Vaccines Against Rna Viruses

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Vaccines against RNA Viruses

Author : Juan Carlos Saiz
Publisher : MDPI
ISBN 13 : 3039436236
Total Pages : 166 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Vaccines against RNA Viruses by : Juan Carlos Saiz

Download or read book Vaccines against RNA Viruses written by Juan Carlos Saiz and published by MDPI. This book was released on 2020-12-28 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2. For years vaccines have had an enormous impact on overcoming the global burden of diseases. Nowadays, a vast number of different approaches, from purified inactivated and live attenuated viruses, nucleic acid (DNA or RNA) based candidates, virus-like particles, subunit elements, and recombinant viruses are been employed to combat viruses. However, for many of them efficient vaccines are not yet available. This will probably change dramatically with the current Covid-19 pandemic, as a vast variety of vaccinology approaches are being tested against it, with hundreds of candidates under development, dozens of them already in clinical trials, a fact that is breaking records in vaccine development and implementation. This is becoming possible thanks to the enormous work carried out during years to have the bases for a quick response, even against unknown pathogens, in an impressive short time. Here, results obtained with different vaccine´s methodological approaches against human (HIV, HCV, HRV) animal (PRRSV, PEDV, FMDV, VHSV) and zoonotic (RVF, WNV), RNA viruses are presented by field experts.

Vaccines Against RNA Viruses

Author : Juan Carlos Saiz
Publisher :
ISBN 13 : 9783039436248
Total Pages : 166 pages
Book Rating : 4.4/5 (362 download)

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Book Synopsis Vaccines Against RNA Viruses by : Juan Carlos Saiz

Download or read book Vaccines Against RNA Viruses written by Juan Carlos Saiz and published by . This book was released on 2020 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2. For years vaccines have had an enormous impact on overcoming the global burden of diseases. Nowadays, a vast number of different approaches, from purified inactivated and live attenuated viruses, nucleic acid (DNA or RNA) based candidates, virus-like particles, subunit elements, and recombinant viruses are been employed to combat viruses. However, for many of them efficient vaccines are not yet available. This will probably change dramatically with the current Covid-19 pandemic, as a vast variety of vaccinology approaches are being tested against it, with hundreds of candidates under development, dozens of them already in clinical trials, a fact that is breaking records in vaccine development and implementation. This is becoming possible thanks to the enormous work carried out during years to have the bases for a quick response, even against unknown pathogens, in an impressive short time. Here, results obtained with different vaccine ́s methodological approaches against human (HIV, HCV, HRV) animal (PRRSV, PEDV, FMDV, VHSV) and zoonotic (RVF, WNV), RNA viruses are presented by field experts.

Viruses, Pandemics, and Immunity

Author : Arup K. Chakraborty
Publisher : MIT Press
ISBN 13 : 0262363453
Total Pages : 224 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Viruses, Pandemics, and Immunity by : Arup K. Chakraborty

Download or read book Viruses, Pandemics, and Immunity written by Arup K. Chakraborty and published by MIT Press. This book was released on 2021-02-16 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: How viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work. Throughout history, humans have contended with pandemics. History is replete with references to plagues, pestilence, and contagion, but the devastation wrought by pandemics had been largely forgotten by the twenty-first century. Now, the enormous human and economic toll of the rapidly spreading COVID-19 disease offers a vivid reminder that infectious disease pandemics are one of the greatest existential threats to humanity. This book provides an accessible explanation of how viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work-- concepts that are a foundation for our public health policies.

RNA Vaccines

Author : Thomas Kramps
Publisher : Humana
ISBN 13 : 9781071637692
Total Pages : 0 pages
Book Rating : 4.6/5 (376 download)

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Book Synopsis RNA Vaccines by : Thomas Kramps

Download or read book RNA Vaccines written by Thomas Kramps and published by Humana. This book was released on 2024-06-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with discussions of the latest technology and advancements in the development of RNA vaccines and proposed solutions on how to tackle currently unmet medical needs. The chapters in this book are organized into four parts and cover topics such as replication and non-replicating RNA vectors, formulation and delivery of RNA vaccines, and clinical and nonclinical development of RNA vaccines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and comprehensive, RNA Vaccines: Methods and Protocols, Second Edition is a valuable resource for any researcher interested in learning more about this important and developing field.

PEPTIDE VACCINES AGAINST MOSQUITO-BORNE RNA VIRUSES BASED ON BACTERIOPHAGE VIRUS-LIKE PARTICLES

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis PEPTIDE VACCINES AGAINST MOSQUITO-BORNE RNA VIRUSES BASED ON BACTERIOPHAGE VIRUS-LIKE PARTICLES by :

Download or read book PEPTIDE VACCINES AGAINST MOSQUITO-BORNE RNA VIRUSES BASED ON BACTERIOPHAGE VIRUS-LIKE PARTICLES written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract : Conventional vaccinology uses live attenuated viruses as well as inactivated viruses as vaccines. Live attenuated vaccines are very immunogenic and offer long lasting immunity to infectious agent but there cannot be used for everyone especially in patients with a compromised immune system. Inactivated vaccines are very safe and can be used to immunize everyone regardless of their immune status. However, unlike attenuated vaccines, their immune response is not long lasting. Given the limitations of conventional vaccinology, reverse vaccinology has recently been explored as an alternative approach to design safe and immunogenic vaccines against viral infections. Some regions in the envelope or the capsid of viruses have been predicted/shown to elicit neutralizing/protective antibodies against viruses. Reverse vaccinology is aimed at developing safe vaccines targeting only these regions (epitopes) on the envelope or the capsid of viruses. Although this approach is very safe, the epitopes (peptide antigens) used in developing these vaccines are less immunogenic due to the size, morphology, and the geometry of the peptide antigen in question. In this dissertation, I assessed the immunogenicity of peptide antigens derived from two mosquito-borne RNA virus, Zika virus (ZIKV) and Chikungunya virus (CHIKV), on a highly immunogenic bacteriophage platform known as virus-like particles (VLPs). Currently, there are no approved vaccines against ZIKV and CHIKV. In this dissertation, I showed that ZIKV and CHIKV peptides displayed on bacteriophage VLPs elicited high antibody titers even at a dose of 5 mg of the VLPs displaying the peptides. Additionally, sera from mice immunized with bacteriophage VLPs displaying ZIKV peptides neutralized ZIKV from infecting monkey kidneys cells. Bacteriophage VLPs is an excellent approach to enhance the immunogenicity of ZIKV and CHIKV peptide antigens. Because VLPs resemble viruses in terms of shape, size, morphology exception that, they lack the viral genome (do not replicate), there are excellent platforms to develop safe and effective peptide vaccines.

Reverse Genetics of RNA Viruses

Author : Anne Bridgen
Publisher : John Wiley & Sons
ISBN 13 : 111840534X
Total Pages : 482 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Reverse Genetics of RNA Viruses by : Anne Bridgen

Download or read book Reverse Genetics of RNA Viruses written by Anne Bridgen and published by John Wiley & Sons. This book was released on 2012-10-07 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.

Vaccines for Cancer Immunotherapy

Author : Nima Rezaei
Publisher : Academic Press
ISBN 13 : 0128140402
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Vaccines for Cancer Immunotherapy by : Nima Rezaei

Download or read book Vaccines for Cancer Immunotherapy written by Nima Rezaei and published by Academic Press. This book was released on 2018-10-17 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

The Vaccine Book

Author : Barry R. Bloom
Publisher : Academic Press
ISBN 13 : 012805400X
Total Pages : 666 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Vaccine Book by : Barry R. Bloom

Download or read book The Vaccine Book written by Barry R. Bloom and published by Academic Press. This book was released on 2016-06-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy

Positive-stranded RNA Viruses as Cancer Vaccines

Author : Stefanie Mandl
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (82 download)

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Book Synopsis Positive-stranded RNA Viruses as Cancer Vaccines by : Stefanie Mandl

Download or read book Positive-stranded RNA Viruses as Cancer Vaccines written by Stefanie Mandl and published by . This book was released on 2001 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prophylactic Ribonucleic Acid Vaccines to Combat RNA Viral Infections in Humans

Author : Irina Vlasova-St. Louis
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Prophylactic Ribonucleic Acid Vaccines to Combat RNA Viral Infections in Humans by : Irina Vlasova-St. Louis

Download or read book Prophylactic Ribonucleic Acid Vaccines to Combat RNA Viral Infections in Humans written by Irina Vlasova-St. Louis and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have evolved as widely applicable and available prophylaxes against infectious diseases. Advances in ribonucleic acid technologies revolutionized the biopharmaceutical field of vaccine manufacturing. Numerous novel mRNA-based vaccines that have been approved by the United States and European regulatory agencies are proven to be safe and effective in preventing disease. This chapter presents the history of RNA vaccine development in the context of preventing diseases caused by RNA viruses such as SARS-CoV-2, HIV, influenza, Chikungunya, Zika, RSV, PIV, HMPV viruses, Rabies, and Ebola. Advantages, disadvantages, and challenges in mRNA vaccine engineering, delivery, and safety are discussed. The formulation, safety, long-term effectiveness, and requirements for booster immunizations are presented using data from clinical trials. The results of these clinical trials highlight important milestones, setbacks, and ultimate advancements in vaccine development. mRNA vaccines have significantly impacted public health in a relatively short time, and they demonstrate great potential in serving as clinical public health prophylaxis against current and future pandemics. Future development is likely to include polyvalent, mosaic, and strain/lineage-specific individualized vaccines.

Reverse Genetics of RNA Viruses

Author : Daniel R. Pérez
Publisher : Springer Nature
ISBN 13 : 1071635336
Total Pages : 274 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Reverse Genetics of RNA Viruses by : Daniel R. Pérez

Download or read book Reverse Genetics of RNA Viruses written by Daniel R. Pérez and published by Springer Nature. This book was released on 2023-12-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with new and updated chapters that highlight the latest methods and approaches for the manipulation of RNA viruses. The chapters in this book explore the fundamental role in studying RNA viruses; identifying markers of host range, disease, and transmission; and aid readers with the further development of in silico computational biology tools and artificial intelligence algorithms that can help predict the emergence of certain pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Reverse Genetics of RNA Viruses: Methods and Protocols, Second Edition is a valuable resource for researchers who are interested in learning more about this developing field.

Structural Virology

Author : Mavis Agbandje-McKenna
Publisher : Royal Society of Chemistry
ISBN 13 : 184973223X
Total Pages : 389 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Structural Virology by : Mavis Agbandje-McKenna

Download or read book Structural Virology written by Mavis Agbandje-McKenna and published by Royal Society of Chemistry. This book was released on 2010-11-11 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

Viruses, Pandemics, and Immunity

Author : Arup K. Chakraborty
Publisher : MIT Press
ISBN 13 : 0262542382
Total Pages : 219 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Viruses, Pandemics, and Immunity by : Arup K. Chakraborty

Download or read book Viruses, Pandemics, and Immunity written by Arup K. Chakraborty and published by MIT Press. This book was released on 2021-02-16 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: How viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work. Throughout history, humans have contended with pandemics. History is replete with references to plagues, pestilence, and contagion, but the devastation wrought by pandemics had been largely forgotten by the twenty-first century. Now, the enormous human and economic toll of the rapidly spreading COVID-19 disease offers a vivid reminder that infectious disease pandemics are one of the greatest existential threats to humanity. This book provides an accessible explanation of how viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work-- concepts that are a foundation for our public health policies.

Non-segmented Negative-sense RNA Viruses as Vectors for Developing Vaccine Candidates Against Zika Virus Infection

Author : Anzhong Li (Virologist)
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Non-segmented Negative-sense RNA Viruses as Vectors for Developing Vaccine Candidates Against Zika Virus Infection by : Anzhong Li (Virologist)

Download or read book Non-segmented Negative-sense RNA Viruses as Vectors for Developing Vaccine Candidates Against Zika Virus Infection written by Anzhong Li (Virologist) and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zika virus (ZIKV) is a member of the family Flaviviridae which includes many other important mosquito-borne viruses such as dengue virus (DENV), West Nile virus (WNV), and yellow fever virus (YFV). Since it was discovered in 1947, sporadic outbreaks of ZIKV have been reported in Africa and Asia. Historically people infected with ZIKV often have no or mild symptoms. However, in 2015 a ZIKV pandemic began in South America, Central America, the Caribbean, and the USA, suddenly becoming a global public health issue. Importantly, ZIKV from these recent outbreaks can cause Congenital Zika Syndrome (including microcephaly), Guillain-Barre syndrome, and other severe neurological disorders. Thus, a safe and efficacious vaccine is urgently needed for ZIKV. Similar to other flaviviruses, the ZIKV genome encodes a single polyprotein that is cleaved into three structural proteins (capsid, C; premembrane, prM, and envelope, E) and seven nonstructural proteins. The E protein mediates cellular attachment and membrane fusion, and is the target for most neutralizing antibodies. Flavivirus prM protein typically associates with E to form heterodimers and is important for proper folding of E. Therefore, prM and E proteins have been the primary targets for subunit and recombinant ZIKV vaccine studies. Meanwhile, the nonstructural protein NS1 of several flaviviruses has been shown to confer some protection against flavivirus infection in animal models in the absence of detectable neutralizing antibody. Whether immunization with the ZIKV NS1 protein has certain protective capabilities is unclear. The goal of my research is to develop vesicular stomatitis virus (VSV) and measles virus (MeV)-based vaccine candidates for ZIKV. Both VSV and MeV are non-segmented negative-sense (NNS) RNA viruses. VSV is an animal virus and has been shown to be an excellent vaccine vector because of its high genetic stability and expression efficiency and no pre-existing immunity in the human population. In 2019, a VSV-based Ebola virus vaccine was approved by FDA for human uses. MeV is another excellent vector to deliver vaccines for human pathogens primarily because of its high safety and efficacy even in the presence of pre-existing anti-MeV vector immunity. Several MeV-based vaccine candidates are highly efficacious in human clinical trials. In Chapter 2, I developed a methyltransferase (MTase)-defective recombinant VSV (mtdVSV)-based ZIKV vaccine platform. The full-length E, E truncation mutants, prM-E, NS1, and prM-E-NS1 of ZIKV were inserted individually into a VSV vector that carrying an MTase mutation in the large polymerase protein.

Pandemic Outbreaks in the 21st Century

Author : Buddolla Viswanath
Publisher : Elsevier
ISBN 13 : 0323900011
Total Pages : 326 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Pandemic Outbreaks in the 21st Century by : Buddolla Viswanath

Download or read book Pandemic Outbreaks in the 21st Century written by Buddolla Viswanath and published by Elsevier. This book was released on 2021-08-24 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience. Provides insight to the lessons learned from past pandemics Gives recommendations, future direction in terms of detection, prevention and treatment of pandemics Guides readers through the status and recent developments of vaccines to overcome or prevent pandemics Shows how to enhance the host innate immunity in infectious diseases Includes a chapter on immunotherapies to combat pandemic outbreaks

RNA Viruses

Author : Decheng Yang
Publisher : World Scientific
ISBN 13 : 981283379X
Total Pages : 722 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis RNA Viruses by : Decheng Yang

Download or read book RNA Viruses written by Decheng Yang and published by World Scientific. This book was released on 2009 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host?virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

Biomedical Innovations to Combat COVID-19

Author : Sergio Rosales-Mendoza
Publisher : Academic Press
ISBN 13 : 0323902499
Total Pages : 411 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Biomedical Innovations to Combat COVID-19 by : Sergio Rosales-Mendoza

Download or read book Biomedical Innovations to Combat COVID-19 written by Sergio Rosales-Mendoza and published by Academic Press. This book was released on 2021-10-15 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Innovations to Combat COVID-19 provides an updated overview on the development of vaccines, antiviral drugs and nanomaterials, and diagnostic methods for the fight against COVID-19. Perspectives on such technologies are identified, discussed, and enriched with figures for easy understanding and applicability. Furthermore, it contains basic aspects of virology, immunology, and antiviral drugs that are needed to fully appreciate these innovations. This book is split into four sections: introduction, presenting basic virologic and epidemiological aspects of COVID-19; vaccines against COVID-19, discussing their different types and applications used to develop them; diagnostic approaches for SARS-CoV-2, encompassing advanced sensing and microfluidic-based biosensors; and drug development and delivery, where antivirals based on nanomaterials or drugs are presented. It is a valuable source for virologists, biotechnologists, and members of biomedical field interested in learning more about how novel technologies can be applied to fasten the eradication of the COVID-19 and similar pandemics. Presents updated literature coverage summarizing the most relevant information on COVID-19 Written by experts from diverse scientific domains in order to provide readers with a thorough view on the subject Encompasses tables, figures and information trees especially developed for the book in order to condense and highlight key points for quick reference