Update On Polymer Based Nanomedicine

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Update on Polymer Based Nanomedicine

Author : Andreas M Nystroem
Publisher : Smithers Rapra
ISBN 13 : 1847357466
Total Pages : 108 pages
Book Rating : 4.8/5 (473 download)

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Book Synopsis Update on Polymer Based Nanomedicine by : Andreas M Nystroem

Download or read book Update on Polymer Based Nanomedicine written by Andreas M Nystroem and published by Smithers Rapra. This book was released on 2012-10-24 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are one of the most applicable and clinically relevant materials for constructing nanomedical systems. These systems are expected to have a future in the clinic; nanomedical constructs will have wide implications for how we treat and diagnose society's most complex diseases, such as cancer, inflammation and genetic disorders. This update focuses on describing the fundamentals of controlled polymerisation techniques and methods for constructing advanced polymer architectures to be used in polymer based nanomedicine. This growing field is reviewed, which uses recent advances in polymer chemistry and conjugation techniques to construct advanced nanoparticles. One focus of this update is to give examples of recent developments in drug delivery, ligand targeted therapy and diagnostic imaging techniques. One section is devoted to the latest developments in nanomedicine - theranostic systems - which combine therapeutic delivery with diagnostic imaging capabilities in the same device. Such systems will play a crucial role in developing personalised medicine.

Update on Polymer Based Nanomedicine

Author : Andreas M. Nyström
Publisher : Smithers Rapra Technology
ISBN 13 : 9781847357472
Total Pages : 100 pages
Book Rating : 4.3/5 (574 download)

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Book Synopsis Update on Polymer Based Nanomedicine by : Andreas M. Nyström

Download or read book Update on Polymer Based Nanomedicine written by Andreas M. Nyström and published by Smithers Rapra Technology. This book was released on 2012 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are one of the most applicable and clinically relevant materials for constructing nanomedical systems. These systems are expected to have a future in the clinic; nanomedical constructs will have wide implications for how we treat and diagnose society's most complex diseases, such as cancer, inflammation and genetic disorders. This book focuses on describing the fundamentals of controlled polymerisation techniques and methods for constructing advanced polymer architectures to be used in polymer based nanomedicine. We review this growing field, which uses recent advances in polymer chemistry and conjugation techniques to construct advanced nanoparticles. One focus of this book is to give examples of recent developments in drug delivery, ligand targeted therapy and diagnostic imaging techniques. One section is devoted to the latest developments in nanomedicine - theranostic systems - which combine therapeutic delivery with diagnostic imaging capabilities in the same device. Such systems will play a crucial role in developing personalised medicine.

Polymer Nanoparticles for Nanomedicines

Author : Christine Vauthier
Publisher : Springer
ISBN 13 : 3319414216
Total Pages : 641 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Polymer Nanoparticles for Nanomedicines by : Christine Vauthier

Download or read book Polymer Nanoparticles for Nanomedicines written by Christine Vauthier and published by Springer. This book was released on 2017-01-07 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.

Polymers in Nanomedicine

Author : Shigeru Kunugi
Publisher : Springer Science & Business Media
ISBN 13 : 3642278558
Total Pages : 290 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Polymers in Nanomedicine by : Shigeru Kunugi

Download or read book Polymers in Nanomedicine written by Shigeru Kunugi and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Polymer Conjugates for Medicinal Nucleic Acid Delivery, by Ernst Wagner Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine, by Takami Akagi, Masanori Baba and Mitsuru Akashi Biodegradable Polymeric Assemblies for Biomedical Materials, by Yuichi Ohya, Akihiro Takahashi and Koji Nagahama PEGylation Technology in Nanomedicine, by Yutaka Ikeda and Yukio Nagasaki Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions, by Kazuhiko Ishihara, Yan Xu and Tomohiro Konno Design of Biointerfaces for Regenerative Medicine, by Yusuke Arima, Koichi Kato, Yuji Teramura and Hiroo Iwata Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration, by Jeremy J. Mercuri and Dan T. Simionescu Functionalized Biocompatible Nanoparticles for Site-Specific Imaging and Therapeutics, by Ranu K. Dutta, Prashant K. Sharma, Hisatoshi Kobayashi and Avinash C. Pandey

Single-Chain Polymer Nanoparticles

Author : José A. Pomposo
Publisher : John Wiley & Sons
ISBN 13 : 3527806393
Total Pages : 312 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Single-Chain Polymer Nanoparticles by : José A. Pomposo

Download or read book Single-Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.

Silk-based Drug Delivery Systems

Author : Elia Bari
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017722
Total Pages : 243 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari

Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Nanoparticles in Polymer Systems for Biomedical Applications

Author : Jince Thomas
Publisher : CRC Press
ISBN 13 : 1351047876
Total Pages : 342 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nanoparticles in Polymer Systems for Biomedical Applications by : Jince Thomas

Download or read book Nanoparticles in Polymer Systems for Biomedical Applications written by Jince Thomas and published by CRC Press. This book was released on 2018-12-12 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume includes presentations of technological and research accomplishments along with novel approaches in nanomedicine and nanotechnology. It explores the different types of nanomedicinal drugs with their production and commercial significance. Other topics discussed are the use of natural and synthetic nanoparticles for the production of drugs, different types of nanoparticles systems, drug carriers, wound-healing antimicrobial activity, effects of natural materials in nanomedicine, and toxicity of nanoparticles. The valuable information presented in this volume will help to keep those in this field up to date on the key findings, observations, and fabrication of drugs related to nanomedicine and nanotechnology. With chapters written by prominent researchers from academia, industry, and government and private research laboratories across the world, the book will prove to be a rich resource.

Polymer Science and Nanotechnology

Author : Ravin Narain
Publisher : Elsevier
ISBN 13 : 0128168072
Total Pages : 488 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Polymer Science and Nanotechnology by : Ravin Narain

Download or read book Polymer Science and Nanotechnology written by Ravin Narain and published by Elsevier. This book was released on 2020-06-16 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Science and Nanotechnology: Fundamentals and Applications brings together the latest advances in polymer science and nanoscience. Sections explain the fundamentals of polymer science, including key aspects and methods in terms of molecular structure, synthesis, characterization, microstructure, phase structure and processing and properties before discussing the materials of particular interest and utility for novel applications, such as hydrogels, natural polymers, smart polymers and polymeric biomaterials. The second part of the book examines essential techniques in nanotechnology, with an emphasis on the utilization of advanced polymeric materials in the context of nanoscience. Throughout the book, chapters are prepared so that materials and products can be geared towards specific applications. Two chapters cover, in detail, major application areas, including fuel and solar cells, tissue engineering, drug and gene delivery, membranes, water treatment and oil recovery. Presents the latest applications of polymers and polymeric nanomaterials, across energy, biomedical, pharmaceutical, and environmental fields Contains detailed coverage of polymer nanocomposites, polymer nanoparticles, and hybrid polymer-metallic nanoparticles Supports an interdisciplinary approach, enabling readers from different disciplines to understand polymer science and nanotechnology and the interface between them

Redox Polymers for Energy and Nanomedicine

Author : Nerea Casado
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018710
Total Pages : 575 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Redox Polymers for Energy and Nanomedicine by : Nerea Casado

Download or read book Redox Polymers for Energy and Nanomedicine written by Nerea Casado and published by Royal Society of Chemistry. This book was released on 2020-10-20 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Redox Polymers for Energy and Nanomedicine highlights trends in the chemistry, characterization and application of polymers with redox properties.

Polymers and Nanomaterials for Gene Therapy

Author : Ravin Narain
Publisher : Woodhead Publishing
ISBN 13 : 0081005210
Total Pages : 302 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Polymers and Nanomaterials for Gene Therapy by : Ravin Narain

Download or read book Polymers and Nanomaterials for Gene Therapy written by Ravin Narain and published by Woodhead Publishing. This book was released on 2016-01-09 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Handbook of Materials for Nanomedicine

Author : Vladimir Torchilin
Publisher : CRC Press
ISBN 13 : 100006705X
Total Pages : 512 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Handbook of Materials for Nanomedicine by : Vladimir Torchilin

Download or read book Handbook of Materials for Nanomedicine written by Vladimir Torchilin and published by CRC Press. This book was released on 2020-03-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of polymeric nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. Beginning with the combinatorial approach for polymer design, it discusses star-shaped amphiphilic polymers, self-assembling polymer–drug conjugates, amphiphilic dendrimers, dendrimer nanohybrids, sustainable green polymeric nanoconstructs, chitosan-based nanogels, and multifunctional hybrid nanogels. The book provides all available information about these materials and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully.

Polymer-based Nanostructures

Author : Pavel Broz
Publisher : Royal Society of Chemistry
ISBN 13 : 1847559964
Total Pages : 389 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Polymer-based Nanostructures by : Pavel Broz

Download or read book Polymer-based Nanostructures written by Pavel Broz and published by Royal Society of Chemistry. This book was released on 2010-02-10 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is about small things and medicine usually deals with bigger things - with patients and their diseases. The ultimate goal of all medical sciences is the healing of diseases whenever possible, otherwise the abatement of suffering. The first step of a successful medical treatment is the correct diagnosis of the disease or disease condition, based on clinical knowledge and experience and on diagnostic tools that give insight into macroscopic, microscopic, and biochemical properties of the disease process. Nanomaterials can improve currently available diagnostic applications in medicine and especially polymer-based nanostructures have an enormous potential to revolutionize the way how clinicians diagnose diseases correctly and efficiently. The second step when treating patients is a powerful and specific therapy that is low in side effects, that can prolong the survival of the patient or that can lower the burden of the disease. Again, polymer-based nanostructures are very promising novel tools that might change the way how certain diseases are being treated. This book combines both viewpoints and presents successful applications of nanotechnological constructs in medicine and the science behind the tools. Supramolecular nanometre-sized structures such as nanoparticles or vesicles built out of new synthetic polymeric materials have aroused enormous interest in recent years - both in chemical and pharmaceutical labs as well as in clinical medicine. They promise to be useful for novel or improved diagnostic and therapeutic applications for important diseases such as arteriosclerosis, cancer, infections, or autoimmune disorders. In the first part of this book, renowned researchers provide a detailed insight into both chemical and biological/pharmacological basics that have to be managed for successful applications of these nanostructures in human beings. In the second part, invited authors review the main literature in both diagnostic and therapeutic applications with polymer-based nanostructures that have already reached clinical practice or will enter it in the next few years. Key features include: -Multidisciplinary: The book is written by both clinicians from world-wide leading University Hospitals as well as researchers coming from natural sciences. Special effort was invested into comprehensibility across the traditional borders of medicine, pharmacology, and chemistry. -State-of-the-art: The book is filled with exciting contributions from some of the leading research groups in the field. This guarantees a clear emphasis on ongoing research and ground-breaking applications and projects -Structure: The book can be read from the beginning to the end, starting with basics that help to understand the current diagnostic and therapeutic applications of polymer-based nanostructures in medicine, ending with innovative multifunctional and "smart" nanostructures that might be the future of medicine. The way leads from solid foundations to nowadays applications and further to more futuristic approaches -References: The internationally renowned authors of the chapters have put great efforts into choosing only the most important and competitive papers for the reference lists. All major projects in this field are included - perfect for students or researchers that want to search the main literature thus avoiding the need to search through huge electronic databases

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128173319
Total Pages : 434 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics by : Prashant Kesharwani

Download or read book Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics written by Prashant Kesharwani and published by Academic Press. This book was released on 2019-06-25 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Smart Drug Delivery System

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
ISBN 13 : 9535122479
Total Pages : 400 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Smart Drug Delivery System by : Ali Demir Sezer

Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Smart Polymeric Nano-Constructs in Drug Delivery

Author : Suresh P Vyas
Publisher : Academic Press
ISBN 13 : 0323913997
Total Pages : 626 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Smart Polymeric Nano-Constructs in Drug Delivery by : Suresh P Vyas

Download or read book Smart Polymeric Nano-Constructs in Drug Delivery written by Suresh P Vyas and published by Academic Press. This book was released on 2022-11-12 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications

Marine Anthropogenic Litter

Author : Melanie Bergmann
Publisher : Springer
ISBN 13 : 3319165100
Total Pages : 447 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Marine Anthropogenic Litter by : Melanie Bergmann

Download or read book Marine Anthropogenic Litter written by Melanie Bergmann and published by Springer. This book was released on 2015-06-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide. The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats. In 16 chapters, authors from all over the world have created a universal view on the diverse field of marine litter pollution, the biological impacts, dedicated research activities, and the various national and international legislative efforts to combat this environmental problem. They recommend future research directions necessary for a comprehensive understanding of this environmental issue and the development of efficient management strategies. This book addresses scientists, and it provides a solid knowledge base for policy makers, NGOs, and the broader public.

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications

Author : Abdel Salam Hamdy Makhlouf
Publisher : Woodhead Publishing
ISBN 13 : 0081019963
Total Pages : 637 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications by : Abdel Salam Hamdy Makhlouf

Download or read book Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications written by Abdel Salam Hamdy Makhlouf and published by Woodhead Publishing. This book was released on 2018-10-24 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource. Focusses on the most advanced technologies, recent evaluation methods, technical aspects, and advanced synthesis techniques stimuli-responsive polymers Examines advanced medical applications of stimuli responsive polymers Analyzes synergistic operational and technological methodologies for the improvement of polymer systems for the production of stimuli-responsive polymers in drug delivery