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Veterinary Clinical Trials From Concept To Completion
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Book Synopsis Veterinary Clinical Trials From Concept to Completion by : Nigel Dent
Download or read book Veterinary Clinical Trials From Concept to Completion written by Nigel Dent and published by CRC Press. This book was released on 2001-12-31 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceived and edited by Nigel Dent and Ramzan Visanji, Veterinary Clinical Trials form Concept to Completion is designed for both established practitioners and novices, offering alternative ways of conducting studies and ensuring that the studies are guided by Good Clinical Practices and are in compliance with regulations. Comprehensive in scope, it provides the scientific, biological, and regulatory background invaluable to teachers, researchers, and regulatory affairs staff, as well as those directly involved in clinical trials. The book covers: Objectives of the clinical study Control of the study Conduct of the study Regulation versus compliance Factors for success International harmonization activities Roles of the investigator, the monitor, and the practicing veterinarian Setting up GCP trials with particular animal species SOPs, the generic protocol, and the study report Contract research farms and multi-site studies Auditing With contributions from experts in every area of veterinary trials, the text has been organized with everyday use in mind. The chapters can be read sequentially for a comprehensive view or individually for coverage of particular topics and issues as needed. Drawing directly from the in-the-trenches experience of the editors and chapter authors, the book is a guide to methods that ensure studies meet regulatory compliance and strategies that ensure avoidance of common pitfalls.
Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis Sharing Clinical Trial Data by : Institute of Medicine
Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Book Synopsis Critical Needs for Research in Veterinary Science by : National Research Council
Download or read book Critical Needs for Research in Veterinary Science written by National Research Council and published by National Academies Press. This book was released on 2005-10-18 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in veterinary science is critical for the health and well-being of animals, including humans. Food safety, emerging infectious diseases, the development of new therapies, and the possibility of bioterrorism are examples of issues addressed by veterinary science that have an impact on both human and animal health. However, there is a lack of scientists engaged in veterinary research. Too few veterinarians pursue research careers, and there is a shortage of facilities and funding for conducting research. This report identifies questions and issues that veterinary research can help to address, and discusses the scientific expertise and infrastructure needed to meet the most critical research needs. The report finds that there is an urgent need to provide adequate resources for investigators, training programs, and facilities involved in veterinary research.
Book Synopsis Guide to Veterinary Clinical Research: from Idea T O Publication by : V. J. Adams
Download or read book Guide to Veterinary Clinical Research: from Idea T O Publication written by V. J. Adams and published by Wiley-Blackwell. This book was released on 2021-03-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Learning from Disease in Pets by : Rebecca A. Krimins
Download or read book Learning from Disease in Pets written by Rebecca A. Krimins and published by CRC Press. This book was released on 2020-11-25 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.
Book Synopsis Handbook of Veterinary Clinical Research by : Mark Holmes
Download or read book Handbook of Veterinary Clinical Research written by Mark Holmes and published by Wiley-Blackwell. This book was released on 2008-01-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first accessible information on how to carry out veterinary clinical research. This book is an aid to increasing the quantity and quality of such research within veterinary clinical practice. Covering all the core research methods as well as aspects specific to veterinary medicine. Clinical research aims to optimize decision making in practice by answering questions on the best diagnostic options and treatments. Reading this book will help you take the intellectually rewarding step towards improving prognoses and outcomes through informed decisions. Special attention is given to ethical and legal issues, how to maximise the power of studies when faced with small numbers of patients, and how to go about research with few obvious resources to hand.
Book Synopsis Veterinary Clinical Epidemiology by : Ronald D. Smith
Download or read book Veterinary Clinical Epidemiology written by Ronald D. Smith and published by CRC Press. This book was released on 2019-11-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: 4* Doody's Review! Ideal for veterinary students, residents and clinicians, the fourth edition of this bestselling textbook has been fully updated in line with developments in research and teaching. The logical chapter progression reflects the stages in a clinical case work-up and how epidemiological concepts and methods contribute. This new edition provides guidelines for improving patient and population health outcomes, and detecting emerging diseases through systematic evaluation of patient encounters and electronic medical records incorporates new methodologies and concepts drawn from the recent veterinary practice literature updates chapter content including expanded coverage of risk, statistical and economic analyses, and surveillance for emerging diseases more than 60 examples of clinical research drawn from the international veterinary practice literature presented as structured abstracts; follow-up questions invite the reader to participate in the analysis of results online links to full text versions of more than half of structured abstracts and more than 40% of the book’s 174 literature citations updates the listing and review of public and private online resources, including guidelines for online literature searching and critical evaluation of clinical reports. Today’s veterinary curricula places greater emphasis on experiential/problem-based learning versus discipline-oriented instruction. This fourth edition is ideally suited to introduce epidemiologic concepts and methodologies to veterinary students in the context of the patient encounter, and should be of use at any point in the veterinary curriculum.
Book Synopsis Management of Animal Care and Use Programs in Research, Education, and Testing by : Robert H. Weichbrod
Download or read book Management of Animal Care and Use Programs in Research, Education, and Testing written by Robert H. Weichbrod and published by CRC Press. This book was released on 2017-09-07 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).
Book Synopsis Military Occupational Classification and Structure by :
Download or read book Military Occupational Classification and Structure written by and published by . This book was released on 1994 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Manual of Veterinary Clinical Chemistry by : Leslie C. Sharkey
Download or read book Manual of Veterinary Clinical Chemistry written by Leslie C. Sharkey and published by CRC Press. This book was released on 2010-04-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This case study based workbook provides veterinary students and non-specialist with a guide to effective use and interpretation of clinical chemistry laboratory methods in domestic animals. The 100+ case studies involve real patients and findings in dogs, cats, horses, lamas, alpacas, pot belled pigs and ferrets. These consist of patient history, physical examination findings, and clinicopthologic data such as CBC, urinalysis, cytology or fluid analysis. A summary is given for each patient that includes a description of follow up tests and response to treatment. Multiple cases of common diseases illustrate the variety of clinciopathologic findings with the same diagnosis depending on individual patient factors. Diagnostic dilemmas in which different diseases may present with similar clinical signs and laboratory data are also included. Published by Teton New Media in the USA and distributed by CRC Press outside of North America.
Book Synopsis The Veterinary Medical Experiment Station by : John M. Bowen
Download or read book The Veterinary Medical Experiment Station written by John M. Bowen and published by . This book was released on 1981* with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proceedings of Symposium on Clinical Trials with Therapeutic Drugs in Animals, [held at Old Colony Inn, ... Alexandria, VA] April 18-19, 1985 by : Jean D. Powers
Download or read book Proceedings of Symposium on Clinical Trials with Therapeutic Drugs in Animals, [held at Old Colony Inn, ... Alexandria, VA] April 18-19, 1985 written by Jean D. Powers and published by . This book was released on 1985 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Veterinary Clinical Parasitology by : Anne M. Zajac
Download or read book Veterinary Clinical Parasitology written by Anne M. Zajac and published by John Wiley & Sons. This book was released on 2012-02-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Clinical Parasitology, Eighth Edition, prepared under the auspices of the American Association of Veterinary Parasitologists (AAVP), emphasizes the morphologic identification of both internal and external parasites of domestic animals. Focusing on the tests and information most relevant to daily practice, the book describes accurate, cost-effective techniques for diagnosing parasitic infections in animals. Including clear, easy-to-find information on the distribution, life cycle, and importance of each parasite, Veterinary Clinical Parasitology offers more than 450 images to aid with diagnosis. The Eighth Edition includes a new chapter on immunologic and molecular diagnosis, increased coverage of ticks and new sections on identification of microfilariae and larvae in diagnostic samples. The new edition also features expanded information on quantitative egg counts, detection of anthelmintic resistance and identification of ruminant strongylid larvae. Additional improvements include many new images throughout the book, revised taxonomic information, a new layout featuring tabs by section to improve user-friendliness, and a companion website offering the images from the book in PowerPoint at www.wiley.com/go/zajac. Veterinary Clinical Parasitology is a highly practical benchside reference invaluable to clinicians, technicians, and students.
Book Synopsis Fundamentals of Veterinary Clinical Pathology by : Steven L. Stockham
Download or read book Fundamentals of Veterinary Clinical Pathology written by Steven L. Stockham and published by John Wiley & Sons. This book was released on 2013-05-31 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth information about common clinical laboratory assays that are used to evaluate domestic mammals, including what assays measure, sample or assay conditions that affect results, and what results indicate about the physiologic or pathologic state of a patient. Whenever possible, diseases and conditions are grouped by common mechanisms or processes to promote a conceptual understanding of laboratory data that can be generally applied across many species. New to the second edition are additional disorders, diagnostic tests, illustrations, images, references, and pathophysiologic explanations. This text has proven valuable to students and veterinarians wanting a fundamental understanding of veterinary clinical pathology.
Book Synopsis Duncan and Prasse's Veterinary Laboratory Medicine by : Kenneth S. Latimer
Download or read book Duncan and Prasse's Veterinary Laboratory Medicine written by Kenneth S. Latimer and published by John Wiley & Sons. This book was released on 2011-07-26 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in full color throughout, Duncan and Prasse’s Veterinary Laboratory Medicine: Clinical Pathology, Fifth Edition offers a comprehensive overview of hematology, hemostasis, clinical chemistry, urinalysis, cytology, and reference intervals in a highly accessible outline format. With information on all major domestic species, the text is designed for the reader to quickly find answers to clinical questions. Taking a problem-solving approach to the interpretation of laboratory data, this book includes clinical cases to illustrate the concepts of laboratory data interpretation, with tables and key words to aid readers in locating and applying information. The fifth edition has been fully revised to reflect the latest knowledge, diagnostic methods, and practices in veterinary laboratory medicine. A companion website provides the images in PowerPoint and references linked to PubMed at www.wiley.com/go/latimer. Duncan and Prasse’s Veterinary Laboratory Medicine is an excellent quick reference for practicing veterinarians, veterinary students, clinical interns and residents, and pathology residents.
Book Synopsis Feline Endocrinology by : Edward C. Feldman
Download or read book Feline Endocrinology written by Edward C. Feldman and published by . This book was released on 2019 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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