protein tertiary structure. Chapter Three details our structural analysis of the racemic form of a [beta]-sheet protein tertiary structure that had resisted previous attempts at conventional crystallization. Chapter Four of this dissertation describes the results of our efforts to crystallize the racemic form of a membrane-embedded peptide segment using two different crystallization media. These studies have provided structural insights into intimate packing interactions that occur between L- and D-polypeptides. Chapter Five details an ongoing study involving substitutions of backbone-modified amino acids into protein loops.
Author : Linus Pauling
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (127 download)
Download or read book X-ray Diffraction Studies of Amino Acids, Peptides and Proteins written by Linus Pauling and published by . This book was released on 1948 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
