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Untangle The Broad Connections And Tight Interactions Between Human Microbiota And Complex Diseases Through Data Driven Approaches
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Book Synopsis Untangle the broad connections and tight interactions between human microbiota and complex diseases through data-driven approaches by : Qi Zhao
Download or read book Untangle the broad connections and tight interactions between human microbiota and complex diseases through data-driven approaches written by Qi Zhao and published by Frontiers Media SA. This book was released on 2023-03-20 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metabonomics and Gut Microbiota in Nutrition and Disease by : Sunil Kochhar
Download or read book Metabonomics and Gut Microbiota in Nutrition and Disease written by Sunil Kochhar and published by Springer. This book was released on 2014-10-21 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.
Book Synopsis Microbiome in Human Health and Disease by : Pallaval Veera Bramhachari
Download or read book Microbiome in Human Health and Disease written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2021-10-18 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
Book Synopsis The Human Microbiota by : David N. Fredricks
Download or read book The Human Microbiota written by David N. Fredricks and published by John Wiley & Sons. This book was released on 2013-02-22 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Microbiota offers a comprehensive review of all human-associated microbial niches in a single volume, focusing on what modern tools in molecular microbiology are revealing about human microbiota, and how specific microbial communities can be associated with either beneficial effects or diseases. An excellent resource for microbiologists, physicians, infectious disease specialists, and others in the field, the book describes the latest research findings and evaluates the most innovative research approaches and technologies. Perspectives from pioneers in human microbial ecology are provided throughout.
Book Synopsis Human Microbiota in Health and Disease by : Bryan Tungland
Download or read book Human Microbiota in Health and Disease written by Bryan Tungland and published by Academic Press. This book was released on 2018-05-25 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion of all the aspects associated with gut microbiota early colonization, its development and maintenance, and its symbiotic relationship with the host to promote health. Chapters illustrate the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, while mediating inflammatory processes involved in the etiology of many chronic disease conditions. Details are provided on the primary etiological factors of chronic disease, the effects of gut dysbiosis and its associated disease conditions, while providing an overview of therapeutic strategies involving dietary fiber and prebiotics, fecal microbiota transplantation therapy and probiotics. Throughout the chapters, a comprehensive review of peer-reviewed animal and human studies is provided as evidence related to the history of human exposure, safety, tolerance, toxicity, nomenclature, and clinical efficacy of utilizing prebiotic fructans, s, as well as probiotic intervention, and dietary modification in the prevention and intervention of chronic disease conditions. With common use today of pharmaceutical medicine in treating symptoms, and frequent overuse of antibiotics in chronic disease within mainstream medical practice, understanding the etiological mechanisms of dysbiosis-induced chronic disease, and natural approaches that offer prevention and potential cures for these diseases is of vital importance to overall human health. Details the complex relationship between human microbiota in the gut, oral cavity, urogenital tract and skin as well as their colonization, development and impact of factors that influence the relationship Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification, and pro- and pre-biotics in preventing and intervening in chronic disease
Download or read book The Microbiome written by and published by Academic Press. This book was released on 2020-10-23 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiome, Volume 176, assembles known facts and provides guidance for their implementation on topics relating to associations between the gut microbiome and personality traits, depression, anxiety, autism, schizophrenia, cognition, dementia and neurodegeneration. Additionally, this volume considers the influence of the maternal microbiome on brain development, with chapters covering Intervention, prevention, and the brain: prebiotics, probiotics, and fecal transplants, The microbiota-gut-brain axis: focus on the fundamental communication pathways, and Microbiome composition and locations. Provides a comprehensive review of the bidirectional interactions between gut microbes and the brain Includes data across the lifespan Focuses on microbiome related therapies with broad appeal within, and beyond, the medical and scientific community
Book Synopsis Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases by : Jun Sun
Download or read book Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases written by Jun Sun and published by Springer. This book was released on 2018-01-26 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.
Book Synopsis The Human Microbiota and Microbiome by : Julian R Marchesi
Download or read book The Human Microbiota and Microbiome written by Julian R Marchesi and published by CABI. This book was released on 2014-05-14 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thousands of different microbial species colonize the human body, and are essential for our survival. This book presents a review of the current understanding of human microbiomes, the functions that they bring to the host, how we can model them, their role in health and disease and the methods used to explore them. Current research into areas such as the long-term effect of antibiotics makes this a subject of considerable interest. This title is essential reading for researchers and students of microbiology.
Book Synopsis The Human Microbiota and Chronic Disease by : Luigi Nibali
Download or read book The Human Microbiota and Chronic Disease written by Luigi Nibali and published by John Wiley & Sons. This book was released on 2016-08-05 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.
Book Synopsis Gut Microbiota in Neurologic and Visceral Diseases by : Tahira Farooqui
Download or read book Gut Microbiota in Neurologic and Visceral Diseases written by Tahira Farooqui and published by Academic Press. This book was released on 2021-03-11 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders. Reviews the relationship between gut microbiome, diseases and disorders Discusses the relationship between diet, microbiota and inflammation Includes neurodegenerative, neuropsychiatric and cardiovascular disorders Covers diabetes, obesity and metabolic disorders Identifies molecular mechanisms and signal transduction processes Encompasses dietary fiber, fat, prebiotics and probiotics
Book Synopsis Characterization of the Human Host Gut Microbiome with an Integrated Genomics by : Alison Russell Erickson
Download or read book Characterization of the Human Host Gut Microbiome with an Integrated Genomics written by Alison Russell Erickson and published by . This book was released on 2011 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new field of 'omics' has spawned the development of metaproteomics, an approach that has the ability to identify and decipher the metabolic functions of a proteome derived from a microbial community that is largely uncultivable. With the development and availabilities of high throughput proteomics, high performance liquid chromatography coupled to mass spectrometry (MS) has been leading the field for metaproteomics. MS-based metaproteomics has been successful in its' investigations of complex microbial communities from soils to the human body. Like the environment, the human body is host to a multitude of microorganisms that reside within the skin, oral cavity, vagina, and gastrointestinal tract, referred to as the human microbiome. The human microbiome is made up of trillions of bacteria that outnumber human genes by several orders of magnitude. These microbes are essential for human survival with a significant dependence on the microbes to encode and carryout metabolic functions that humans have not evolved on their own. Recently, metaproteomics has emerged as the primary technology to understand the metabolic functional signature of the human microbiome. Using a newly developed integrated approach that combines metagenomics and metaproteomics, we attempted to address the following questions: i) do humans share a core functional microbiome and ii) how do microbial communities change in response to disease. This resulted in a comprehensive identification and characterization of the metaproteome from two healthy human gut microbiomes. These analyses have resulted in an extended application to characterize how Crohn's disease affects the functional signature of the microbiota. Contrary to measuring highly complex and representative gut metaproteomes is a less complex, controlled human-derived microbial community present in the gut of gnotobiotic mice. This human gut model system enhanced the capability to directly monitor fundamental interactions between two dominant phyla, Bacteroides and Firmicutes, in gut microbiomes colonized with two or more phylotypes. These analyses revealed membership abundance and functional differences between phylotypes when present in either a binary or 12-member consortia. This dissertation aims to characterize host microbial interactions and develop MS-based methods that can provide a better understanding of the human gut microbiota composition and function using both approaches.
Book Synopsis Revealing Host-gut Microbiome Interactions by : Carlos Gutierrez Gonzalez
Download or read book Revealing Host-gut Microbiome Interactions written by Carlos Gutierrez Gonzalez and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The host gut and its associated microbiome, the resident bacteria, eukaryotes, viruses, and archaea, are part of a dynamic community that spans the entire digestive tract. Their various interactions, often through the use of lipids, metabolites, nucleic acids, and proteins, result in highly complex biological networks that play a large role host. Indeed, to date, gut-microbiome interactions have been linked to a myriad of healthy and diseased states including irritable bowel disease, cancer, autoimmune disorders, and neuropsychiatric conditions. These complex networks are bolstered further complicated by the addition of dietary constituents to the intestinal environment, which act as a nutrient substrate for both the host and microbes. Together, the proteins present in these three constituents, host, microbes, and diet, comprise the host gut metaproteome. Given their importance to health, efforts have recently begun to attempt to unravel these networks using ingenious biological and computational methods. Despite the current efforts, our understanding of the gut metaproteome is far from complete. This thesis will describe my contributions to the field of metaproteomics. Chapter 1 describes current efforts in the field of mass-spectrometry-based gut metaproteomics. More specifically, it describes the promise metaproteomics holds in helping biomedical science understand the myriad of ways in which microbes and hosts communicate and the pathways involved. Moreover, it documents current computational and theoretical challenges that must be overcome in order for metaproteomics to develop into a readily useful technology. Chapter 2 describes the mass-spectrometry-based gut metaproteomics interrogation of a model of multiple sclerosis, experimental autoimmune encephalomyelitis. We focus specifically on the latent period prior to disease onset to show that metaproteomics can be used to distinguish pre- and post-immunization states. Furthermore, we show that a specific class of proteins are inversely correlated with disease severity. Lastly, we show that combining multi-omic strategies may be useful in elucidating connections between microbe and protein levels. Chapter 3 describes the invention of a novel stool proteomic pipeline development, the Stool High Throughput Proteomic Pipeline (SHT-PP). We show that compared to the previous pipeline, it can process samples at over 80% faster, leading to increased sample throughput and as a result, an increased ability to tackle larger sample sets from large longitudinal studies. When this was applied to such a data set, we revealed a subtle but distinct difference that correlated with increased ingestion of either fiber or fermented food diet augmentation. Data generated from these studies were successful in classifying diet participants based solely on a handful of host- or microbe generated proteins. This protocol may serve as a springboard that launches stool-based metaproteomics into a commonly used assay for both biological questions and diagnostic biomarker discovery. Chapters 4 describes one of my collaborative efforts with the Sonnenburg lab where we highlight the discovery of shifting seasonal microbial patterns in hunter-gatherer tribes (Hadza) in Africa. These patterns were largely driven by the alternating seasonal diets consumed by tribe members. We compared this population of subjects to those eating a more westernized diet and noted the absence of some of the more dynamically regulated in western diet subjects. Overall, these results shed light on the loss of microbial diversity resulting from western diets, as well as give us insight into more traditional patterns of microbiome seasonal changes.
Book Synopsis Of Mice and Humans by : Kristopher D. Parker
Download or read book Of Mice and Humans written by Kristopher D. Parker and published by . This book was released on 2018 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Murine models have become essential tools for understanding the complex interactions between gut microbes, their hosts, and disease. While many intra-facility factors are known to influence the structure of mouse microbiomes, the contribution of inter-facility variation to mouse microbiome composition remains under-investigated. We replicated microbiome experiments using identical mouse lines housed in two geographically separated animal facilities and report dramatic differences in composition of microbiomes based upon facility of origin. We observed facility-specific microbiome signatures in the context of a disease model (Ednrb) and in a widely used normal inbred mouse strain (C57BL/6J). Furthermore, we investigated the reproducibility of microbiome dysbiosis previously associated with Ednrb knock-out mice. While we detected genotype-based differences in composition between knock-out mice and wild-type littermates, the differences were not identical across facilities and were inconsistent with the previously published conclusions. Our findings raise the possibility that previously reported microbiome-disease associations from murine studies conducted in a single facility may be heavily influenced by facility-specific effects. These results provide a strong rationale for replication of murine microbiome studies in multiple animal facilities. The colonization of murine models with microbiota derived from human samples represents a powerful approach for mechanistic examinations into the potential causality of dysbiosis-disease associations. These ‘humanized’ murine models are traditionally generated by transferring foreign microbiota into germ-free recipient animals. Although this approach has become the ‘gold standard’ for causality-based investigations, the dependence on germ-free animals presents a variety of drawbacks that may limit their use or access in all research applications. Using conventionally raised C57BL/6J inbred mice housed in two geographically separated animal facilities, we investigated an alternative approach for creating humanized mouse lines. Mice were treated with broad-spectrum antibiotics to deplete resident microbial populations, followed by fecal microbiota transplantation of microbial communities from a distantly related mouse strain (FVB). Our analysis identified similar bacterial sequence variants between donor communities and communities in recipient mice treated with antibiotics. Consistent with the aforementioned findings, microbiome composition was facility-specific in baseline fecal samples. Interestingly, this facility-specific signature diminished following fecal transfer in antibiotic-treated mice, underscoring the potential value of applying this approach for standardizing murine microbiome experiments across animal facilities where technology, infrastructure, and operating procedures are highly variable. Overall, this pilot study provides a foundation to improve study design for the establishment of viable humanized models derived from conventionally raised inbred mouse strains. The developmental failure of neural-crest cells to migrate into the distal portion of the colon results in colorectal aganglionosis called Hirschsprung Disease (HSCR). Despite effective surgery that restores proper gut motility function, neonates with HSCR remain at high risk for developing a potentially life-threating enterocolitis, for which the etiology remains unknown. Several recent studies suggest potential involvement of gut microbiota in the underlying pathogenesis of Hirschsprung-associated enterocolitis (HAEC). We analyzed bacterial communities from fecal samples collected longitudinally for timepoints encompassing active HAEC and disease remission. We observed compositional differences between patients largely attributed to variability in patient age. This inter-patient variability was primarily observed in HAEC samples. In contrast, remission samples exhibited compositional similarity across patients. Our results suggest a potential role for remission-associated microbiota in protection from enterocolitis and more broadly provide continued support for the role of GI microbiota in the pathogenesis of HAEC.
Book Synopsis Using In Vitro Approaches to Study Relationships Between Key Members of the Murine Gut Microbiota by : Emma Brownlie
Download or read book Using In Vitro Approaches to Study Relationships Between Key Members of the Murine Gut Microbiota written by Emma Brownlie and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The gut microbiota comprises a diverse community of organisms that have co-evolved intricate relationships with each other, leading to its involvement in a number of key roles in the host. Investigating the interactions between microbes in this community is integral to understanding these complex microbial ecosystems and their effects on the host. Mice are one of the most commonly used animal models yet their gut microbiota remains relatively uncharacterized, complicating the interpretation of data. My research has leveraged in vitro techniques to explore the mouse gut microbiota. I have shown that, unlike human gut bacteria, diverse communities of mouse gut bacteria cannot be cultured despite testing a range of growth conditions. I have also identified and characterized both antagonistic and synergistic relationships between prevalent members of the mouse gut microbiota. These findings provide valuable insight into the mouse gut microbiota and the bacterial interactions that influence this microbial ecosystem.
Book Synopsis The Human Microbiota in Health and Disease by : Mike Wilson
Download or read book The Human Microbiota in Health and Disease written by Mike Wilson and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "A human being is a symbiotic system that consists of a mammalian component interacting with a multiplicity of microbes, collectively referred to as the microbiota. The microbiota associated with humans is comprised of a variety of communities, the composition of each being dependant on the particular body site it inhabits. This book describes the various communities inhabiting humans as well as their important roles in human health and disease. An ecological approach has been adopted throughout the book to explain why the microbial community at a particular body site has a particular composition when in balance with the host (eubiosis), and why certain factors can disrupt the balance and induce dysbiosis. The techniques used to determine microbial community composition are discussed and a chapter is devoted to the many factors that underlie this mammalian-microbe symbiosis. The Human Microbiome In Health And Disease is aimed at senior undergraduates and graduates whose courses include a module on the indigenous microbiota of humans. It will also be useful to professional scientists, clinicians, and others who are keen to know more about the human microbiota and its role in health and disease. "--Provided by publisher.
Book Synopsis The Microbiota in Gastrointestinal Pathophysiology by : Martin H. Floch
Download or read book The Microbiota in Gastrointestinal Pathophysiology written by Martin H. Floch and published by Academic Press. This book was released on 2016-11-16 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309450314 Total Pages :575 pages Book Rating :4.3/5 (94 download)
Book Synopsis Finding a Path to Safety in Food Allergy by : National Academies of Sciences, Engineering, and Medicine
Download or read book Finding a Path to Safety in Food Allergy written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-05-27 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.
