Vaccine Cell Substrates 2004

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Vaccine Cell Substrates 2004

Author : Rebecca Sheets
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Vaccine Cell Substrates 2004 by : Rebecca Sheets

Download or read book Vaccine Cell Substrates 2004 written by Rebecca Sheets and published by S. Karger AG (Switzerland). This book was released on 2006 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication comprises the proceedings of the Vaccine Cell Substrates 2004 conference. The purpose of this conference was to review current data and progress in the field of cell substrates, discuss the continued use of existing tests and the appropriateness of new ones at this time, and develop consensus recommendations on how to address these issues, by either recommending implementation or identifying research gaps that preclude decision-making. Scientific topics covered oncogenicity of cellular components, both latent viruses and cellular DNA, viral adventitious agent test methods, level of assurance provided by the current tests, bovine (and porcine) viruses in (primarily) bovine-derived raw materials, and bovine spongiform encephalopathy agents as potential contaminants of cell substrates. Also presented were tests that ensure the safety and quality of novel vaccine cell substrates for investigational vaccine production. Academia, regulators, the vaccine industry and the testing industry developing, regulating or testing viral vaccines will greatly benefit from the wealth of new findings.

Cell Substrates

Author : J. C. Petricciani
Publisher : Springer Science & Business Media
ISBN 13 : 1468409972
Total Pages : 218 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Cell Substrates by : J. C. Petricciani

Download or read book Cell Substrates written by J. C. Petricciani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume stems from a symposium sponsored by the W. Alton Jones Cell Science Center, Lake Placid New York. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and Their Use in the Production of Vaccines and Other Biologicals was held October 23-26, 1978. The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational and research activities. During the past 20 years there have been numerous national and international conferences on the topic of cell cultures used to produce biological products. Those largely dealt with the technology and associated issues that were current at the time of the meetings. For example, as human diploid cells were developed and proposed for use in vaccine production, a number of meetings were held to examine the pros and cons of human diploid cells. A large amount of data was provided at those conferences which formed the basis for the eventual acceptance of that cell system. Each meeting added to the general base of knowledge in the area of cell cultures and their application to the current and novel set of problems encountered. In general, the participants reaffirmed the basic premises that were formulated in the early days of polio virus vaccine production regarding the criteria for acceptability of cells when used in the manufacture of biologics intended for humans.

Evolving Scientific and Regulatory Perspectives on Cell Substrates for Vaccine Development

Author : Fred Brown
Publisher :
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Evolving Scientific and Regulatory Perspectives on Cell Substrates for Vaccine Development by : Fred Brown

Download or read book Evolving Scientific and Regulatory Perspectives on Cell Substrates for Vaccine Development written by Fred Brown and published by . This book was released on 2001 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September 1999, the cell substrate workshop entitled 'Evolution of Cell Substrates Used in the Manufacture of Biologicals' was held as a means to consider in depth the issues raised by the need to use neoplastic, i.e. continuous, cells as substrates for viral vaccine manufacture. Workshop goals included identifying the risks and concerns associated with the use of neoplastic cell substrates and determining the manner in which these could be assessed. Volume 106 of Developments in Biologicals presents the edited proceedings of this workshop. It is the latest in a series of monographs that go back to 1967 and record the proceedings of meetings devoted to issues concerning the use of cells cultured in vitro as substrates for the manufacture of viral vaccines. The current workshop covered the following: - a review of the history of cell substrate use in the production of biologicals - scientific issues related to the development of the neoplastic state and tumorigenicity - viral-viral and viral-cell interactions - the oncogenic potential of residual cell-substrate DNA - adventitious agent testing - ways to generate immortalized cells in vitro The purpose of these discussions was to build on the concepts and precedents for the scientifically based, regulatory management of viral vaccines documented in the earlier monographs. It is the hope of the meeting organizers and sponsors that this volume will assist in generating confidence among vaccine developers, manufacturers, regulatory agencies and the general public that the use of neoplastic cell substrates, within an effective, reasoned, regulatory approach, is feasible.

Biological Safety

Author : Dawn P. Wooley
Publisher : John Wiley & Sons
ISBN 13 : 1683673131
Total Pages : 953 pages
Book Rating : 4.6/5 (836 download)

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Book Synopsis Biological Safety by : Dawn P. Wooley

Download or read book Biological Safety written by Dawn P. Wooley and published by John Wiley & Sons. This book was released on 2017-02-01 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk—no matter how small—must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference. Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom. Specifically, Biological Safety covers protection and control elements—from biosafety level cabinets and personal protection systems to strategies and decontamination methods administrative concerns in biorisk management, including regulations, guidelines, and compliance various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

The Virus and the Vaccine

Author : Debbie Bookchin
Publisher : Macmillan + ORM
ISBN 13 : 1466848995
Total Pages : 541 pages
Book Rating : 4.4/5 (668 download)

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Book Synopsis The Virus and the Vaccine by : Debbie Bookchin

Download or read book The Virus and the Vaccine written by Debbie Bookchin and published by Macmillan + ORM. This book was released on 2013-07-02 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jonas Salk's polio vaccine has taken on an almost legendary quality as a medical miracle, for it largely eradicated one of the most feared diseases of the 20th century. But the story of the vaccine has a dark side, one that has never been fully told before... Between 1954 and 1963, close to 98 million Americans received polio vaccinations contaminated with a carcinogenic monkey virus, now known as SV40. A concerted government effort downplayed the incident, and it was generally accepted that although oncogenic to laboratory animals, SV40 was harmless to humans. But now SV40 in showing up in human cancers, and prominent researchers are demanding a serious public health response to this forgotten polio vaccine contaminant. A gripping medical detective story, The Virus and the Vaccine raises major questions about vaccine policy.

Industrial Scale Suspension Culture of Living Cells

Author : Hans-Peter Meyer
Publisher : John Wiley & Sons
ISBN 13 : 3527335471
Total Pages : 642 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Industrial Scale Suspension Culture of Living Cells by : Hans-Peter Meyer

Download or read book Industrial Scale Suspension Culture of Living Cells written by Hans-Peter Meyer and published by John Wiley & Sons. This book was released on 2014-08-04 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects.

Vaccines and Diagnostics for Transboundary Animal Diseases

Author : J.A. Roth
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318023655
Total Pages : 231 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Vaccines and Diagnostics for Transboundary Animal Diseases by : J.A. Roth

Download or read book Vaccines and Diagnostics for Transboundary Animal Diseases written by J.A. Roth and published by Karger Medical and Scientific Publishers. This book was released on 2013-04-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transboundary animal diseases (TADs) are a major threat to livestock. They are highly contagious or transmissible, and they have the potential to cause high morbidity and mortality in both susceptible animal populations and humans. In addition, not only are TADs detrimental to national economies, they are also a serious threat to world food security. This volume presents the proceedings of an international workshop on Vaccines and Diagnostics for Transboundary Animal Diseases that was held in Ames (Iowa, USA) in 2012. Experts and scientists from academia, industry and government reviewed the current status of vaccines and diagnostics for high priority TADs, decision-making and regulatory processes for veterinary biologics, and the roles and responsibilities of government agencies. The discussions also addressed achievements and gaps in vaccine and diagnostics development for 11 important TADs as well as the translation of research findings into licensed novel vaccines and diagnostics for high-priority TADs.

Vaccines

Author : Stanley A. Plotkin
Publisher : Elsevier Health Sciences
ISBN 13 : 1437721583
Total Pages : 1748 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Vaccines by : Stanley A. Plotkin

Download or read book Vaccines written by Stanley A. Plotkin and published by Elsevier Health Sciences. This book was released on 2008-02-11 with total page 1748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety...recommendations for vaccine use, with rationales...data on the impact of vaccination programs on morbidity and mortality...and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most! Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues. Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage. Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies. Analyses the cost-benefit and cost-effectiveness of vaccines. Discusses the proper use of immune globulins and antitoxins. Illustrates concepts and objective data with approximately 600 tables and figures. Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.

Animal Genomics for Animal Health

Author : Marie-Hélène Pinard
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805586191
Total Pages : 455 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Animal Genomics for Animal Health by : Marie-Hélène Pinard

Download or read book Animal Genomics for Animal Health written by Marie-Hélène Pinard and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: "It includes a review of the state of the art in animal genomics and its applications to animal health. The contributions describe the new tools available, such as HapMaps for chicken and cattle, and show how the understanding of gene structure and function can be successfully applied to delineate the molecular mechanisms of disease and determine complex phenotypes associated with health traits. A critical evaluation of future needs and future applications of animal genomics is also presented. The integration of animal genomics in animal health research is likely to revolutionize the way scientists approach the challenges of discovering highly effective drugs and vaccines for animal diseases."--BOOK JACKET.

New Diagnostic Technology

Author : Philippe Vannier
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis New Diagnostic Technology by : Philippe Vannier

Download or read book New Diagnostic Technology written by Philippe Vannier and published by S. Karger AG (Switzerland). This book was released on 2006 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances have resulted in the development of several new biochemistry-based test procedures such as DNA micro-arrays, rapid sequencing and multiple applications of polymerase chain reaction. The limitations of such tests and the problems of standardization and validation related to their use for the detection of agents and toxins, diagnosis of human and animal diseases, and quality control of human and veterinary biological products must be considered. Practical examples of the use of these new technologies, but also the difficulties, limits and uncertainties encountered in their application need to be shared. This volume presents the proceedings of a conference in Saint-Malo, France, held to facilitate discussion between government authorities, industry, scientists and other users of these new techniques. Information on the principles of these novel methods, the need for standardization and validation, applications in diagnosis and surveillance, certainties and uncertainties in agent or toxin identification as well as examples of quality control of human and veterinary biological products were addressed. Conclusions and recommendations concerning the development and standardization of these new technologies were developed by the participants and are published in these proceedings. Professionals involved in biological standardization, diagnosis, and human and animal health programs should find this to be a very valuable book.

Advances in Virus Research

Author :
Publisher : Academic Press
ISBN 13 : 0080921701
Total Pages : 292 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Advances in Virus Research by :

Download or read book Advances in Virus Research written by and published by Academic Press. This book was released on 2009-02-24 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2006 is 3.48 placing it 7th in the highly competitive category of virology. Contributions from leading authorities Informs and updates on all the latest developments in the field

Influenza Vaccines for the Future

Author : Rino Rappuoli
Publisher : Springer Science & Business Media
ISBN 13 : 3034602790
Total Pages : 447 pages
Book Rating : 4.0/5 (346 download)

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Book Synopsis Influenza Vaccines for the Future by : Rino Rappuoli

Download or read book Influenza Vaccines for the Future written by Rino Rappuoli and published by Springer Science & Business Media. This book was released on 2010-10-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Towards the Elimination of Rabies in Eurasia

Author : Betty Dodet
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 616 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis Towards the Elimination of Rabies in Eurasia by : Betty Dodet

Download or read book Towards the Elimination of Rabies in Eurasia written by Betty Dodet and published by S. Karger AG (Switzerland). This book was released on 2008 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the second conference on rabies organized by the World Organisation for Animal Health in collaboration with the World Health Organization and the European Union in May 2007. Up-to-date information on rabies epidemiology in humans and animals throughout Europe, The Middle East and Asia, and the most recent data on rabies virus and its structure, as well as the basic mechanisms of rabies infection are included here. Experts in the field present their experience and opinions on the prevention and control of rabies in dogs, wildlife including bats, and the most recent developments in rabies prevention and management in humans. Further presentations address advances in technology, diagnosis and vaccine development. To conclude, resolutions and recommendations are given in English, French and Russian for the elimination of rabies not only in Europe and Asia, but also the rest of the world. This book is highly valuable to regulatory veterinary services, public health services, medical and veterinary practitioners, scientists and researchers interested in combating this neglected disease, which kills more than 50,000 persons annually, mainly children. Rabies elimination is at hand, through a 'One Health' strategic collaboration between veterinary and human health authorities, political will and community involvement, and application of the knowledge gained from this volume.

Cancer Vaccines as Immunotherapy of Cancer

Author : Luigi Buonaguro
Publisher : Academic Press
ISBN 13 : 0128239026
Total Pages : 273 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cancer Vaccines as Immunotherapy of Cancer by : Luigi Buonaguro

Download or read book Cancer Vaccines as Immunotherapy of Cancer written by Luigi Buonaguro and published by Academic Press. This book was released on 2022-03-04 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide

Rabies and Rabies Vaccines

Author : Hildegund C.J. Ertl
Publisher : Springer Nature
ISBN 13 : 3030210847
Total Pages : 207 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Rabies and Rabies Vaccines by : Hildegund C.J. Ertl

Download or read book Rabies and Rabies Vaccines written by Hildegund C.J. Ertl and published by Springer Nature. This book was released on 2020-05-04 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine.

Vaccines for Biodefense and Emerging and Neglected Diseases

Author : Alan D.T. Barrett
Publisher : Academic Press
ISBN 13 : 0080919022
Total Pages : 1519 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Vaccines for Biodefense and Emerging and Neglected Diseases by : Alan D.T. Barrett

Download or read book Vaccines for Biodefense and Emerging and Neglected Diseases written by Alan D.T. Barrett and published by Academic Press. This book was released on 2009-03-05 with total page 1519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace Each chapter will include a map of the world showing where that particular disease is naturally found

Low Temperature Materials and Mechanisms

Author : Yoseph Bar-Cohen
Publisher : CRC Press
ISBN 13 : 149870039X
Total Pages : 518 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Low Temperature Materials and Mechanisms by : Yoseph Bar-Cohen

Download or read book Low Temperature Materials and Mechanisms written by Yoseph Bar-Cohen and published by CRC Press. This book was released on 2016-08-19 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the growing interest in low temperature technologies. Since the subject of low temperature materials and mechanisms is multidisciplinary, the chapters reflect the broadest possible perspective of the field. Leading experts in the specific subject area address the various related science and engineering chemistry, material science, electrical engineering, mechanical engineering, metallurgy, and physics.