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Unified Hypothesis Testing Point Estimation And Interval Estimation For Group Sequential Trials
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Book Synopsis Unified Hypothesis Testing, Point Estimation and Interval Estimation for Group Sequential Trials by : Jason Daniel Grossman
Download or read book Unified Hypothesis Testing, Point Estimation and Interval Estimation for Group Sequential Trials written by Jason Daniel Grossman and published by . This book was released on 1992 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bayesian Biostatistics by : Donald A. Berry
Download or read book Bayesian Biostatistics written by Donald A. Berry and published by CRC Press. This book was released on 2018-10-03 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides descriptions, explanations and examples of the Bayesian approach to statistics, demonstrating the utility of Bayesian methods for analyzing real-world problems in the health sciences. The work considers the individual components of Bayesian analysis.;College or university bookstores may order five or more copies at a special student price, available on request from Marcel Dekker, Inc.
Book Synopsis Applied Sequential Methodologies by : Nitis Mukhopadhyay
Download or read book Applied Sequential Methodologies written by Nitis Mukhopadhyay and published by CRC Press. This book was released on 2004-01-28 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: A technically precise yet clear presentation of modern sequential methodologies having immediate applications to practical problems in the real world, Applied Sequential Methodologies communicates invaluable techniques for data mining, agricultural science, genetics, computer simulation, finance, clinical trials, sonar signal detection, randomizati
Book Synopsis An Analysis of an Approximate Sequential Procedure for Interval Estimation by : D. A. Walters
Download or read book An Analysis of an Approximate Sequential Procedure for Interval Estimation written by D. A. Walters and published by . This book was released on 1963 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents an approximate sequential method of interval estimation suitable for hypothesis testing in current research in artificial intelligence, a study of its properties, and a method of choosing parameter values to maximize its effectiveness. Relationships were found between the parameters of the procedure and its significant properties, including the probabilities of the two types of error and the expected number of samples required by the process. Several sets of parameters were chosen. (Author).
Book Synopsis Group Sequential Methods with Applications to Clinical Trials by : Christopher Jennison
Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
Book Synopsis Problems of Parameter Estimation Arising from Sequential Hypothesis Testing by : H. N. Hassan
Download or read book Problems of Parameter Estimation Arising from Sequential Hypothesis Testing written by H. N. Hassan and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Annual Review of Pubic Health by : Gilbert S. Omenn
Download or read book Annual Review of Pubic Health written by Gilbert S. Omenn and published by . This book was released on 1995-05 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Electronic Business Interoperability: Concepts, Opportunities and Challenges by : Kajan, Ejub
Download or read book Electronic Business Interoperability: Concepts, Opportunities and Challenges written by Kajan, Ejub and published by IGI Global. This book was released on 2011-03-31 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interoperability is a topic of considerable interest for business entities, as the exchange and use of data is important to their success and sustainability. Electronic Business Interoperability: Concepts, Opportunities and Challenges analyzes obstacles, provides critical assessment of existing approaches, and reviews recent research efforts to overcome interoperability problems in electronic business. It serves as a source of knowledge for researchers, educators, students, and industry practitioners to share and exchange their most current research findings, ideas, practices, challenges, and opportunities concerning electronic business interoperability.
Download or read book Annual Review of Public Health written by and published by . This book was released on 1995 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Group Sequential and Confirmatory Adaptive Designs in Clinical Trials by : Gernot Wassmer
Download or read book Group Sequential and Confirmatory Adaptive Designs in Clinical Trials written by Gernot Wassmer and published by Springer. This book was released on 2016-07-04 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application. The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.
Book Synopsis Practical Considerations for Adaptive Trial Design and Implementation by : Weili He
Download or read book Practical Considerations for Adaptive Trial Design and Implementation written by Weili He and published by Springer. This book was released on 2014-10-15 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
Book Synopsis Adaptive Design Methods in Clinical Trials by : Shein-Chung Chow
Download or read book Adaptive Design Methods in Clinical Trials written by Shein-Chung Chow and published by CRC Press. This book was released on 2011-12-01 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clini
Book Synopsis The Estimation and Evaluation of Optimal Thresholds for Two Sequential Testing Strategies by : Amber R. Wilk
Download or read book The Estimation and Evaluation of Optimal Thresholds for Two Sequential Testing Strategies written by Amber R. Wilk and published by . This book was released on 2013 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many continuous medical tests often rely on a threshold for diagnosis. There are two sequential testing strategies of interest: Believe the Positive (BP) and Believe the Negative (BN). BP classifies a patient positive if either the first test is greater than a threshold [theta]1 or negative on the first test and greater than [theta]2 on the second test. BN classifies a patient positive if the first test is greater than a threshold [theta]3 and greater than [theta]4 on the second test. Threshold pairs [theta] = ([theta]1, [theta]2) or ([theta]3, [theta]4), depending on strategy, are defined as optimal if they maximized GYI = Se + r(Sp - 1). Of interest is to determine if these optimal threshold, or optimal operating point (OOP), estimates are "good" when calculated from a sample. The methods proposed in this dissertation derive formulae to estimate [theta] assuming tests follow a binormal distribution, using the Newton-Raphson algorithm with ridging. A simulation study is performed assessing bias, root mean square error, percentage of over estimation of Se/Sp, and coverage of simultaneous confidence intervals and confidence regions for sets of population parameters and sample sizes. Additionally, OOPs are compared to the traditional empirical approach estimates. Bootstrapping is used to estimate the variance of each optimal threshold pair estimate. The study shows that parameters such as the area under the curve, ratio of standard deviations of disease classification groups within tests, correlation between tests within a disease classification, total sample size, and allocation of sample size to each disease classification group were all influential on OOP estimation. Additionally, the study shows that this method is an improvement over the empirical estimate. Equations for researchers to use in estimating total sample size and SCI width are also developed. Although the models did not produce high coefficients of determination, they are a good starting point for researchers when designing a study. A pancreatic cancer dataset is used to illustrate the OOP estimation methodology for sequential tests.
Book Synopsis Multiple Comparisons Using R by : Frank Bretz
Download or read book Multiple Comparisons Using R written by Frank Bretz and published by CRC Press. This book was released on 2016-04-19 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.
Book Synopsis Statistical Theory and Method Abstracts by :
Download or read book Statistical Theory and Method Abstracts written by and published by . This book was released on 1991 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Index to Statistics, Applications, Methods and Theory by :
Download or read book Current Index to Statistics, Applications, Methods and Theory written by and published by . This book was released on 1999 with total page 948 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Current Index to Statistics (CIS) is a bibliographic index of publications in statistics, probability, and related fields.
Book Synopsis Multiple Testing Problems in Pharmaceutical Statistics by : Alex Dmitrienko
Download or read book Multiple Testing Problems in Pharmaceutical Statistics written by Alex Dmitrienko and published by CRC Press. This book was released on 2009-12-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
