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Author : Muhammad Abbas
Publisher : Frontiers Media SA
ISBN 13 : 2832513638
Total Pages : 142 pages
Book Rating : 4.8/5 (325 download)
Download or read book Updates on Combination Therapy for Lung Cancer written by Muhammad Abbas and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joan H. Schiller
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 9783805565578
Total Pages : 202 pages
Book Rating : 4.5/5 (655 download)
Download or read book Updates in Advances in Lung Cancer written by Joan H. Schiller and published by Karger Medical and Scientific Publishers. This book was released on 1997-01-01 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains a major cause of cancer deaths throughout the world. It is an extremely lethal neoplasm: 80-90% of patients who develop lung cancer will die of their disease. The purpose of this book is to update cancer specialists, pulmonary physicians, thoracic surgeons and general practitioners about the many recent advances in the treatment, prevention and biology of lung cancer. Despite the overall poor prognosis for patients, a number of new chemotherapeutic drugs and regimens have been developed which result in a clinically meaningful improvement in survival for patients with nonsmall cell lung carcinoma. Four chapters in this book are devoted to reviewing these new drugs and drug combinations (paclitaxel, docetaxel, vinorelbine, gemcitabine, topoisomerase inhibitors). Advances in the management of locally advanced nonsmall cell and small cell lung cancer are considered, including combined-modality treatments using chemotherapy, surgery, and radiation therapy. Results of recent trials involving chemoprevention agents are also reported. Finally, the latest progress in understanding the molecular biology of this disease, and how it might impact on the clinical management of lung cancer patients, is discussed.
Author : Anne C. Chiang
Publisher : Springer Nature
ISBN 13 : 3030740285
Total Pages : 263 pages
Book Rating : 4.0/5 (37 download)
Download or read book Lung Cancer written by Anne C. Chiang and published by Springer Nature. This book was released on 2021-09-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach. For targeted and immunotherapeutic approaches, understanding the biology of acquired resistance is a key strategy that has yielded productive advances in the subsequent treatment. Future advances also include incorporating biomarker data obtained from solid and liquid biopsies, as well as combination of immunotherapy with radiotherapy and in special populations such patients with CNS involvement.
Author : Vera Hirsh
Publisher : Frontiers Media SA
ISBN 13 : 2889453979
Total Pages : 95 pages
Book Rating : 4.8/5 (894 download)
Download or read book Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine written by Vera Hirsh and published by Frontiers Media SA. This book was released on 2018-01-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we’ve started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.
Author : Khalid A. El Sayed
Publisher : Frontiers Media SA
ISBN 13 : 2889718573
Total Pages : 180 pages
Book Rating : 4.8/5 (897 download)
Download or read book Novel Combination Therapies for the Treatment of Solid Cancers written by Khalid A. El Sayed and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Arthur T. Skarin
Publisher : CRC Press
ISBN 13 : 9780824702366
Total Pages : 502 pages
Book Rating : 4.7/5 (23 download)
Download or read book Multimodality Treatment of Lung Cancer written by Arthur T. Skarin and published by CRC Press. This book was released on 2000-01-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the organizer of a pioneering, multidisciplinary clinic for lung cancer patients, now emulated at cancer centers worldwide! This up-to-date reference presents the treatment and management of lung cancer, as well as accurate evaluation and assessment procedures for small-cell and non-small-cell lung cancers, written by experts in various disciplines of the subject, including biology, chemoprevention, radiographic and surgical staging, and video-assisted thoracoscopic surgery. Offering a better understanding of the molecular events leading to lung cancer for improved therapeutic strategies, response rates, and cure rates, Multimodality Treatment of Lung Cancer discusses recent advances in the biology of lung cancer such as the role of oncogenes, tumor suppressor genes, and the role of telomerase in carcinogenesis details cellular and biological processes operating in malignant cells compares ongoing international chemoprevention trials in lung, head, and neck cancer contrasts cost advantages and disadvantages of several noninvasive procedures, including chest x-ray, CT, and MRI scans illustrates the newest TNM staging classification system, including mediastinoscopy in assessment of the mediastinum emphasizes technological advances in VATS procedure for evaluating and treating lung cancer with lower morbidity and cost furnishes a thorough review of all active chemotherapeutic agents and modern chemotherapy regimens explores new drugs and drug combinations measured for activity, as well as toxicity in preclinical animal model systems and more! Featuring over 1000 references, tables, micrographs, x-rays, and illustrations, Multimodality Treatment of Lung Cancer is an excellent hands-on reference for pulmonologists and pulmonary disease specialists, oncologists, thoracic surgeons, radiologists and radiation therapists, oncoradiologists, pathologists, epidemiologists, physiologists, molecular and cellular biologists, public health professionals, regulatory and public health policy personnel, and graduate and medical students in these disciplines.
Author : S. M. Lee
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (969 download)
Download or read book Treatment of Small Cell Lung Cancer with Cyclophosphamide, Adriamucin and Vincristine (CAV) Combination Therapy written by S. M. Lee and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sara Kurim
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (19 download)
Download or read book Towards Novel Effective Combination Therapy for KRAS Mutant Non-Small Cell Lung Cancer written by Sara Kurim and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-small-cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers and is associated with significant mortality. As epidermal-growth-factor receptor (EGFR) is over-expressed in 80-90% of NSCLC, its inhibition via EGFR-Tyrosine Kinase inhibitors (EGFR-TKIs) is a main therapeutic strategy. However, patients with mutations in KRAS are resistant to EGFR-TKIs. A study in mutant KRAS-driven lung cancer in transgenic mice showed that tumor growth was dependent on the activity of focal adhesion kinase (FAK). Therefore, we hypothesized that KRAS-mutant NSCLC will be sensitive to FAK-TKIs and, given known FAK-EGFR cross-talk, FAK inhibition will sensitize KRAS-mutant NSCLC to EGFR-TKIs. We performed cell viability assays of WT versus mutant KRAS NSCLC cell lines following treatment with FAK-TKI alone or in combination with a clinically relevant EGFR-TKI. We found that KRAS-mutant cells were more sensitive to FAK-TKI than KRAS-WT NSCLC. In addition, we found that the combination treatment including FAK and EGFR TKIs resulted in reduced tumor cell viability as compared to treatment with either drug alone. This enhanced anti-tumor response could be due to FAK-TKI's ability to down-regulate EGFR downstream targets. Our preliminary data suggests that in KRAS-mutant cells the drug combination appears to more effectively inhibit Akt activity than single drug treatment alone. This suggests an enhanced ability to impair cell survival following treatment with the drug combination. We also found that treatment with FAK TKI in KRAS mutant NSCLC cells resulted in increased activation of EGFR which was due in part to modulation of EGFR recycling and production of endogenous EGFR ligands. Thus, the combination of FAK- and EGFR-TKIs may be more effective in KRAS mutant NSCLC as treatment with EGFR-TKI overcomes the unexpected 'side effect' of treatment with FAK-TKI, namely activation of the EGFR pathway by this drug. The findings of our study are novel and have uncovered previously unrecognized outcomes of FAK inhibition on EGFR activity. Moreover, our data support the notion that the combination of FAK- and EGFR-TKIs could be an effective treatment for KRAS mutant NSCLC patients.
Author : W.D. Travis
Publisher : Springer Science & Business Media
ISBN 13 : 3642600492
Total Pages : 139 pages
Book Rating : 4.6/5 (426 download)
Download or read book Histological Typing of Lung and Pleural Tumours written by W.D. Travis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by Pathologists from 14 Countries
Author :
Publisher :
ISBN 13 :
Total Pages : 21 pages
Book Rating : 4.:/5 (982 download)
Download or read book A Combination Therapy for KRAS-driven Lung Adenocarcinomas Using Lipophilic Bisphosphonates and Rapamycin written by and published by . This book was released on 2014 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the most common human malignancy and leads to about one-third of all cancer-related deaths. Lung adenocarcinomas harboring KRAS mutations, in contrast to those with EGFR and EML4-ALK mutations, have not yet been successfully targeted. Here in this paper, we describe a combination therapy for treating these malignancies using two agents: a lipophilic bisphosphonate and rapamycin. This drug combination is much more effective than either agent acting alone in the KRAS G12D induced mouse lung model. Lipophilic bisphosphonates inhibit both farnesyl and geranylgeranyldiphosphate synthases, effectively blocking prenylation of the KRAS and other small G-proteins critical for tumor growth and cell survival. Bisphosphonate treatment of cells initiated autophagy but was ultimately unsuccessful and led to p62 accumulation and concomitant NF-[kappa]B activation, resulting in dampened efficacy in vivo. However, we found that rapamycin, in addition to inhibiting the mTOR pathway, facilitated autophagy and prevented p62 accumulation-induced NF-[kappa]B activation and tumor cell proliferation. Lastly, these results suggest that using lipophilic bisphosphonates in combination with rapamycin may provide an effective strategy for targeting lung adenocarcinomas harboring KRAS mutations.
Author : Jyothi Kallu
Publisher :
ISBN 13 :
Total Pages : 41 pages
Book Rating : 4.:/5 (953 download)
Download or read book Development of Novel Magnetic Nanotheranostics for the Combination Therapy of K-RAS Driven Non Small Cell Lung Cancer written by Jyothi Kallu and published by . This book was released on 2016 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ravi Salgia
Publisher : Springer
ISBN 13 : 3030178323
Total Pages : 238 pages
Book Rating : 4.0/5 (31 download)
Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 1461431972
Total Pages : 217 pages
Book Rating : 4.4/5 (614 download)
Download or read book Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2012-06-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Author : Steven E. Schild, MD
Publisher : Demos Medical Publishing
ISBN 13 : 1935281801
Total Pages : 260 pages
Book Rating : 4.9/5 (352 download)
Download or read book Thoracic Malignancies written by Steven E. Schild, MD and published by Demos Medical Publishing. This book was released on 2010-03-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice
Author : Guido Bocci
Publisher : Springer
ISBN 13 : 3662436043
Total Pages : 302 pages
Book Rating : 4.6/5 (624 download)
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Author : Mohmmad Younus Wani
Publisher : Academic Press
ISBN 13 : 0128205784
Total Pages : 270 pages
Book Rating : 4.1/5 (282 download)
Download or read book Combination Therapy Against Multidrug Resistance written by Mohmmad Younus Wani and published by Academic Press. This book was released on 2020-04-30 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria
Author : Dominik Wodarz
Publisher : World Scientific
ISBN 13 : 9814566381
Total Pages : 533 pages
Book Rating : 4.8/5 (145 download)
Download or read book Dynamics Of Cancer: Mathematical Foundations Of Oncology written by Dominik Wodarz and published by World Scientific. This book was released on 2014-04-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.
