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Ultrahigh Speed Optical Coherence Tomography For Ophthalmic Imaging Applications
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Book Synopsis Ultrahigh Speed Optical Coherence Tomography for Ophthalmic Imaging Applications by : Jonathan Jaoshin Liu
Download or read book Ultrahigh Speed Optical Coherence Tomography for Ophthalmic Imaging Applications written by Jonathan Jaoshin Liu and published by . This book was released on 2014 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-contact, non-invasive, micron-scale optical imaging technology that has become a standard clinical tool in ophthalmology. Fourier domain OCT detection methods have enabled higher sensitivity and imaging speeds compared to previous generation timedomain OCT. Spectral / Fourier domain OCT (SD-OCT) detects the interference spectrum using a broadband light source and spectrometer. Swept-source / Fourier domain OCT (SS-OCT) detects the interference spectrum over time using a wavelength-swept laser. Current standard commercial ophthalmic clinical systems based on SD-OCT technology have imaging speeds of 20,000 - 40,000 axial scans per second and axial resolutions of 5 - 7 ptm. In this thesis, ultrahigh speed OCT for ophthalmic imaging applications are presented. SD-OCT systems using high speed CMOS camera technology can achieve imaging speeds over 70,000 axial scans per second. Axial resolutions better than 3 ptm can be achieved with multiplexed broadband superluminescent diodes. A novel registration motion-correction algorithm for volumetric OCT datasets reducing motion artifacts and improving signal quality is investigated. Ultrahigh speed, ultrahigh resolution SD-OCT ophthalmic imaging applications including small animal retinal imaging and clinical imaging of age-related macular degeneration (AMD) are illustrated. SS-OCT systems using short cavity wavelength-swept laser light sources can achieve imaging speeds over 100,000 axial scans per second with 6 pm axial resolution for small animal and clinical imaging. The high sensitivity of SS-OCT enables enhanced vitreous imaging, visualizing features in the vitreous and vitreoretinal interface. Finally, a new vertical cavity surface-emitting (VCSEL) technology based wavelength-swept laser light source SS-OCT system with tunable speed and wavelength range as well as long coherence length enabling ultrahigh speed and ultralong range OCT imaging applications is demonstrated. In addition to comprehensive structural imaging, the emergence of functional OCT imaging of retinal blood flow using ultrahigh speed OCT may also improve the understanding of ocular disease pathogenesis. Therefore, ultrahigh speed OCT is a promising tool for the diagnosis and management of diseases in ophthalmology.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis Medical Imaging Systems by : Andreas Maier
Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Advanced Functional and Intraoperative Ophthalmic Optical Coherence Tomography Imaging by : Chen David Lu
Download or read book Advanced Functional and Intraoperative Ophthalmic Optical Coherence Tomography Imaging written by Chen David Lu and published by . This book was released on 2018 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-contact, non-invasive imaging technique that uses optical interferometry to generate high-resolution, depth-resolved images of tissue in vivo. Ophthalmologists now use commercial OCT systems as a standard diagnostic instrument for imaging the retina to detect or monitor pathologies. However, prototype OCT research instruments exceed commercial systems in terms of faster imaging speeds and higher resolutions. Finding applications for these improvements will improve clinical utility for future OCT systems. This thesis describes the design and use of an ultrahigh resolution spectral domain OCT system for detecting the photoreceptor changes during flash stimulus and an ultrahigh resolution swept source OCT system for use in eye surgery. The ultrahigh axial resolution of our system enabled visualization of thickness changes in the outer retinal layers after flash stimulus and subsequent dark adaptation. This finding could be used as a marker for photoreceptor health in retinal diseases that influence dark adaptation such as age-related macular degeneration. In the operating room, the ultrahigh speed system attaches to the operating microscope to share the surgeon's view and provide depth-resolved information that is not possible with the standard surgeon's stereoscopic view. This allows for imaging during surgical procedures and the ultrahigh speed enables acquisition of dense, widefield data sets as well as rapid volume acquisition to generate 3D visualizations in time. These data sets will enable 3D planning of procedures, assessment of outcomes before leaving the operating room, and feedback for surgical procedures.
Book Synopsis Selected Topics in Optical Coherence Tomography by : Gangjun Liu
Download or read book Selected Topics in Optical Coherence Tomography written by Gangjun Liu and published by BoD – Books on Demand. This book was released on 2012-02-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.
Book Synopsis Retinal Optical Coherence Tomography Image Analysis by : Xinjian Chen
Download or read book Retinal Optical Coherence Tomography Image Analysis written by Xinjian Chen and published by Springer. This book was released on 2019-07-05 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.
Book Synopsis Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography by : Woo Jhon Choi
Download or read book Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography written by Woo Jhon Choi and published by . This book was released on 2014 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current state-of-the-art spectral domain and swept source OCT provide ultrahigh imaging speeds of >200kHz A-scan rates. These speeds enable functional imaging of retinal blood flow, OCT angiography of the retinal and choroidal microvasculature, and wide field volumetric structural imaging of the retina and choroid. In this thesis, advances in structural and functional ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh speed spectral domain imaging in the small animal eye for measuring total retinal blood flow, (3) development of ultrahigh speed phase stable swept source OCT system for human retinal imaging, (4) OCT angiography of the choriocapillaris in the human eye, (5) clinical applications of OCT angiography in retinal diseases, including diabetic retinopathy and age-related macular degeneration, (6) small animal anesthesia protocol for functional hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
Book Synopsis Optical Coherence Tomography Angiography of the Eye by : David Huang
Download or read book Optical Coherence Tomography Angiography of the Eye written by David Huang and published by CRC Press. This book was released on 2024-06-01 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) angiography is an important new imaging modality that is already being used by ophthalmologists in retina centers worldwide. It uses motion as intrinsic contrast, thus obviating the need to inject any intravenous dye. It uses infrared light that is invisible to the patient, and only requires few seconds per scan. This makes it both easier to use and much better tolerated by patients than traditional dye-based fluorescein angiography (FA) and indocyanine green (ICG) angiography. Inside Optical Coherence Tomography Angiography of the Eye Drs. David Huang, Bruno Lumbroso, Yali Jia, and Nadia Waheed include detailed information on clinical applications and fundamental principles needed to understand and use this new technology. This includes information on high-speed OCT systems, algorithms to extract flow contrast, the appearance of the normal eye, the findings in myriad diseases, and tips on how to deal with artifact and pitfalls. The 3-dimensional nature of OCT angiography provides visualization that was not possible before with either FA or ICG and readers will come to appreciate how this enables the visualization of previously difficult to image vascular beds such as the 4 retinal vascular plexuses (radial peripapillary, superficial, intermediate, and deep), the choriocapillaris, and the deeper choroidal vessels. Given its noninvasive nature and ease of use, OCT angiography imaging is rapidly taking an important place in everyday ophthalmology and may soon replace fluorescein angiography in everyday practice. Optical Coherence Tomography Angiography of the Eye is designed to be the definitive text on this cutting-edge technology for the retina specialist and comprehensive ophthalmologist.
Book Synopsis Anterior Segment Optical Coherence Tomography by : Roger Steinert
Download or read book Anterior Segment Optical Coherence Tomography written by Roger Steinert and published by CRC Press. This book was released on 2024-06-01 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-speed anterior segment optical coherence tomography (OCT) offers a non-contact method for high resolution cross-sectional and three-dimensional imaging of the cornea and the anterior segment of the eye. As the first text completely devoted to this topic, Anterior Segment Optical Coherence Tomography comprehensively explains both the scientific principles and the clinical applications of this exciting and advancing technology. Anterior Segment Optical Coherence Tomography enhances surgical planning and postoperative care for a variety of anterior segment applications by expertly explaining how abnormalities in the anterior chamber angle, cornea, iris, and lens can be identified and evaluated using the Visante OCTTM. Inside Anterior Segment Optical Coherence Tomography, Dr. Roger Steinert and Dr. David Huang, along with 22 of the field's leading professionals, provide a wealth of useful clinical and physiological material about this new diagnostic imaging technique. Valuable images are included to assist in the pre- and postoperative assessment of various anterior segment disorders. Additionally, this unique resource contains detailed information on biometric measurements to enhance diagnostic capability. On the leading edge of anterior segment imaging: Mapping of corneal thickness and keratoconus evaluation Measurement of LASIK flap and stromal bed thickness Visualization and measurement of anterior chamber angle and diagnosis of narrow angle glaucoma Measuring the dimensions of the anterior chamber and assessing the fit of intraocular lens implants Visualizing and measuring the results of corneal implants and lamellar procedures Imaging through corneal opacity to see internal eye structures With the increase in popularity of anterior chamber imaging, and anterior segment OCT proving to be the best tool for high resolution biometry, Anterior Segment Optical Coherence Tomography is a must-have for anterior segment, refractive, cornea, and glaucoma surgeons.
Book Synopsis Optical Coherence Tomography by : Rui Bernardes
Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.
Book Synopsis Ophthalmic Imaging Applications with Optical Coherence Tomography and Graphics Processing Units by : Kevin Siu Kwun Wong
Download or read book Ophthalmic Imaging Applications with Optical Coherence Tomography and Graphics Processing Units written by Kevin Siu Kwun Wong and published by . This book was released on 2014 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: In ophthalmology, Optical Coherence Tomography (OCT) is becoming one of the dominant imaging technologies for both clinical diagnostics and vision research. In a previous bachelor's thesis prior to this project, we described a highly optimized Graphics Processing Unit (GPU) implementation of the Fourier Domain (FD)OCT processing and visualization pipeline that was capable of real-time volume rendering at video rate.In this thesis, we describe three applications that build upon the GPU-based processing software: Speckle Variance (sv)OCT, Compressive Sample (CS)OCT, and Wavefront Sensorless Adaptive Optics (WSAO)OCT. We first demonstrate that svOCT can be a powerful fundus imaging technique for visualizing the retinal vasculature network, which may be comparable to the gold-standard technique called Fluorescein Angiography (FA). The strongest attribute of svOCT is that it bypasses the use of intravenous fluorescein for vascular contrast enhancement, and can be highly suitable for longitudinal monitoring of patients with vasculature-related pathologies in the retina. In our second application, we present a GPU-accelerated CS-OCT processing pipeline. The principle behind CS-OCT is to take advantage of the redundancy in biological structures, such as the retina, for reconstructing volumes acquired at a sampling density below the Nyquist criterion; the purpose is to justify decreasing volume acquisition time by significantly subsampling the datasets. In our final application, we present a WSAO-OCT system as a novel technique for cellular resolution imaging of the human photoreceptor layer. This technique leverages on the ultrahigh speed processing rates in our GPU-based processing software in order to produce a real-time intensity-based merit function for en face image quality optimization.
Book Synopsis Imaging the Eye from Front to Back with RTVue Fourier-domain Optical Coherence Tomography by : David Huang
Download or read book Imaging the Eye from Front to Back with RTVue Fourier-domain Optical Coherence Tomography written by David Huang and published by SLACK Incorporated. This book was released on 2010 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fourier-Domain optical coherence tomography (OCT) is the latest technology available to provide high-speed, high-resolution imaging of the cornea, anterior chamber angle, macula, and optic nerve head. It is uniquely suited for ophthalmologists that treat diseases from the front to the back of the eye. Inside Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography, Drs. David Huang, Jay S. Duker, James G. Fujimoto, Bruno Lumbroso, Joel S. Schuman, and Robert N. Weinreb cover up-to-date OCT technology and diagnostic software of the RTVue. It is the first book that covers clinical applications from the front to the back of the eye, as opposed to concentrating either on posterior segment imaging or anterior segment imaging. Inside you'll find: * Explanation of Fourier-Domain OCT technology * Teaching of scan pattern selection * Step-by-step instruction for scan acquisition * Teaching of the interpretations of OCT images and measurements by many case examples * Interpretation of en face images Some chapters covered: * Anterior segment * Cornea * Posterior segment * Retina * Age-related macular degeneration * Diabetic retinopathy * Glaucoma Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography is the must-have book for general ophthalmologists, glaucoma specialists, retina specialists, cornea specialists, and refractive surgeons, as well as biomedical engineers.
Book Synopsis Optical Coherence Tomography Angiography of the Eye by : David Huang
Download or read book Optical Coherence Tomography Angiography of the Eye written by David Huang and published by Kugler Publications. This book was released on 2024-01-08 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography angiography (OCTA) has undergone tremendous growth since its first commercial introduction in 2014. Because it provides injection-free, capillary-resolution, 3-dimensional angiography of the retina and choroid, OCTA is likely to overtake fluorescein as the most important angiographic imaging technique in the eye. Nearly all manufacturers of ophthalmic OCT now offer OCTA products. A PubMed search now yields over 5700 articles on OCTA and related terms. Clinical investigators have already found a use for OCTA in almost every category of retinal and optic nerve diseases. This book is meant to bring together all this information so clinicians can have one authoritative text to turn to as we begin to use this new imaging modality that was never taught when we were in formal training. Table of contents Introduction Dedication About the Editors Contributors 1. Optical coherence tomography systems for angiography 2. Optical coherence tomographic angiography algorithms 3. Vascular anatomy of the normal retina and choroid 4. OCTA of the normal anterior eye circulations 5. Artifacts 6. Quantification 7. Artificial intelligence in optical coherence tomographic angiography 8. Terminology: a new standard 9. AngioVue SSADA OCTA on the Optovue SOLIX Spectral-Domain OCT 10. Optical microangiography with AngioPlex® and PLEX® Elite systems 11. Optical coherence tomography angiography imaging on the Topcon Triton and Maestro2 systems 12. NIDEK Mirante OCT angiography 13. OCTA on the Heidelberg spectralis spectral-domain OCT 14. OCTA on the Optopol REVO NX spectral-domain OCT 15. OCTA on the Canon OCT-HS100 and Xephilio OCT-A1 Spectral-Domain OCT 16. Exudative neovascular age-related macular degeneration—Type 1, 2 and 3 neovascularization 17. Retinal angiomatous proliferation—type 3 choroidal neovascularization 18. Short- and long-term follow-up of macular neovascularization response to antiangiogenic treatment 19. Nonexudative neovascular age-related macular degeneration 20. Non-neovascular age-related macular degeneration 21. Polypoidal choroidal vasculopathy 22. Macular telangiectasia 23. Central serous chorioretinopathy 25. Nonproliferative diabetic retinopathy 26. Subclinical neovascular diabetic retinopathy 27. Proliferative diabetic retinopathy 28. Retinal venous occlusion 29. Retinal arterial occlusion 30. Plexus-specific occlusions in retinal vascular diseases 31. Paracentral acute middle maculopathy 32. Inherited retinal degenerations 33. Pathologic myopia 34. Multimodal imaging and the role of optical coherence tomography angiography in retinal vasculitis 35. White spot syndromes 36. Choroidal tumors 37. Radiation retinopathy 38. Open-angle glaucoma 39. Primary angle-closure glaucoma 40. Optic neuritis and multiple sclerosis 41. Alzheimer’s disease 42. Corneal neovascularization 43. Ocular surface and iris tumors
Book Synopsis Clinical Applications of Optical Coherence Tomography Angiography by : Francesco Bandello
Download or read book Clinical Applications of Optical Coherence Tomography Angiography written by Francesco Bandello and published by S. Karger AG (Switzerland). This book was released on 2020 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often introduced as a routine exam in clinical practice, granting the opportunity to non-invasively investigate retinal and choroidal circulation. In this book, many major experts in posterior eye imaging share their experiences and their latest images and ideas about OCTA"--
Book Synopsis Optical Coherence Tomography in Glaucoma by : Ahmet Akman
Download or read book Optical Coherence Tomography in Glaucoma written by Ahmet Akman and published by Springer. This book was released on 2018-09-17 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the practical aspects of Optical Coherence Tomography (OCT) in glaucoma diagnostics offering important theoretical information along with many original cases. OCT is a non-invasive imaging technique that acquires high-resolution images of the ocular structures. It enables clinicians to detect glaucoma in the early stages and efficiently monitor the disease. Optical Coherence Tomography in Glaucoma features updated information on technical applications of OCT in glaucoma, reviews recently published literature and provides clinical cases based on Cirrus and Spectralis OCT platforms. In addition, newer techniques like event and trend analyses for progression, macular ganglion cell analysis, and OCT angiography are discussed. This book will serve as a reference for ophthalmologists and optometrists worldwide with a special interest in OCT imaging providing essential guidance on the application of OCT in glaucoma.
Book Synopsis Clinical OCT Angiography Atlas by : Marco Rispoli
Download or read book Clinical OCT Angiography Atlas written by Marco Rispoli and published by Jaypee Brothers Medical Publishers. This book was released on 2021-11-30 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography angiography (OCTA) is a non-invasive technique for imaging the microvasculature of the retina and the choroid. The advent of OCTA has allowed ophthalmologists to identify new pathologies, recognise new syndromes, and organise disorders with new classifications. This atlas provides clinicians with state-of-the-art principles of clinical OCTA imaging, helping them interpret and understand the features of the angiographic images. Following the success of the first edition (9789351528999) published in 2015, this second edition has been fully revised, with all chapters rewritten and new topics added to provide the very latest advances in the field. New knowledge about existing diseases and new disorders are described in depth, and operating principles, clinical applications, and future developments are explained thoroughly by the pioneers of the technology. The first part of the atlas covers the basic principles of OCT angiography, methods and technology, image interpretation, vascular anatomy of the retina, and clinical applications. Part two provides a general update on current research into OCT angiography in various retinal, choroid and anterior chamber disorders. The third and final part of the book describes future clinical applications and implications of next generation devices. This new edition is an invaluable guide for ophthalmologists and trainees for use in everyday practice.
