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Book Synopsis Nonviral Vectors for Gene Therapy by : Leaf Huang
Download or read book Nonviral Vectors for Gene Therapy written by Leaf Huang and published by Elsevier. This book was released on 2005-08-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.
Book Synopsis An Introduction to Vectors, Vector Operators and Vector Analysis by : Pramod S. Joag
Download or read book An Introduction to Vectors, Vector Operators and Vector Analysis written by Pramod S. Joag and published by Cambridge University Press. This book was released on 2016 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideal for undergraduate and graduate students of science and engineering, this book covers fundamental concepts of vectors and their applications in a single volume. The first unit deals with basic formulation, both conceptual and theoretical. It discusses applications of algebraic operations, Levi-Civita notation, and curvilinear coordinate systems like spherical polar and parabolic systems and structures, and analytical geometry of curves and surfaces. The second unit delves into the algebra of operators and their types and also explains the equivalence between the algebra of vector operators and the algebra of matrices. Formulation of eigen vectors and eigen values of a linear vector operator are elaborated using vector algebra. The third unit deals with vector analysis, discussing vector valued functions of a scalar variable and functions of vector argument (both scalar valued and vector valued), thus covering both the scalar vector fields and vector integration.
Book Synopsis Non-viral Vectors for Gene Therapy by : Leaf Huang
Download or read book Non-viral Vectors for Gene Therapy written by Leaf Huang and published by Gulf Professional Publishing. This book was released on 2005 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs of the plasmid DNA for reduced toxicity, prolonged expression and tissue or disease specific genes. New developments such as the toxicity of the non-viral vectors and recent advances in nucleic acid therapeutics are fully covered in these volumes.
Book Synopsis Vectors in Physics and Engineering by : Alan Durrant
Download or read book Vectors in Physics and Engineering written by Alan Durrant and published by Routledge. This book was released on 2019-02-25 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is an introduction to the use of vectors in a wide range of undergraduate disciplines. It is written specifically to match the level of experience and mathematical qualifications of students entering undergraduate and Higher National programmes and it assumes only a minimum of mathematical background on the part of the reader. Basic mathematics underlying the use of vectors is covered, and the text goes from fundamental concepts up to the level of first-year examination questions in engineering and physics. The material treated includes electromagnetic waves, alternating current, rotating fields, mechanisms, simple harmonic motion and vibrating systems. There are examples and exercises and the book contains many clear diagrams to complement the text. The provision of examples allows the student to become proficient in problem solving and the application of the material to a range of applications from science and engineering demonstrates the versatility of vector algebra as an analytical tool.
Book Synopsis Parasites and their vectors by : Yvonne Ai Lian Lim
Download or read book Parasites and their vectors written by Yvonne Ai Lian Lim and published by Springer Science & Business Media. This book was released on 2014-01-29 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Southeast Asia is a region where a myriad of infections are endemic. It is a hotspot region for parasitic diseases. Currently, information on parasitic infections and vectors found in Southeast Asia is sporadic and there has been no attempt to extensively collate and integrate these data. Gaps in our knowledge, which include disease patterns, transmission dynamics and vectors still exist. This book highlights parasitic diseases that are peculiar to Southeast Asia, pinpoints similarities and differences between disease patterns in the respective member countries and provide information on new emerging parasitic diseases in this region. Critically, this book will heighten understanding of parasitic diseases and their vectors in this diverse region and this knowledge will be significant for future regional research efforts in this field.
Book Synopsis From Vectors to Tensors by : Juan R. Ruiz-Tolosa
Download or read book From Vectors to Tensors written by Juan R. Ruiz-Tolosa and published by Springer Science & Business Media. This book was released on 2005-12-08 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook deals with tensors that are treated as vectors. Coverage details such new tensor concepts as the rotation of tensors, the transposer tensor, the eigentensors, and the permutation tensor structure. The book covers an existing gap between the classic theory of tensors and the possibility of solving tensor problems with a computer. A complementary computer package, written in Mathematica, is available through the Internet.
Book Synopsis Vectors of Plant Pathogens by : Kerry F. Harris
Download or read book Vectors of Plant Pathogens written by Kerry F. Harris and published by Academic Press. This book was released on 2013-10-02 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vectors of Plant Pathogens is a collection of papers that discusses the interrelationship of plant pathogens with their vectors. This collection deals with the numerous vector groups associated with plant pathogens. One paper describes the biology, feeding behavior and distribution of aphids, leafhoppers, plant hoppers, mealy bugs, whiteflies, psyllids, membracids. Another paper addresses the virus transmission characteristics of the mealy bugs during preliminary fasting or feeding, acquisition access time, post-acquisition fasting or feeding, and the inoculation access time. Other papers also discuss the involvement of insects in transmitting bacterial and fungal pathogens; the authors list unresolved issues such as the role of insects in overwintering of bacterial pathogens or the association of the fungus with a particular vector. One author describes some suspected fungi transmission such as the pea stem necrosis virus, red clover necrotic mosaic virus, and the tomato bushy stunt virus. Another paper examines the fate of plant viruses in mite vectors and convectors particularly the viruses found in wheat, barley, or brome grass. Agriculturists, botanists, and researchers in the field of botany, conservation, and plant genealogy will find this book useful.
Book Synopsis Viral Vectors for Treating Diseases of the Nervous System by : David S. Latchman
Download or read book Viral Vectors for Treating Diseases of the Nervous System written by David S. Latchman and published by Gulf Professional Publishing. This book was released on 2003-08-22 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy offers considerable potential for the treatment of various incurable diseases of the nervous system. Viral Vectors for Treating Disease of the Nervous System describes a number of different viral vectors developed for achieving high efficiency gene delivery to the brain. Vectors described include those based on adenovirus, adeno-associated virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It also discusses the potential application of such viruses in treating brain tumors, Parkinson's disease, and other diseases of the nervous system. Provides up-to-date account of gene therapy approaches for incurable neurological disorders Describes a range of gene delivery methods based on different viruses
Book Synopsis Minicircle and Miniplasmid DNA Vectors by : Martin Schleef
Download or read book Minicircle and Miniplasmid DNA Vectors written by Martin Schleef and published by John Wiley & Sons. This book was released on 2013-02-14 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
Book Synopsis Approaches to Blocking the Immune Response to Gene Transfer with Viral Vectors by : Katherine High
Download or read book Approaches to Blocking the Immune Response to Gene Transfer with Viral Vectors written by Katherine High and published by Frontiers E-books. This book was released on with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral vectors are superior tools for gene therapy and as a genetic vaccine platform because viruses have evolved to efficiently infect and transfer their genomes to cells. Several impressive successes in viral vector-based gene therapies have been reported in humans, including restoration of vision in patients with Leber’s congenital amaurosis by retinal gene transfer and cures for severe immune deficiencies by gene transfer to hematopoietic stem cells. However, the mammalian immune system has evolved in parallel to fend off invading pathogens such as viruses. Innate and antigen-specific adaptive immune responses against viral vectors and therapeutic transgene products pose serious hurdles for successful gene therapy. Pre-existing immunity in humans, resulting from prior exposure to the parent virus that forms the basis for the gene transfer vehicle may be derived from, often prevents efficient gene transfer. This problem also reduces our ability to use certain vectors for genetic vaccination or in anti-cancer therapy. For these reasons, the gene transfer community has been extensively studying the mechanisms of immune responses against viral vectors and has started to develop strategies and protocols to block or circumvent such responses. Choice, design and engineering of a vector as well as the route of administration/target tissue can be optimized/ altered to minimize immune responses or evade pre-existing immunity. Immune suppression and modulation strategies are being developed in order to minimize inflammation, prevent antibody or T cell responses against vectors, and to promote tolerance to therapeutic gene products. Combinations of these approaches will likely facilitate clinical applications of gene therapy for many target diseases and also aid in vaccine development.
Book Synopsis Vectors and 3D Geometry for JEE Advanced, 3E (Free Sample) by : G. Tewani
Download or read book Vectors and 3D Geometry for JEE Advanced, 3E (Free Sample) written by G. Tewani and published by Cengage India Private Limited. This book was released on 2022-05-19 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vectors and 3D Geometry for JEE (Advanced), a Cengage Exam Crack Series® product, is designed to help aspiring engineers focus on the subject of mathematics from two standpoints: To develop their caliber, aptitude, and attitude for the engineering field and profession. To strengthen their grasp and understanding of the concepts of the subjects of study and their applicability at the grassroots level. Each book in this series approaches the subject in a very conceptual and coherent manner. While its illustrative, solved examples facilitate easy mastering of the concepts and their applications, an array of solved problems exposes the students to a variety of questions that they can expect in the examination. The coverage and features of this series of books make it highly useful for all those preparing for JEE Main and Advanced and aspiring to become engineers.
Book Synopsis Immune responses to AAV vectors, from bench to bedside by : Federico Mingozzi
Download or read book Immune responses to AAV vectors, from bench to bedside written by Federico Mingozzi and published by Frontiers Media SA. This book was released on 2015-06-30 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic. Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
Book Synopsis Insect Vectors and Plant Pathogens by : Nachhattar Singh Butter
Download or read book Insect Vectors and Plant Pathogens written by Nachhattar Singh Butter and published by CRC Press. This book was released on 2018-08-14 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of pathogens and vectors, unique symptoms of diseases and economic importance of important viral diseases have been dealt with in the introductory chapter of this book. While highlighting the role of arthropods, nematodes, and fungi; other agents of the spread of plant pathogens have also been included. Important aspects of insect vectors with direct bearing on transmission, i.e. vector identification, biology, feeding apparatus, and mechanism of spread including control of pathogens through vectors are covered comprehensively. As aphids and other hemipterous insects are major insect vectors, the book stresses on this order. There is a focus on the transmission of determinants under different categories of the transmission mechanism. The transmission determinant paradigm comprising coat protein and helper component has been expounded with recent cases. A brief description of new diseases at least one from each genus of plant viruses has been included in this compendium to elucidate the interaction of vector and virus. Phytoplasmal etiology of pathogens has been detailed separately on account of their importance. The transmission of plant viruses through insects with biting and chewing type of mouth parts has been discussed in detail as separate chapter. The latest research in the field of mites, nematodes, and fungi as vectors of plant viruses has been included. How the phytotoxemia is different from other crop disorders, has been critically explained with support from suitable and common examples of crop disorders. The book also highlights the effects of plant viruses on their vectors. An account of classification of plant viruses has also been given for better understanding of subject matter. Likewise, the information on the electron microscope along with its use has been included so as to define the procedure of examining sub-microscopic entities. The latest developments in the management of plant pathogens through vector management have been discussed with special reference to the use of biotechnology, crop protection, and plant resistance. The book will be of value to the teachers and to researchers. It will also be useful for extension workers in managing crop disorders. Students and researchers of entomology, plant pathology, plant protection and virology disciplines will obtain the latest in the field, through this book.
Book Synopsis The Molecular Biology of Insect Disease Vectors by : J.M. Crampton
Download or read book The Molecular Biology of Insect Disease Vectors written by J.M. Crampton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only one generation ago, entomology was a proudly isolated discipline. In Comstock Hall, the building of the Department of Entomology at Cornell University where I was first introduced to experimental science in the laboratory of Tom Eisner, those of us interested in the chemistry of life felt like interlopers. In the 35 years that have elapsed since then, all of biology has changed, and entomology with it. Arrogant molecular biologists and resentful classical biologists might think that what has happened is a hostile take-over of biology by molecular biology. But they are wrong. More and more we now understand that the events were happier and much more exciting, amounting to a new synthesis. Molecular Biology, which was initially focused on the simplest of organisms, bacteria and viruses, broke out of its confines after the initial fundamental questions were answered - the structure of DNA, the genetic code, the nature of regulatory genes - and, importantly, as its methods became more and more generally applicable. The recombinant DNA revo lution of the 1970s, the development of techniques for sequencing macromolecules, the polymerase chain reaction, new molecular methods of genetic analysis, all brought molecular biology face to face with the infinite complexity and the exuber ant diversity of life. Molecular biology itself stopped being an isolated diScipline, pre occupied with the universal laws of life, and became an approach to addressing fas cinating specific problems from every field of biology.
Book Synopsis Locally Analytic Vectors in Representations of Locally -adic Analytic Groups by : Matthew J. Emerton
Download or read book Locally Analytic Vectors in Representations of Locally -adic Analytic Groups written by Matthew J. Emerton and published by American Mathematical Soc.. This book was released on 2017-07-13 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this memoir is to provide the foundations for the locally analytic representation theory that is required in three of the author's other papers on this topic. In the course of writing those papers the author found it useful to adopt a particular point of view on locally analytic representation theory: namely, regarding a locally analytic representation as being the inductive limit of its subspaces of analytic vectors (of various “radii of analyticity”). The author uses the analysis of these subspaces as one of the basic tools in his study of such representations. Thus in this memoir he presents a development of locally analytic representation theory built around this point of view. The author has made a deliberate effort to keep the exposition reasonably self-contained and hopes that this will be of some benefit to the reader.
Book Synopsis When vectors collide with cultures: 'anthropo-vector ecology', who is controlling who? by : Scientific committee
Download or read book When vectors collide with cultures: 'anthropo-vector ecology', who is controlling who? written by Scientific committee and published by BRILL. This book was released on 2023-09-04 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 20th European Society for Vector Ecology Conference 2016 wants to draw attention to the impact and importance of vectors and vector-borne diseases on landscapes inhabited by human beings and how to make this paradigm most effective to benefit public health. Session subjects are: invasive species: ecology and their potential role as vectors; citizen science and social approaches on vector control; epidemiology of vector-borne diseases and their vectors; ecology and behaviour of vectors; emerging vector-borne diseases and risk assessment; vector-pathogens interactions; taxonomy, systematic and phylogeny of vectors; and advance technologies on vector control.
Book Synopsis Plant Diseases and Vectors: Ecology and Epidemiology by : Karl Maramorosch
Download or read book Plant Diseases and Vectors: Ecology and Epidemiology written by Karl Maramorosch and published by Elsevier. This book was released on 2012-12-02 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Diseases and Vectors: Ecology and Epidemiology is the fourth in a five-volume series of books on vectors of plant disease agents. It is comprised of 10 chapters representing the expertise of 13 outstanding scientists from a total of seven different countries. This book begins with a discussion on the ecological involvement of wild plants in plant virus pathosystems. This is followed by the principles and applications of enzyme-linked immunosorbent assay (ELISA) in diagnosing plant viruses and monitoring their movement in the environment. The next two chapters detail the epidemiologies of diseases caused by leafhopper-borne viruses, mollicutes, and rickettsia-like organisms. This book also covers the developments in understanding the importance of helper agents to the transmission ecologies of many aphid-borne plant viruses. It also encompasses the factors that can contribute to the epidemiology and control of a disease affecting a major agricultural crop of the world. A vector of plant viruses not covered in earlier volumes of the series (the host plant, itself) and the man-made epidemiological hazards in major crops of developing countries are also described. This volume will broaden the knowledge of transmission ecology and disease epidemiology, not only by serving as a valuable supplemental textbook, reference work, and bibliographical source, but also by catalyzing novel syntheses of thinking and stimulating further research in the area.
